LOCUS       NM_001130918            3573 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase like 6 (TTLL6), transcript
            variant 1, mRNA.
ACCESSION   NM_001130918
VERSION     NM_001130918.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Zhong,Y., Yan,W., Ruan,J., Fang,M., Yu,C., Du,S., Rai,G., Tao,D.,
            Henderson,M.J. and Fang,S.
  TITLE     XBP1 variant 1 promotes mitosis of cancer cells involving
            upregulation of the polyglutamylase TTLL6
  JOURNAL   Hum Mol Genet 31 (15), 2639-2654 (2022)
   PUBMED   35333353
  REMARK    GeneRIF: XBP1 variant 1 promotes mitosis of cancer cells involving
            upregulation of the polyglutamylase TTLL6.
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Ruderfer,D.M., Fanous,A.H., Ripke,S., McQuillin,A., Amdur,R.L.,
            Gejman,P.V., O'Donovan,M.C., Andreassen,O.A., Djurovic,S.,
            Hultman,C.M., Kelsoe,J.R., Jamain,S., Landen,M., Leboyer,M.,
            Nimgaonkar,V., Nurnberger,J., Smoller,J.W., Craddock,N., Corvin,A.,
            Sullivan,P.F., Holmans,P., Sklar,P. and Kendler,K.S.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Bipolar Disorder Working Group of the Psychiatric Genomics
            Consortium; Cross-Disorder Working Group of the Psychiatric
            Genomics Consortium
  TITLE     Polygenic dissection of diagnosis and clinical dimensions of
            bipolar disorder and schizophrenia
  JOURNAL   Mol Psychiatry 19 (9), 1017-1024 (2014)
   PUBMED   24280982
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Lee,J.E., Silhavy,J.L., Zaki,M.S., Schroth,J., Bielas,S.L.,
            Marsh,S.E., Olvera,J., Brancati,F., Iannicelli,M., Ikegami,K.,
            Schlossman,A.M., Merriman,B., Attie-Bitach,T., Logan,C.V.,
            Glass,I.A., Cluckey,A., Louie,C.M., Lee,J.H., Raynes,H.R.,
            Rapin,I., Castroviejo,I.P., Setou,M., Barbot,C., Boltshauser,E.,
            Nelson,S.F., Hildebrandt,F., Johnson,C.A., Doherty,D.A.,
            Valente,E.M. and Gleeson,J.G.
  TITLE     CEP41 is mutated in Joubert syndrome and is required for tubulin
            glutamylation at the cilium
  JOURNAL   Nat Genet 44 (2), 193-199 (2012)
   PUBMED   22246503
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Chen,X.H., Shi,H., Liu,X.L. and Su,B.
  TITLE     The testis-specific apoptosis related gene TTL.6 underwent adaptive
            evolution in the lineage leading to humans
  JOURNAL   Gene 370, 58-63 (2006)
   PUBMED   16443334
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068531.9 and AK302952.1.
            
            On Jul 12, 2019 this sequence version replaced NM_001130918.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence data to make the sequence
            consistent with the reference genome assembly. The extent of this
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302952.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393382.8/ ENSP00000377043.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC068531.9         112282-112457       c
            177-2990            AK302952.1         1-2814
            2991-3573           AC068531.9         57462-58044         c
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..3573
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /note="tubulin tyrosine ligase like 6"
                     /db_xref="GeneID:284076"
                     /db_xref="HGNC:HGNC:26664"
                     /db_xref="MIM:610849"
     exon            1..260
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2833
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubulin polyglutamylase TTLL6; tubulin--tyrosine
                     ligase-like protein 6; tubulin tyrosine ligase-like family
                     member 6; protein polyglutamylase TTLL6"
                     /codon_start=1
                     /product="tubulin polyglutamylase TTLL6 isoform 1"
                     /protein_id="NP_001124390.1"
                     /db_xref="CCDS:CCDS45724.1"
                     /db_xref="GeneID:284076"
                     /db_xref="HGNC:HGNC:26664"
                     /db_xref="MIM:610849"
                     /translation="MGALLLHPSRRGPAGVVASWTSSPAGRDGGVGIAGAWYFPRASS
                     QAREMPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKK
                     KRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQ
                     KINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNK
                     TYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSC
                     DPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRK
                     LSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEIL
                     GFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEE
                     ERQRGQFLQQCCSREMRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKF
                     FQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKG
                     MRGWQQKQQQKDKAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTE
                     EASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHL
                     TSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKM
                     LKSFLPTKSKSFWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLG
                     MNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDP
                     RPCRSHASAMRDPCMQDQEAYSHCLISGQKGCERS"
     exon            261..480
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            481..518
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            519..637
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            638..768
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            769..925
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1069
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1155
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1381
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1557
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1746
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1918
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2197
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2567
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2833
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3573
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3545..3550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /note="hexamer: AATAAA"
     polyA_site      3573
                     /gene="TTLL6"
                     /gene_synonym="TTL.6"
                     /note="major polyA site"
ORIGIN      
        1 agcgcctggg cggttaattg gattcgggag ggagggggca tggcagctac tgcaggggcc
       61 aatcgaaggc ctagaaggcc ccgtatgcaa atatgagggc cgggcggacc caaagttagg
      121 gcgagcgcgg gttggggttg gggctgtctg gcagccaatg ggagcgttac tccttcatcc
      181 ttcgaggagg gggccggcag gtgtggttgc aagctggact agcagcccag cggggcgaga
      241 cgggggagta ggaattgcgg gggcctggta tttccccaga gcctcctccc aggccaggga
      301 gatgccacag tgcccgactt tggaaagcca ggaaggggaa aactccgaag agaaggggga
      361 cagttccaaa gaagatccaa aagaaaccgt cgcgctggct tttgtgagag agaacccagg
      421 ggcacaaaac ggacttcaga atgcccagca gcaaggcaag aagaagagga agaaaaagag
      481 attggtgatc aatctatcca gctgccggta tgagagtgtg cgcagggctg cccaacagta
      541 cggctttaga gagggagggg aagacgatga ctggactctc tattggacag attactcagt
      601 gtcactggag cgggtgatgg aaatgaaaag ttaccagaag atcaatcact tccccgggat
      661 gagtgaaatc tgccggaagg acttgctggc caggaacatg agccgcatgt taaagatgtt
      721 ccctaaagat ttccgctttt tccctaggac ctggtgtctt cctgctgact ggggagattt
      781 gcagacctac agcaggtcaa gaaaaaataa gacatacatt tgtaagccgg attcgggctg
      841 ccaagggaaa ggtatattca tcacccggac agtgaaagaa atcaaaccag gggaggatat
      901 gatctgtcag ctgtatattt caaagccctt tatcattgat gggtttaagt ttgacctacg
      961 gatttatgta ctggtgacat cctgtgaccc tctcaggatt tttgtgtaca atgaaggact
     1021 ggcccgcttt gcgacgacct cttactcccg cccttgcaca gacaacctgg atgatatctg
     1081 catgcacctg actaattatt ccattaataa gcacagttca aatttcagtc gagatgcaca
     1141 ctctggcagt aagaggaagc tctccacctt cagtgcatac ttggaggacc acagctacaa
     1201 cgtggagcag atatggaggg atattgagga cgtcatcatc aagaccctca tctcggccca
     1261 ccccatcatc aggcataact accacacctg cttccccaac cacacactca acagcgcctg
     1321 ctttgagatc ctgggctttg acattttgtt ggaccacaaa ctcaaaccct ggctgctgga
     1381 ggtcaaccac tctccaagct tctccaccga ctctcggttg gataaagagg tgaaagatgg
     1441 tctgctgtat gacaccttag tcctgatcaa cctggaaagc tgtgacaaga agaaagtctt
     1501 ggaggaggag agacaacggg ggcagttcct gcagcagtgt tgttctcggg agatgaggat
     1561 tgaggaagcc aagggtttcc gggccgtgca gttaaagaaa actgaaacgt atgagaagga
     1621 aaactgtgga gggttccgac tgatttatcc cagtctgaat tcggagaagt atgagaagtt
     1681 tttccaggac aacaactccc tcttccagaa tactgttgct tccagggctc gggaggagta
     1741 tgcccggcaa ctgatccagg agctgagact aaaacgggag aaaaagccct tccaaatgaa
     1801 gaagaaggta gagatgcagg gggaatcggc aggcgagcaa gtgagaaaga agggcatgag
     1861 gggctggcaa cagaaacaac agcagaaaga caaggccgcc acccaagcct ccaaacagta
     1921 catccagcca ttgacattag tatcctacac acctgacttg ctcttgagtg tcagaggtga
     1981 aaggaaaaat gaaacagaca gcagcctcaa ccaggaggct cccacggagg aggccagctc
     2041 tgttttcccc aagctgacgt ctgcgaagcc cttcagttct ctacccgatc tgaggaatat
     2101 caatctcagc agctcgaagt tggagcccag taaacccaac ttcagcatca aggaggccaa
     2161 gtctgcctct gcagtgaacg tattcactgg cactgtgcac ttaacctccg tagaaaccac
     2221 cccagaatcc accacccaac tctcaatctc cccaaagtct ccgccaaccc tggctgtgac
     2281 cgccagctct gagtacagtg gcccagagac ggacagggtg gtatccttta aatgcaagaa
     2341 gcagcagacc cctccacact taacccagaa gaaaatgtta aaatcttttc tgcccacaaa
     2401 atccaagagc ttctgggaga gtccgaacac aaactggact ttgctaaaga gtgacatgaa
     2461 caagccacat ttgatatccg agctactcac caagcttcaa ctgagtggga agctctcctt
     2521 cttcccagct cactacaacc ccaagctggg gatgaataac ctgtcacaaa acccctccct
     2581 gcctggggag tgccactccc gcagtgacag ctctggcgag aagaggcagc tggatgtgtc
     2641 ctccctcctc ttgcagagtc ctcagagcta taatgttact ctgagggacc tgctggtgat
     2701 tgccactcca gcccaactgg atccaaggcc ttgtagaagc cacgcaagtg ctatgaggga
     2761 cccatgtatg caggatcaag aagcatacag ccattgcctg atctctggcc aaaaaggatg
     2821 tgagaggagc tagaatcaga ctggatctct gccacttttc ccttcctacc tcttaacttg
     2881 caggaaacaa tgtgtctctt ccgacagtgt ctccagtgtt cacagaatca actgaagttt
     2941 tgtttgctca tctagatata ctggtcttcc attagttcct agtagcagca atggggccaa
     3001 cagccctgcc tctgttccct cccagttagc ttacagtgct acaggaccat gatttctggg
     3061 gttggattgg tgctgcccca ggacacactc cagttgccgt accagtggca cttctctggg
     3121 ttcttcacat ggcaccatca tccagaatac tcccccagat aaagcaactt cgggagtagt
     3181 gtttcagaga aggactcatg atttccagga gtcaaaagcc ctcagtccac caacagaact
     3241 atgccagttg gtcttcgtct ccaagataaa agatgaggtc agggatgggc atggtgcata
     3301 actctgagcc ctgagtgaga gaactgaggc agctgcaact tcacaaggtc aaggcccgac
     3361 ctccgcccat ccccaccagc ccaaagactt gccacctcag tgcccgagca tcctctggtg
     3421 acctccctca ccagcccaac ttaatctcac cagtgaaaac agaggtgagg cgagagtacc
     3481 cagcctgaag atgcttcttc tatcagcctg cagaaatgtt acactttccc ttcaggcatc
     3541 cattaataaa agaaattgcc atgcttactg cca
//
