LOCUS       NM_015072               4716 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase like 5 (TTLL5), mRNA.
ACCESSION   NM_015072 XM_495998
VERSION     NM_015072.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4716)
  AUTHORS   Kolawole,O.U., Gregory-Evans,C.Y., Bikoo,R., Huang,A.Z. and
            Gregory-Evans,K.
  TITLE     Novel pathogenic variants in Tubulin Tyrosine Like 5 (TTLL5)
            associated with cone-dominant retinal dystrophies and an abnormal
            optical coherence tomography phenotype
  JOURNAL   Mol Vis 29, 329-337 (2023)
   PUBMED   38264610
  REMARK    GeneRIF: Novel pathogenic variants in Tubulin Tyrosine Like 5
            (TTLL5) associated with cone-dominant retinal dystrophies and an
            abnormal optical coherence tomography phenotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4716)
  AUTHORS   Cehajic-Kapetanovic,J., Martinez-Fernandez de la Camara,C.,
            Birtel,J., Rehman,S., McClements,M.E., Charbel Issa,P., Lotery,A.J.
            and MacLaren,R.E.
  TITLE     Impaired glutamylation of RPGRORF15 underlies the cone-dominated
            phenotype associated with truncating distal ORF15 variants
  JOURNAL   Proc Natl Acad Sci U S A 119 (49), e2208707119 (2022)
   PUBMED   36445968
  REMARK    GeneRIF: Impaired glutamylation of RPGR[ORF15] underlies the
            cone-dominated phenotype associated with truncating distal ORF15
            variants.
REFERENCE   3  (bases 1 to 4716)
  AUTHORS   Oh,J.K., Vargas Del Valle,J.G., Lima de Carvalho,J.R. Jr.,
            Sun,Y.J., Levi,S.R., Ryu,J., Yang,J., Nagasaki,T., Emanuelli,A.,
            Rasool,N., Allikmets,R., Sparrow,J.R., Izquierdo,N.J., Duncan,J.L.,
            Mahajan,V.B. and Tsang,S.H.
  TITLE     Expanding the phenotype of TTLL5-associated retinal dystrophy: a
            case series
  JOURNAL   Orphanet J Rare Dis 17 (1), 146 (2022)
   PUBMED   35365235
  REMARK    GeneRIF: Expanding the phenotype of TTLL5-associated retinal
            dystrophy: a case series.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4716)
  AUTHORS   Smirnov,V., Grunewald,O., Muller,J., Zeitz,C., Obermaier,C.D.,
            Devos,A., Pelletier,V., Bocquet,B., Andrieu,C., Bacquet,J.L.,
            Lebredonchel,E., Mohand-Said,S., Defoort-Dhellemmes,S., Sahel,J.A.,
            Dollfus,H., Zanlonghi,X., Audo,I., Meunier,I., Boulanger-Scemama,E.
            and Dhaenens,C.M.
  TITLE     Novel TTLL5 Variants Associated with Cone-Rod Dystrophy and
            Early-Onset Severe Retinal Dystrophy
  JOURNAL   Int J Mol Sci 22 (12), 6410 (2021)
   PUBMED   34203883
  REMARK    GeneRIF: Novel TTLL5 Variants Associated with Cone-Rod Dystrophy
            and Early-Onset Severe Retinal Dystrophy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4716)
  AUTHORS   Bompard,G., van Dijk,J., Cau,J., Lannay,Y., Marcellin,G.,
            Lawera,A., van der Laan,S. and Rogowski,K.
  TITLE     CSAP Acts as a Regulator of TTLL-Mediated Microtubule Glutamylation
  JOURNAL   Cell Rep 25 (10), 2866-2877 (2018)
   PUBMED   30517872
  REMARK    GeneRIF: Binding of CSAP to TTLL5 promotes relocalization of TTLL5
            toward microtubules.
REFERENCE   6  (bases 1 to 4716)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4716)
  AUTHORS   He,Y., Blackford,J.A. Jr., Kohn,E.C. and Simons,S.S. Jr.
  TITLE     STAMP alters the growth of transformed and ovarian cancer cells
  JOURNAL   BMC Cancer 10, 128 (2010)
   PUBMED   20374646
  REMARK    GeneRIF: This study indicates that a physiological function of
            STAMP in several settings is to modify cell growth rates in a
            manner that can be independent of steroid hormones.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4716)
  AUTHORS   van Dijk,J., Miro,J., Strub,J.M., Lacroix,B., van Dorsselaer,A.,
            Edde,B. and Janke,C.
  TITLE     Polyglutamylation is a post-translational modification with a broad
            range of substrates
  JOURNAL   J Biol Chem 283 (7), 3915-3922 (2008)
   PUBMED   18045879
REFERENCE   9  (bases 1 to 4716)
  AUTHORS   He,Y. and Simons,S.S. Jr.
  TITLE     STAMP, a novel predicted factor assisting TIF2 actions in
            glucocorticoid receptor-mediated induction and repression
  JOURNAL   Mol Cell Biol 27 (4), 1467-1485 (2007)
   PUBMED   17116691
  REMARK    GeneRIF: STAMP is an important new, downstream component of GR
            action in both gene activation and gene repression.
REFERENCE   10 (bases 1 to 4716)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA195275.1, BC136472.1,
            AY237126.1 and GD137472.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015072.4.
            
            Summary: This gene encodes a member of the tubulin tyrosine ligase
            like protein family. This protein interacts with two glucocorticoid
            receptor coactivators, transcriptional intermediary factor 2 and
            steroid receptor coactivator 1. This protein may function as a
            coregulator of glucocorticoid receptor mediated gene induction and
            repression. This protein may also function as an alpha tubulin
            polyglutamylase.[provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.61814.1, AY237126.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298832.14/ ENSP00000298832.9
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                DA195275.1         39-110
            73-4185             BC136472.1         1-4113
            4186-4715           AY237126.1         4154-4683
            4716-4716           GD137472.1         70-70
FEATURES             Location/Qualifiers
     source          1..4716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..4716
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /note="tubulin tyrosine ligase like 5"
                     /db_xref="GeneID:23093"
                     /db_xref="HGNC:HGNC:19963"
                     /db_xref="MIM:612268"
     exon            1..142
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            143..311
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..4083
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /note="SRC1 and TIF2 associated binding protein; SRC1 and
                     TIF2-associated modulatory protein; tubulin tyrosine
                     ligase-like family, member 5"
                     /codon_start=1
                     /product="tubulin polyglutamylase TTLL5"
                     /protein_id="NP_055887.3"
                     /db_xref="CCDS:CCDS32124.1"
                     /db_xref="GeneID:23093"
                     /db_xref="HGNC:HGNC:19963"
                     /db_xref="MIM:612268"
                     /translation="MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVF
                     HADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTG
                     SHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLP
                     AEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLID
                     DFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNYSVNKKS
                     GDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIAT
                     ACKTFVPHRSSCFELYGFDVLIDSTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMF
                     TVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKG
                     PGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYM
                     LATRLFQDRMTADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRP
                     KYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTA
                     LVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSA
                     YLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLA
                     LLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEA
                     ELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQ
                     QTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHLSSVTTSDLSPGPCH
                     HSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGP
                     FSSFQSAAHIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVT
                     AELQRLAEKQAARQYSPSSHINLLTQQVTNLNLATGIINRSSASAPPTLRPIISPSGP
                     TWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSY
                     QLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATAS
                     GQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASKGSSAEGQLNGLQSSL
                     NPAAFVPITSSTDPAHTKI"
     exon            312..418
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            419..501
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            502..608
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            609..739
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            740..822
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            823..892
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            893..977
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1079
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1171
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1279
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1361
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1423
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1518
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1632
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1724
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1787
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1945
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2252
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2373
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2520
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2624
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2752
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2839
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3223
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3408
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3563
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3759
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3977
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..4060
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4716
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4439..4444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /note="hexamer: TATAAA"
     polyA_site      4466
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
     regulatory      4696..4701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /note="hexamer: AATAAA"
     polyA_site      4716
                     /gene="TTLL5"
                     /gene_synonym="CORD19; KIAA0998; STAMP"
                     /note="major polyA site"
ORIGIN      
        1 gggcggttgc ttgttggttg ttgtagtaac cggggaagca gccgtcggcg gctgccctga
       61 gccttcctgg ggaaggagga gggaggtagg cgcagagcgc ggtccacgcc tgctcgcccc
      121 gaaccatggg aagatgagac aggaatctgt gccatccaaa ttgcttgatc cagtgaatct
      181 gctaggaaag gtctctgagg cccccgtctg ctgactgcat gacaaaccct aaaggaaatg
      241 ccaatcgtga tggcccggga cctggaggaa acagcatcat cctcagagga tgaggaggtc
      301 ataagtcaag aggatcatcc atgcatcatg tggactggag gctgcaggag aattccagtt
      361 ttggtattcc atgccgacgc tattcttaca aaggacaaca atattagagt aattggagaa
      421 cgttatcatt tgtcttataa gattgtacga acggacagtc gcctagtacg cagcattctg
      481 acagcccatg gatttcatga agttcaccca agcagcactg actataacct aatgtggaca
      541 ggatcccacc tgaagccctt cttactgcgc accctctctg aagcacaaaa agttaatcac
      601 tttcccaggt cttatgaact tacccggaag gaccgactgt acaaaaacat tattcgaatg
      661 cagcatacac atggattcaa ggcttttcac atcctccccc agaccttcct cctgccagct
      721 gagtacgcgg aattttgtaa ttcatattcg aaggaccggg gaccttggat agtaaaacca
      781 gtggcatctt caagggggcg gggcgtctac ctgatcaaca atccaaacca gatctccctg
      841 gaagagaaca ttttggtctc ccgttacatt aacaaccccc tgctcataga tgatttcaag
      901 tttgacgtgc gcctctatgt gctcgtgact tcctatgatc ctcttgtcat ctatctctat
      961 gaagaaggat tggctaggtt tgcaactgtg cgatatgatc aaggagccaa gaacattcgg
     1021 aaccagttca tgcatctgac aaactacagt gtcaacaaga aaagtggaga ttacgtcagt
     1081 tgtgacgatc cagaagtgga ggattatgga aacaaatgga gcatgagtgc tatgcttagg
     1141 tacctgaaac aagaaggcag agatacaacc gcattgatgg cccatgtaga agacctgatc
     1201 attaagacta taatctctgc tgaactagct attgctactg cctgtaaaac ctttgttcct
     1261 catcgcagca gttgttttga actctatggc tttgacgtgc tcatagattc tactctgaag
     1321 ccatggttgt tggaagtgaa tctctctcct tctttggcct gtgatgcgcc tctggaccta
     1381 aagattaaag ccagtatgat ttcagatatg ttcactgttg taggatttgt gtgccaagat
     1441 cctgcccagc gggcatcaac tcggccaatt tatcccacct ttgagtcttc caggcgaaac
     1501 cctttccaga aacctcagcg ttgccgtcca ctctctgcca gtgatgcgga aatgaaaaac
     1561 ctcgtgggct cagcccggga gaaagggcca gggaagttgg gtggttctgt gcttggtctg
     1621 tcaatggagg agatcaaagt tttacgaagg gtgaaggagg agaatgatcg gcgaggtgga
     1681 tttattcgca tatttcctac atctgagaca tgggaaatat atgggtccta cctcgagcat
     1741 aagacctcaa tgaactatat gctggcaaca cgcctcttcc aggacagaat gactgctgat
     1801 ggagcgccag aattgaagat agagagtctg aattcaaagg ccaagctgca tgctgcactt
     1861 tacgagagga agctcctgtc tctggaggtg cgaaaacgta gacgacggag tagcagattg
     1921 agggcaatga ggccaaaata cccagtgatt acccaaccag ctgaaatgaa tgttaaaact
     1981 gagacagaga gtgaagagga ggaagaagtc gcattagata atgaagatga agaacaggag
     2041 gcttcccagg aggagtctgc aggatttctt agagaaaatc aagccaaata tacaccctca
     2101 ttgacagctt tggtagaaaa tacacccaaa gaaaattcca tgaaagttcg tgaatggaat
     2161 aataaaggtg gacactgctg caaacttgag actcaggagc tagagcctaa atttaacctg
     2221 atgcagattc ttcaagataa tggcaatctt agcaaaatgc aggcccgaat agcattctct
     2281 gcctatctcc agcatgttca aattcgcctg atgaaagaca gtggcggtca gacgttcagt
     2341 gccagttggg ctgccaaaga ggatgaacag atggagctgg ttgttcgttt cctcaagcga
     2401 gcatcaaata acctccagca ttcactgagg atggtattac ccagtcgacg attggcactt
     2461 ctggaacgca gaagaatcct ggcccaccag ctgggtgact ttatcattgt atacaacaag
     2521 gaaacagaac aaatggctga aaagaaatca aagaagaaag ttgaggaaga agaggaagat
     2581 ggggtgaata tggaaaactt tcaggagttc atcagacaag caagtgaggc tgaactggag
     2641 gaggtgttga ctttttatac ccaaaagaac aagtctgcta gtgtcttcct ggggactcac
     2701 tctaaaattt ctaagaacaa caacaattat tctgatagtg gggcaaaagg tgatcaccct
     2761 gagactataa tggaagaagt gaaaataaag ccacctaaac agcaacagac gacagaaatt
     2821 cattctgata aattatctcg atttaccact tcagcagaaa aagaggcaaa attagtttat
     2881 agcaattcct cctctggtcc tactgctact ctgcagaaaa ttcccaacac ccatttgtca
     2941 tctgttacaa cctctgacct ctctccaggg ccttgccacc attcttcttt atctcaaatt
     3001 ccttcagcta tccccagcat gcctcaccag ccaacaattt tactgaacac agtctctgcc
     3061 agtgcttctc cctgcctaca tcccggggca cagaacatcc caagccctac tggcctgcca
     3121 cgctgtcgat caggaagtca caccattggt cccttttctt ccttccaaag tgctgcacac
     3181 atctatagcc agaaactgtc tcgtccctct tcagcaaagg caggatcgtg ctatctaaac
     3241 aagcatcatt caggaatagc caaaacacaa aaagagggag aagatgcttc tttatatagc
     3301 aaacggtaca accaaagtat ggttacagct gaacttcagc ggctagctga gaagcaggca
     3361 gcgagacagt attctccatc cagccacatc aacctcctca cccaacaggt aacaaacctg
     3421 aatttggcaa ctggcatcat aaacagaagc agtgcttcag ctcccccaac cctccgaccc
     3481 atcatcagtc ctagtggccc gacatggtct acacagtcag acccccaagc tcccgagaat
     3541 cactccagct ctcctggaag caggagcctg cagacagggg gatttgcctg ggaaggagaa
     3601 gtagaaaaca acgtgtacag ccaggctaca ggggtggtcc cccagcacaa gtatcacccc
     3661 acagcaggca gctatcagct tcaatttgcc ctgcagcaac ttgaacaaca aaaacttcag
     3721 tcccggcagc tcctggacca gagtcgagcc cggcaccagg caatctttgg cagccagaca
     3781 ctacctaact ccaatttatg gacaatgaat aatggtgcag gttgtagaat ttccagtgcc
     3841 acagctagtg gccagaagcc aaccactctg ccacaaaaag tggtaccacc tccaagttct
     3901 tgcgcctccc tggttcccaa acccccaccc aaccacgaac aagtgctcag aagggcaaca
     3961 tcccagaaag cttccaaagg gtcctccgcg gaagggcagc tgaatggact ccagagcagc
     4021 cttaaccctg cagcctttgt gcccatcacc agctctacag atcctgctca cactaaaata
     4081 tgaaccacaa acacacagag aaacaacctg ttcaccactc ctgggtgcat gattgagggt
     4141 gaagcatcca ccagcacttc aaggggtcca tagtattttt ttttttgctg cctcaaagtc
     4201 cccaaagcct tcgagcagaa gtggcagtag atggttgcca atcagccaat gcagactttc
     4261 actgggacaa caagaaagca gatcttctgg gttttgatgg aacttggcag tggggacatt
     4321 cagctgatgc attatatacc ccgtcagagc acacttgtat cttttacctt ccctttgccc
     4381 catgccccca aactgcttag gtcttctctg tccctttact gctgctgcac agagatgata
     4441 taaaagaggc tctttggcta tttgcatttt gcttcctctt cttttccaga ttacagtatg
     4501 aagctttatt ttctttgtac aagcttaaaa tttcaacatc atcatccgcc aaagttgttc
     4561 ctcccttttc ggaggatcta gggggaaaga ggagcattca tcacaagttt cctagagaga
     4621 ggagacaaat cggtgtgcca ttgacaacat gagccagggt aaaggcaccc tttggaatta
     4681 ctgatttcaa agattaataa agtaattcta ttttta
//
