LOCUS       NM_001387446            3498 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase like 3 (TTLL3), transcript
            variant 4, mRNA.
ACCESSION   NM_001387446
VERSION     NM_001387446.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Rogowski,K., Juge,F., van Dijk,J., Wloga,D., Strub,J.M.,
            Levilliers,N., Thomas,D., Bre,M.H., Van Dorsselaer,A., Gaertig,J.
            and Janke,C.
  TITLE     Evolutionary divergence of enzymatic mechanisms for
            posttranslational polyglycylation
  JOURNAL   Cell 137 (6), 1076-1087 (2009)
   PUBMED   19524510
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Trichet,V., Ruault,M., Roizes,G. and De Sario,A.
  TITLE     Characterization of the human tubulin tyrosine ligase-like 1 gene
            (TTLL1) mapping to 22q13.1
  JOURNAL   Gene 257 (1), 109-117 (2000)
   PUBMED   11054573
  REMARK    GeneRIF: Characterization of another human tubulin tyrosine
            ligase-like gene family member
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022382.4 and AC018809.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000685419.1/ ENSP00000510679.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC022382.4         25136-25268         c
            134-222             AC022382.4         24821-24909         c
            223-391             AC022382.4         22419-22587         c
            392-489             AC022382.4         22185-22282         c
            490-618             AC022382.4         19328-19456         c
            619-733             AC022382.4         17771-17885         c
            734-832             AC022382.4         16610-16708         c
            833-1028            AC022382.4         14789-14984         c
            1029-1177           AC022382.4         9582-9730           c
            1178-1421           AC022382.4         8290-8533           c
            1422-1857           AC022382.4         6135-6570           c
            1858-1999           AC022382.4         2285-2426           c
            2000-2226           AC022382.4         623-849             c
            2227-2662           AC022382.4         1-436               c
            2663-3498           AC018809.5         142724-143559       c
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..3498
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /note="tubulin tyrosine ligase like 3"
                     /db_xref="GeneID:26140"
                     /db_xref="HGNC:HGNC:24483"
                     /db_xref="MIM:619195"
     exon            1..133
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            134..222
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2622
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /note="isoform 3 is encoded by transcript variant 4;
                     tubulin monoglycylase TTLL3; tubulin--tyrosine ligase-like
                     protein 3; tubulin tyrosine ligase-like family, member 3"
                     /codon_start=1
                     /product="tubulin monoglycylase TTLL3 isoform 3"
                     /protein_id="NP_001374375.1"
                     /db_xref="CCDS:CCDS93199.1"
                     /db_xref="GeneID:26140"
                     /db_xref="HGNC:HGNC:24483"
                     /db_xref="MIM:619195"
                     /translation="MNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRRGWVEKKM
                     VHRSGPTLLPPQKDLDSSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTH
                     ALMSRMVQNEIPYFIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPW
                     FDEVDANSFFPRCYCLGAEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEA
                     SGDKQPKKQEKNPVLVSPEFVDEALCACEEYLSNLAHMDIDKDLEAPLYLTPEGWSLF
                     LQRYYQVVHEGAELRHLDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGR
                     GIMCMDHLEEMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPL
                     TVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMWSSQRF
                     QAHLQEMGAPNAWSTIIVPGMKDAVIHALQTSQDTVQCRKASFELYGADFVFGEDFQP
                     WLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRMLDRNCDTGAFELIYKQPAVEV
                     PQYVGIRLLVEGFTIKKPMAMCHRRMGVRPAVPLLTQRGSGEARHHFPSLHTKAQLPS
                     PHVLRHQGQVLRRQHSKLVGTKALSTTGKALRTLPTAKVFISLPPNLDFKVAPSILKP
                     RKAPALLCLRGPQLEVPCCLCPLKSEQFLAPVGRSRPKANSRPDCDKPRAEACPMKRL
                     SPLKPLPLVGTFQRRRGLGDMKLGKPLLRFPTALVLDPTPNKKKQVKYLGLDSIAVGG
                     SRVDGARPCTPGSTARA"
     exon            223..391
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            392..489
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            490..618
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            619..733
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            734..832
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1028
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1177
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1421
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1857
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1999
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2226
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..3498
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3465..3470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /note="hexamer: AATAAA"
     polyA_site      3498
                     /gene="TTLL3"
                     /gene_synonym="HOTTL"
                     /note="major polyA site"
ORIGIN      
        1 agccccgccc ctgcgcgccg cctcagcggc gccttcaaga cgctggtccc aggcacccac
       61 gcccagggcg cctcggatac ccaccccctc ggccccccgc acaccccggt cctcgacccc
      121 tctccgcagg atggtttccc ggtcctctgg cgaggatcct ccaaggcgtc tcacatgaac
      181 cggctcagaa acgccaaaat ctacgtggag agagctgtca agcagaagaa gatctttaca
      241 atccaaggct gctacccggt gatccggtgt ctcttgcgcc ggaggggctg ggtggagaag
      301 aagatggtcc atcgctcagg ccccaccctg ctgccacccc agaaggatct ggatagctca
      361 gcgatgggtg acagtgacac cactgaggat gaggatgaag atgaggacga ggagttccag
      421 ccatcacagc tgttcgactt cgatgattta ctgaaatttg atgacctaga tggaacacat
      481 gctctgatgt cccgcatggt ccagaatgag atcccctact tcatctggac cactcggcgg
      541 gatgtgctcg actgtcgctt cctctccaag gatcagatga taaaccacta cgcccgggct
      601 ggctccttta ccacaaaggt gggtctatgt ctcaatctcc ggaatttgcc gtggtttgat
      661 gaggttgatg ccaactcctt cttcccacgc tgctactgcc tgggggctga ggatgacaaa
      721 aaagccttca tagaggactt ctggctgact gctgcccgca acgttctcaa gctggtggtg
      781 aagtctgagt ggaagtcata ccctattcag gcagtagagg aagaggcctc aggagacaag
      841 cagcccaaga aacaggagaa aaacccagtg ttggtgtccc cagagtttgt ggatgaagct
      901 ctgtgtgcgt gcgaggagta ccttagcaac ttggcccaca tggacatcga caaggacctg
      961 gaggccccgc tgtacctcac ccccgagggc tggtccctct tcctccagcg ctactaccaa
     1021 gtggtccacg aaggggcaga actcaggcac ctcgacactc aggtccagcg ctgtgaggac
     1081 atcctgcagc agctgcaggc cgtggtaccc cagatagaca tggaagggga tcgcaacatc
     1141 tggatcgtga agccaggagc caagtcccgc ggacgaggca tcatgtgcat ggaccacctg
     1201 gaggagatgc tgaagctggt gaacggcaac cccgtggtga tgaaggacgg caagtgggtg
     1261 gtgcagaagt atattgagcg gcccctcctc atctttggca ccaagtttga cctcagacag
     1321 tggttcctgg taactgactg gaacccactt accgtgtggt tctaccgcga cagctatatc
     1381 cgcttttcca cgcagccctt ctccctgaag aacctggaca actcagtgca cctgtgcaac
     1441 aactccatcc agaagcacct ggagaactca tgccatcggc atccactgct tccgccagac
     1501 aacatgtggt ctagccagag gttccaggcc cacctgcagg agatgggtgc cccaaatgct
     1561 tggtccacca tcatcgtgcc tggcatgaag gatgctgtga tccacgcact tcagacctcc
     1621 caggacaccg tgcagtgtcg gaaggccagc tttgagctct atggcgctga cttcgtgttc
     1681 ggggaggact tccagccctg gctgattgag atcaacgcca gccccacgat ggcaccctcc
     1741 acagcagtca ctgcccggct ctgtgctggc gtgcaagctg acaccctgcg cgtggtcatt
     1801 gaccggatgc tggaccgcaa ctgtgacaca ggagcctttg agctcatcta taagcagcct
     1861 gctgtggagg tgcctcaata tgtgggcatc cggctcctgg tagagggctt caccatcaag
     1921 aagcccatgg cgatgtgtca tcggcggatg ggggtccgcc cagcagtccc tctgctgacc
     1981 cagcgaggct ctggggaagc ccgtcaccac ttccccagcc tccacaccaa ggcccagctg
     2041 ccttctcccc atgtactccg acaccagggc caggtcctca gacgacagca cagcaagctg
     2101 gtgggcacta aggccctgtc gaccacaggc aaggccttga ggactctacc cacggctaag
     2161 gtcttcattt ccctcccacc gaaccttgat ttcaaggtgg cacccagcat cctgaagcca
     2221 agaaaggctc ctgctctcct gtgcctccga ggcccccagc tggaagtgcc ttgttgcctc
     2281 tgccctttga agtcggaaca attcctagca cctgtcggaa ggtcaaggcc aaaggcaaat
     2341 tcaaggccag actgtgacaa acccagggct gaggcctgcc ccatgaagag gctgagcccc
     2401 ctgaaacccc tgccccttgt tggtacattc cagaggcgca ggggcctggg ggatatgaag
     2461 ctagggaagc ccctgcttcg attccccact gcccttgtcc tggatccaac accaaataaa
     2521 aagaaacaag tgaagtattt ggggcttgac tccattgctg ttggagggtc aagagtggat
     2581 ggggcgaggc cgtgtacccc agggtccaca gcaagagcct gaggccatca gcagctcctc
     2641 cgtgcagcga ggcccagaat tcccacctaa ggacagacat ggggcttcct atttagggac
     2701 tcccccagca tctccgatcc aggggtgggg agcgtgagcc ttcactttac agatgaagaa
     2761 actgagtctg aaagaggagg catggcttac ccaagatcac gtggcagtga gtcgacgcag
     2821 ggacatattg ccagaactgc cgagcactgg gagcccccca accccagaga acaagccaag
     2881 ctagcagaat gacacctacc gggcatagga acgttaatgc catgagacag gggaaggaat
     2941 tggccttgcc taaacctcag cccttctgca gagggcatgg gtctatccct tcttcagcaa
     3001 ggggccaagg tcacctaaaa atgaaacatc caataagcca cacccacctg aagaaaagtg
     3061 tggcactgct tagttgtagt gggttgaact gtggtcccct gaaaagagat gtctacttgg
     3121 accctgtgaa tgtgacctta tgtgggaaaa gagtctttgt agctgggtat ggtggctcac
     3181 acctgttatc ccagcacttt gagaggccaa ggcaggagat cgcttgagcc cgcaagttca
     3241 agaccagtct gggcaacatg gtgaaaccgt ttctacagaa aattagctgg gtgtggtggc
     3301 acacacctgt agtcctagct actcgggagg cctaggtggg aggattacct gagcctggga
     3361 agatcaaaac tgtggtgagc tgtgatcacg ccactgcgct ctgagcctgg gagacagagt
     3421 gaaaccctaa atcaaaaaaa aaaaaaaagg tctttgcaga tgtaaataaa tttaagatct
     3481 taaatgagat aatcccaa
//
