LOCUS       NM_031949               2876 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase like 2 (TTLL2), transcript
            variant 1, mRNA.
ACCESSION   NM_031949
VERSION     NM_031949.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2876)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2876)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 2876)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   4  (bases 1 to 2876)
  AUTHORS   Trichet,V., Ruault,M., Roizes,G. and De Sario,A.
  TITLE     Characterization of the human tubulin tyrosine ligase-like 1 gene
            (TTLL1) mapping to 22q13.1
  JOURNAL   Gene 257 (1), 109-117 (2000)
   PUBMED   11054573
  REMARK    GeneRIF: Characterization of another human tubulin tyrosine
            ligase-like gene family member
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093039.1 and AL021331.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031949.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093039.1, BC047411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239587.10/ ENSP00000239587.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AK093039.1         1-390
            391-2876            AL021331.1         78552-81037
FEATURES             Location/Qualifiers
     source          1..2876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..2876
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
                     /note="tubulin tyrosine ligase like 2"
                     /db_xref="GeneID:83887"
                     /db_xref="HGNC:HGNC:21211"
     exon            1..135
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1867
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable tubulin polyglutamylase TTLL2; testis-specific
                     protein NYD-TSPG; tubulin--tyrosine ligase-like protein 2;
                     tubulin tyrosine ligase-like family, member 2"
                     /codon_start=1
                     /product="probable tubulin polyglutamylase TTLL2 isoform
                     1"
                     /protein_id="NP_114155.4"
                     /db_xref="CCDS:CCDS5301.1"
                     /db_xref="GeneID:83887"
                     /db_xref="HGNC:HGNC:21211"
                     /translation="MRGRDLCSSTQSQALGSLRTTTPAFTLNIPSEANHTEQPPAGLG
                     ARLQEAGVSIPPRRGRPTPTLEKKKKPHLMAEDEPSGALLKPLVFRVDETTPAVVQSV
                     LLERGWNKFDKQEQNAEDWNLYWRTSSFRMTEHNSVKPWQQLNHHPGTTKLTRKDCLA
                     KHLKHMRRMYGTSLYQFIPLTFVMPNDYTKFVAEYFQERQMLGTKHSYWICKPAELSR
                     GRGILIFSDFKDFIFDDMYIVQKYISNPLLIGRYKCDLRIYVCVTGFKPLTIYVYQEG
                     LVRFATEKFDLSNLQNNYAHLTNSSINKSGASYEKIKEVIGHGCKWTLSRFFSYLRSW
                     DVDDLLLWKKIHRMVILTILAIAPSVPFAANCFELFGFDILIDDNLKPWLLEVNYSPA
                     LTLDCSTDVLVKRKLVHDIIDLIYLNGLRNEGREASNATHGNSNIDAAKSDRGGLDAP
                     DCLPYDSLSFTSRMYNEDDSVVEKAVSVRPEAAPASQLEGEMSGQDFHLSTREMPQSK
                     PKLRSRHTPHKTLMPYASLFQSHSCKTKTSPCVLSDRGKAPDPQAGNFVLVFPFNEAT
                     LGASRNGLNVKRIIQELQKLMNKQHS"
     exon            136..292
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
                     /inference="alignment:Splign:2.1.0"
     exon            293..2876
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
                     /note="hexamer: ATTAAA"
     polyA_site      2075
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
                     /note="major polyA site"
     regulatory      2856..2861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
                     /note="hexamer: AATAAA"
     polyA_site      2876
                     /gene="TTLL2"
                     /gene_synonym="C6orf104; dJ366N23.3; NYD-TSPG"
ORIGIN      
        1 agtgctccct ccagcctccg cgcatttcag ctggcgctgc agctgctgca cagagaccca
       61 cagaggccac cctcggaacc agcgcccaat gagagggcgg gacctgtgtt cctccacaca
      121 aagccaggcg ctgggatctt tgagaaccac caccccagcc tttaccctta acattccatc
      181 cgaggcaaac cacactgagc agccgcctgc aggcctggga gcaaggctac aggaagcagg
      241 tgtttccatc cctcccaggc gaggccgccc aacaccaaca ctggagaaga agaaaaaacc
      301 tcatttgatg gcggaagatg aaccttcagg ggccctcttg aagccgctgg tttttcgcgt
      361 tgacgagacc accccggctg tggtgcaaag cgtcctcctg gagagggggt ggaataagtt
      421 tgataagcag gagcagaacg cggaggactg gaacctgtac tggaggacat cctctttccg
      481 aatgaccgaa cacaacagtg ttaaaccgtg gcagcagcta aaccaccacc ctggaaccac
      541 caagcttacc aggaaagact gtttggccaa acacctgaag cacatgagga ggatgtatgg
      601 cacttccctg taccagttca tccccctgac gttcgtcatg cccaatgact ataccaagtt
      661 cgtggctgaa tactttcagg agaggcagat gctgggcacc aagcatagct attggatttg
      721 caagcctgct gagttatctc gtgggagggg gatactaatt ttcagtgact ttaaagactt
      781 catctttgat gatatgtaca tagtgcagaa atatatctcc aatcctttac ttattggcag
      841 atataaatgt gatctccgca tctatgtttg tgttactggc tttaagcctt tgaccattta
      901 tgtttatcag gaagggttgg ttcggtttgc cacggaaaag tttgacctca gtaatttgca
      961 aaacaattat gcccatttga ccaacagcag catcaataaa tccggggcct cttatgagaa
     1021 gatcaaagaa gtgattggtc atggttgtaa atggacgctc agcagatttt tttcctacct
     1081 tcgtagctgg gatgtggacg atctgctttt gtggaagaaa atccaccgca tggttattct
     1141 caccattctc gccattgcac catctgtccc ctttgctgcc aattgctttg agctctttgg
     1201 gtttgatatt ttgattgatg acaacttgaa accatggctt ttagaggtca actacagccc
     1261 agccttgacc ttggattgtt caacagatgt gttggtgaag agaaaacttg tccatgatat
     1321 tattgacctg atttacttaa atggtctaag aaatgagggg agagaagcca gtaatgccac
     1381 acatggaaat tccaacatcg acgctgcaaa aagtgacaga ggtgggcttg atgctcctga
     1441 ctgtcttcct tatgattctc tttcgttcac aagcagaatg tacaacgagg atgactctgt
     1501 ggtggagaaa gctgtgagtg tgcgtcctga agctgcacct gcctcccagc tggaaggaga
     1561 gatgagtggg caggattttc atctgtcaac aagggagatg ccacaaagca agcccaagtt
     1621 acggagcagg cacacgcctc acaagacact catgccctac gcgtccctct tccagtcgca
     1681 ctcctgcaag accaagacct ccccgtgtgt cctgtcagac cgtggcaaag ctccagatcc
     1741 ccaagcaggc aactttgttc ttgtttttcc tttcaatgaa gcaactctcg gagcttccag
     1801 gaatggatta aatgtcaaaa gaataatcca agagctccag aaactaatga ataagcaaca
     1861 ttcctaagtg gtaaaaaatc aaatcaagaa aaagtgacat ggatttttaa aaaccaagga
     1921 tcctgtccta gagaaagcaa tagttcaagt ccctacctgt gccaccagca tgttaactat
     1981 gacattggga ctgaagatgt ggccatatgt ataaatataa cagctctgac aaagcacaat
     2041 atgttcaagt ggtgattaaa ctacattaca tcccatgttt atttgctcag gtgtcttgaa
     2101 agaattctac aaataccaca cagcctccca ccagtaattg aatgtgctac actacgatta
     2161 tgctatgtat gtatttaaag aggagaaaaa gattattcta atatttttaa aggattatta
     2221 ggtgaaaaca gtacaaaaga agccaggagt taactttctg tgtgtttttt tttaaatcaa
     2281 ccagttattt gttaaaatta ttttgttaac ttaagatcag acaatcattc agagtgagat
     2341 aaatcactga aagccctaat gactctgttg tttacaaatc ctgggcttga aatcagactt
     2401 tgcaccaaag agctccctgt gggggcatct ttgggctgta tttaaatagt ggccccttgg
     2461 ccttgtcacc atttgtttac catcacagca tgtgaggtca tggcctccca gatcaaagta
     2521 tgctgtcatt cctgccacat aaaaagcatc tgcagtccta agacataaaa attccagtag
     2581 gttacttgaa aacattattc tagtgaaagt agtcagatac aaaaggccac atgttgtatg
     2641 actccgttga tatggaatgt cagaattggc aaatccatca aaagcagatt ggtggcttag
     2701 gggaggggta atgaggagtg cctactgatg ggtagggggc ttccctttgg ggtgacagaa
     2761 atgttctgga actatataga ggtgatggtt gcacaacacg gggaattcac taagtatcac
     2821 tcatggtaca ttttgtgtta tgtgtgtttt accacaataa aaaagttaaa agctgg
//
