LOCUS       NM_015140               3386 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase like 12 (TTLL12), mRNA.
ACCESSION   NM_015140
VERSION     NM_015140.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Ceglowski,J., Hoffman,H.K., Neumann,A.J., Hoff,K.J., McCurdy,B.L.,
            Moore,J.K. and Prekeris,R.
  TITLE     TTLL12 is required for primary ciliary axoneme formation in
            polarized epithelial cells
  JOURNAL   EMBO Rep 25 (1), 198-227 (2024)
   PUBMED   38177908
  REMARK    GeneRIF: TTLL12 is required for primary ciliary axoneme formation
            in polarized epithelial cells.
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3386)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3386)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3386)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3386)
  AUTHORS   Brants,J., Semenchenko,K., Wasylyk,C., Robert,A., Carles,A.,
            Zambrano,A., Pradeau-Aubreton,K., Birck,C., Schalken,J.A., Poch,O.,
            de Mey,J. and Wasylyk,B.
  TITLE     Tubulin tyrosine ligase like 12, a TTLL family member with SET- and
            TTL-like domains and roles in histone and tubulin modifications and
            mitosis
  JOURNAL   PLoS One 7 (12), e51258 (2012)
   PUBMED   23251473
  REMARK    GeneRIF: results suggest that hTTLL12 has non-catalytic functions
            related to tubulin and histone modification, which could be linked
            to its effects on mitosis and chromosome number stability
REFERENCE   7  (bases 1 to 3386)
  AUTHORS   Wasylyk,C., Zambrano,A., Zhao,C., Brants,J., Abecassis,J.,
            Schalken,J.A., Rogatsch,H., Schaefer,G., Pycha,A., Klocker,H. and
            Wasylyk,B.
  TITLE     Tubulin tyrosine ligase like 12 links to prostate cancer through
            tubulin posttranslational modification and chromosome ploidy
  JOURNAL   Int J Cancer 127 (11), 2542-2553 (2010)
   PUBMED   20162578
  REMARK    GeneRIF: Results raise the possibility that TTLL12 could contribute
            to tumorigenesis through effects on the cytoskeleton, tubulin
            modification and chromosome number stability.
REFERENCE   8  (bases 1 to 3386)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
REFERENCE   9  (bases 1 to 3386)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   10 (bases 1 to 3386)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z82214.23, BX411143.2, BC001070.2 and BE785973.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015140.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001070.2, SRR1803615.158732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267761 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216129.7/ ENSP00000216129.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 Z82214.23          41583-41585         c
            4-39                BX411143.2         1-36
            40-2302             BC001070.2         1-2263
            2303-2360           BE785973.1         402-459
            2361-3386           BC001070.2         2322-3347
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..3386
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /note="tubulin tyrosine ligase like 12"
                     /db_xref="GeneID:23170"
                     /db_xref="HGNC:HGNC:28974"
                     /db_xref="MIM:619410"
     exon            1..242
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2000
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /note="tubulin tyrosine ligase-like family, member 12;
                     inactive tubulin--tyrosine ligase-like protein 12"
                     /codon_start=1
                     /product="tubulin--tyrosine ligase-like protein 12"
                     /protein_id="NP_055955.1"
                     /db_xref="CCDS:CCDS14047.1"
                     /db_xref="GeneID:23170"
                     /db_xref="HGNC:HGNC:28974"
                     /db_xref="MIM:619410"
                     /translation="MEAERGPERRPAERSSPGQTPEEGAQALAEFAALHGPALRASGV
                     PERYWGRLLHKLEHEVFDAGEVFGIMQVEEVEEEEDEAAREVRKQQPNPGNELCYKVI
                     VTRESGLQAAHPNSIFLIDHAWTCRVEHARQQLQQVPGLLHRMANLMGIEFHGELPST
                     EAVALVLEEMWKFNQTYQLAHGTAEEKMPVWYIMDEFGSRIQHADVPSFATAPFFYMP
                     QQVAYTLLWPLRDLDTGEEVTRDFAYGETDPLIRKCMLLPWAPTDMLDLSSCTPEPPA
                     EHYQAILEENKEKLPLDINPVVHPHGHIFKVYTDVQQVASSLTHPRFTLTQSEADADI
                     LFNFSHFKDYRKLSQERPGVLLNQFPCENLLTVKDCLASIARRAGGPEGPPWLPRTFN
                     LRTELPQFVSYFQQRERWGEDNHWICKPWNLARSLDTHVTKSLHSIIRHRESTPKVVS
                     KYIESPVLFLREDVGKVKFDIRYIVLLRSVRPLRLFVYDVFWLRFSNRAFALNDLDDY
                     EKHFTVMNYDPDVVLKQVHCEEFIPEFEKQYPEFPWTDVQAEIFRAFTELFQVACAKP
                     PPLGLCDYPSSRAMYAVDLMLKWDNGPDGRRVMQPQILEVNFNPDCERACRYHPTFFN
                     DVFSTLFLDQPGGCHVTCLV"
     exon            243..412
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..611
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..771
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..905
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..982
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1099
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1294
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1406
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1558
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1640
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1709
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1848
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..3386
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3366..3371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /note="hexamer: AATAAA"
     polyA_site      3386
                     /gene="TTLL12"
                     /gene_synonym="dJ526I14.2"
                     /note="major polyA site"
ORIGIN      
        1 agggccgacg gacggcgggc ggcggcggcg gtggcggcgc tggagtcggc gcgggtgctg
       61 gcgccatgga ggccgagcgg ggtcccgagc gccggcctgc ggagcgtagc agcccgggcc
      121 agacgccgga ggagggcgcg caggccttgg ccgagttcgc ggcgctgcac ggcccggcgc
      181 tgcgcgcttc gggggtcccc gaacgttact ggggccgcct cctgcacaag ctggagcacg
      241 aggttttcga cgctggggaa gtgtttggga tcatgcaagt ggaggaggta gaagaggagg
      301 aggacgaggc agcccgggag gtgcggaagc agcagcccaa cccggggaac gagctgtgct
      361 acaaggtcat cgtgaccagg gagagcgggc tccaggcagc ccaccccaac agcatcttcc
      421 tcatcgacca cgcctggacg tgccgtgtgg agcacgcgcg ccagcagctg cagcaggtgc
      481 ccgggctgct gcaccgcatg gccaacctga tgggcattga gttccacggt gagctgccca
      541 gtacagaggc tgtggccctg gtgctggagg agatgtggaa gttcaaccag acctaccagc
      601 tggcccatgg gacagctgag gagaagatgc cggtgtggta tatcatggac gagttcggtt
      661 cgcggatcca gcacgcggac gtgcccagct tcgccacggc acccttcttc tacatgccgc
      721 agcaggtggc ctacacgctg ctgtggcccc tgagggacct ggacactggc gaggaggtga
      781 cccgagactt tgcctacgga gagacggacc ccctgatccg gaagtgcatg ctgctgccct
      841 gggcccccac cgacatgctg gacctcagct cttgcacacc cgagccgccc gccgagcact
      901 accaggccat tctggaggaa aacaaggaga agctgccact tgacatcaac cccgtggtgc
      961 acccccacgg ccacatcttc aaggtctaca cggacgtgca gcaggtggcc agcagcctca
     1021 cccacccgcg cttcaccctc acccagagtg aggcggacgc cgacatcctc ttcaacttct
     1081 cacacttcaa ggactacagg aaactcagcc aggagaggcc aggcgtgctg ctgaaccagt
     1141 tcccctgcga gaacctgctg actgtcaagg actgcctggc ctccatcgcg cgccgggcag
     1201 gtggccccga gggcccaccc tggctgcccc gaaccttcaa cctgcgcact gagctgcccc
     1261 agtttgtcag ctacttccag cagcgggaaa ggtggggcga ggacaaccac tggatctgca
     1321 agccctggaa cctggcgcgc agcctggaca cccacgtcac caagagcctg cacagcatca
     1381 tccggcaccg agagagcacc cccaaggttg tgtccaagta catcgaaagt cccgtgttgt
     1441 tccttcgaga agacgtggga aaggtcaagt tcgacatccg ctacatcgtg ctgctgcggt
     1501 cagtgaggcc cctacggttg ttcgtgtatg atgtgttctg gctgcggttc tccaaccggg
     1561 cctttgcact caacgacctg gatgactacg agaagcactt cacggtcatg aactatgacc
     1621 cggatgtggt gctgaagcag gtgcactgtg aagagttcat ccccgagttt gagaagcaat
     1681 acccagaatt tccctggacg gacgtccagg ctgagatctt ccgggccttc acggagctgt
     1741 tccaggtggc ctgtgccaag ccaccacccc tgggcctctg cgactacccc tcatcccggg
     1801 ccatgtatgc cgtcgacctc atgctgaagt gggacaacgg cccagatgga aggcgggtga
     1861 tgcagccgca gatcctggag gtgaacttca accccgactg tgagcgagcc tgcaggtacc
     1921 accccacctt cttcaacgac gtcttcagca ccttgtttct ggaccagccc ggtggctgcc
     1981 acgttacctg ccttgtctag gcactcgctg tccccaaaac ctgtgcttgg ggcaggattc
     2041 caacctcagt tctctgagct gcttctgcaa aggcccccat gtccctcccc acaccggccc
     2101 tgggcatagc ctcagcccca ggcctctgtc ctgccgagcc atcctcccgg cgccacactc
     2161 cgggagcaca gcatcctcct ctcacctgtg ggtcagagca ggacagtgat ggtgtcccca
     2221 gggctgagca ccaccccacg ccctgccctc acccctcacc accatctgtg cactgatgag
     2281 tctccagttt agccaagggc tttgttcctg gcatggagaa tttgttcctg gctgctgtgt
     2341 ttccaggggg tgctggggga agggttccgt ggagcgagac aaggtgtcct cgggagcagg
     2401 gttccaccgg gaagcgtttg ggagccctgt atcacacggg gcaggcgggt ttctcttccg
     2461 gggtctctgc tcttatgcat caggacgacc ccgggacggc tgtggggccc cacactgcac
     2521 ccacagggct ctatgcgaca ggggcccagg aacagcctga ggccaccacc cagcaagccc
     2581 gccttatcac ccattccagc tcacccagaa ccttcaccag caaacctcct gctgaggtcc
     2641 tggcaggagg ccaccgtctt gttaccgttt ccttttcgtt tgctgagggt cacagacccc
     2701 aacagggaaa tcagtatctg tcttcccagt ggttgccctg ctcgccgggc actccacggg
     2761 gtcccgccct tgtgtgagat gggccaggat ccttcggcaa ggggcgcctg gggctggggc
     2821 tgattgtggg cggtggagcg ccagacagaa aaggattcca atgagaactt caggttaaag
     2881 tcagatgcca cctaccaggg tctacagtca aaatgttggc tttttcttat tttttaatgt
     2941 atgggagaaa aatgtaaaat tccagttctt ttctaattgt gtttctgaaa ttaggagtca
     3001 gctgccagcg tttttgtgtg gctgcagtgt gcctgggccc agctcacggg cagtgggtgg
     3061 acctaactgc ccaggcaggc gagagctact tccagagcct tccagtgcat gggagggcag
     3121 ggctaggtgt agcggtgtct cctctttgaa attaagaact atctttcttg tagcaaagct
     3181 gcacctgatg atgctgcctc tcctctctgt gttgtctggg cccttgttta caagcacgcg
     3241 ttacccttcc tgaggggagc catgctctag cccctggagg gcctgttgca ggggcagggc
     3301 gggcccgtcg cctttggcag ctcctggaga gctgtggaca tgcagtcccc ctcagttcgt
     3361 gctgcaataa aggccatctt ctctta
//
