LOCUS       NM_001139442            9206 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens tubulin tyrosine ligase like 11 (TTLL11), transcript
            variant 1, mRNA.
ACCESSION   NM_001139442 XM_001714037
VERSION     NM_001139442.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9206)
  AUTHORS   Liu,H., Zhao,X., Xue,G., Chen,C., Dong,Q., Gao,X., Yang,L. and
            Chen,C.
  TITLE     TTLL11 gene is associated with sustained attention performance and
            brain networks: A genome-wide association study of a healthy
            Chinese sample
  JOURNAL   Genes Brain Behav 22 (1), e12835 (2023)
   PUBMED   36511133
  REMARK    GeneRIF: TTLL11 gene is associated with sustained attention
            performance and brain networks: A genome-wide association study of
            a healthy Chinese sample.
REFERENCE   2  (bases 1 to 9206)
  AUTHORS   Mathieu,H., Patten,S.A., Aragon-Martin,J.A., Ocaka,L., Simpson,M.,
            Child,A. and Moldovan,F.
  TITLE     Genetic variant of TTLL11 gene and subsequent ciliary defects are
            associated with idiopathic scoliosis in a 5-generation UK family
  JOURNAL   Sci Rep 11 (1), 11026 (2021)
   PUBMED   34040021
  REMARK    GeneRIF: Genetic variant of TTLL11 gene and subsequent ciliary
            defects are associated with idiopathic scoliosis in a 5-generation
            UK family.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9206)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   4  (bases 1 to 9206)
  AUTHORS   Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
            Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
  TITLE     Genome-wide association study of periodontal pathogen colonization
  JOURNAL   J Dent Res 91 (7 Suppl), 21S-28S (2012)
   PUBMED   22699663
REFERENCE   5  (bases 1 to 9206)
  AUTHORS   Letra,A., Menezes,R., Govil,M., Fonseca,R.F., McHenry,T.,
            Granjeiro,J.M., Castilla,E.E., Orioli,I.M., Marazita,M.L. and
            Vieira,A.R.
  TITLE     Follow-up association studies of chromosome region 9q and
            nonsyndromic cleft lip/palate
  JOURNAL   Am J Med Genet A 152A (7), 1701-1710 (2010)
   PUBMED   20583170
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 9206)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
REFERENCE   7  (bases 1 to 9206)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162423.18, AL442634.13, AL445587.10 and AL596244.9.
            
            On Jun 3, 2020 this sequence version replaced NM_001139442.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.811480.1,
                                           SRR14038191.1030287.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321582.11/ ENSP00000321346.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               AL162423.18        16146-16767         c
            623-719             AL442634.13        18674-18770         c
            720-853             AL442634.13        11125-11258         c
            854-1429            AL445587.10        139659-140234       c
            1430-1525           AL445587.10        125348-125443       c
            1526-1641           AL445587.10        124473-124588       c
            1642-1893           AL445587.10        20961-21212         c
            1894-2000           AL445587.10        10801-10907         c
            2001-9206           AL596244.9         7607-14812          c
FEATURES             Location/Qualifiers
     source          1..9206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..9206
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /note="tubulin tyrosine ligase like 11"
                     /db_xref="GeneID:158135"
                     /db_xref="HGNC:HGNC:18113"
                     /db_xref="MIM:620694"
     exon            1..622
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2293
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /note="isoform a is encoded by transcript variant 1;
                     tubulin polyglutamylase TTLL11; tubulin--tyrosine
                     ligase-like protein 11; tubulin tyrosine ligase-like
                     family, member 11; tubulin tyrosine ligase like11; TTLL11
                     intronic transcript 1; TTLL11 intronic transcript 1
                     (non-protein coding)"
                     /codon_start=1
                     /product="tubulin polyglutamylase TTLL11 isoform a"
                     /protein_id="NP_001132914.2"
                     /db_xref="CCDS:CCDS48012.2"
                     /db_xref="GeneID:158135"
                     /db_xref="HGNC:HGNC:18113"
                     /db_xref="MIM:620694"
                     /translation="MRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQVRVD
                     AGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPH
                     GKPRDKGRSCKRSSGHGSGENGSQRPVTVDSSKARTSLDALKISIRQLKWKEFPFGRR
                     LPCDIYWHGVSFHDNDIFSGQVNKFPGMTEMVRKITLSRAVRTMQNLFPEEYNFYPRS
                     WILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRLAGTLQS
                     RPAVVQEYICKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPTPKN
                     LHRIFMHLTNYSLNIHSGNFIHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISV
                     VIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPILLEVNANPSMRI
                     EHEHELSPGVFENVPSLVDEEVKVAVIRDTLRLMDPLKKKRENQSQQLEKPFAGKEDA
                     LDGELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTM
                     KLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAF
                     FFLAQRKFKMLPLHEQVASLIDLCEYHLSLLDEKRLVCGRGVPSGGRPPHRGPPQEPS
                     PSAQPAGDNPPPRTSCANKLSHPRHTLS"
     exon            623..719
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..853
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1429
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1525
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1641
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1893
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2000
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..9206
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4667..4672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /note="hexamer: AATAAA"
     polyA_site      4691
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
     regulatory      9158..9163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /note="hexamer: AATAAA"
     polyA_site      9206
                     /gene="TTLL11"
                     /gene_synonym="bA244O19.1; C9orf148; C9orf20; TTLL11-IT1"
                     /note="major polyA site"
ORIGIN      
        1 gactgccgct gtcaacccga gcctgagcga tcatggcaac gggctcgggc ggggaacgcg
       61 tggcagcggc tgcagcggcg gcagtttggt ggcggactgg ggcggcggag cggcggcggc
      121 ggcggcggtg gcactggcac tggccccggc cctgagcacc atgcggcggg gcagctccga
      181 gagcgagctg gcggcccggt gggaggcgga ggcggtggct gcggccaaag cggcggccaa
      241 agctgaggcc gaggccacag cggagacggt ggcggaacag gtccgcgtgg acgcgggcgc
      301 ggccggggaa ccggagtgca aggcagggga ggagcagccc aaggtcctgg ccccggcccc
      361 ggcgcagccc agtgcggctg aggaggggaa cacccaggtc cttcagcggc cgccgcccac
      421 gctgcccccg tccaagccga agccggtgca gggcctctgc ccgcacggga agccccggga
      481 caagggccga agctgcaagc ggagctcggg ccacggttcc ggcgagaacg gctcccagcg
      541 gccggtcacc gtggacagct ccaaggccag gacctccctg gatgccctga agatcagcat
      601 ccgccagctc aagtggaagg agttcccatt tggccggcgc ttgccttgtg acatctactg
      661 gcatggagtt tcatttcacg acaatgacat attctccggt caagtgaaca agtttccagg
      721 catgacggag atggtgcgta aaattactct gagcagagca gtgagaacca tgcagaatct
      781 ctttcctgag gagtacaact tctaccctcg ctcatggatt ctgcctgacg agttccagct
      841 ctttgttgct caggttcaaa tggtgaaaga cgatgacccc tcctggaagc ccacttttat
      901 cgtgaaacct gatggtggtt gtcagggtga tggaatctac ctcattaaag accccagtga
      961 catccgcctg gcagggaccc tccagagcag gccagcggtg gtccaggagt acatctgcaa
     1021 acctctcctt atcgacaagc tcaagtttga tattcgtctg tatgtcttac tcaagtcctt
     1081 agacccctta gagatttata tagccaaaga cggactctct aggttttgta ccgagccata
     1141 tcaggagccc acccccaaaa acctgcaccg catctttatg cacttaacca actattcact
     1201 gaacatccac agcggcaact tcatccactc ggacagtgct agcactggca gcaaaaggac
     1261 tttttccagc atcctttgta gactgtcttc caaaggcgtt gacatcaaga aggtctggtc
     1321 tgacatcatc tccgtggtga ttaagacggt catcgcgctg actccagagc tcaaagtctt
     1381 ctaccagtca gacatcccca cggggaggcc gggccccacg tgcttccaga ttttaggctt
     1441 tgacattctt ctaatgaaaa atctgaagcc tatactactt gaagtaaatg caaatcccag
     1501 tatgagaatc gaacatgagc acgaactttc tccaggggtg tttgaaaatg tccccagcct
     1561 cgttgatgaa gaagtgaaag tggctgtgat cagagacact ctgcgcctca tggacccact
     1621 taagaagaaa agagagaatc agtctcagca gcttgaaaaa ccattcgctg gaaaggaaga
     1681 tgctttggac ggcgagctga ccagtgctcc agactgcaac gccaaccccg aagcccacct
     1741 gccttccatt tgcctcaagc aggtgttccc caagtacgca aaacagttca actacctgcg
     1801 cctggtggac aggatggcaa atttgtttat ccggttcctg ggcatcaagg ggacaatgaa
     1861 gttggggcca acaggctttc gtaccttcat aaggagctgc aaactcagca gcagcagcct
     1921 gtccatggct gccgtggaca tcctctacat tgacatcaca cggaggtgga actccatgac
     1981 cctggaccag cgggactcag ggatgtgtct gcaggccttc gtagaagctt tctttttcct
     2041 ggctcagagg aagttcaaga tgctgccact tcatgagcag gtggcctcac tgattgacct
     2101 ttgcgagtac cacctgtccc tgctggatga aaaacgcctg gtgtgtggcc ggggcgtccc
     2161 gtcggggggc cggcccccac accgtggccc tccccaggag ccctccccct cggcccagcc
     2221 agcaggggac aaccccccac cccgcaccag ctgtgccaat aagctctccc atcccagaca
     2281 taccctgtcc tgagggccac tctgtcctcc tggaaaacgg aagacgagag cagctttcag
     2341 ggctggagcg ccccaggcat tctgcctgca gaggaatggc aggcaggctg ccgaggggcc
     2401 cagctgaggt ccccacgaac tgtctctgtg tgcggctgag ctgtgcttca ccaggctggc
     2461 tggttctcac ctgccttcct cctcacacct cctggtgata caccctgttt ctgagtcatc
     2521 agtcatcgga catatgacat ctaaaacgtg acagatggca ccttctattc tgggctcaca
     2581 ggaagcacca actggggcaa atctgttgta tttggggcac aggacacaat cgatcccaag
     2641 gcccggagct gtggagagga agccgagtgt taggatctgc tgccggggcc tccacgcgcc
     2701 caccgggaaa agcctgagaa catcgtgttt atttcctgcc gcccgttccg agagaaggaa
     2761 gtggaaatat caagtaggca tctgcgaatc tcccatccca gtcatgtgct acatgggtgt
     2821 agtgaacaga ttaacctcat ttagttcatt agcttgcctg ttgctgcaat atttggtttg
     2881 ttattaatta agaaaaaatt aattaagaag taactaagac tcctggagcc tcagagctgg
     2941 caggagcctc agagatcatt ttgtttgatt ttgtttgact gtgaccccaa agcaggaatc
     3001 ccatctttag cctccctgac cagatggtct gagtggaccc ctgcataggt ggggtgctgg
     3061 tcatgtggcc agcgtgtcca caacaagcac tgccaggggt ccctgcatgc ccagcactgt
     3121 gctgggagcc ctgggtgagg gaaggaaatc agacatggat aagaaccaga gcaagaggag
     3181 tagtgtatgt cagacctggt gccagggtca ggggagctca cactgtcttc catgagaccc
     3241 tttccttgtc tccatctgta tccccaggta gcccccctct cggaggaaac gcctcacagg
     3301 cagcagaagg tggcattttg gaaacagcct tgggcatgcc aaggtccagg gcctattgaa
     3361 gacaggcagg caggacctgg caaagccaag ctctccagag tgtggttgga tttggggtta
     3421 atgtggccct ttcctggagg atccctttaa aggatgctga ggaacctggg aagagtcagt
     3481 catcgtgctc caagcgaggt gcaggaaagt atttgaggcg ctagtactgt gcctggtgtg
     3541 gtgcactgta ggactcagaa aatgctcgta gtgcgtggca agggagggtt ctgggaggca
     3601 gaggtgcatc ccaaataagc tcctgcagct ttctcctcct tccttccaac atcctgtccc
     3661 tgactcctga cccaaactga taagagcagt tgacctggtt cataacaggt actcaaaagc
     3721 atctgtggaa acaagttact tgaatccgcc ctccccagat atttttaaac ccaaaggcaa
     3781 gattgttaat ccaagatgtc tccaattgtt ggcaagcgat ttcagagcag gggctgctct
     3841 gttcatcctt gcctggagct ccttcctgcc aggagttcac cctctcaaag aggaaaacct
     3901 gtttccccca cggtgtggct gccgcgcagc accccttccc tgctgctagc agagcccaaa
     3961 ggccgctgcc cttccccagc ctagaggggc cgtggaactg agccctgcag agcccactct
     4021 ggggtgttca gtgagtgaca gcagacttct gcaatcactt tattttccca agcagaaggc
     4081 aggacaggtg ggaaggtggc actggcagga tgtgcctcct gaggtgtgtc gagtgttctc
     4141 tacatggggc actgtggagg tgtcatcggc tcagttcccc aggtagtagg gcaggtctgt
     4201 aatgctgctc ccctttcaga tgaggaaagg aaggcccagg aggccatgta gtcaggactt
     4261 ggtccaggtg tgtctgtctt tggctccttg tccctgggtg agaatgaatt cagctccaag
     4321 taaagaccct gcagctaccc cgctcggggc tgcctggggt ccgtcatggt ctggtggcat
     4381 gggacaaggc agtcagggct cctaaatggt ccattgtgag aaacaatgtt tgaagccccc
     4441 atgcagctct cccagtcccc tttggcagaa caaatggatt tcccagagaa agaccagagt
     4501 aagcatgtct gggcacactt gtcatcagct gggagccacc agaagtctta acaaagctct
     4561 cacgtgacac catttcttga agttggtctt cagaaagtac tcgcttgcca aagtggagcg
     4621 caatgttcag gtctaaaacc aaccaagcac attgaatatt ttgaaaaata aaatcaagag
     4681 gttgaattcc agccaccttg tttggggtga tatgaaaaca tcagctctcc tggtgagggc
     4741 ctctcccacc ccatgccatc atctggaggc gggctgctcc gcccaccatg gcccctctgt
     4801 cccgggagca gccccctcct ctgcagacaa ggccccgata gccccaccca cccgcagggc
     4861 acagagcctc cctgctgatt gttagggaaa tgaggctgtg gttttatgag aggccagtcc
     4921 tgacagattg gcccttttca gtttaactga aagcatttcg aggctgctcc attgtcagaa
     4981 tgagtgataa ctgaatcacc ccgcctcctc cattcctaat aagaagcacc actgtgttta
     5041 cccctttggt aatcggccac tcgttttatt ggatgtaatt gaaacgatag caaaagcaga
     5101 tggttccttc ctccgagaag ataggaagta gagccgggag tctggctggc ccagaggcac
     5161 ggcacacata gctgggcagc ccctgtgctt tgctgcagga taagccccat ccctgcaagc
     5221 gccctcagga tccatctcca gcgtcttctc cctcccgctc tcttgcccct tcccgctcct
     5281 cctgacgcct gtctctcccc accctcaatg cacacacagt cctctcccta gtctgctggc
     5341 tgagttcctg gagagctggg cactccgggg gcttggaatg aacgggtaag aagatcaagc
     5401 tcagcctgtg ctcagtttgg ggggttcaca tccaagtatg acaagttagt gggaccaatc
     5461 tggggaggga agcatcagga gaacaggaca gacccacaga actgggccca cctacccttt
     5521 ctttgggtgt gccccggggc agcctccttg ctcctgcctt gctgacactg cctgctccct
     5581 tccttccaac ctcctagggg gacgggctca gcatttctgt tgttaggggc gggagctttg
     5641 tcctcacggc ctggccaaaa tggagcctgc aataggtgct tatacttata aagacccgct
     5701 agattcagtg cagctgttag caagtgctgg tcccaacaga cccctcccag tgggcagagg
     5761 cagggcctcc aggagagagc agcatccatc cctaaaacaa accacctggc ttcctcttac
     5821 ttctcctccc agcctctgtc cagtccccca aactcggaca cggtctctcg cctgggcttc
     5881 cgctgcctcc ctgcctctca cccctccacc ctaccctcca tctccatagg tctggaagga
     5941 acttggagag ccacagagct gacgtccagt cacctattga aagcagccct tatcggcacc
     6001 cttcccttct ttccatccta aggcccgcac ctgacccctg cacctcagga ccaggctctg
     6061 cagcctccct gagcccctgt ccgacccctg ctcccaggac tgtttgtatc tgttgtcatg
     6121 agacaggagg aggatgtgct atttcccacc acccttgtct tgctggcccc tctgcctgga
     6181 atggccttcc tctgcccagt ggcaaacaga ctttcaaggt tcagttccag tgtccccgct
     6241 gcaatccccc aaacagagtg agcggttcct tccatctact tccaagaact ggaaagttcc
     6301 tgtcttgtcg cgcgcactgt gggaccacag cattggttcc cacccagctg tgcgttcctg
     6361 cagggtcagg catgtgctgg gtccacgttg gcacagagca ggggccagca ggtgcttgct
     6421 gtgaatagga acgtttagca gaacccggga gaggagacag tgttaccaca cttgctctcc
     6481 actttgcctg cgggtgcctt taagaagcac agatttctaa accttgccaa gccgatccgc
     6541 tgaacacctc tacattcccg gctgccttgt tggctccctg ggacacggca gctgtcctgt
     6601 gtccgtaaac agataatagc tcctccgact ctaggtgtct ctccatggcc ctttgtggcc
     6661 aggcctgggc tgcgtaccca tgggcacccc ctcccattca atctcacaga caggacacca
     6721 ggctgggcag tcctcaccaa cacccctcca gccggctagc cagcctcctt tcaactctgc
     6781 attgccctga gtttgtgtgg ggttgttgag ttcccagcag gtcctccgga tgtgcatgta
     6841 ggtagtcagg ggaatggagt gggaggatag gagcccagac acttgaaatg gtgttccatg
     6901 cctttctaga ccccaggccc tttcctgcat gattttatca gcacatgctc aatccttcac
     6961 agtttacaaa gcacttctag atccatccaa cccaccaagg atgaggatca ctggcactct
     7021 gttttcccag gcagggaagt ggcttccagg aggcttagtg actgaccaag gtctcgaggt
     7081 ctcgtgctgg tgaagtgcag agccaggatc cacctgagcc ccccggctgg ctccagatcc
     7141 cacactcctt cctcggcact tcctcggttc tgcacggtgc ctcagcactc cccaaaacat
     7201 cccattttgc aggtgtggaa acccacgtcc cgcagaggct gggtgtttgc tccactcagt
     7261 tctggggact tagcttgagg ctctctgatc tgttctcctg ctgagcaccc caggaagggc
     7321 tccaggtctc ccagccactt agtgagagtg gcaagtcctg tctcacttga tctttgggag
     7381 cataagacga gatcacagaa aatgtcatca atgtgaaagt gttttgtaaa cgaaggcgct
     7441 gctcaaacgt agtgttatct tcagcctggc tactggcttc ctacaaagtg tgaagggatg
     7501 aaggtaaaag ctctttcttg aataatgtta tccatcaaga cagatgaaac cacactggtc
     7561 agctcctcct gccctccccc caacgcccca cctccccttc attcccacat gtttaaagac
     7621 attcgtaggc tgagaaatga ttcctgctgc tcctctgaca cccggaatgt gccttgtgat
     7681 tggcagagtg tccctccaga atagcttaat tttttcccca tttcttgact aatgtcctct
     7741 actccttggc cctgtaattg agaattgggc ttgcaatggc cagcacacga gcatcttccc
     7801 tgaaagctca gaaatgatgg ctctcccggc agggagctgg cattccccat ggctgagagc
     7861 gctgtcctcc tcgcacggag ggatcattca ccaccgtgtg tattaacctg aaatccacct
     7921 caccttgatg gatatttttg ccaatctccc atttggtttg atgaatgtga gagaaatttt
     7981 cccctatggc atatgaattt ctccctcaca aaataagtct aaattttttt ctgttcctgg
     8041 agatgaagga gctctgcaga ataggccacg tcttcattta cctttatctc tagtagccaa
     8101 aagtcttgat ttttatataa ctggaaaaac cacgcagcat aatgcttata cacacacgcg
     8161 cgcatgcatg cacacacacg cacgcacaca cgatgcacac gcatgcacac acgcacacat
     8221 gcacacacac gcatgtgcgc gcacacacca cacatgcaca cacgtacaca atgcacacat
     8281 gcacacacgc acacacatgc acacacgcac acgcatgcac acacgtgcgc acgcacacac
     8341 acacactgag caccgttgag ctttggtaga aaatggcaaa attacgatgt ttttctcatt
     8401 tctggtgatt ggcttccgag tgttatttag agagcggagt ggagagggct ctttgcagcc
     8461 ctgcggtagt gtcttgtgct caccaagagg ctcacgggaa acatgtcctc caacatgaag
     8521 gtgtttgcta agattccaac caggacccag tcttgggcca cagaacactg actgctcccc
     8581 caagcccctc gcagaccgca gggatatttt cccttcagaa cctgttgcat cagaatgggg
     8641 aaagcgaggg ctgagaatcc cagaggaggc cgtgaactgt tctggaaaag cgagggcttt
     8701 gcagtcagac cttcatatgc actttgttct atctgttgcg ctctgcctaa atgaccacgg
     8761 gccagtgact ttacctctct gatccctgct ccttgcctag atagtgggga tcacgtcgta
     8821 atgtatgtaa agaaccgggt gcgggacttg gcacctggga agtgtcttaa tacatgtctg
     8881 tcgagaaaag gaagggtctc gacgtgcgga aacaagacgg atgccaggaa atacgtctgc
     8941 ccacctccac gcccctgaca gcggaggctc ctggaggtct ggtgagaggc cccacgtgct
     9001 ccagccccct ccgctctgtg ctgagctctg cctttaagag actgcagctc ctgcctctaa
     9061 aaagcctttc aaaattcttt attaaatttt catggcgcat aaagtcaagg ttctgttact
     9121 tggcctcagt tgtcttggca acttcataaa acgcaataat aaaacgaagc tgagtgttgc
     9181 taaacacagg ctcattgtat aaacga
//
