LOCUS       NM_001130045            2288 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase like 10 (TTLL10), transcript
            variant 1, mRNA.
ACCESSION   NM_001130045
VERSION     NM_001130045.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2288)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2288)
  AUTHORS   Rogowski,K., Juge,F., van Dijk,J., Wloga,D., Strub,J.M.,
            Levilliers,N., Thomas,D., Bre,M.H., Van Dorsselaer,A., Gaertig,J.
            and Janke,C.
  TITLE     Evolutionary divergence of enzymatic mechanisms for
            posttranslational polyglycylation
  JOURNAL   Cell 137 (6), 1076-1087 (2009)
   PUBMED   19524510
REFERENCE   3  (bases 1 to 2288)
  AUTHORS   Ikegami,K., Horigome,D., Mukai,M., Livnat,I., MacGregor,G.R. and
            Setou,M.
  TITLE     TTLL10 is a protein polyglycylase that can modify nucleosome
            assembly protein 1
  JOURNAL   FEBS Lett 582 (7), 1129-1134 (2008)
   PUBMED   18331838
REFERENCE   4  (bases 1 to 2288)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390719.47 and AL162741.44.
            
            On Jul 19, 2019 this sequence version replaced NM_001130045.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Both variants 1 and 3 encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379289.6/ ENSP00000368591.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL390719.47        112971-113017
            48-84               AL390719.47        113376-113412
            85-150              AL390719.47        113515-113580
            151-295             AL390719.47        118280-118424
            296-376             AL390719.47        118748-118828
            377-683             AL390719.47        119125-119431
            684-802             AL390719.47        119574-119692
            803-932             AL390719.47        119822-119951
            933-1007            AL390719.47        120832-120906
            1008-1093           AL390719.47        121452-121537
            1094-1265           AL390719.47        121967-122138
            1266-1437           AL390719.47        123011-123182
            1438-1578           AL390719.47        124060-124200
            1579-1695           AL162741.44        6712-6828
            1696-1789           AL162741.44        7205-7298
            1790-2288           AL162741.44        7550-8048
FEATURES             Location/Qualifiers
     source          1..2288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2288
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /note="tubulin tyrosine ligase like 10"
                     /db_xref="GeneID:254173"
                     /db_xref="HGNC:HGNC:26693"
     exon            1..47
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            48..84
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            85..150
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            151..295
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2199
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /EC_number="6.-.-.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubulin tyrosine ligase-like family, member 5; inactive
                     polyglycylase TTLL10; tubulin tyrosine ligase-like family,
                     member 10; tubulin--tyrosine ligase-like protein 10"
                     /codon_start=1
                     /product="inactive polyglycylase TTLL10 isoform 1"
                     /protein_id="NP_001123517.1"
                     /db_xref="CCDS:CCDS44036.1"
                     /db_xref="GeneID:254173"
                     /db_xref="HGNC:HGNC:26693"
                     /translation="MDHSCTRFIHRRGPPTRTRAGFKRGKRPRIQQRPRARVSGTIPA
                     SRLHPAPASQPGPCPAPGHCPVGPAHERPMGSSQEEGLRCQPSQPDHDADGHCGPDLE
                     GAERASATPGPPGLLNSHRPADSDDTNAAGPSAALLEGLLLGGGKPSPHSTRPGPFFY
                     IGGSNGATIISSYCKSKGWQRIHDSRRDDYTLKWCEVKSRDSYGSFREGEQLLYQLPN
                     NKLLTTKIGLLSTLRGRARAMSKASKVPGGVQARLEKDAAAPALEDLPWTSPGYLRPQ
                     RVLRMEEFFPETYRLDLKHEREAFFTLFDETQIWICKPTASNQGKGIFLLRNQEEVAA
                     LQAKTRSMEDDPIHHKTPFRGPQARVVQRYIQNPLLVDGRKFDVRSYLLIACTTPYMI
                     FFGHGYARLTLSLYDPHSSDLGGHLTNQFMQKKSPLYMLLKEHTVWSMEHLNRYISDT
                     FWKARGLAKDWVFTTLKKRMQQIMAHCFLAAKPKLDCKLGYFDLIGCDFLIDDNFKVW
                     LLEMNSNPALHTNCEVLKEVIPGVVIETLDLVLETFRKSLRGQKMLPLLSQRRFVLLH
                     NGEADPRPHLGGSCSLRRWPPLPTRQAKSSGPPMPHAPDQPGARRPAPPPLVPQRPRP
                     PGPDLDSAHDGEPQAPGTEQSGTGNRHPAQEPSPGTAKEEREEPENARP"
     exon            296..376
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            377..683
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            684..802
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            803..932
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1007
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1093
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1265
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1437
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1578
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1695
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1789
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2288
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /note="hexamer: TATAAA"
     polyA_site      2288
                     /gene="TTLL10"
                     /gene_synonym="TTLL5"
                     /note="major polyA site"
ORIGIN      
        1 actgttgttt cctggcccag gctcccagga ccttgtgggc tgggcagcgg cctccggccg
       61 ggaggcacca gctcttcgaa caatgtttaa aagtctcttc tgttcatcct accggggtgc
      121 cgtctcctgc cggtcttttc atctcaccag ggccctcgcc cgggcacccc ccggccaatg
      181 gaccacagct gcacccggtt catccaccgc cggggaccac ccactcggac ccgagccggc
      241 ttcaagaggg gcaagaggcc aaggatccag cagaggcctc gggctcgagt ctcagggacc
      301 atccctgcgt cacgtctgca cccagcaccg gcctcacagc ccggcccctg ccctgcacca
      361 ggccactgcc ctgttggccc ggcccacgag aggccaatgg ggagcagcca ggaggaggga
      421 ctccggtgtc agccaagcca gccagaccac gacgcagatg gacactgtgg gccggacctg
      481 gagggggcag aaagagcctc tgccacaccc ggaccccctg ggctcctgaa cagccaccgg
      541 cctgcagact cggatgacac taacgccgcc gggccctcag ctgccctcct ggaggggctc
      601 ctgctggggg gtgggaagcc atcgccccac agcacccggc cggggccctt cttctacatt
      661 ggaggcagca acggggccac aatcatcagc tcctactgca aaagcaaggg ctggcagcgc
      721 atccatgaca gccgccggga cgactacacg ctgaagtggt gtgaggtcaa gagccgagac
      781 agctacggca gcttccggga aggagagcag ctgctgtacc agcttcccaa caacaagctc
      841 ctcaccacca agatcgggct gctcagcacc cttcggggac gggcacgggc catgagcaag
      901 gccagcaagg tgccgggggg ggtccaggcc aggctggaaa aggacgcagc agcgcccgcc
      961 ctggaggacc tcccgtggac aagcccagga tacctcaggc cacagagggt cctgagaatg
     1021 gaagagtttt tcccagagac ctaccgcctg gacctcaaac acgagagaga ggcctttttc
     1081 accttgtttg atgaaaccca gatatggatc tgcaagccca cagcctccaa ccagggcaaa
     1141 ggcatcttcc tgctccggaa ccaggaggaa gttgccgccc tgcaggccaa gacccggagc
     1201 atggaggacg accccatcca ccacaagacg ccgttccggg ggcctcaggc gcgggtggtg
     1261 cagaggtaca tccagaaccc gctgctggtg gacgggagaa agtttgacgt gcgctcctac
     1321 ctgctcattg cctgcaccac accctacatg atcttctttg gccacggcta tgctcgcctc
     1381 acccttagcc tttacgaccc ccattccagc gacctcggcg gccacttgac caaccagttc
     1441 atgcagaaga agagccctct gtacatgctg ctgaaggagc acacggtgtg gagcatggaa
     1501 cacctcaacc gctacatcag tgacacgttc tggaaggccc ggggcctcgc caaggactgg
     1561 gtcttcacca ccctcaagaa gcggatgcag cagatcatgg cccactgctt tctggccgcc
     1621 aagcccaagc tggactgcaa gctgggttac tttgacctca ttggctgtga cttcctgatt
     1681 gatgacaact tcaaggtatg gctgctggag atgaattcta acccagccct gcacaccaac
     1741 tgcgaggtcc tgaaggaggt catcccaggt gtggtcatcg agaccctgga cctggtgctc
     1801 gagaccttcc ggaagagcct gcgcggccag aagatgttgc ctctgctgtc ccagcgccgc
     1861 ttcgtgctcc tgcacaacgg tgaggccgac ccgcggccgc acctgggggg ctcgtgcagc
     1921 ctccgccgct ggccgcccct gcccacccgc caggccaagt cctccgggcc acccatgccg
     1981 catgccccag accagccggg cgcccgcagg cctgcgccac ctcccttggt gccgcagcgt
     2041 ccccggccac ccggccccga cctggacagc gcccacgatg gggagcccca ggccccgggc
     2101 acggagcagt cgggcacagg caacaggcac ccggcgcaag agccttcccc ggggacagcc
     2161 aaggaggaac gcgaggagcc tgagaacgcg aggccctagg ggcagccacc cgcgcccagc
     2221 gccccgcgcc ccgcgcccca gccgtgctgc ctgccctcag ggacctataa agcccacttt
     2281 gctacaaa
//
