LOCUS       NM_153712              14267 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase (TTL), transcript variant 1,
            mRNA.
ACCESSION   NM_153712
VERSION     NM_153712.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14267)
  AUTHORS   Barisic,M., Silva e Sousa,R., Tripathy,S.K., Magiera,M.M.,
            Zaytsev,A.V., Pereira,A.L., Janke,C., Grishchuk,E.L. and Maiato,H.
  TITLE     Mitosis. Microtubule detyrosination guides chromosomes during
            mitosis
  JOURNAL   Science 348 (6236), 799-803 (2015)
   PUBMED   25908662
REFERENCE   2  (bases 1 to 14267)
  AUTHORS   Dick,D.M., Meyers,J., Aliev,F., Nurnberger,J. Jr., Kramer,J.,
            Kuperman,S., Porjesz,B., Tischfield,J., Edenberg,H.J., Foroud,T.,
            Schuckit,M., Goate,A., Hesselbrock,V. and Bierut,L.
  TITLE     Evidence for genes on chromosome 2 contributing to alcohol
            dependence with conduct disorder and suicide attempts
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (6), 1179-1188 (2010)
   PUBMED   20468071
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 14267)
  AUTHORS   Erck,C., MacLeod,R.A. and Wehland,J.
  TITLE     Cloning and genomic organization of the TTL gene on mouse
            chromosome 2 and human chromosome 2q13
  JOURNAL   Cytogenet Genome Res 101 (1), 47-53 (2003)
   PUBMED   14571137
REFERENCE   4  (bases 1 to 14267)
  AUTHORS   Mialhe,A., Lafanechere,L., Treilleux,I., Peloux,N., Dumontet,C.,
            Bremond,A., Panh,M.H., Payan,R., Wehland,J., Margolis,R.L. and
            Job,D.
  TITLE     Tubulin detyrosination is a frequent occurrence in breast cancers
            of poor prognosis
  JOURNAL   Cancer Res 61 (13), 5024-5027 (2001)
   PUBMED   11431336
REFERENCE   5  (bases 1 to 14267)
  AUTHORS   Ersfeld,K., Wehland,J., Plessmann,U., Dodemont,H., Gerke,V. and
            Weber,K.
  TITLE     Characterization of the tubulin-tyrosine ligase
  JOURNAL   J Cell Biol 120 (3), 725-732 (1993)
   PUBMED   8093886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012442.7.
            
            On Nov 23, 2018 this sequence version replaced NM_153712.4.
            
            Summary: TTL is a cytosolic enzyme involved in the
            posttranslational modification of alpha-tubulin (see MIM 602529).
            Alpha-tubulin within assembled microtubules is detyrosinated over
            time at the C terminus. After microtubule disassembly, TTL restores
            the tyrosine residues and consequently participates in a cycle of
            tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed
            14571137]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.85951.1,
                                           SRR1803616.219745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233336.7/ ENSP00000233336.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               AC012442.7         35588-35933
            347-425             AC012442.7         39349-39427
            426-658             AC012442.7         47575-47807
            659-794             AC012442.7         54638-54773
            795-1064            AC012442.7         56344-56613
            1065-1208           AC012442.7         73714-73857
            1209-14267          AC012442.7         82113-95171
FEATURES             Location/Qualifiers
     source          1..14267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..14267
                     /gene="TTL"
                     /note="tubulin tyrosine ligase"
                     /db_xref="GeneID:150465"
                     /db_xref="HGNC:HGNC:21586"
                     /db_xref="MIM:608291"
     exon            1..346
                     /gene="TTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1323
                     /gene="TTL"
                     /EC_number="6.3.2.25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2410003M22Rik"
                     /codon_start=1
                     /product="tubulin--tyrosine ligase isoform 1"
                     /protein_id="NP_714923.1"
                     /db_xref="CCDS:CCDS2096.1"
                     /db_xref="GeneID:150465"
                     /db_xref="HGNC:HGNC:21586"
                     /db_xref="MIM:608291"
                     /translation="MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGER
                     NRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYP
                     TNLKTPVAPAQNGIQPPISNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGI
                     LISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYRE
                     GVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALN
                     ITLESSILLQIKHIIRNCLLSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNG
                     APACAQKLYAELCQGIVDIAISSVFPPPDVEQPQTQPAAFIKL"
     exon            347..425
                     /gene="TTL"
                     /inference="alignment:Splign:2.1.0"
     exon            426..658
                     /gene="TTL"
                     /inference="alignment:Splign:2.1.0"
     exon            659..794
                     /gene="TTL"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1064
                     /gene="TTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1208
                     /gene="TTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..14267
                     /gene="TTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4914..4919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTL"
                     /note="hexamer: AGTAAA"
     polyA_site      4934
                     /gene="TTL"
                     /note="major polyA site"
     regulatory      5226..5231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTL"
                     /note="hexamer: AATAAA"
     polyA_site      5252
                     /gene="TTL"
     regulatory      14250..14255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTL"
                     /note="hexamer: AATAAA"
     polyA_site      14267
                     /gene="TTL"
ORIGIN      
        1 gctttcctct ccggcacccg gcgggcgccc gggcgcggcg ccgccggcac ccgagaggcg
       61 cggtagccgg cgcgggcggc gggggccggg ccgcggcggg cgcccgggcg gggtccgcgc
      121 tgagccgcct tctcggccgc ctggtccctg cggcggctgc ccggcggccc gggcgcgcgg
      181 cgcttcgcca tgtacacctt cgtggtacgc gatgagaaca gcagcgtcta cgccgaggtc
      241 tcccggctgc tcctcgccac cggccactgg aagaggctgc ggcgagacaa ccccagattc
      301 aacctgatgc tgggagagag gaatcggctg cccttcggga gactgggtca cgagcccggg
      361 ctggtacagt tggtgaatta ctacaggggt gctgacaaac tgtgtcgcaa agcttcttta
      421 gtgaagctaa tcaagacaag ccctgaactg gctgagtcct gcacatggtt ccctgaatct
      481 tatgtgattt atccaaccaa tctcaagact ccagttgctc cagcacagaa tggaattcag
      541 ccaccaatca gtaactcaag gacagatgaa agagaattct ttctcgcctc ttataacaga
      601 aagaaagagg atggagaggg caacgtttgg attgcaaagt catcagccgg tgccaaaggt
      661 gaaggcattc tcatctcctc agaggcttca gagcttctcg atttcataga caaccagggc
      721 caagtgcacg tgatccagaa atatcttgag caccctctgc tgcttgagcc aggtcatcgc
      781 aagtttgaca tccgaagctg ggtcttggtg gatcatcagt ataatatcta cctctataga
      841 gagggtgtgc ttcggactgc ttcagaacca tatcatgttg ataatttcca agacaaaacc
      901 tgccatttga ccaatcactg cattcaaaaa gagtattcaa agaactacgg gaagtatgaa
      961 gaaggaaatg aaatgttctt caaggagttc aatcagtacc taacaagtgc tttgaacatt
     1021 accctagaaa gtagtatctt actacaaatc aaacatataa taaggaactg cctcctgagc
     1081 gtggagcctg ccattagcac caagcacctc ccttaccaga gcttccagct cttcggcttt
     1141 gacttcatgg tcgatgagga gctgaaggtg tggctcattg aggtcaacgg tgcccctgca
     1201 tgtgctcaga agctctatgc agaactgtgc caaggcatcg tggacatagc catttccagt
     1261 gtcttcccac ccccagatgt ggagcaacct cagacccagc cagctgcctt catcaagctg
     1321 tgacagaggg cactccctgc tgccttggaa aaagcacggg gtcctgctcc agggaatggt
     1381 gaaatgactg gattgctctt tatccagccc acagcagggg aaagaaaggc aactcgcaaa
     1441 gatgagatgg aagaaggcac gtgagcagag gaggcagctc ccaaagagag ggctgctcag
     1501 ggggcttccc agatgtagct ctcagcagtg ctgttgagac ttttgaaaac aactttggta
     1561 cacaaaggca gctttgtgag cagagctcct tcccctctcc ccgggaacgg cagggcactg
     1621 ggacctctgg tcggtgcctc ccacccactg cagccctagt gccttagctc catgcccggc
     1681 tgcagcccca ctgctctgga ctatggattg gacgtcagag catattggag gttgcctgtg
     1741 tgttccccac ccatcccttc ggtaacactc tgccacacta agctctgtac aagcatgcac
     1801 caacagtcct tagttttgtg ctgtgcactg gcctctcggc aaaggtggtt tccctcatca
     1861 ccttcctgat ggtgtttggt cagtcacctg tcagggtttg tgcgggttgg gccccaaaac
     1921 agcatatgct gctctaagtc tgctctctgc atgttttaga aacaaagtgg caagtctgcc
     1981 ctgaacctgt aagcatcaaa taagcatgag agagaaaaaa acatgatata ttgctttact
     2041 taataggttg aatatggtag gtctttgaaa atatgatgat tcaattttct caattttctt
     2101 tgctttaacc aaaattctaa atgcagtttt gcctagttcc cttttttttt ctttttttac
     2161 ttttttttaa acgtttgtaa aaacctcttt gaggatgagg agtcagtaaa attccactcc
     2221 ccaagtggcc ctgccccaga caaaggttgc tttccccctt tttgttcttt ttatgccccc
     2281 aagcactttc tgcagtagct agagggacag gtttccttcc aggaaggatt cgagttcctg
     2341 tgcctgtggg tattaggaga gtatatatcc tgcctgaatg gggaagtctt ctaaaatggg
     2401 aaagaagtgg tttcatctcc acacagtgtc ttgtaaatct caacaaatgt gtactgttag
     2461 aagtggcttc cgcttactgg attaactaat actttatagg cttttcagga ggccacatca
     2521 ctagcagtag ggagaacaag atgtcatttg tgttcagtgt aagctgagta aacaggccct
     2581 tcctagagtg tcctggaaat cacagcaacc cattgaaaac tgccctcccc accagaacgt
     2641 gctacgttct ttcttcatgc ctatgtgtgc tccattcctc atttctactt ggctcaagaa
     2701 aacatttctg cagtcaggtg agacttttac aaaagaggag aaaatcaatg cctccttgaa
     2761 catgatgaga tgtgagaact tacaatgaaa aaggcaataa tgatagaaat tatttcttag
     2821 gtacagcaat agttgatagg atgtgagggt gttaccttgg ggtgaagtgg agaaggtccc
     2881 aggtgaattg gctctcatgg aaatttggaa ttacaaaata aacgtcctgg gggttaccca
     2941 gaatacagat ttaaaagttt gcctgtagag caaaataaaa cagtcagttg tagtcattaa
     3001 tccttgaggc ccaacgcagc cgatgggttg gtgtttggga aattctgaga tgggagtgag
     3061 atctgatcgg atcctgggaa gatgtatacc cagttagaac gtgtagggtt ctgggtccct
     3121 ggcaagtcta ggtgggcggg tgacagggaa agcatgggca tttttgtatt gctgtcacat
     3181 gctaacagag gtttgtaatt atcttttgga cccaaattat agagacattc acgagttttc
     3241 tagccctcac agtaacagag ctaagaattc agatgtcagg aagtctgtga atcttgatgg
     3301 attttctgag aaacctgact caatggcata tataagaggg aagtaagact tttaagaaaa
     3361 gaaaaagtta tgcctcattc ctcatgtggc ttccaataag tatcttagga acttatttcc
     3421 tttttaaaaa atatttttta aatttttaaa atttgatttt aaatttcaaa taaatttaaa
     3481 taaattttaa ataaatttta aataaaattt tacagagacg tggtctcact gtgttgccca
     3541 ggctggattg cagtggctat tcgcagttgt aatcatagca cactgcagcc tcgaatttct
     3601 gggcttgagc agtcctcccg tctcagcctc ctgagtagct gagactacag gtgcacacca
     3661 ccaagcctgg ctttatgtat ttatttctgt tcatgcggaa tgattggttc agaactgttc
     3721 ctttcccttc catgatgtcc ttgacacaga aggttatgcc tggctcccag tcaggcttca
     3781 tacttttggt ccatgtaagt gctacccgtt gctgggggag gagtcatggt ttatttggaa
     3841 atgtcagttg caatcatggt tctgtcattt gactgcacag tatcagagga gcctgttaac
     3901 ctctctgtgc cttagtttct tagcccatga aagagatcat tgcctgaccc agggactacc
     3961 tcaagggctt ttgatgagga caagtgacag taggaagatg caagagcctt tagtaccaag
     4021 gttctcaaca ctgactacat gctggaatga ctgtgaagct tttaaaaaat gttagtgccc
     4081 actcttcccc tgtacccccg gacagttaaa tcagaacctc agacagcaat atgccttgag
     4141 atgccttgaa ccatgcttga gaaggaagga caaacacatt attatcttgg aagaattgca
     4201 taaggcttat gacttaaaaa aaaaaattct ttttggaaac acaagcattt ctttaaggat
     4261 gaccggatgt tgccgtatgt atttatggca caagcaggtg ttgtctaagc agtttctctg
     4321 tttgcttgtc atagcagcat ttggaaactc aaacatgctt tcatttacat aaatagttta
     4381 tgaagctttg acaacaaatg taaacagaca cgaaattata aatctgctaa atatgtatta
     4441 agggtattaa ttattgaaag tccctttccc caaaactcaa ctcctatggc aattatgaac
     4501 tccattttac caagaacatt taagtgcctc agcatctgta tgatatagtg gagcaggtgc
     4561 tgacataggt accagctgac atgatgtgtc actagctctg tgggatgatt gccacataca
     4621 tggaacacct gggagtgctg gaaatgtact gtgatcgaag tgacaaagtg tgttttcatt
     4681 cacagtggag gctacatcaa gcaaggggag gtccagccct cttgcaagtg tggtgagagg
     4741 ctctactagc aaagacatgg gcaccggagt aggtcccgtg tagcatgcgg gtgctgtaga
     4801 gaaaattcag tgacgtacat ggctctggtt ctggacacaa aatctgtact ggagaggaaa
     4861 tgactgctga aataaggcga ttgtatgaat atttaaaatg cctggaacac taaagtaaag
     4921 taatgatatt tcaagtgttt ttgtgctctt tggttcttgt tgtaggtatt gactgtcctg
     4981 ggatatcact ggtcatttaa attcaccata taattagccg ggcatggtgg catgtggtgg
     5041 tggctgaggt gggaggatcg cttgaggctg aggtgtgagg ctgcagtgaa ccatgttcac
     5101 accactgtac tctagcttga gcaacagagc aagaccctgt ctcaaaagta aataaataat
     5161 aaagtaaata taaatccatg atgccgttac tcaggggtag acagactttc tgtaaaaggc
     5221 cagataataa atctgctagg ctttgcaaac catgtagggc cttttttgca tactttttgt
     5281 ttttttctcc aactcttagc tcataggccg tataaaagca ggccagatgt gcagtaattt
     5341 gctgacccca ggatgttacc caatacataa gccaacagat tgtccttcaa aactgatgag
     5401 cttctcagtg aagcactgag actatttcag ctgccaaagt cccagcccat cgtttcttac
     5461 gtgtcttgtg tatcgagttc ttgtaaagca tttcaccaag gccaggtttt taaataccta
     5521 taaacctcac acacctgaga tgcttagtct tgtggataga aagagtttca ttaatgcaaa
     5581 ttgttattaa cttgtaactt cttgtgcaat aaggctgaat gctttggaca tctttccttt
     5641 gtatggctgg cctgccttct gtggctgctt ccacttcata aatatacctc tggcacagag
     5701 gaggtttcca tgccagaagc cctgtgtagg cactccactc caaacaggtt tcacatacac
     5761 tatgacacat tcccagtgga ctcagcagag attgcatggg cagggtgcag ggtgcagggt
     5821 gcaagcagac atggatccag gcaggcacct acttaggacc ctgagagtgg acaggcccaa
     5881 agcctttgga agacttctct taaagactgg tcccacttcc tgtcagtagc tacacctcct
     5941 tcttaacctg aagttctccc ataacccata ttttagaagt gttttcccca aagcatccct
     6001 ccatatctta gtctattttg tattgccata acagaatgtt acagagaagt gtatgtggct
     6061 cacggttctg gaggatgaga agtccaatat caaggggcta tatctggtga gggccttctt
     6121 gctgcctcag catggcagaa ggcatcacat ggcaagagag gaatggagtc taactcaccc
     6181 tttaactagc aacccattcc tgtgataact aacccactcc tggcataaca tcattaattt
     6241 attcatgagg gtagagctct cgtgacctaa cctcttacag gtcccacctc tcaacactat
     6301 tgcagtagag attaagtttc caacacattt actttgggga acacattcaa accatagcag
     6361 tccctgaagg caaaggaaaa tgaacccctc tccaatgcaa tacatagtag cagaacttga
     6421 agattgttgc aagcataatt cctttcaaaa attatgagag gacatcagtg ggcataatag
     6481 agtaacaacc tctgaaaacc ctctcttcca taaaagcaat gagaacacta gcaaaactgt
     6541 ctagacatta accagaggct tgcagcaatc catttattca agaaaaggcc tgtaatccca
     6601 gcacttcggg aggccaaggc gggcgatcac gaggtcagga gatggagacc atcctggcta
     6661 acacagtgaa accccatctc tactaaaaat acaaaaaatt agccgggcgc ggtggcaggt
     6721 gcctgtagtc ccagctactt gggaggctga ggcaggagaa tggcgtgaac ctaggaggca
     6781 gagcttgcag tgagccgaga tcacgccact gcactccatc cagcctgggt gacagtgcga
     6841 gactctgtct caaaaaaaaa aaaaaaaaaa aaaggaaagg gttgcatctg ggtaagaaaa
     6901 gcaagctttc tgacatttta atgtacccta ttcccactcc ccctttcccc agctccacaa
     6961 cagcctcggc cacacaatca tgctgacatc cagcagcaga gcagccaccg tagggctcag
     7021 aaggggattg gaactcctcc aaagcttcat taccagagaa ttgccatttg gcctttttgg
     7081 tagttccatg taagtcccta ctcctaggtc ttgtctttat ttgatgtgac taagaggtta
     7141 cccagtgtga acaacctttt ccctgggtgc atttgtcaaa aaaaatcaac agcaattgtt
     7201 gaacatctca gcttcctaag gtggctgtaa cagttggaac aaacaaactg accaaaagac
     7261 ttagaaggaa aaactgggaa tgagatttct ataggacgtt ttgaaaagct tcaacctatt
     7321 cctaagaatg cagaaggcca cacacatgtg taggactgtg cacatgccca gaagagacct
     7381 gagaattccc cagctctttc gtctgacctt aagtgtctgc acaaacagag aggacagagg
     7441 cagaaggagg gaaagaggga gggaggaaag gtaggaaggg gagaaagaga gaggaagaaa
     7501 gagaaaggaa agaaaggcag gcagaaagaa ggagaaaggg agggagggag ggaaaggagg
     7561 gagggaagaa aagagaaaga ttgagaaaga aaaaagagaa agaagaaaga aaagaaaaaa
     7621 ggaaagaaag ttagtttata aaatagaacc aagtagaaat tttagagttg caaagtacaa
     7681 aaatgcaaat gaaagattta cttgagaagt ttaaaaaatg tgtgaactgg taaaagaagt
     7741 aatcagcaaa ttagaagtca tttgagatta tccagtctgt ggaacagaaa aaaaaaatca
     7801 gcaaagaaaa atgatcagtg cttcagacac ccgtcagaca ccatcaaaca taccaacata
     7861 cacataatag gagtcctaga atagataagt gagagagagg gaaggggata aaacatatac
     7921 tggaagaaat agtggccaaa acctttccca ctttgaggaa aaacattaaa gtgaatccaa
     7981 gaagctcaac aaattctaag caggaaagac tcaaagagtc cacctcaaga cacaccagcc
     8041 actaagtaaa taattttaaa tatatagtaa aaaatgacaa ggaaacagaa atgttacact
     8101 agaaaatata taagaaaaga gaaggaagta atgaaaaata gaggagaaaa aaaaggcaag
     8161 aggcctaaag aaaccaacag taaaatggta gataaatcct gccttatcag taatttcatt
     8221 aaatgcaaat gaattaaata ctccaatcag aaggtagaga ttggcaaatt gatttttttt
     8281 aaaaatcatg atccaactat atgctatcta caaaaaacac acttcatttt atttttattt
     8341 ttattattta gagacagagt cttgctctgt tgcctaggtt ggagtctagt ggtgtaatga
     8401 tagctcactg cagcctcaaa cttctggttt caagtaatct tcccacctta gccacccaag
     8461 tagctggaac tataggtgcc tgccaccata cttggctaat ttaaaacaat ttttttagag
     8521 ataggacctg gcttacttca aaacttacct ggctaatttc acttcacata acgatcttca
     8581 gttccatcca tgttgttgga agtgacagga tctcactctt tatggctgaa cagtactcca
     8641 ttgtgtataa gcaatatatt ttctttatcc attcatctgc tgatggacac ttaggtcgct
     8701 tccaaatctt ggctattgca aacaaggctg cagtaaacat gggagtgcag atatctctcc
     8761 aaaaaaaatt tttttttttt tagagatagg gtcgtactgt gtttcccaag ctggtcttga
     8821 actcccgtcc tcaggcaatc ctcctgcctc agtctcccct aagcagctgg gattacaggc
     8881 atcagccaat gcacctggca aaacacactt tagattcaaa aacacaaaca ggttgaaagt
     8941 aaaatgatgg aaaaagatat accatgcaaa cagtaactca aagagaagtg gagtagctat
     9001 actaatgtta gacaacataa actttaagaa aaaaattgtt tctatagaca aagaaggact
     9061 tttttttaat agttccaact tttattttaa attctggagg tacatacaca ggtttgttac
     9121 atgggtcctg aggttggggt acagatccca ttacccaagt agtaagcata gtacctaatg
     9181 gttagctttc caatccttgc acccctccct cccttctccc tcttgtcatc tttagtgtct
     9241 cttgttgcca tttttgtgtc catgtgtatc taatgtttgg ctcccactta tgagactgtg
     9301 caatatttgg ttttctgttc ctgtgttatt tcacttagga taatggcctc cagcagcatc
     9361 catgttactg caaaggacat gatttcattc ttttttatgg ctgcatagta ttccatggta
     9421 tatatgtact atattttctt tatccaatcc actgttgatg ggcacctagg ttgattccat
     9481 gtctttgctc ttgtgaatag cactgtgata aacatatagg tgcatgtgtc tttctggtag
     9541 aatgaattgt tttcttttgg atatataccc agtaatggga ggctatgttg aatggtagct
     9601 ctgtttttgt ttgtttgttt gtttgtttgg tggagtctct ctctgtcacc caggctggag
     9661 tgcagtggtg tgatctgtgc tcactgcaac ctccgcctcc tgggtttaag cgattctcct
     9721 gcctcagcct cccaagtagc tgggactaca ggcgtgtgcc gccatgccca gctaatttct
     9781 gtatttttag cagagacagg gtttcaccat gttggctagg ctggtcttga actcctgacc
     9841 tcaggtgatc gacctgcctc agcctcccaa agtgctggga ttacaggcat gagccaccat
     9901 gcccagctgc tctgttttaa attctttgag aaatctccaa acttctttcc acagtggttc
     9961 aaccaattta cattcctgcc agcagtgtat aagcattctc tttttttcct tagcctcttc
    10021 agcatctgtt attttttgac tttttaatat agctattctg actggcgtga gatgatatct
    10081 tattgtggtt gtgatttcca tttctctgtt gattagtgat gatgaacatt gtctcatatg
    10141 tttcttggcc acttgtatgc caaggacatt ttatattgat aaaagggtca gtccattagg
    10201 aaaatatgac aattataaac atatgtacct agcaatacag cctaaagata catgacataa
    10261 aaacttagag aattgaagga agaaacagac aatttaacta caatagttgg aaccctcaaa
    10321 actccatttc aataatagct agagcaacta ggcagaagat caacaagaaa atagaaaaca
    10381 ctataaacca actagacttg acaaatatct acaaggcact ccacccaaca gcagcaaaat
    10441 acacatcctt ctcaagtgca catggaacat tctctggggt agatcacatg ctaggccata
    10501 aaacaagtct cagtaaattt aaaagaattg aaattatact acatatgttc tctgaccatg
    10561 ttggaataaa atcagaaatc agtaacaaat tttgttaatt tctgtattaa tgaagaaata
    10621 tacaagtaaa gaggttggac taataataat tcttttaaaa cttcccacag ggaaaagccc
    10681 aggaccagat tgtaagccag atggtaagga attaacacca atatttcata gagtctccta
    10741 aaaaatagaa gagaagaaaa tactcctcaa ttgagaagag tgtcctcaac tttatgaggt
    10801 cactcttaat accctgatac caaaaccaga caaagatgtc acaagaaaag caaatagcag
    10861 accaataatc tcttgggaat acaaacggaa aaaatcttca acaaaatact agtaaaccaa
    10921 atccagcaac atagaaaaag gattatacat tatgactaag tgggacttat cctaagatta
    10981 caaagtttgg aataactcat gttctcttgt aagtggaagc taggctgagc acggtggctc
    11041 actcctataa tctcagcact tttaggaggc caaggtgggc agatcaaatg aggccaggag
    11101 tttgagtcca gcctgggcaa catgattaaa tctggtctct ataaaaaata caagaattag
    11161 ccaggcatgg tggtgcatgc ctgtaatccc agctactctg atggctgagg cacaagaatc
    11221 gcttgaacct gagaagagga ggttgcagtg agcagagatc gcacaactgc tctctgtcct
    11281 aggtgacaga gcaagtcctg tctcaaaaaa attaaaaagt gggagctaaa cattgggtac
    11341 acatggacat aaagttggga agaggccagt cgcggtggct cacgcctgtc atcccagcac
    11401 tttgggaggc caaggcgggc ggatcatgag gtccggagat caagaccatc ctggctaata
    11461 tggtgaaacc ccgtctccac taaaaataca aaaaattagc cgggcgtggt agcaggcgcc
    11521 tgtaatccca gctactcagg aggctgaagc aggggaatca cttgaacctg gaaggcggag
    11581 gttgcagtga gccgagattg cgccactgca ctccagcctg ggtgacagag actctgtcta
    11641 aaaaaaaaaa aaaaaaaaaa aaagatggga acagcagaca ctggggacta ctagagccag
    11701 gagagaagga ggggagcaaa gattgaaaac tacctattgg atactgtgct cgctacctgg
    11761 gtgacaggtt caaccatacc ccagacctca gcatcaccca atataccttt gtaacaaatt
    11821 cgcacatgta cccccctgat tctaaaataa acgttgagaa ggggaaaaga aagaatgcaa
    11881 ggttttttta acatacaaaa tttacttaat ataatatacc actttaatag aaaaaagagg
    11941 acaaaaagca catgatcatt tcaatataca ctgaaaaagc atttggcaat acacaacact
    12001 ctttcttgga aaaaaccttt caacaaacta gaaataaatt acttcctcaa catgataaag
    12061 agcatctttg gaaaaaccca cagcctacat catattaatg gtgatgtgaa agctccagtt
    12121 gggagctttc ttcccaatat caggcacaaa acaagtatat ttattcttgt cacttcaaca
    12181 ttgtattaaa tgttctagac agagcaattc gacaaaagga aggaaagaag actgcgcatt
    12241 cagattggaa agggagaagt atgatgatct ctctttgcag acgacaagat accatataga
    12301 aaaagtccta agaaatccac ttacgctgtt agaactaata aagagtttag caagattgcc
    12361 agacacaaga tcaatataca aaactcaatg gtatttctac atattacaaa caatttgaag
    12421 ttaagaaaac aattccattt atatcaacac caaaaagaat gaaatactta ggaataaatt
    12481 taacaaaagt tcatttctac accaaatact acaaaacatc tctgaaagaa attaaagaac
    12541 acctaaataa atggaaagac atcccatgtt tatggattgg gagataatta ttgttaggat
    12601 gaaaataggc cccaaattga tctaccaatt gaacacaatc ctgatcaaga atctcagcct
    12661 tctttgcaga aattgacaag ctgggccggg tgtggtggct cacacctgta atcccagcac
    12721 tttgggcggc caaggcagat ggattacttg aggtcaggaa ttcaagacca gcttggccaa
    12781 catggtaaaa ccctgtctct attaaaaata caaaattagc caggcatggt ggtgcatgcc
    12841 tgtaatctca gctatttggg aggctgaggc aggaggtaga ggttgcagtg agccaagatc
    12901 atgccactgc actccatcct cagcaacaag agcaaaactc tgtctcaaaa aaacaaaaaa
    12961 caaaaaaaaa aaaaaaagag aaagaaattg acaagctaag ctgacgctaa aatccatatt
    13021 gaaatacaaa ggatcaaata aatctggaga aagaagaaca aagttggagg atgtgcactt
    13081 cctgatttca aaatttatta caaagctgta ttaatcaaat ctgtgtagtt tgtagacaga
    13141 tatacagata aatgtagata gacatacaga tcaagagaat agaactgaga gtcaaaaata
    13201 aacccttgca tctatagtga actgattttc gacaaggagg ccaagacaat ttgatgaggg
    13261 aaagaatagt ctttttaaca aatggtgtta ggacaactgg atatccacat gcaaaggaat
    13321 aaagtgatat gcctttctca caccatatac aaaaattagc tcagaatgag tcaaagactt
    13381 aaatgtaaga gttgaaacta caaaactctt agtagaaaat ataggtgaaa atccccatga
    13441 ttgaaaaata tctagtattt gatagcacaa cagggtgact gcagtcagca ataatttgtt
    13501 gtaccttcaa aaataactga ggaagtacaa ttggaatgtt catgacagaa atgatgaatg
    13561 cttgaggtga tggaaacccc atctaccctc ctgtgatgat tacatcgtat gcctatatga
    13621 aaacatctca tatacctcat aaatatgcta attatgtacc cataaatttt tttttaaatc
    13681 ctcatgacct tggattacac aatgatgtct tagatatgat ataaaaagac aggcaacaaa
    13741 agaaaaaaac tacacttcaa aattaaaacg ttttgcttca aaggacacca gcaagaaagt
    13801 aaaaacccac agaatgggag aaaaatattt gcaaatcatg gatctgacaa ggactagtat
    13861 aggctatata aagaactaca actactcagt tggccgggcg cgcgcggtgg ctcatgcctg
    13921 taatcccagc atttagggag gcaaggcgag aggatcacta gaggccggaa gttcaagacc
    13981 agcctgtgca acagactccc ggctcgaatt ttttataaaa agtgatatag gaatgaaaag
    14041 taccagctga actaggaaag gggaagttga cagtaaggag ggactatcag gggcaggagg
    14101 atactgggta gtggtggttt aattcattgt tttaattgtg gtgatggctg catggttgta
    14161 tacataggtc aaaacttaac gcgtacactt taaatgtgtg gtttattgta tgccagttat
    14221 aacgcaatat agctgttaaa cacaaacaca ataaagttga aaaacca
//
