LOCUS       NM_003594               9439 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transcription termination factor 2 (TTF2), mRNA.
ACCESSION   NM_003594
VERSION     NM_003594.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9439)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 9439)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   3  (bases 1 to 9439)
  AUTHORS   Jiang,Y. and Price,D.H.
  TITLE     Rescue of the TTF2 knockdown phenotype with an siRNA-resistant
            replacement vector
  JOURNAL   Cell Cycle 3 (9), 1151-1153 (2004)
   PUBMED   15467445
  REMARK    GeneRIF: Importantly, the mitotic phenotype seen with TTF2-siRNA is
            rescued by expression of the siRNA-resistant GFP-tagged TTF2
            proving that reduced TTF2 is responsible for the retention of RNA
            polymerase II on mitotic chromosomes.
REFERENCE   4  (bases 1 to 9439)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   5  (bases 1 to 9439)
  AUTHORS   Jiang,Y., Liu,M., Spencer,C.A. and Price,D.H.
  TITLE     Involvement of transcription termination factor 2 in mitotic
            repression of transcription elongation
  JOURNAL   Mol Cell 14 (3), 375-385 (2004)
   PUBMED   15125840
  REMARK    GeneRIF: TTF2 is the only ATP-dependent termination activity
            associated with Pol II transcription elongation complexes, is
            largely unaffected by template position, and is impervious to the
            phosphorylation state of the polymerase.
REFERENCE   6  (bases 1 to 9439)
  AUTHORS   Leonard,D., Ajuh,P., Lamond,A.I. and Legerski,R.J.
  TITLE     hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA
            splicing
  JOURNAL   Biochem Biophys Res Commun 308 (4), 793-801 (2003)
   PUBMED   12927788
  REMARK    GeneRIF: hLodestar/HuF2 interacts with CDC5L and is involved in
            pre-mRNA splicing
REFERENCE   7  (bases 1 to 9439)
  AUTHORS   Hara,R., Selby,C.P., Liu,M., Price,D.H. and Sancar,A.
  TITLE     Human transcription release factor 2 dissociates RNA polymerases I
            and II stalled at a cyclobutane thymine dimer
  JOURNAL   J Biol Chem 274 (35), 24779-24786 (1999)
   PUBMED   10455150
REFERENCE   8  (bases 1 to 9439)
  AUTHORS   Liu,M., Xie,Z. and Price,D.H.
  TITLE     A human RNA polymerase II transcription termination factor is a
            SWI2/SNF2 family member
  JOURNAL   J Biol Chem 273 (40), 25541-25544 (1998)
   PUBMED   9748214
REFERENCE   9  (bases 1 to 9439)
  AUTHORS   Girdham,C.H. and Glover,D.M.
  TITLE     Chromosome tangling and breakage at anaphase result from mutations
            in lodestar, a Drosophila gene encoding a putative nucleoside
            triphosphate-binding protein
  JOURNAL   Genes Dev 5 (10), 1786-1799 (1991)
   PUBMED   1916263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445231.8, AF073771.1,
            BC030058.1, AF080255.1, BQ422564.1, BI857056.1, BU182600.1,
            AW027795.1, H81916.1, AI991355.1 and AL391476.20.
            
            On Nov 23, 2018 this sequence version replaced NM_003594.3.
            
            Summary: This gene encodes a member of the SWI2/SNF2 family of
            proteins, which play a critical role in altering protein-DNA
            interactions. The encoded protein has been shown to have
            dsDNA-dependent ATPase activity and RNA polymerase II termination
            activity. This protein interacts with cell division cycle 5-like,
            associates with human splicing complexes, and plays a role in
            pre-mRNA splicing. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.123353.1, AF080255.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369466.9/ ENSP00000358478.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL445231.8         124232-124232
            2-86                AF073771.1         1-85
            87-1804             BC030058.1         70-1787
            1805-2873           AF080255.1         1814-2882
            2874-3334           BQ422564.1         121-581
            3335-3592           AF073771.1         3334-3591
            3593-4147           AF080255.1         3602-4156
            4148-4160           BI857056.1         655-667
            4161-4217           BU182600.1         549-605
            4218-4639           AW027795.1         11-432              c
            4640-4853           H81916.1           1-214               c
            4854-4856           AI991355.1         6-8                 c
            4857-9439           AL391476.20        39933-44515
FEATURES             Location/Qualifiers
     source          1..9439
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1"
     gene            1..9439
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="transcription termination factor 2"
                     /db_xref="GeneID:8458"
                     /db_xref="HGNC:HGNC:12398"
                     /db_xref="MIM:604718"
     exon            1..49
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..3510
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="lodestar protein; human factor 2; lodestar homolog;
                     transcription release factor 2; RNA polymerase II
                     termination factor; zinc finger, GRF-type containing 6;
                     transcription termination factor, RNA polymerase II"
                     /codon_start=1
                     /product="transcription termination factor 2"
                     /protein_id="NP_003585.3"
                     /db_xref="CCDS:CCDS892.1"
                     /db_xref="GeneID:8458"
                     /db_xref="HGNC:HGNC:12398"
                     /db_xref="MIM:604718"
                     /translation="MEEVRCPEHGTFCFLKTGVRDGPNKGKSFYVCRADTCSFVRATD
                     IPVSHCLLHEDFVVELQGLLLPQDKKEYRLFFRCIRSKAEGKRWCGSIPWQDPDSKEH
                     SVSNKSQHASETFHHSSNWLRNPFKVLDKNQEPALWKQLIKGEGEEKKADKKQREKGD
                     QLFDQKKEQKPEMMEKDLSSGLVPKKKQSVVQEKKQEEGAEIQCEAETGGTHKRDFSE
                     IKSQQCQGNELTRPSASSQEKSSGKSQDVQRESEPLREKVTQLLPQNVHSHNSISKPQ
                     KGGPLNKEYTNWEAKETKAKDGPSIQATQKSLPQGHFQERPETHSVPAPGGPAAQAAP
                     AAPGLSLGEGREAATSSDDEEEDDVVFVSSKPGSPLLFDSTLDLETKENLQFPDRSVQ
                     RKVSPASGVSKKVEPSDPVARRVYLTTQLKQKKSTLASVNIQALPDKGQKLIKQIQEL
                     EEVLSGLTLSPEQGTNEKSNSQVPQQSHFTKTTTGPPHLVPPQPLPRRGTQPVGSLEL
                     KSACQVTAGGSSQCYRGHTNQDHVHAVWKITSEAIGQLHRSLESCPGETVVAEDPAGL
                     KVPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKKEEKEK
                     STALTWLSKDDSCDFTSHGTLIICPASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSR
                     ARVLSTYDIVITTYSLVAKEIPTNKQEAEIPGANLNVEGTSTPLLRIAWARIILDEAH
                     NVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQV
                     DNGSKKGGERLSILTKSLLLRRTKDQLDSTGRPLVILPQRKFQLHHLKLSEDEETVYN
                     VFFARSRSALQSYLKRHESRGNQSGRSPNNPFSRVALEFGSEEPRHSEAADSPRSSTV
                     HILSQLLRLRQCCCHLSLLKSALDPMELKGEGLVLSLEEQLSALTLSELRDSEPSSTV
                     SLNGTFFKMELFEGMRESTKISSLLAELEAIQRNSASQKSVIVSQWTNMLKVVALHLK
                     KHGLTYATIDGSVNPKQRMDLVEAFNHSRGPQVMLISLLAGGVGLNLTGGNHLFLLDM
                     HWNPSLEDQACDRIYRVGQQKDVVIHRFVCEGTVEEKILQLQEKKKDLAKQVLSGSGE
                     SVTKLTLADLRVLFGI"
     exon            50..152
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            153..239
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            240..306
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            307..1296
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1411
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1594
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1722
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1804
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1924
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2075
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2181
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2363
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2517
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2609
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2692
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2826
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2997
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3056
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3207
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3290
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3365
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..9439
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4568..4573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="hexamer: ATTATA"
     polyA_site      4588
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="major polyA site"
     polyA_site      4639
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="major polyA site"
     regulatory      4825..4830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="hexamer: AATAAA"
     polyA_site      4849
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="major polyA site"
     regulatory      7111..7116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="hexamer: AATAAA"
     polyA_site      7130
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
     regulatory      9413..9418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="hexamer: AATAAA"
     polyA_site      9439
                     /gene="TTF2"
                     /gene_synonym="F2; HuF2; ZGRF6"
                     /note="major polyA site"
ORIGIN      
        1 gaacttgggg gacccagcga aatggaagaa gttaggtgtc cagagcacgg gactttctgc
       61 tttcttaaga ccggcgtccg cgatggcccg aataaaggaa agagcttcta cgtgtgccgg
      121 gcagacacgt gcagcttcgt gcgggccacc gacattcctg tttcccattg cttattgcat
      181 gaggactttg tggtagagct tcagggtttg cttctgccac aggacaagaa agaatacaga
      241 ttgttcttcc gatgcattag aagtaaggca gaggggaaac gctggtgtgg aagtattcca
      301 tggcaggatc ctgattccaa agaacattct gtatccaata agtctcagca tgcatctgag
      361 acatttcatc attcttccaa ctggctgaga aatccattca aggtacttga caagaatcaa
      421 gaaccagctc tctggaaaca gctcatcaaa ggtgaaggtg aggaaaagaa ggctgataag
      481 aagcaaagag aaaagggaga tcagcttttc gatcaaaaga aagaacagaa gcctgaaatg
      541 atggagaaag acctctcatc tggcctggta ccaaagaaaa aacaatctgt agttcaagag
      601 aagaagcaag aagagggagc agagattcag tgtgaggcag agactggagg cacacacaaa
      661 agagactttt ctgaaattaa atctcaacag tgccaaggta atgagcttac aagaccatct
      721 gcatcttctc aggagaaatc aagtggtaag agtcaagatg tccaaagaga atcagaacct
      781 ctgagagaaa aggttaccca gcttttgcct caaaatgttc acagtcacaa ctcaataagc
      841 aagccccaga aagggggacc cctcaacaag gagtacacga actgggaggc taaagaaaca
      901 aaggcaaagg atggccctag catacaggcc acccagaaaa gcctgcctca ggggcatttc
      961 caagagcggc cggagaccca cagtgtgcct gctcctggag gaccagcggc tcaggctgca
     1021 ccagcagcac cagggctttc cctgggtgag ggccgtgaag ctgccacaag cagtgacgac
     1081 gaggaggaag atgatgttgt ttttgtttcc tctaagcctg ggagccccct actctttgac
     1141 tcgactctgg acttagagac gaaggaaaac ctccaattcc ctgatcgaag tgtgcaaaga
     1201 aaggtgtctc ctgcctcagg tgtttccaag aaggtagaac cctcagaccc agtagcccgg
     1261 cgtgtctacc ttacaacaca actgaaacaa aagaagagca cactggcatc agtgaacatc
     1321 caggctcttc cagacaaggg tcagaagttg atcaaacaaa tccaggagct ggaggaagta
     1381 ctcagtggtc ttaccctttc cccagagcaa ggaactaatg agaagagtaa cagtcaagta
     1441 ccacagcaga gtcacttcac caaaactacc actggccctc cccacctggt gcctccccaa
     1501 ccccttcctc gtcgtggtac ccaacctgtg ggttctctag aactaaagtc tgcctgccag
     1561 gtgactgctg gaggatccag tcagtgctat cgaggccata caaaccaaga tcacgttcat
     1621 gcagtgtgga aaatcacaag tgaagccatc ggtcaactgc atcgctcact tgagtcatgt
     1681 cctggtgaga cggttgtggc agaagatccc gccgggctga aggtcccttt gctactacac
     1741 cagaagcagg cattggcttg gttactatgg cgagaaagtc agaagccaca aggaggaatt
     1801 ctggcagatg atatgggctt aggaaaaacc ctgacaatga ttgcgctcat cctgacccag
     1861 aagaatcaag agaaaaagga agaaaaggag aaaagcacag ctttgacgtg gctctccaaa
     1921 gatgactctt gtgactttac ttcccatgga acactaatca tctgtcctgc ctccctgatc
     1981 catcattgga aaaatgaggt ggagaaacgg gtgaacagca acaaactaag agtctatctc
     2041 taccatgggc caaaccggga ttcacgtgcc agagtcctct ctacatatga catcgtgatc
     2101 actacctata gcctcgtggc caaggagatt cccacaaaca agcaagaggc agagatccca
     2161 ggtgcaaacc tcaatgtgga gggcacctca acacctttgc ttcgaatagc ctgggctcga
     2221 atcatattgg atgaagctca caatgttaag aatccccgag tgcagacttc catagctgtg
     2281 tgtaagctac aagcctgtgc ccgttgggct gtcactggaa cccccattca aaacaactta
     2341 ttggatatgt attcgctgct gaagtttctc cgttgctctc catttgatga gttcaatctg
     2401 tggaggagtc aggttgacaa tggctcaaag aaaggaggag aacggttaag tattttaacc
     2461 aagagccttt tgctgaggag aacaaaagac cagctggact ctactggcag acctttggtg
     2521 atactgcccc agcgtaaatt tcagttgcac catttaaagc tttctgaaga tgaagagact
     2581 gtttacaatg tgttttttgc aagatcaagg tcagctctgc aatcctatct aaaaagacat
     2641 gaaagtagag gcaaccaatc tggaagaagc cctaataatc cattcagtag agtggcactg
     2701 gagtttgggt ctgaggagcc tagacactcg gaggcagcag actcaccgag atccagcacc
     2761 gtccacatac tgtcccagtt gctgagactc cgccagtgtt gctgtcatct ttctttactg
     2821 aagtcggccc tggatccaat ggaactgaag ggtgaaggtc ttgtcctttc cctggaagaa
     2881 cagctcagtg ctttgacctt gtcagaactc cgtgactcag agccatcttc cactgtttcc
     2941 cttaacggca ccttcttcaa gatggagctt tttgaaggca tgcgagagag caccaagatt
     3001 tcatctctgt tggcagaatt ggaggcaatt caaagaaatt cagcatccca aaagagtgtc
     3061 attgtctctc agtggaccaa catgctgaaa gttgtagcat tgcacctgaa gaagcatgga
     3121 ctgacttatg ccaccatcga tggctctgtc aatcccaagc agagaatgga cttggtagag
     3181 gcatttaacc actccagagg ccctcaggta atgctaatct ctctcttggc cggaggtgtt
     3241 ggtctaaacc tgactggagg aaatcacctc tttcttttgg acatgcactg gaatccatca
     3301 cttgaagatc aagcttgtga ccgaatttac cgagtagggc agcagaaaga tgttgtcata
     3361 cacagatttg tttgtgaggg aacagtagaa gaaaagatct tacagctcca agaaaaaaag
     3421 aaagatttgg ccaaacaagt tctatcaggg tctggagaat ctgtcaccaa gctcaccttg
     3481 gctgacctca gagtcctttt tggcatctaa cctcctgtgg ataagggctc agaatagcac
     3541 cattgctggt ttgtattagg atctgggaat aacaacctaa ccatgagcct tgaactctgt
     3601 tctttgcatt tcaatttcac cgtcaagcct ttcaccttcc tcaaaatgag gcataatctt
     3661 atccccagaa ttgaggaggg gttgtgttaa ccaattagtt aaccaattat gttaataatt
     3721 tatttaatga gtggtatgga aaccaattga tttttttaga taaaagaata tgttttagag
     3781 ttggatgatt ttggaaaaca actctggcag aattgtatat aagcttcagt aaagttcaaa
     3841 aagcgggcca ggtgtggtgg ctcatgcctg taatcccgac actttgggag gccaaggcag
     3901 gaggatggct tgaagccagt agttcaagac cagcctgggc aacatagtaa gaccccatct
     3961 ctatgaagaa taaaaaaatg agctaggcgt ggtagtgcac acctgtagtc ctagctactt
     4021 gggaggctga ggcaggagga tcccttgagt ccaggaggtt gaggctgcag tgagctgtga
     4081 ttgtgccact gttttccagc ctgggcaata cagtgagacc ctgtctcaaa aaaaggaaaa
     4141 aaaagctcaa aaagttctgt gttgcctttc tcttcttagc tgatgatggg agaaccagtt
     4201 actaccttct ctaacacagg ctccatccta tctcttcatc tcttcttgcc agtgatgttg
     4261 cacctgtaac catcttttta tgggtggagc agagagtcaa tccctgcagc caccctgcag
     4321 ccagccatct ctgcagttct ctcagtgcag gcagttcttc ctctcaggct gaagatcaag
     4381 gagatgcttt gtacatgaac agatgctgag tatctgttat cattgtattg tttagtgtca
     4441 gtgtatcatt tagtatttgt atcactgtac catttagtgt tgtatatcac tcagtcattt
     4501 aatattggtt atcaccatac agtttaatat ttgtatcatt tggttcattg tatcgtttag
     4561 tatttctatt ataacatttc tatttgtagt atttgtataa tatttgtgtc atttttaata
     4621 gtatttgtat ttttacaaat ttgcagtatt tgtagcattt agtatcattg tttcatttag
     4681 tatttggtac aatctaataa atactaatcc agtccaatac taatccaatc caatactaat
     4741 aatactattg gtacaatcca atactaataa tactattggt acaatccaat actaataata
     4801 ctaacagtag tattgataca atctaataaa taatgtgttt gacagtgtag cagaaataat
     4861 gctatgtgtt caccaaaccc acttcctttt cctcccgggc acccagagag actgtatttc
     4921 ccagtttttg ctgcagtttg acggggtcca tatcaatgga ctgtggagag aagcgattga
     4981 tgtaagtcac ttctaggtgg ccctctacca ctttccaaaa gatcattcat gctgtttctt
     5041 ccctcctcag cctatgggat gcaaaggaac tgatggaaga ttacaaggcc ctagggaagg
     5101 tgaagccact agctcagcag ttcttagcct agtttttggc catcagccct tctattagac
     5161 tagtgaagcc tcagtcccag gatggctccc catgtacact tccctcctcg ccccagctca
     5221 cctacactgg actatgacat gatcaaggaa tctttttttt taagctactg agatttctgt
     5281 gttgtttaca tagcagtttg taccctaaac aaacacttga gattttatac ttcaggaaac
     5341 tattcagatt tccttctcat tagcaattgt tccaaaaaca cttactctgc taatttctgc
     5401 tagaaagaat cacagttctt ctaacacaga aacatttctg tcccttgagt tgggaaacaa
     5461 gaccctatgt taacccagtc agagtgtgga ctgaggcatt cggagcctat ttaagcagaa
     5521 gttttctata aggacaagat ttaaaggctt acaaaggtaa agacaatggc ctggtgggaa
     5581 gaattctagt ctagaacgtt tgagatttga ctctagttct aggttcatct tagctgggtg
     5641 tgtaacgttg aaaaaattgg ccgggtgcag tggctcaggc ctgtcatccc agcactttgg
     5701 gaggccgagg cagacggatc acgaggtcaa gagatcaaga ccatcttggc caacatggtg
     5761 aaaccccgtc tctactaaaa atacaaaaat tagctgagcg tggtggcgtg cgcctgtagt
     5821 cccagctact ggggaggata aggcaggaga atcgcttgaa cctgggaggt ggaggttgca
     5881 gtgagctgag atcgcgccat tgcactccag cctggtgaca gagcgagact ccgtctcaaa
     5941 aaaaaaaaaa aaaaaaaaga gagagaaaaa aatccttact ttctctacac tctgatttcc
     6001 tcatttgtaa ggtgggcagt tttcagaact tagcagcaat aaggtttctg ataaaatcaa
     6061 gaagcaaagg aagtaacatt gcctttttga agttttgcta taagattgac ataccaaggt
     6121 aaagattgag tcacctgaga agcagtggct cccaggccag caagaatgta caaacctggc
     6181 tctgccattt gctgattgat attaggcaag ttgcagattc cttggacatc tcaatccttt
     6241 catctgtaaa atgtgtggat tagcatgtat ctcatgctcc actgggaatt tcatagcaaa
     6301 tatatatact acaacatggt tgaccagata gatcagtaat gtcaactaga aggtattaga
     6361 tgaacattgt cagtctccaa tcaagcattg tttaggggag aggaattctt tcaggttcaa
     6421 gcattctggc ttttagtttg gagagggatg cagggattgt aacttaaaat cttcagatat
     6481 tgaggccatt gacaagtaat ctactgtaag gtagatgcct cctggtattt taaaacagct
     6541 tttctaattt ctcatgttat tgtacataag caaagcaacc tagttatgtc ttgggtaggt
     6601 gttcttatag ccgtgagatg ctactgactt gaggtggatg cagaaaaaaa tggaaccact
     6661 gccttaatgg gatggaatat actaaacatg cattcttaaa tcctagtgct gggatggatt
     6721 acatgaatta cattgtggag ctgcatatgt gtctcccctc ttccctccct gggggttagg
     6781 ctgggtttgt ttggtttttt ttgttttgtc ctcatgaggc ttagcatcta agggagacag
     6841 gcatgaatta acagaagtgg cattctggta tctgtctcag cctcatattc attttagtgt
     6901 aaatcagttt cgtcaagtct aggtatgaca aggtgggtct ttgcaccttc tagcgatggg
     6961 cagcatccca caacacagtg gtctaattga ggtgctgcac tatgagtcct gcctgtgtta
     7021 accagccttc cttcatgtca caatactgct gctggatttg ctttttacat ctgcctattg
     7081 cacctgactt gggcatggat gatatgaggt aataaatgct ttgaaaacca tgaagggcca
     7141 cacaagtgct agtgttattg ctgtgggaca aggtctggga atatgagaac cagcagcagc
     7201 atgggtgcag ctgagaacca gatggtgaac atctgtctcc aaagtgcaac attcctgagc
     7261 accggattta taaggcattt cttactcgac agaattgact tcatggaagg tatgtagttt
     7321 gactttgcct tagccatgtt gatcaaatag gagtattgtg catgccgcag ctagacagag
     7381 tcctgggccc tttaaaaacc ttgtcagtga ctcccattgc aggcccagcg cagtggttca
     7441 cacctgtaat cccagcattt gggaggctga ggcaggcaga tcacttgagg ccaagagttc
     7501 gagaccagac tggccaacat ggcaaaacct cctctctact aaaaatacaa aagttagcca
     7561 ggcgtgatgt tgggtgcctg taattgcagc tactcgggag gctgaggcag gagaatcact
     7621 tgaatccagg aggcggaggt tacagtgagc tgagatcata ccactgcact ccagcctggg
     7681 ccacagagaa agaacggtga ttctttctag cagaaattag cagagtaagt gtttttggaa
     7741 caattgctaa tgaaaagaag gaaaaacaga aaaaaaaaat tttctgttta tgggaggtga
     7801 cttatttctc tatcaatcct gtgagtgatt tagcatggca attcatgaac actgagttgt
     7861 ttccttgctc tgattgtctg ttgctcaatg aaatggcttt tagcagggct caaaggtgaa
     7921 gccagattct cctgcactaa taggataagc atggagacac cagtgttcag tgtggcctct
     7981 ggttgtctga aattttgctg tcaactctaa taccttgaaa gaattaggtt tccaaagtgg
     8041 gatattgtgc tgctgtttgt gatatagcat ctagacttag gaaagggcag gaacaattta
     8101 aaagcacatc tgtaggcaca aagagaatta taatagaaat tcagaattcc taggcatatg
     8161 acctagacta aaatgtcttc ataactacaa atgaaatcag ggtcatttat agtacaaact
     8221 accacagaag tcagtagtta ggggatggag atagatatga aaaaaaaaaa aagcaaaccc
     8281 agcctaactc ccagggaggg aagaggggcg acagatatgc agctacacaa tgtttttact
     8341 atcttgagtt ctttttaccc agattccata gctaaatcca gatgtattaa taggtagaga
     8401 ctacttcaga aaggatgaga ctattttctt gcttaattat ccacacagta attcagaaat
     8461 gtatattgaa cactttttat atgccaggca ctgctgggca ctggaaatat aaaagtaagc
     8521 aaaaatgaaa aactatcctg tcctcctgag gcttagcatc taagggagac aggcattagt
     8581 caaccccgtg tggctgtgaa tcagccatga tgctgagtgc tacaagagag gactgtgcgg
     8641 ctgggagggc ttataacagg atttgaccta gttagggaag atctgaggaa gtgatgaaag
     8701 aatggaaatc aatatgtaag agctcacaag tcagagtgag atgtttcttc ctatactgcc
     8761 tgcttctaat gagcatccac ttcattgaac cacctcttca ttgagccaaa cctaccatac
     8821 agggatacat tctctggagg aaagttgagc aactattgca tttgggacat tagagtatgg
     8881 gtgggctgac aggtatgtgt atgtttatta tccaagacag ccaaggtgtt tatcctgtta
     8941 caacatccca gaggacagag gctcttattt gtgactcttt tttcttacct gtaacaccag
     9001 aggcataacg tacatcataa tgctgcatct tgttgacgct tcaatgctca caattcaaag
     9061 gtgatttctg aagcactttg ttacactggg gacagctcct aaatcctccc actctttttt
     9121 tgcctcacct tggagtcttg ggctctgttg atcactgact ctgccaggtc tttcagcagg
     9181 caagacagct cagttaaatt gagtttggac tccactgtag tgcatgcatg agacagcacc
     9241 cccaatcccc aacacccaca cacaaacttt aaatatttgt aacagaattg ttaccattaa
     9301 tattgcttaa aggctaacac attagccaga acctagatgt cttctggaaa ttttttattg
     9361 caatgttact tcatctacat aaagttgtcc aatcactgaa acctccaact gaaataaatg
     9421 gtaagctttt tgttctcaa
//
