LOCUS       NM_007344               3143 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transcription termination factor 1 (TTF1), transcript
            variant 1, mRNA.
ACCESSION   NM_007344
VERSION     NM_007344.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3143)
  AUTHORS   Ji,N., Lee,Y., Lee,S.H. and Kim,H.S.
  TITLE     Diagnostic Value of Immunostaining for Thyroid Transcription Factor
            1 (TTF1) and Paired Box 8 (PAX8) in Distinguishing Pulmonary
            Metastases of Mesonephric and Mesonephric-like Adenocarcinomas from
            Primary Lung Adenocarcinomas
  JOURNAL   Anticancer Res 44 (5), 2159-2170 (2024)
   PUBMED   38677751
REFERENCE   2  (bases 1 to 3143)
  AUTHORS   Gloriane C Luna,H., Severino Imasa,M., Juat,N., Hernandez,K.V., May
            Sayo,T., Cristal-Luna,G., Marie Asur-Galang,S., Bellengan,M., John
            Duga,K., Brian Buenaobra,B., De Los Santos,M.I., Medina,D.,
            Samo,J., Minerva Literal,V., Andrew Bascos,N. and Sy-Naval,S.
  TITLE     Expression landscapes in non-small cell lung cancer shaped by the
            thyroid transcription factor 1
  JOURNAL   Lung Cancer 176, 121-131 (2023)
   PUBMED   36634573
REFERENCE   3  (bases 1 to 3143)
  AUTHORS   Dutta,R., Sharma,M.C., Suri,V., Sarkar,C., Garg,A., Suri,A. and
            Kale,S.S.
  TITLE     TTF-1: A Well-Favored Addition to the Immunohistochemistry
            Armamentarium as a Diagnostic Marker of SEGA
  JOURNAL   World Neurosurg 159, e62-e69 (2022)
   PUBMED   34871801
  REMARK    GeneRIF: TTF-1: A Well-Favored Addition to the Immunohistochemistry
            Armamentarium as a Diagnostic Marker of SEGA.
REFERENCE   4  (bases 1 to 3143)
  AUTHORS   Tanaka,I., Dayde,D., Tai,M.C., Mori,H., Solis,L.M., Tripathi,S.C.,
            Fahrmann,J.F., Unver,N., Parhy,G., Jain,R., Parra,E.R.,
            Murakami,Y., Aguilar-Bonavides,C., Mino,B., Celiktas,M.,
            Dhillon,D., Casabar,J.P., Nakatochi,M., Stingo,F.,
            Baladandayuthapani,V., Wang,H., Katayama,H., Dennison,J.B.,
            Lorenzi,P.L., Do,K.A., Fujimoto,J., Behrens,C., Ostrin,E.J.,
            Rodriguez-Canales,J., Hase,T., Fukui,T., Kajino,T., Kato,S.,
            Yatabe,Y., Hosoda,W., Kawaguchi,K., Yokoi,K., Chen-Yoshikawa,T.F.,
            Hasegawa,Y., Gazdar,A.F., Wistuba,I.I., Hanash,S. and Taguchi,A.
  TITLE     SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a
            Subset of TTF-1-Negative Lung Adenocarcinomas
  JOURNAL   J Natl Cancer Inst 114 (2), 290-301 (2022)
   PUBMED   34524427
REFERENCE   5  (bases 1 to 3143)
  AUTHORS   Rao,S., Sunitha,K., Lanka,V., Kulanthaivelu,K., Arivazhagan,A.,
            Chowdary,R., Raghavendra,K., Rao,R., Nandeesh,B.N., Bharath,R.D.,
            Saini,J., Sinha,S., Santosh,V., Yasha,T.C., Rajeswaran,J.,
            Malla,B.R. and Mahadevan,A.
  TITLE     Exploring immunoreactivity of TTF-1 and AVP in hypothalamic
            hamartoma
  JOURNAL   Clin Neuropathol 41 (1), 18-24 (2022)
   PUBMED   34142952
  REMARK    GeneRIF: Exploring immunoreactivity of TTF-1 and AVP in
            hypothalamic hamartoma.
REFERENCE   6  (bases 1 to 3143)
  AUTHORS   Ueda,M., Iguchi,T., Nambara,S., Saito,T., Komatsu,H., Sakimura,S.,
            Hirata,H., Uchi,R., Takano,Y., Shinden,Y., Eguchi,H., Masuda,T.,
            Sugimachi,K., Yamamoto,H., Doki,Y., Mori,M. and Mimori,K.
  TITLE     Overexpression of Transcription Termination Factor 1 is Associated
            with a Poor Prognosis in Patients with Colorectal Cancer
  JOURNAL   Ann Surg Oncol 22 Suppl 3, S1490-S1498 (2015)
   PUBMED   26036188
  REMARK    GeneRIF: Overexpression of Transcription Termination Factor 1 is
            Associated with Colorectal Cancer
REFERENCE   7  (bases 1 to 3143)
  AUTHORS   Lessard,F., Morin,F., Ivanchuk,S., Langlois,F., Stefanovsky,V.,
            Rutka,J. and Moss,T.
  TITLE     The ARF tumor suppressor controls ribosome biogenesis by regulating
            the RNA polymerase I transcription factor TTF-I
  JOURNAL   Mol Cell 38 (4), 539-550 (2010)
   PUBMED   20513429
  REMARK    GeneRIF: Depletion of TTF-I recapitulates the effects of ARF on
            ribosomal RNA synthesis and is rescued by the introduction of a
            TTF-I transgene.
REFERENCE   8  (bases 1 to 3143)
  AUTHORS   Richard,P. and Manley,J.L.
  TITLE     Transcription termination by nuclear RNA polymerases
  JOURNAL   Genes Dev 23 (11), 1247-1269 (2009)
   PUBMED   19487567
REFERENCE   9  (bases 1 to 3143)
  AUTHORS   Sirri,V., Roussel,P. and Hernandez-Verdun,D.
  TITLE     The mitotically phosphorylated form of the transcription
            termination factor TTF-1 is associated with the repressed rDNA
            transcription machinery
  JOURNAL   J Cell Sci 112 (Pt 19), 3259-3268 (1999)
   PUBMED   10504331
REFERENCE   10 (bases 1 to 3143)
  AUTHORS   Evers,R. and Grummt,I.
  TITLE     Molecular coevolution of mammalian ribosomal gene terminator
            sequences and the transcription termination factor TTF-I
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 5827-5831 (1995)
   PUBMED   7597036
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353701.15.
            
            On Nov 22, 2018 this sequence version replaced NM_007344.3.
            
            Summary: This gene encodes a transcription termination factor that
            is localized to the nucleolus and plays a critical role in
            ribosomal gene transcription. The encoded protein mediates the
            termination of RNA polymerase I transcription by binding to Sal box
            terminator elements downstream of pre-rRNA coding regions.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. This gene shares the
            symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known
            as thyroid transcription factor 1, which plays a role in the
            regulation of thyroid-specific gene expression. [provided by
            RefSeq, Apr 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302902.1, SRR14038197.2571817.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334270.3/ ENSP00000333920.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL353701.15        87903-87953         c
            52-1425             AL353701.15        82568-83941         c
            1426-1649           AL353701.15        81148-81371         c
            1650-1835           AL353701.15        79254-79439         c
            1836-1914           AL353701.15        77546-77624         c
            1915-2045           AL353701.15        73189-73319         c
            2046-2280           AL353701.15        71710-71944         c
            2281-2370           AL353701.15        69252-69341         c
            2371-2436           AL353701.15        67669-67734         c
            2437-2522           AL353701.15        60172-60257         c
            2523-3143           AL353701.15        56661-57281         c
FEATURES             Location/Qualifiers
     source          1..3143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.13"
     gene            1..3143
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /note="transcription termination factor 1"
                     /db_xref="GeneID:7270"
                     /db_xref="HGNC:HGNC:12397"
                     /db_xref="MIM:600777"
     exon            1..51
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            52..1425
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2776
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription termination factor, RNA polymerase I"
                     /codon_start=1
                     /product="transcription termination factor 1 isoform 1"
                     /protein_id="NP_031370.2"
                     /db_xref="CCDS:CCDS6948.1"
                     /db_xref="GeneID:7270"
                     /db_xref="HGNC:HGNC:12397"
                     /db_xref="MIM:600777"
                     /translation="MEGESSRFEIHTPVSDKKKKKCSIHKERPQKHSHEIFRDSSLVN
                     EQSQITRRKKRKKDFQHLISSPLKKSRICDETANATSTLKKRKKRRYSALEVDEEAGV
                     TVVLVDKENINNTPKHFRKDVDVVCVDMSIEQKLPRKPKTDKFQVLAKSHAHKSEALH
                     SKVREKKNKKHQRKAASWESQRARDTLPQSESHQEESWLSVGPGGEITELPASAHKNK
                     SKKKKKKSSNREYETLAMPEGSQAGREAGTDMQESQPTVGLDDETPQLLGPTHKKKSK
                     KKKKKKSNHQEFEALAMPEGSQVGSEVGADMQESRPAVGLHGETAGIPAPAYKNKSKK
                     KKKKSNHQEFEAVAMPESLESAYPEGSQVGSEVGTVEGSTALKGFKESNSTKKKSKKR
                     KLTSVKRARVSGDDFSVPSKNSESTLFDSVEGDGAMMEEGVKSRPRQKKTQACLASKH
                     VQEAPRLEPANEEHNVETAEDSEIRYLSADSGDADDSDADLGSAVKQLQEFIPNIKDR
                     ATSTIKRMYRDDLERFKEFKAQGVAIKFGKFSVKENKQLEKNVEDFLALTGIESADKL
                     LYTDRYPEEKSVITNLKRRYSFRLHIGRNIARPWKLIYYRAKKMFDVNNYKGRYSEGD
                     TEKLKMYHSLLGNDWKTIGEMVARSSLSVALKFSQISSQRNRGAWSKSETRKLIKAVE
                     EVILKKMSPQELKEVDSKLQENPESCLSIVREKLYKGISWVEVEAKVQTRNWMQCKSK
                     WTEILTKRMTNGRRIYYGMNALRAKVSLIERLYEINVEDTNEIDWEDLASAIGDVPPS
                     YVQTKFSRLKAVYVPFWQKKTFPEIIDYLYETTLPLLKEKLEKMMEKKGTKIQTPAAP
                     KQVFPFRDIFYYEDDSEGEDIEKESEGQAPCMAHACNSSTLGGQGRWII"
     exon            1426..1649
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1835
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1914
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2045
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2280
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2370
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2436
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2522
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..3143
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3051..3056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /note="hexamer: AATAAA"
     polyA_site      3072
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /note="major polyA site"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
                     /note="hexamer: ATTAAA"
     polyA_site      3143
                     /gene="TTF1"
                     /gene_synonym="TTF-1; TTF-I"
ORIGIN      
        1 ctcaacagca gcacttccgg gttgggagaa aggtggcggc gctttcggag ggaataaaat
       61 ggaaggagaa tcaagcagat ttgaaatcca cactccagtt tctgacaaga aaaagaaaaa
      121 gtgttctata cataaggaaa gacctcagaa acattcccac gaaattttca gagactcctc
      181 cctggtgaat gaacagtctc aaataactag gaggaaaaag aggaaaaaag atttccagca
      241 tctcatttct tctcctttga aaaaatccag aatctgtgat gagactgcaa atgccacttc
      301 cacactcaaa aagagaaaaa agagaagata tagtgctttg gaggtggacg aggaagcagg
      361 tgttacagtt gtccttgtgg ataaagaaaa tattaacaac acaccaaagc attttagaaa
      421 ggatgttgat gttgtttgtg ttgatatgag catagaacag aagttaccaa gaaagcctaa
      481 aacagacaaa tttcaggtac ttgctaagtc acatgcacat aaatcagaag ccctgcacag
      541 taaagttagg gagaaaaaga ataaaaagca tcagaggaaa gctgcatcct gggagagcca
      601 gcgggcaagg gacaccctgc ctcagtcaga atcccaccag gaggagtcct ggctttctgt
      661 gggtccaggg ggtgaaatta cagaactacc agcatctgct cataaaaaca agtctaagaa
      721 aaaaaagaaa aagtccagta accgggaata tgagacactg gccatgcctg aaggatcgca
      781 agcaggcaga gaggccggga ctgatatgca ggaatcccag cctactgtgg gcttggatga
      841 tgaaactcca caactactag gacctactca caaaaaaaag tctaagaaaa aaaagaagaa
      901 aaagtccaat caccaggaat ttgaggcatt ggccatgcct gaaggatcac aagtgggcag
      961 tgaggttggg gctgatatgc aggaatcccg gcctgctgtg ggcctgcatg gtgaaactgc
     1021 aggaatacca gcacctgctt ataaaaacaa gtctaagaaa aaaaagaaaa agtccaatca
     1081 ccaggaattt gaggcagtgg ccatgcctga gagcctcgag agtgcatacc ctgaaggatc
     1141 acaggtgggc agtgaggttg ggactgtgga aggcagtaca gctcttaaag ggttcaagga
     1201 atccaacagt acaaagaaga agtctaagaa aaggaagctt acgtctgtca aaagggcacg
     1261 agtgtctggt gatgattttt cagtgcccag taagaactct gagagcacac tctttgattc
     1321 agtagaaggt gatggcgcca tgatggaaga aggtgtgaaa tctaggcccc gacaaaagaa
     1381 aacccaggcc tgtttggcaa gcaagcacgt gcaagaggcg ccaaggttag aacctgcaaa
     1441 tgaagaacac aatgtggaaa cagctgaaga ttccgaaata agatacttat ctgcagattc
     1501 aggagatgcc gatgattcag atgcggattt gggttctgcc gtgaaacagc ttcaggagtt
     1561 cattcctaac atcaaggaca gggccaccag cacaatcaag cggatgtacc gggacgactt
     1621 ggaacggttt aaggaattta aagcacaagg tgtcgctatt aaatttggca agttttctgt
     1681 aaaggaaaat aagcagttag agaaaaatgt ggaagacttt ctagccctga caggcattga
     1741 gagtgcagac aagctgctgt acacggacag atatcctgag gaaaaatctg tgatcaccaa
     1801 cttaaaaagg agatactcgt ttagattaca cattggtagg aacattgccc ggccctggaa
     1861 acttatatac tatcgagcaa agaagatgtt cgatgtcaac aattacaaag gcaggtatag
     1921 cgaaggagat actgagaagt taaagatgta ccattctctc cttgggaatg actggaagac
     1981 gattggtgag atggtggccc gaagtagcct ctccgtggcc ctcaagttct cacagatcag
     2041 cagtcaaaga aatcgtggtg cttggagtaa gtctgaaacc cggaaactaa tcaaggctgt
     2101 cgaagaagtg attctgaaga agatgtctcc ccaggagtta aaagaggtgg attccaaact
     2161 ccaagaaaat cctgaaagtt gcctatcaat tgttcgggaa aaactctaca agggcatatc
     2221 ttgggtagaa gtagaagcta aagtgcaaac cagaaattgg atgcagtgta aaagtaagtg
     2281 gacagaaatt ctaaccaaga ggatgactaa tggtcggcgt atctactatg gcatgaatgc
     2341 cctgcgggcc aaggtcagcc ttattgaaag gttgtatgaa ataaatgtgg aagatactaa
     2401 tgaaatagac tgggaagatc ttgctagtgc cataggtgat gttcctccat cttacgttca
     2461 aactaaattt tctaggctga aagctgtcta tgttccattt tggcagaaaa agacttttcc
     2521 agagatcatc gactaccttt atgagacgac tctacctttg ctgaaggaaa agttagaaaa
     2581 aatgatggag aaaaaaggca ctaaaatcca gactcctgca gcacccaagc aagttttccc
     2641 atttcgagac atcttttatt atgaagacga tagtgaagga gaggacatag aaaaagaaag
     2701 cgaaggccag gcgccatgca tggctcacgc ctgtaattcc agtactttgg gaggccaagg
     2761 ccggtggatc atctgaggtc aggagttcga gaccggcctg accaacatgg tgaagacctg
     2821 tcactattaa aaatgcaaaa attagccggg tgtggtagtg cacacctgta atttcaacta
     2881 cttgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagcca
     2941 agatcgcacc accgcatgag agagagagat tactatttct tgtccctttt tctcagtttg
     3001 attatattta tatacatatg tcagtaaatc tgttttcagt attgatgttt aataaagaat
     3061 gtacaatggc cagagttcta ctctttcctc tggagcatta aaatatattg ccattcctat
     3121 taaaacgtat ttgaatgtga aaa
//
