LOCUS       NM_173810               1133 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 9C (TTC9C), transcript
            variant 1, mRNA.
ACCESSION   NM_173810
VERSION     NM_173810.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1133)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1133)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1133)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   4  (bases 1 to 1133)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
            Maccarrone,G., Dias-Neto,E. and Turck,C.W.
  TITLE     Prefrontal cortex shotgun proteome analysis reveals altered calcium
            homeostasis and immune system imbalance in schizophrenia
  JOURNAL   Eur Arch Psychiatry Clin Neurosci 259 (3), 151-163 (2009)
   PUBMED   19165527
  REMARK    GeneRIF: Using shotgun mass spectrometry, we found this protein
            differentially expressed in the dorsolateral prefrontal cortex from
            patients with schizophrenia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032123.2.
            
            On Nov 24, 2018 this sequence version replaced NM_173810.3.
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1,
            2, and 3 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032123.2, SRR1660803.105027.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316461.9/ ENSP00000325266.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1133              BC032123.2         7-1139
FEATURES             Location/Qualifiers
     source          1..1133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1133
                     /gene="TTC9C"
                     /note="tetratricopeptide repeat domain 9C"
                     /db_xref="GeneID:283237"
                     /db_xref="HGNC:HGNC:28432"
     exon            1..601
                     /gene="TTC9C"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..879
                     /gene="TTC9C"
                     /note="isoform a is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 9C; TPR repeat protein
                     9C"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 9C isoform a"
                     /protein_id="NP_776171.1"
                     /db_xref="CCDS:CCDS8033.1"
                     /db_xref="GeneID:283237"
                     /db_xref="HGNC:HGNC:28432"
                     /translation="MEKRLQEAQLYKEEGNQRYREGKYRDAVSRYHRALLQLRGLDPS
                     LPSPLPNLGPQGPALTPEQENILHTTQTDCYNNLAACLLQMEPVNYERVREYSQKVLE
                     RQPDNAKALYRAGVAFFHLQDYDQARHYLLAAVNRQPKDANVRRYLQLTQSELSSYHR
                     KEKQLYLGMFG"
     exon            602..784
                     /gene="TTC9C"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1133
                     /gene="TTC9C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1115..1120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC9C"
                     /note="hexamer: AATATA"
     polyA_site      1133
                     /gene="TTC9C"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcccag gcgttctcac gcccgcaaca attcctgagt agggccttgc ttgagttctt
       61 cggaaagtct catccacccc cacatcgcct ctttaggaag tcacttaatg ttgggcttca
      121 ttattcccac atccctttcc ttactacttg cctgcacttc ttgagaaaaa gactgcagaa
      181 aggagaggtg gggctttcag tagaaacaag caaaccgcag gtccctgtgg ggggactctc
      241 caggaagaag ggtaatttcc tgcctcctta aattggctgc tactgtcagt tattttgctc
      301 ccaaccccag agcttcactt gctccttcac ttcccagttc cgcaagaacc gtgggcgaca
      361 gttatggaga agcgtctgca ggaggctcag ctgtacaagg aggaagggaa ccagcgctac
      421 cgggaaggga agtaccgaga tgctgtgagt aggtaccatc gagctctgct tcagctgcgg
      481 ggtctggatc cgagtctgcc ctctccgtta cctaatctcg gacctcaggg cccggccctc
      541 acgcctgaac aagaaaacat attgcatacc acccagacag actgctataa caatctagct
      601 gcttgtctcc ttcagatgga gcccgtgaac tacgaacgag tgagagaata tagtcagaaa
      661 gtcctggaac gacagcctga taatgccaag gccttgtatc gggccggagt ggcctttttc
      721 catctgcagg actatgacca ggcccgccac tacctcctgg ctgccgtgaa taggcagcct
      781 aaagatgcca acgtccggcg gtacctccag ctgacacagt cagaactcag cagctaccat
      841 agaaaagaga agcagctcta cctgggcatg tttggttaac aaagaagaaa gatgctcctc
      901 cagttgaact taggtggacc attaaacatg catgaaggag aaatctgagc ctcagcaaga
      961 gaaattaacc ctatacctct gacccaggtg gatttttgtt tctagttctg cacaaacttc
     1021 actacttaga cagtctgagt ctttttctgt ctatccatct gtttatttct atacctttca
     1081 atacatgtta ttgttgcaga tatttggctt gagaaatata atcagaaaac ata
//
