LOCUS       NM_152479                828 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 9B (TTC9B), mRNA.
ACCESSION   NM_152479
VERSION     NM_152479.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 828)
  AUTHORS   Osborne,L., Clive,M., Kimmel,M., Gispen,F., Guintivano,J.,
            Brown,T., Cox,O., Judy,J., Meilman,S., Braier,A., Beckmann,M.W.,
            Kornhuber,J., Fasching,P.A., Goes,F., Payne,J.L., Binder,E.B. and
            Kaminsky,Z.
  TITLE     Replication of Epigenetic Postpartum Depression Biomarkers and
            Variation with Hormone Levels
  JOURNAL   Neuropsychopharmacology 41 (6), 1648-1658 (2016)
   PUBMED   26503311
  REMARK    GeneRIF: DNA methylation at early antenatal time points associated
            with changes in estradiol and allopregnanolone and postpartum
            depression
REFERENCE   2  (bases 1 to 828)
  AUTHORS   Kaminsky,Z. and Payne,J.
  TITLE     Seeing the future: epigenetic biomarkers of postpartum depression
  JOURNAL   Neuropsychopharmacology 39 (1), 233-234 (2014)
   PUBMED   24317310
  REMARK    GeneRIF: found two biomarker loci at HP1BP3 and TTC9B, which
            predicted postpartum depression
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118344.2.
            
            On Feb 9, 2021 this sequence version replaced NM_152479.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029539.1, AK289550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311308.7/ ENSP00000311760.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AC118344.2         150071-150500
            431-613             AC118344.2         151086-151268
            614-828             AC118344.2         152183-152397
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..828
                     /gene="TTC9B"
                     /note="tetratricopeptide repeat domain 9B"
                     /db_xref="GeneID:148014"
                     /db_xref="HGNC:HGNC:26395"
     exon            1..430
                     /gene="TTC9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..723
                     /gene="TTC9B"
                     /note="TPR repeat protein 9B"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 9B"
                     /protein_id="NP_689692.2"
                     /db_xref="CCDS:CCDS12550.1"
                     /db_xref="GeneID:148014"
                     /db_xref="HGNC:HGNC:26395"
                     /translation="MQRGALSPVLMLSAAPEPPPRPPPALSPPGSGPGSGSRHGSARP
                     GPTPEPSGSLGAALDSSLRAAVAFKAEGQRCYREKKFREAIGKYHRALLQLKAAQGAR
                     PSGLPAPAPGPTSSPGPARLSEEQRRLVESTEVECYDSLTACLLQSELVNYERVREYC
                     LKVLEKQQGNFKATYRAGIAFYHLGDYARALRYLQEARSREPTDTNVLRYIQLTQLKM
                     NRCSLQREDSGAGSQTRDVIG"
     exon            431..613
                     /gene="TTC9B"
                     /inference="alignment:Splign:2.1.0"
     exon            614..828
                     /gene="TTC9B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      828
                     /gene="TTC9B"
                     /note="major polyA site"
ORIGIN      
        1 acaatgcagc gcggcgcgct gtccccggtg ctgatgctca gcgctgcccc ggagcctccg
       61 ccgcgcccgc ctcccgccct ctccccaccg ggctcgggcc caggctcggg ctcccgccat
      121 ggctcggctc gtcccggtcc taccccagag ccgtcgggga gcctgggcgc ggcgctcgac
      181 agcagcctgc gtgccgccgt ggcgttcaag gcagagggcc agcgctgcta tcgagagaag
      241 aagttccggg aggccatcgg caagtaccac cgagcgctgc tgcagctgaa ggcggcgcag
      301 ggggcccgcc ctagcggcct gcccgccccc gcccccgggc ccaccagcag ccccgggccg
      361 gcgcgcctca gcgaggagca gcggcgcctg gtggagagca cggaggtgga gtgttacgac
      421 tccctcacgg cttgcctgct gcagtcggag ctggtaaact acgagcgcgt gcgcgagtac
      481 tgtctcaagg tactggagaa gcagcagggc aacttcaagg ccacctaccg tgccggcatt
      541 gccttctacc acctgggcga ctacgcacgc gcgctgcgct acctgcagga ggcccgcagc
      601 cgggaaccca cagacaccaa tgtgctccgc tacatccagc tgactcagct gaagatgaat
      661 cgttgcagcc tccagcggga agacagtggg gctgggtccc agactcggga tgtaattggc
      721 tgaggccaat ccagggggac ctctctatcc ctcgccctcc cacctcacca tgtaacttcc
      781 cccgactcat gtgtttgttg gtaaaacact tgtcactggt gatcataa
//
