LOCUS       NM_020458               5095 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 7A (TTC7A), transcript
            variant 2, mRNA.
ACCESSION   NM_020458 XM_372927
VERSION     NM_020458.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5095)
  AUTHORS   Gajardo,T., Bernard,M., Lo,M., Turck,E., Leveau,C., El-Daher,M.T.,
            Deslys,A., Panikulam,P., Menche,C., Kurowska,M., Le Lay,G.,
            Barbier,L., Moshous,D., Neven,B., Farin,H.F., Fischer,A.,
            Menasche,G., de Saint Basile,G., Vargas,P. and Sepulveda,F.E.
  TITLE     Actin dynamics regulation by TTC7A/PI4KIIIalpha limits DNA damage
            and cell death under confinement
  JOURNAL   J Allergy Clin Immunol 152 (4), 949-960 (2023)
   PUBMED   37390900
  REMARK    GeneRIF: Actin dynamics regulation by TTC7A/PI4KIIIalpha limits DNA
            damage and cell death under confinement.
REFERENCE   2  (bases 1 to 5095)
  AUTHORS   Dannheim,K., Ouahed,J., Field,M., Snapper,S., Raphael,B.P.,
            Glover,S.C., Bishop,P.R., Bhesania,N., Kamin,D., Thiagarajah,J. and
            Goldsmith,J.D.
  TITLE     Pediatric Gastrointestinal Histopathology in Patients With
            Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A
            Rare Condition Leading to Multiple Intestinal Atresias, Severe
            Combined Immunodeficiency, and Congenital Enteropathy
  JOURNAL   Am J Surg Pathol 46 (6), 846-853 (2022)
   PUBMED   34985046
  REMARK    GeneRIF: Pediatric Gastrointestinal Histopathology in Patients With
            Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A
            Rare Condition Leading to Multiple Intestinal Atresias, Severe
            Combined Immunodeficiency, and Congenital Enteropathy.
REFERENCE   3  (bases 1 to 5095)
  AUTHORS   Mou,W., Yang,S., Guo,R., Fu,L., Zhang,L., Guo,W., Du,J., He,J.,
            Ren,Q., Hao,C., Gui,J. and Huang,J.
  TITLE     A Novel Homozygous TTC7A Missense Mutation Results in Familial
            Multiple Intestinal Atresia and Combined Immunodeficiency
  JOURNAL   Front Immunol 12, 759308 (2021)
   PUBMED   34975848
  REMARK    GeneRIF: A Novel Homozygous TTC7A Missense Mutation Results in
            Familial Multiple Intestinal Atresia and Combined Immunodeficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5095)
  AUTHORS   Dhingani,N., Guo,C., Pan,J., Li,Q., Warner,N., Jardine,S.,
            Leung,G., Kotlarz,D., Gonzaga-Jauregui,C., Klein,C., Snapper,S.B.,
            Navas-Lopez,V.M. and Muise,A.M.
  TITLE     The E3 ubiquitin ligase UBR5 interacts with TTC7A and may be
            associated with very early onset inflammatory bowel disease
  JOURNAL   Sci Rep 10 (1), 18648 (2020)
   PUBMED   33122718
  REMARK    GeneRIF: The E3 ubiquitin ligase UBR5 interacts with TTC7A and may
            be associated with very early onset inflammatory bowel disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5095)
  AUTHORS   Ashton,J.J., Mossotto,E., Beattie,R.M. and Ennis,S.
  TITLE     TTC7A Variants Previously Described to Cause Enteropathy Are
            Observed on a Single Haplotype and Appear Non-pathogenic in
            Pediatric Inflammatory Bowel Disease Patients
  JOURNAL   J Clin Immunol 40 (1), 245-247 (2020)
   PUBMED   31814065
  REMARK    GeneRIF: TTC7A Variants Previously Described to Cause Enteropathy
            Are Observed on a Single Haplotype and Appear Non-pathogenic in
            Pediatric Inflammatory Bowel Disease Patients.
REFERENCE   6  (bases 1 to 5095)
  AUTHORS   Bigorgne,A.E., Farin,H.F., Lemoine,R., Mahlaoui,N., Lambert,N.,
            Gil,M., Schulz,A., Philippet,P., Schlesser,P., Abrahamsen,T.G.,
            Oymar,K., Davies,E.G., Ellingsen,C.L., Leteurtre,E.,
            Moreau-Massart,B., Berrebi,D., Bole-Feysot,C., Nischke,P.,
            Brousse,N., Fischer,A., Clevers,H. and de Saint Basile,G.
  TITLE     TTC7A mutations disrupt intestinal epithelial apicobasal polarity
  JOURNAL   J Clin Invest 124 (1), 328-337 (2014)
   PUBMED   24292712
  REMARK    GeneRIF: TTC7A deficiency results in increased Rho kinase activity,
            which disrupts polarity, growth, and differentiation of intestinal
            epithelial cells in multiple intestinal atresia.
REFERENCE   7  (bases 1 to 5095)
  AUTHORS   Chen,R., Giliani,S., Lanzi,G., Mias,G.I., Lonardi,S., Dobbs,K.,
            Manis,J., Im,H., Gallagher,J.E., Phanstiel,D.H., Euskirchen,G.,
            Lacroute,P., Bettinger,K., Moratto,D., Weinacht,K., Montin,D.,
            Gallo,E., Mangili,G., Porta,F., Notarangelo,L.D., Pedretti,S.,
            Al-Herz,W., Alfahdli,W., Comeau,A.M., Traister,R.S., Pai,S.Y.,
            Carella,G., Facchetti,F., Nadeau,K.C., Snyder,M. and
            Notarangelo,L.D.
  TITLE     Whole-exome sequencing identifies tetratricopeptide repeat domain
            7A (TTC7A) mutations for combined immunodeficiency with intestinal
            atresias
  JOURNAL   J Allergy Clin Immunol 132 (3), 656-664 (2013)
   PUBMED   23830146
  REMARK    GeneRIF: These data strongly suggest that TTC7A gene defects cause
            combined immunodeficiency with multiple intestinal atresias.
REFERENCE   8  (bases 1 to 5095)
  AUTHORS   Samuels,M.E., Majewski,J., Alirezaie,N., Fernandez,I., Casals,F.,
            Patey,N., Decaluwe,H., Gosselin,I., Haddad,E., Hodgkinson,A.,
            Idaghdour,Y., Marchand,V., Michaud,J.L., Rodrigue,M.A.,
            Desjardins,S., Dubois,S., Le Deist,F., Awadalla,P., Raymond,V. and
            Maranda,B.
  TITLE     Exome sequencing identifies mutations in the gene TTC7A in
            French-Canadian cases with hereditary multiple intestinal atresia
  JOURNAL   J Med Genet 50 (5), 324-329 (2013)
   PUBMED   23423984
  REMARK    GeneRIF: Exome sequencing identifies mutations in the gene TTC7A in
            French-Canadian cases with hereditary multiple intestinal atresia.
REFERENCE   9  (bases 1 to 5095)
  AUTHORS   Nakatsu,F., Baskin,J.M., Chung,J., Tanner,L.B., Shui,G., Lee,S.Y.,
            Pirruccello,M., Hao,M., Ingolia,N.T., Wenk,M.R. and De Camilli,P.
  TITLE     PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its
            impact on plasma membrane identity
  JOURNAL   J Cell Biol 199 (6), 1003-1016 (2012)
   PUBMED   23229899
REFERENCE   10 (bases 1 to 5095)
  AUTHORS   White,R.A., McNulty,S.G., Nsumu,N.N., Boydston,L.A., Brewer,B.P.
            and Shimizu,K.
  TITLE     Positional cloning of the Ttc7 gene required for normal iron
            homeostasis and mutated in hea and fsn anemia mice
  JOURNAL   Genomics 85 (3), 330-337 (2005)
   PUBMED   15718100
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093732.3 and AC073283.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 4, 2018 this sequence version replaced NM_020458.3.
            
            Summary: This gene encodes a protein containing tetratricopeptide
            repeats. Mutations in this gene disrupt intestinal development and
            can cause early onset inflammatory bowel disease and intestinal
            atresia. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jun 2014].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. It encodes
            isoform 2, which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1340947.1,
                                           SRR14038191.3912137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319190.11/ ENSP00000316699.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               AC093732.3         16111-16612
            503-666             AC093732.3         25250-25413
            667-835             AC093732.3         31726-31894
            836-966             AC093732.3         49860-49990
            967-1082            AC093732.3         53679-53794
            1083-1161           AC093732.3         68337-68415
            1162-1319           AC093732.3         69244-69401
            1320-1383           AC093732.3         70023-70086
            1384-1521           AC093732.3         80809-80946
            1522-1605           AC093732.3         81528-81611
            1606-1710           AC093732.3         86218-86322
            1711-1828           AC093732.3         96749-96866
            1829-1886           AC093732.3         98295-98352
            1887-1959           AC093732.3         99174-99246
            1960-2120           AC093732.3         104111-104271
            2121-2237           AC093732.3         121202-121318
            2238-2335           AC093732.3         124836-124933
            2336-2470           AC093732.3         126633-126767
            2471-2673           AC073283.8         4446-4648
            2674-5095           AC073283.8         17379-19800
FEATURES             Location/Qualifiers
     source          1..5095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..5095
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /note="tetratricopeptide repeat domain 7A"
                     /db_xref="GeneID:57217"
                     /db_xref="HGNC:HGNC:19750"
                     /db_xref="MIM:609332"
     exon            1..502
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..2895
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /note="isoform 2 is encoded by transcript variant 2; TPR
                     repeat protein 7A"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 7A isoform 2"
                     /protein_id="NP_065191.2"
                     /db_xref="CCDS:CCDS33193.1"
                     /db_xref="GeneID:57217"
                     /db_xref="HGNC:HGNC:19750"
                     /db_xref="MIM:609332"
                     /translation="MAAKGAHGSYLKVESELERCRAEGHWDRMPELVRQLQTLSMPGG
                     GGNRRGSPSAAFTFPDTDDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEA
                     KNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLY
                     QMRLLSEAFVIKGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTT
                     NNSTSRHLKGCHPLDYELTYFLEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKAT
                     QNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQALRKPHLYEGDN
                     LYCPKDNIEEALLLLLISESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGR
                     RGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTV
                     PLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSLQATDATLKS
                     KQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEALKVRKDDA
                     HALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCR
                     QVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAA
                     SRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGL
                     FPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLA
                     QKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPVLPFSIIPR
                     EL"
     exon            503..666
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            667..835
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            836..966
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1082
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1161
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1319
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1383
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1521
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1605
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1710
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1828
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1886
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1959
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2120
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2237
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2335
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2470
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2673
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..5095
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3116
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /note="major polyA site"
     regulatory      4505..4510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /note="hexamer: AAGAAA"
     polyA_site      4524
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
     regulatory      5076..5081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /note="hexamer: ATTAAA"
     polyA_site      5095
                     /gene="TTC7A"
                     /gene_synonym="GIDID; MINAT; TTC7"
                     /note="major polyA site"
ORIGIN      
        1 gtggcagcag ctgcagcggc ggcggcggcg gcagcgccag gagctgctac agcagaggcg
       61 gaggttgctc ctgtacgcgt acgggccgct cggccggagc cgcagcccgg aggcgccggg
      121 cggtgcgctg ggagctgctg gtgctgctgc tgctgctgct gcccaccctc cgccgcccgg
      181 gcccccgctg ccgcccgggc cccggctgcc gtctgcgccc ccgtcgaccc cgcccgcgag
      241 tgcgccccag ccaggacgcc gcccccggcc gggtctccac ttcttggccg caccttccat
      301 gacagcgccc gcgagaagat ggctgcgaag ggcgcgcacg gctcctacct gaaggtggag
      361 agcgagctgg agcgctgccg cgccgagggc cactgggacc gcatgccgga gctggtccgg
      421 cagctgcaga cgctgagcat gcccggcggc ggaggtaaca ggcgaggcag cccgagcgca
      481 gcgttcacct ttccggacac cgatgacttt gggaaattgc tgctggctga ggccctcctg
      541 gagcagtgtt tgaaggagaa ccatgccaaa ataaaagact ccatgccttt gctggagaag
      601 aatgagccga agatgagcga agccaaaaat tatctaagca gtatccttaa ccatgggagg
      661 ctctcgccac agtacatgtg tgaggccatg ctgatcctgg gcaaactgca ttacgtggag
      721 ggctcatacc gagatgccat cagcatgtac gcacgggccg ggattgatga catgtccatg
      781 gagaacaagc ccctgtatca gatgcggctg ctgtcggagg cttttgtcat caaaggcctc
      841 tctctggaac gcctacccaa ctccatcgcc tcccgcttcc gcctgacaga gagggaggag
      901 gaagtgatca cctgttttga gagggcctcc tggatcgctc aggtgttcct gcaggaattg
      961 gagaagacca caaataacag cacgtcgagg catctgaaag gctgtcaccc gcttgactat
     1021 gagctcacct acttcctgga agctgccctc cagagcgcct atgtgaaaaa cctgaagaag
     1081 gggaacatcg tgaagggcat gagagagctc cgggaggtgc tgcggactgt ggagaccaaa
     1141 gcaactcaga acttcaaagt gatggcggcc aagcacctgg cgggggtcct gctgcactcc
     1201 ctgagtgagg agtgctactg gagccccctg tcccaccctc tgcctgagtt catgggcaag
     1261 gaggagagtt ctttcgccac tcaggccctg cggaaacctc acctctatga aggagacaac
     1321 ctctactgcc ccaaggacaa catcgaggaa gccctcctgc tcctcctcat cagcgaatcc
     1381 atggcaactc gagatgtggt gctgagccgg gtgccggagc aggaggagga ccggacagtg
     1441 agcttgcaga atgccgcagc catctatgac ctcctgagca tcacgttggg cagaagggga
     1501 cagtacgtca tgctctcgga gtgcctggag cgagccatga agtttgcgtt tggagaattt
     1561 cacctttggt accaggtggc cctctccatg gtggcttgtg ggaagtcagc ctacgctgtg
     1621 tccctgctgc gggagtgtgt gaagttgcgg ccctcggacc ccaccgtgcc cctgatggcc
     1681 gcgaaggtct gcatcgggtc ccttcgctgg ctagaggaag cagagcactt tgccatgatg
     1741 gtgatcagcc tcggagagga agccggggag ttcctcccca agggctacct ggctctgggt
     1801 ctcacctata gcctgcaggc caccgacgcc accctgaagt ccaagcaaga tgaattgcac
     1861 cggaaggcac tgcagacgct ggagagggct cagcagctgg cgcccagtga cccccaggtc
     1921 atcctctatg tctcgctgca gctggccctc gtccgacaga tctccagtgc catggagcag
     1981 ctgcaggagg ccctgaaggt acgcaaggat gatgcccacg ccctccacct gctggcactg
     2041 ctcttctctg cccagaagca ccaccagcat gccctggatg ttgtcaacat ggccatcacc
     2101 gagcaccctg agaacttcaa cctgatgttc accaaggtga agctggagca ggtgctgaaa
     2161 ggcccagagg aagccctcgt gacctgcaga caagtgctga ggctgtggca gaccctgtac
     2221 agcttctccc agctgggagg cctagaaaag gatggcagct tcggtgaggg cctcaccatg
     2281 aagaagcaga gtggcatgca cctgactttg cctgatgccc atgatgcaga ctctggctcc
     2341 cggcgggctt cgtccatcgc cgcctcccgg ctggaggagg ccatgtcaga gctgactatg
     2401 ccctcttcgg tcctgaagca gggccccatg cagctgtgga ccacgctgga acagatctgg
     2461 ctgcaggctg ctgagctgtt catggagcag cagcacctca aggaagcagg tttctgcatc
     2521 caggaggcgg cgggcctctt ccccacttct cactcagtac tctatatgcg gggccggctg
     2581 gctgaggtga agggcaacct ggaggaggcc aagcagctgt acaaggaggc gctcacggtg
     2641 aacccagatg gcgtgcgcat catgcatagc ctgggtctga tgctgagtcg gctgggccac
     2701 aagagcttgg cccagaaggt gcttcgtgat gccgtggaga ggcagagtac gtgccacgag
     2761 gcgtggcagg gcctgggcga ggtgctgcag gcccagggcc agaacgaggc tgccgttgac
     2821 tgcttcctca ccgcccttga gctggaggcc agcagccctg tactgccctt ctccatcatc
     2881 cccagagagc tctgacgacg ctgcagccgc agggagggag gggctggcca gagggagagg
     2941 cagcagggaa cgtgggtcag ggtggggcaa cagtggcatc aggtgcgggg cctcagggaa
     3001 atacatcttt agtgaacgcc tctgcagctg cagccctcgt tctcttggct gggccaagag
     3061 ggccttcctg gatttctttg ttggtgcctt gggaaacagt ctgacttgaa ccctaagtgc
     3121 ctttggagag ttttgtggtg accagacttg ctccccaaga gctgggcagc ggggagcctc
     3181 acagctgtcc ttcaccctca cccatgcctc tggcttggag tctgggtggg gggttctcac
     3241 tccccactct cagcacagta cagacttctg gatctctctc aggtcttgcc cagggcggtc
     3301 acaatgtgaa gaaactgcgg gcaagtggga agactatgag atttctgggt tcccttctca
     3361 gacttggagt tagtagatga ttcctgcatt gcccctgctt gccctctgag accagctggg
     3421 ccccaccttg ctctttcccc ctgctaccaa gtgcctttgg ggtctgacca ggggtactga
     3481 gcaccggccc taacacttcc atctccaccc accccatctc cctggcgatg tgctccagcc
     3541 caagcagcct ccgtaggctt tagatcctgt ggttgctaga tccagtcctt tctaataccc
     3601 tgagtcaaca cattactcct gcaggtctta ggctacaatg caggtccctt gagggccacc
     3661 aacatggagg taggcagttt ctaggactgt ccccagtaca tctcaccacc cacagccctt
     3721 tttttgcctt gattcgagcc tcaccctggc cttttggctt cccctgcctg agagagacct
     3781 gaggagggga cagagcccag cccctctcct gtggctgagc aggcctctgt gtccatgaca
     3841 cctgtcttcc gggcctgggg gctgtgggtg tatgtcctcc ctactggctt ccccggcccc
     3901 tgctgcatga tgctcttgga actcttctcc aaggagtcag tcccccaggc ctatcagggg
     3961 atccttttgt atctgcactt tgggttttag tttcaaagct ccatcaggta cagcttgcat
     4021 ttcaggatgt gtggaaagct cgggtgaggg ctgccctggt tcatcatagc tccaccttcc
     4081 tcggaaggag tgggctgttg gagacccccc atccatggca cactagctca gcactgcatt
     4141 tcccgagatg attcccaaga cagctggtgc ctcctggctt tcctgtgcca ggccaagggg
     4201 caccacagag gaccctggat cctttgcctc ttcttggttg aaggatctct atgtatgtgt
     4261 gtatataaat atagtttttt atctatatat ataaaataga gatctatttt ttttctggaa
     4321 ttctgttaga aaagtaaaga aaaagcaaat gctgttggtt tatctcaggg tgcccaaagt
     4381 ggttatagtc aatttttggt actaggaaag gcacccaatg catttcctga cttttaagca
     4441 tttccttgtt ggaagcagca gagggccagg ccaagttgct gacagtgact ttgcaggttg
     4501 aataaagaaa cccttggagg ggaagcaggc ttgtctgaag cagcatgtat attcactggg
     4561 catgtagctc ccacaccagc cttgagccag gccctggaca ggaggggctg ttgcaggatg
     4621 agggaggcca gagaaggcat cgaagccaag acctgggccc acctggggag ggatgtggga
     4681 aaggaaggat gggagggagg accctctggg aaaatgtgga tttgagctgg tgagagtgtt
     4741 gctaaggctg ggctaaagcc tggagagggt aggaggaggc aagaggggtc caggcagggc
     4801 tgatcctggc ctctgacctg tccagggcga cccctgaagc ccctgctgcc tctgggcatt
     4861 gctgggagag gccaaggcag gactcacgtc tgaacagaga tcccctcggg cattgctgat
     4921 gggccacctt cagctgcagg gaagaagcct aggagaggag gcatgggagg gacctgggcc
     4981 ttgttcagat tggccacctc tgctgagaag tccataccag tacaccccta ataagttatg
     5041 ccacatacca acgtactgtg gatattataa cctgcattaa aacaactcta aagaa
//
