LOCUS       NM_001310135            6562 bp    mRNA    linear   PRI 18-SEP-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 6 (TTC6), transcript
            variant 1, mRNA.
ACCESSION   NM_001310135 XM_006720346 XM_006726554
VERSION     NM_001310135.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6562)
  AUTHORS   Wang,Z., Fang,K., Wan,Y., Yin,Y., Li,M., Xu,K., Li,T., Cao,Y.,
            Lv,Y., Lu,G., Liu,H. and Huang,T.
  TITLE     TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the
            Rapid and Directed Motion of Sperm
  JOURNAL   Cells 12 (16), 2091 (2023)
   PUBMED   37626901
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6562)
  AUTHORS   Hinds,D.A., McMahon,G., Kiefer,A.K., Do,C.B., Eriksson,N.,
            Evans,D.M., St Pourcain,B., Ring,S.M., Mountain,J.L., Francke,U.,
            Davey-Smith,G., Timpson,N.J. and Tung,J.Y.
  TITLE     A genome-wide association meta-analysis of self-reported allergy
            identifies shared and allergy-specific susceptibility loci
  JOURNAL   Nat Genet 45 (8), 907-911 (2013)
   PUBMED   23817569
REFERENCE   3  (bases 1 to 6562)
  AUTHORS   Guey,L.T., Garcia-Closas,M., Murta-Nascimento,C., Lloreta,J.,
            Palencia,L., Kogevinas,M., Rothman,N., Vellalta,G., Calle,M.L.,
            Marenne,G., Tardon,A., Carrato,A., Garcia-Closas,R., Serra,C.,
            Silverman,D.T., Chanock,S., Real,F.X. and Malats,N.
  CONSRTM   EPICURO/Spanish Bladder Cancer Study investigators
  TITLE     Genetic susceptibility to distinct bladder cancer subphenotypes
  JOURNAL   Eur Urol 57 (2), 283-292 (2010)
   PUBMED   19692168
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121790.4, AL136296.3 and AL163151.1.
            
            On Jun 19, 2021 this sequence version replaced NM_001310135.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2153427,
                              SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000553443.6/
                                                ENSP00000451131.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AL121790.4         124198-124577
            381-460             AL121790.4         135232-135311
            461-1414            AL121790.4         150619-151572
            1415-1525           AL136296.3         60286-60396
            1526-1732           AL136296.3         62893-63099
            1733-1851           AL136296.3         76852-76970
            1852-2046           AL136296.3         81467-81661
            2047-2188           AL136296.3         94790-94931
            2189-2293           AL136296.3         105033-105137
            2294-2383           AL136296.3         116056-116145
            2384-2458           AL136296.3         117795-117869
            2459-2838           AL136296.3         118911-119290
            2839-3301           AL136296.3         129074-129536
            3302-3431           AL136296.3         129849-129978
            3432-3604           AL136296.3         131188-131360
            3605-3741           AL136296.3         133234-133370
            3742-3911           AL136296.3         167603-167772
            3912-4032           AL136296.3         170852-170972
            4033-4183           AL136296.3         172399-172549
            4184-4266           AL136296.3         175405-175487
            4267-4343           AL136296.3         176429-176505
            4344-4504           AL136296.3         176922-177082
            4505-4639           AL136296.3         184815-184949
            4640-4789           AL136296.3         186496-186645
            4790-4930           AL136296.3         187455-187595
            4931-5044           AL136296.3         188868-188981
            5045-5164           AL163151.1         136389-136508       c
            5165-5238           AL163151.1         131171-131244       c
            5239-5449           AL163151.1         124865-125075       c
            5450-5602           AL163151.1         122475-122627       c
            5603-5773           AL163151.1         121456-121626       c
            5774-5999           AL163151.1         107152-107377       c
            6000-6562           AL163151.1         106105-106667       c
FEATURES             Location/Qualifiers
     source          1..6562
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..6562
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /note="tetratricopeptide repeat domain 6"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
     exon            1..380
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            381..460
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            461..1414
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..6136
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 6; TPR repeat protein 6"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 6 isoform 1"
                     /protein_id="NP_001297064.2"
                     /db_xref="CCDS:CCDS91870.1"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
                     /translation="MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKP
                     AVDESPVHSLHAPGPARPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSG
                     LGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVK
                     RRARGVLESSRHAAPRRVFHLGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEAS
                     SGRRKVRIRSNFVSESGAREAREAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTS
                     IEEIIASLQSEAQLASDQTIKELIRSVLGQNYDITMEDISLMGKMYLKTSPMQAETPE
                     IQAEYKFQMGAEESQMSVHKELSETMSSILQIEQEDIEWGPSEAESIVFKPQEISQVQ
                     PAEELSKPLEDGQPTSDSKEAKWVSLTAKSPEFLQIEGKEIKRMRKRKSLRPRKSSKP
                     LCDKKLHKKIPQDYSMPHLHDLCTTIPAQELPVDLRLASRVYHTANRKGHDTLLGKFG
                     TSFLDDRFTDEEQTDRILYGIPVMDDNQEYVHIPPTPQGIPPELAQGTRERAHKPHLE
                     VLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKETLYPKYESVQASRLLTDKLSYKSSV
                     ITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQLRRVKSSVDLRKEKIIAPLEIKN
                     DMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKESIDDIFDNMCEKHSLRNLSLT
                     LIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELSKPPKSLERSASHGILPGQ
                     KKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPRTWALDRLIEYKDASIP
                     VKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYESEVKILTEEINDKTK
                     YPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALD
                     DLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYE
                     ITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA
                     RTYRGIAYVKWKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSA
                     LINDGYENLGCFLHRGIVYAHLKLWLLAICDFETVISLERTITLAYVNIGLIHLLHLD
                     NYTEAIWQFSEAIRIDPLCIQSYLCRAETYFKLHKLKKAVNELSRAIHLQPDGIQLYI
                     RRGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGIS
                     WNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGL
                     CYMEEGNLQMAFDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKH
                     YQAYLSRVAFYGLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNKTYKLAITDL
                     TTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIY
                     VELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFL
                     DAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWN
                     HFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEF
                     MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYV
                     LMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKA
                     LSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI"
     exon            1415..1525
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1732
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1851
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2046
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2188
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2293
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2383
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2458
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2838
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..3301
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3431
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3604
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3741
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            3742..3911
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4032
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4183
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4266
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4343
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4504
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4639
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            4640..4789
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            4790..4930
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            4931..5044
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            5045..5164
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5238
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            5239..5449
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            5450..5602
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            5603..5773
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            5774..5999
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..6562
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6512..6517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /note="hexamer: ATTAAA"
     regulatory      6535..6540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /note="hexamer: AATAAA"
     polyA_site      6541
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
     polyA_site      6562
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /note="major polyA site"
ORIGIN      
        1 ggagaaggcc gggggcggtg gcgtcggaga ctgggcttag agaccttgtg ggataactga
       61 ccccggggtc cctccccaga ggtacacgcc accttccgag cgcgggctgc ggcccagtct
      121 cgcgcccctc ctgctctttg cttcctccct cctgattcct gacccaaagt tcaaccccgg
      181 gagactggag aatacagact tttttttttc tttcctcctg agagcttcag actagaaaag
      241 ggaaaaagcc ccacttttgc ttcgtcacta gaaaccgggt catctgagtc agccgagcca
      301 agtgacgtta ggccgacccg ggccccgggc tagcagagcg gaggcgctgc cacgaaactc
      361 gtacctgcgg ctaagagcag gaaaaccctt tcctgtatgc catctgtttt ctgtggggcc
      421 ctgagtgatg aggagaggaa caaggattca tggaagtgag gtcaaatttg tcaagatgtc
      481 cacaatcccg agacactttg gcctgaaata caaagaggaa tcgtatatgt ttaaagagct
      541 tgagaaagtt cggcaggaaa ctaaaaagga ttttctccga ttcaagcaga agttggcctc
      601 caagccggct gtagatgaaa gcccagtcca cagcctccat gcccccggcc cggcccgccc
      661 cgcgcgcgtt tcctgcgccg cagcccggac gtcgagaaga tacccttcgc ttaaaggccc
      721 tgcgatgtcc gcggccgccc tcctgcagga ggtgctcgga ggcgcgccgc gtccctcggg
      781 cctgggtgag gcggcggctc caggcaagac ccggtcgttt cgcccccggg acttttactt
      841 gcggagctcc gcgttcctac ggcaccaggc cctgaaaaag cccccagtca tcgcctcggg
      901 gttcggcacg gccagacccg tggtcctgct gcctccgccc gagccacccg tgaagcgcag
      961 agcgcgcggg gtcttggaga gctcgcggca cgcggctccc aggcgggtct tccacttggg
     1021 aagggagcgc gaacagagcc aggaggtagc tcctctcgca gggccctgca tggccaaaga
     1081 gaggaaggcc agctccgtct ccgcagagga cggctacatg gaggccagca gcgggcggag
     1141 gaaagtgagg atccgcagca acttcgtgag cgagagcggg gcccgcgagg cgcgggaagc
     1201 ggcggggtta ggagcccagg gagaacagga gagctggccg cccagcgacg cgcgggaggc
     1261 cgcctggcag gcgctgctgc cctcccgcgt gatccccacg tccatcgaag agatcatcgc
     1321 ctctctgcag tccgaggccc agctggcctc cgaccagacc atcaaagagc tcatacggag
     1381 cgtccttggc cagaactacg acattacaat ggaagatatt tctttaatgg gaaaaatgta
     1441 cctcaaaaca tcacctatgc aagcagaaac acctgagata caagcagagt ataaattcca
     1501 gatgggtgct gaggaatcgc aaatgagcgt gcataaggaa ctttctgaaa ccatgtcaag
     1561 tattctccag attgaacaag aggatataga atggggaccc tcagaagcag aaagcatagt
     1621 atttaaacct caggaaattt cgcaagttca gccagcagag gaattaagta aacctttgga
     1681 agatggacag cccacaagtg attcaaaaga agccaagtgg gtgtctttaa cggcaaaatc
     1741 accagaattc ttgcaaatcg aaggaaaaga aattaagcga atgcggaaac gtaaatcact
     1801 gagaccaaga aagtcttcaa aacctctttg tgataaaaaa ctacataaaa aaattccaca
     1861 agactactcc atgccgcacc ttcatgatct gtgcaccacc atcccagccc aggagctgcc
     1921 tgttgacttg cgcctggctt ctcgagtgta tcacactgct aacaggaaag gccacgatac
     1981 cctgcttgga aaatttggaa cctctttctt agatgatcgc tttacagatg aagaacaaac
     2041 agatagaata ttgtatggaa ttcctgttat ggatgacaac caagaatatg tccatattcc
     2101 tccgacaccg caagggatac cacctgaatt ggcacaagga actagagagc gtgctcacaa
     2161 accacacttg gaagtcttgg gagaggaaat gtatgcttat ccagaattca cgaagttgtt
     2221 ttggaataca gctgcaccta aattctctgt tccagaatct gtcatgaagg aaactctata
     2281 tccaaaatat gagagtgttc aagcaagcag acttttaact gataaattgt catataaaag
     2341 cagtgtcatt actttacatc aacatagcag aacaaatttt tggtgtttct taccaagaaa
     2401 atctgcatca tttgaaagta tccaaaaatg gtttagtgca caacctacac aactaaggcg
     2461 agtaaaatct tctgtagact tgaggaagga gaagatcata gctcctttgg aaatcaagaa
     2521 tgatatgcaa agcagtataa aagaggttat gtttcagaaa gcaaaggaat tgaaacgtca
     2581 gctccagctc actaagcaaa ataaaactga ggagcccaac tatgtgaaag aaagtataga
     2641 tgacatcttt gataacatgt gcgaaaaaca cagtttgaga aatctctctt tgactctcat
     2701 tgaagcgtct aaaaaagctg gcattagtta cattgtttat cccaagaaaa agaagatgag
     2761 atggaagaaa agattgaaac aacaaaaact tatattcgtg catgaagagt tatccaagcc
     2821 tccaaaatct cttgaaagat cagcatctca tggaatactt ccgggacaga agaaatattt
     2881 gttcaaagtt ccattatatg aacgtcaaat acggtgtccc agtttacctt tgtatttaaa
     2941 ttttgaaaaa ttcgtccaag ctaagggagg aattccagaa aatattgatc ctcggacatg
     3001 ggctcttgat aggctcattg agtacaaaga tgcgagcata cctgtaaaag agaaagatga
     3061 taaaatatca gttcctgaag acccacctga aagagtgaaa gaaccaccaa aactaaaatt
     3121 aaatgattat gtggagtctg atcttccaca agaggtcatt aaatattatg aatctgaagt
     3181 gaagattttg actgaagaaa taaatgataa gacaaaatat cctgcatttg catattgtag
     3241 gcgtggagct atttatagga aactgggaaa gttgcagagt gccatgaatg atctgcagag
     3301 agtaatactc ttggaaccat tgtttctcaa tgcctattgg catcgacatt taatttatct
     3361 tttccaagac aaaattaatg aagctttgga tgacttgaat tatatacata aatataataa
     3421 aaataataca gaggcatatt tgtcaaaagc agaaatttac aggggaaaaa aagacataac
     3481 tttggcaatt ctaaactata cccaggcaat taaatccacg cccacagatg ctgatatcta
     3541 tttcaggagg ggtgagatgt atgaaataac aaacaaagta ctggccattg atgacttttc
     3601 gaaatgtatt ttttatgatc ccaaaagaac agatgcatta ttgaaacgtg ggctgtttta
     3661 ttgtgaaaat gaaaactggt ttgcagccat agaggatttt acagccttgt taaatataga
     3721 tcaccaaaat tctcaagcaa ggacataccg agggattgca tatgttaaat ggaaatttta
     3781 taaagaagca actcaagatt tttctgctgc aattcactta gatcctaata actggttagc
     3841 gttgtattat cgaggttgct tattcagaaa gagtaaccct tttagagcgc tacaggatta
     3901 tagtgtttca gcactcataa atgatggcta tgagaatctt ggttgttttc tacatcgggg
     3961 aatagtctat gcacatctaa aactttggct gctggcaatt tgtgactttg aaactgtcat
     4021 ttctctagaa agaactatta ctttggctta tgtaaatatt ggcctcatac atctgctaca
     4081 cctggataac tacacggaag ctatttggca attttctgag gctattagaa ttgatccttt
     4141 atgtattcaa agctatcttt gtcgggcgga aacctatttt aagttgcata aattgaaaaa
     4201 ggcagtaaat gaattgtctc gtgctatcca ccttcagcca gatggaatcc aattatacat
     4261 aagaagagga caatatcttc ttatgatgaa atattatgat cttgcaaagt ttactattta
     4321 tcaaatagca gaaatggaca aaggtctcag tgagttgagt cctatgcagc aagcccttat
     4381 ttattcattt tgtgaaaacc atgacaaggc cattgaggtc ttggacggaa tcagctggaa
     4441 tagagctgag atgaccatgt gtgctctatt agcaaaagtt caaatgaagg ccaagagaac
     4501 caaggaagct gtggaagtgc ttaagaaggc tttggatgcc atttctcatt ctgataaagg
     4561 accagatgcc acagcaattt cagcagactg tctgtataac ttgggtcttt gttacatgga
     4621 ggaaggcaat ttacaaatgg cttttgattc ttttacaaaa gctgtgaaag caaatccaga
     4681 ttttgcagaa agcttttatc agcgagggct ttgtaaagtg aaactccaca aggatagctc
     4741 gattctggat tttaatcgtg caattaccct caatccaaaa cattaccagg catatttaag
     4801 ccgagtagca ttctatggtt taaaaggcag gtattccaaa gcaatcttga attgtaacaa
     4861 ggctattaaa atttaccctg aaagcgtacg tgcctatctc tacagaggag ttctgaaata
     4921 ctacaacaag acttataagc tagcaattac agatttaact acagctatca gcatggacaa
     4981 aaatagttat acagcatttt ataacagagc attatgttac accaagataa gggaacttca
     5041 aatggcatta acagattatg gaattgtgct gcttcttgat gctacagaaa ctgtaaaact
     5101 aaataccttc cttaatcgtg gactcatcta cgtagaacta ggccagtatg gctttgcact
     5161 agaggatttt aaacaagctg cactgataag ccggactaac gggagccttt gtcacgccac
     5221 tgccatgtgc catcacagaa ttaatgagtt tgaagaagct gtcaatttct ttacttgggc
     5281 tcttaaaatt aacccatgtt ttctggatgc ttatgttgga cggggaaatt cttacatgga
     5341 atacggtcat gatgaagcca ccaagcaagc acagaaagac tttctgaaag cactgcatat
     5401 taatccagca tacataaaag ccagaattag ttttggctat aatttgcagg cccaaggaaa
     5461 attccagaaa gcttggaacc actttaccat tgccatagat actgatccaa agaactacct
     5521 agcctatgaa ggaagagctg tggtctgtct tcagatgggt aataattttg ctgcaatgca
     5581 ggatattaat gctgccatga agatcagtac tacagcagaa ttcttaacaa atcgtggggt
     5641 gattcatgag tttatgggcc acaaacagaa tgcaatgaaa gactaccaag atgcaattac
     5701 tctaaacccc aagtactcgc tggcttactt taatgcagga aatatctact ttcaccacag
     5761 gcagttttcc caggccagtg actacttctc aaaagcttta aaatttgatc cagaaaatga
     5821 atatgttctc atgaatcgag ctattacaaa tacaatatta aagaaatatg aagaagcaaa
     5881 agaagatttt gcaaatgtaa ttgaaagctg tcccttttgg gctgcagtat attttaatag
     5941 agcacatttc tactactgct taaagcaata tgaactagct gaggaagacc ttaataaagc
     6001 cctgtctttg aagcctaatg atgctctagt atataatttt agagcaaaag ttcgtggtaa
     6061 aataggtctg attgaggaag ctatggctga ctataaccaa gcacttgatc ttgaagacta
     6121 tgcctcagtt atatgattac atagactgtg gttgctatag tagtttacac agctgttctc
     6181 tctgaaacgg aaacatattt gttgtctaaa aggttctacc attttcatta ttgtattcgt
     6241 tatgcttagt cttccatata accttctatg cattttaata aaatgtttgt tatacattaa
     6301 ttataaaaca tatatcattt gctgcatatt tggaatacct tgagaactga atttttccaa
     6361 ggttgcagaa tctcaaggaa aatgtttctt aaggaattaa ataggaatgt ctcttaacat
     6421 ttaaaatatt ttctttaatt ctttttgaaa taatactata cattgtagaa aaagtgtcac
     6481 tgaccttttc atcaatcctt gctgacaatg tattaaacag tatacagatt aaaaaataaa
     6541 ccgatgacta taaaaaactg aa
//
