LOCUS       NM_004623               2356 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 4 (TTC4), transcript
            variant 1, mRNA.
ACCESSION   NM_004623 XM_001726392 XM_001726400 XM_001726506
VERSION     NM_004623.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   He,X., Lin,Z., Ning,J., Li,N., Cui,X., Zhao,B., Hong,F. and Miao,J.
  TITLE     Promoting TTC4 and HSP70 interaction and translocation of annexin
            A7 to lysosome inhibits apoptosis in vascular endothelial cells
  JOURNAL   FASEB J 34 (9), 12932-12945 (2020)
   PUBMED   33000523
  REMARK    GeneRIF: Promoting TTC4 and HSP70 interaction and translocation of
            annexin A7 to lysosome inhibits apoptosis in vascular endothelial
            cells.
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Shang,J., Xia,T., Han,Q.Q., Zhao,X., Hu,M.M., Shu,H.B. and Guo,L.
  TITLE     Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a
            Positive Regulator of SeV-Induced Innate Immunity
  JOURNAL   Proteomics 18 (2) (2018)
   PUBMED   29251827
  REMARK    GeneRIF: Study identified TTC4 as a TBK1 interactor and positive
            regulator of Sendai virus-induced innate immunity.
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Crevel,G., Bennett,D. and Cotterill,S.
  TITLE     The human TPR protein TTC4 is a putative Hsp90 co-chaperone which
            interacts with CDC6 and shows alterations in transformed cells
  JOURNAL   PLoS One 3 (3), e0001737 (2008)
   PUBMED   18320024
  REMARK    GeneRIF: TTC4 is highly expressed in malignant melanoma
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Poetsch,M., Dittberner,T., Cowell,J.K. and Woenckhaus,C.
  TITLE     TTC4, a novel candidate tumor suppressor gene at 1p31 is often
            mutated in malignant melanoma of the skin
  JOURNAL   Oncogene 19 (50), 5817-5820 (2000)
   PUBMED   11126369
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Su,G., Casey,G. and Cowell,J.K.
  TITLE     Genomic structure of the human tetratricopeptide repeat-containing
            gene, TTC4, from chromosome region 1p31 and mutation analysis in
            breast cancers
  JOURNAL   Int J Mol Med 5 (2), 197-200 (2000)
   PUBMED   10639601
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Hey,Y., Brintnell,B., James,L.A. and Varley,J.M.
  TITLE     Assignment of TTC4 to human chromosome band 1p31.3 and a pseudogene
            TTC4P to 7p14-->p13 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 272-274 (2000)
   PUBMED   10828607
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Su,G., Roberts,T. and Cowell,J.K.
  TITLE     TTC4, a novel human gene containing the tetratricopeptide repeat
            and mapping to the region of chromosome 1p31 that is frequently
            deleted in sporadic breast cancer
  JOURNAL   Genomics 55 (2), 157-163 (1999)
   PUBMED   9933562
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK025524.1, AK222562.1 and
            DB362353.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004623.4.
            
            Summary: This gene encodes a protein that contains
            tetratricopeptide (TPR) repeats, which often mediate
            protein-protein interactions and chaperone activity. The encoded
            protein interacts with heat shock proteins 70 and 90. Alternative
            splicing results in multiple transcript variants.
            Naturally-occuring readthrough transcription occurs from upstream
            gene MROH (maestro heat-like repeat family member 7) to this gene.
            [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025524.1, SRR1803614.121838.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371281.4/ ENSP00000360329.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AK025524.1         40-225
            187-2007            AK222562.1         179-1999
            2008-2324           AK025524.1         2047-2363
            2325-2339           DB362353.1         1-15                c
            2340-2356           AK025524.1         2379-2395
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..2356
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /note="tetratricopeptide repeat domain 4"
                     /db_xref="GeneID:7268"
                     /db_xref="HGNC:HGNC:12394"
                     /db_xref="MIM:606753"
     exon            1..159
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1212
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /note="isoform 1 is encoded by transcript variant 1; TPR
                     repeat protein 4"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 4 isoform 1"
                     /protein_id="NP_004614.3"
                     /db_xref="CCDS:CCDS596.1"
                     /db_xref="GeneID:7268"
                     /db_xref="HGNC:HGNC:12394"
                     /db_xref="MIM:606753"
                     /translation="MEQPGQDPTSDDVMDSFLEKFQSQPYRGGFHEDQWEKEFEKVPL
                     FMSRAPSEIDPRENPDLACLQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISY
                     TEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALC
                     HLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIEQRDVRKANLKEKKERNQ
                     NEALLQAIKARNIRLSEAACEDEDSASEGLGELFLDGLSTENPHGARLSLDGQGRLSW
                     PVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDR
                     AELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLRGRKVYQIR"
     exon            160..277
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..439
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..517
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..729
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..944
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1026
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1109
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..2356
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2007
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /note="major polyA site"
     regulatory      2318..2323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /note="hexamer: AATACA"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC4"
                     /gene_synonym="CNS1"
                     /note="hexamer: AGTAAA"
     polyA_site      2340
                     /gene="TTC4"
                     /gene_synonym="CNS1"
     polyA_site      2356
                     /gene="TTC4"
                     /gene_synonym="CNS1"
ORIGIN      
        1 gctcgcttca cggcgctggg acccgggctg gaaggcaggg catcagctat ggaacaacct
       61 gggcaggatc ccacctcaga cgacgtcatg gactcgttcc tggaaaagtt ccagagccag
      121 ccttaccgtg gcggctttca tgaggaccag tgggagaagg aatttgaaaa ggtcccccta
      181 tttatgtcga gagcgccatc agaaattgat cccagggaga atcctgactt ggcttgtctc
      241 cagtcaatta tttttgatga ggagcgttct ccagaagaac aggccaagac ctataaagat
      301 gagggcaatg attactttaa agaaaaagac tacaagaaag ctgtaatttc atacactgaa
      361 ggcttaaaga agaaatgtgc agatcctgat ttgaatgctg tcctttatac caaccgggca
      421 gcagcacagt actatctggg caattttcgt tctgctctca atgatgtgac agctgccaga
      481 aagctaaaac cctgccacct caaagcaata ataagaggtg ccttatgcca tctggaactg
      541 aaacactttg ccgaggccgt gaactggtgt gatgagggac tgcaaataga tgccaaagag
      601 aagaagcttc tggaaatgag ggctaaagca gacaagctga agcgaattga acagagggat
      661 gtgaggaaag ccaacttgaa agaaaagaag gagaggaatc agaatgaggc tttactccag
      721 gccatcaagg ctaggaatat caggctctca gaagctgcct gtgaggatga agattcagcc
      781 tcagaaggtc taggtgagct tttcctggat ggactcagca ctgagaaccc ccatggagcc
      841 aggctgagtc tagatggcca gggcaggctg agctggcctg tgctctttct gtacccagag
      901 tatgcccagt cggacttcat ctctgctttt catgaggact ccaggtttat tgatcatcta
      961 atggtgatgt ttggtgaaac accctcttgg gacctagagc aaaaatattg ccctgataat
     1021 ttggaggtct actttgagga tgaggacagg gcagaactat accgggtgcc tgccaagagc
     1081 accttgctac aggttctaca gcaccagagg tactttgtaa aagccctgac accagcattt
     1141 ttggtctgtg taggatcctc tcctttttgc aagaattttc tccgggggag aaaggtgtac
     1201 cagatacgat gactaagcca gggcccctgg atctcctccc ttaccctcct ctgctgggaa
     1261 cctagcacac ctgaatcagc tggacatact gctggagtcc agtgctttct ttccgtcacc
     1321 ctggggatag tccttcctgg catcgtggtg ggggaggagc ctctggcttc cctaaactgc
     1381 agcctctctg gctggtcttc actttcctca gttgatataa aactctgggt cttggccatg
     1441 atgtccttgg actccatcgc taaagggacc atctgctgca gttaccacag caactgacct
     1501 gagcggcacc ctggtctgtg gagatggact caggatccag tgacatgatt ctgaactttt
     1561 gtggagtttg acaccttaga gaagctaccc ctcaaactgc acatctacac acaaacaaac
     1621 aatgcatagg attccaaggc tttaaagctg agagaccctg gcctcaagtt atttcatgcg
     1681 cacagaggga agccatgtgg ggttgctgaa gatgccttga ggtgaaatgg gggcaggaaa
     1741 gccacatctt gctctgcatt tataaagacc gtacaaactc agatccttgg tacccctaaa
     1801 aagattgcca attttcttca tctttgccat atggaggact gtgacagact ttggacagtg
     1861 gcctcttgag ttcctctgca gttttgacat ttaggatttt gtgtctttta aactggaaaa
     1921 tcttctagca tgttgggttg ttacagagta tatttttgtc tgcagctgtt tgttgcccca
     1981 ttcctaagag gagtttatcc atcctgactt gtagctgtgt gacttcttgc agtgccccca
     2041 ccccatcccc ccgggagagt gtacttccct gctcccaatg cagagggata tgcacaggca
     2101 tgagctgtcc tgcgtctgac agaagcctga agagtcatgt gtggttggcc tgtgctcttc
     2161 cctctgctgt gagaacacat ttcccacaga ggagccgttc catggagccg agctacagca
     2221 gctggcctgc agccactgag tgtcacagca atgagagagc aatgtttgct gtagtaagca
     2281 gtgagattta ggggttggtt gttactatag cagagctaat acatgagtaa actgaagcca
     2341 gctgctgtcc ttaaaa
//
