LOCUS       NM_001135993            4896 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 39C (TTC39C),
            transcript variant 1, mRNA.
ACCESSION   NM_001135993
VERSION     NM_001135993.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4896)
  AUTHORS   Rong,H., Peng,J., Ma,K., Zhu,J. and He,J.T.
  TITLE     Ttc39c is a potential target for the treatment of lung cancer
  JOURNAL   BMC Pulm Med 22 (1), 391 (2022)
   PUBMED   36303158
  REMARK    GeneRIF: Ttc39c is a potential target for the treatment of lung
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4896)
  AUTHORS   Meng,W., Chan,B.W., Ezeonwumelu,C., Hebert,H.L., Campbell,A.,
            Soler,V. and Palmer,C.N.
  TITLE     A genome-wide association study implicates that the TTC39C gene is
            associated with diabetic maculopathy with decreased visual acuity
  JOURNAL   Ophthalmic Genet 40 (3), 252-258 (2019)
   PUBMED   31264924
  REMARK    GeneRIF: Single Nucleotide Polymorphism in the TTC39C gene is
            associated with diabetic maculopathy with decreased visual acuity.
REFERENCE   3  (bases 1 to 4896)
  AUTHORS   Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
            Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
            Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
            Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
            Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
            Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
            Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
            Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
            Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
            Birren,B.W., Sakaki,Y. and Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 18
  JOURNAL   Nature 437 (7058), 551-555 (2005)
   PUBMED   16177791
  REMARK    Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010754.10, AC090772.9 and KF456356.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001135993.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.19101.1,
                                           SRR1163655.475257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317571.8/ ENSP00000323645.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AC010754.10        123187-123471
            286-334             AC010754.10        172573-172621
            335-463             AC010754.10        174445-174573
            464-578             AC010754.10        177590-177704
            579-933             AC010754.10        189018-189372
            934-1102            AC090772.9         173173-173341       c
            1103-1196           KF456356.1         99-192
            1197-1304           AC090772.9         138022-138129       c
            1305-1414           AC090772.9         132311-132420       c
            1415-1538           AC090772.9         130704-130827       c
            1539-1636           AC090772.9         127271-127368       c
            1637-1741           AC090772.9         125837-125941       c
            1742-1780           AC090772.9         124334-124372       c
            1781-4896           AC090772.9         120654-123769       c
FEATURES             Location/Qualifiers
     source          1..4896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..4896
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /note="tetratricopeptide repeat domain 39C"
                     /db_xref="GeneID:125488"
                     /db_xref="HGNC:HGNC:26595"
     exon            1..285
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1870
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 39C; TPR repeat protein
                     39C"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 39C isoform 1"
                     /protein_id="NP_001129465.1"
                     /db_xref="CCDS:CCDS45839.1"
                     /db_xref="GeneID:125488"
                     /db_xref="HGNC:HGNC:26595"
                     /translation="MAGSEQQRPRRRDDGDSDAAAAAAAPLQDAELALAGINMLLNNG
                     FRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCESEEA
                     GVIETIKNKIKKNVDVRKSAPSMVDRLQRQIIIADCQVYLAVLSFVKQELSAYIKGGW
                     ILRKAWKIYNKCYLDINALQELYQKKLTEESLTSDAANDNHIVAEGVSEESLNRLKGA
                     VSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLMYASESKDMKAPLATLALL
                     WYHTVVRPFFALDGSDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLECQINSA
                     LTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAY
                     LTAVCQGATGDVDGAQIVFKEVQKLFKRKNNQIEQFSVKKAERFRKQTPTKALCVLAS
                     IEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAVQYF
                     QRAVKDELCRQNNLYVQPYACYELGCLLLDKPETVGRGRALLLQAKEDFSGYDFENRL
                     HVRIHAALASLRELVPQ"
     exon            286..334
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            335..463
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            464..578
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            579..933
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1102
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1196
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1304
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1414
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1538
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1636
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1741
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1780
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..4896
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1922..1927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /note="hexamer: AATAAA"
     polyA_site      1940
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /note="major polyA site"
     regulatory      4875..4880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /note="hexamer: AATAAT"
     polyA_site      4896
                     /gene="TTC39C"
                     /gene_synonym="C18orf17; HsT2697"
                     /note="major polyA site"
ORIGIN      
        1 cccctcccct cccggctccg cttggctccg ggcaggtaga gccgggctcc gggcgcgcgc
       61 ggggccgcag cagctgctcc cgatctcgcc tcggcccagc gcagggcctc gcacgcccat
      121 ggccggctcg gagcagcagc ggccgcggcg gcgggacgac ggagactcgg acgcggcagc
      181 ggcggcggcg gcgcccctgc aggacgcgga gctggccctg gccggcatca acatgctgct
      241 caacaacggc ttcagggagt cggaccagct tttcaaacaa tacagaaatc atagcccact
      301 aatgagtttt ggagccagct ttgtcagttt tttgaatgcc atgatgacat ttgaggaaga
      361 aaaaatgcag ttggcatgtg atgacttaaa aaccacagaa aaactgtgtg aaagtgaaga
      421 ggctggagta attgaaacaa tcaagaataa aattaagaag aacgttgatg tccgaaaatc
      481 cgccccctct atggttgatc ggcttcagag gcagataatc atagctgact gccaggttta
      541 cctggctgtg ctttcatttg taaaacaaga attgtcagct tatatcaaag gtgggtggat
      601 ccttaggaaa gcctggaaga tttacaataa atgctatctg gacatcaatg cccttcagga
      661 gctgtatcag aagaagctaa ctgaagagtc cttgacttct gatgctgcaa atgataatca
      721 cattgtggct gaaggggtgt ctgaggagtc tctgaacaga ctgaaaggtg ctgttagctt
      781 tggatatggc ctttttcacc tttgcatatc catggtgccc ccaaacctgc tcaaaatcat
      841 caacctgctg ggttttcctg gagaccgcct acaggggctt tcttcactga tgtatgcaag
      901 cgaaagtaag gacatgaagg cccctttagc tacattagct ctgctctggt atcatactgt
      961 agtccgcccg ttttttgcct tggatggcag tgataacaag gcaggcctgg atgaagctaa
     1021 ggaaattctc cttaaaaaag aagctgctta tccaaattct tccctcttta tgtttttcaa
     1081 gggacggata caacgactag agtgtcaaat caacagtgcc ttgacatctt tccacactgc
     1141 tttggaactt gcagtagacc agagagaaat tcaacatgtc tgtctgtatg aaattggttg
     1201 gtgcagcatg atagagctca atttcaagga tgcatttgat tcctttgaga ggctaaaaaa
     1261 tgagtccagg tggtcccagt gctattatgc ctacttgact gcagtttgtc agggagccac
     1321 tggtgatgtg gatggggcac agattgtctt taaagaagtt cagaaactct tcaaaaggaa
     1381 aaacaatcag attgaacagt tctcggtgaa aaaggcagag cgatttcgga agcaaacccc
     1441 aaccaaagcg ctctgtgtgt tggcgtctat tgaagtgttg tacttgtgga aagctcttcc
     1501 aaactgttcc ttccccaacc tgcagaggat gagtcaagct tgccatgaag tggatgactc
     1561 atctgttgtt ggattaaagt atttgcttct tggtgccata cacaaatgtc taggaaactc
     1621 agaagatgct gttcagtact tccagcgagc tgttaaagat gaattgtgtc gtcagaataa
     1681 cttatatgtt cagccgtatg cctgttatga acttggctgt cttctattag acaaaccaga
     1741 gactgtagga agaggcagag ctctacttct tcaagcaaag gaggatttct ctggctacga
     1801 ctttgaaaac agattgcatg tccgcatcca tgctgctctg gcctctctga gggaattggt
     1861 tcctcagtga cagacccgga acacccgctc cgtccctccc cacccagggt ccgcacttta
     1921 aaataaaagc agaggacaaa gctcttgtga agatgggctt ttcttctgaa aaccacctgt
     1981 gccagggaca cattttccca gttaagctga catattaaag atctcctctt ttaaacatgt
     2041 agctgaaaag taataatgat gttgaggagg atgatgatgg taataataac taaccacctg
     2101 gggagagggt taagtgacct tgctcaaacg ttttagtttt gtgatttatt atttttaaaa
     2161 taaaatcaaa cggaacatcc aacccaagat cctgtaggaa cacctacctt aagcacatat
     2221 ctgaatgggt aacatgatga ggtacctgta aaattattaa caatatcatg acatagcatt
     2281 tatatttgtg ttttgaaaaa ataaaagtgc tttctagtgt tttactttat cctcaaaata
     2341 ctccagtgaa taacatagca cagatattct taaccccact ttgcagacag tgaaactcag
     2401 gcacaaaaag gcaaattgac ttatcccaat taattattcc tgttatcagc agagcaatga
     2461 atagaaagca gatctcctga ccaccaactg acttttattg taaaaataat tcatgttaat
     2521 aggccagaat tccatgtttt acttattaaa agaacaaaat cttcagctga agttatgtca
     2581 ccagaaatag tcatctccag attgtctaca gaatgtttca aagcgatgga cactcttttt
     2641 cctttgaaag ccaaccaagt aagagcaaat attaatagaa gataatttta caactaaaag
     2701 tgtgactctt ttgctaatct attagcctag tctatagatt agacaaacag tatctacatt
     2761 ttaggagttt acctttcttt gtgaaaattg tcaaattacc aacttttgga aatcttttga
     2821 cacattactt gaaaaggtta ttcgtgaatg aacatagatt ttggcctcaa aatatttgct
     2881 ggtggaacat ttgctgggct acacagtgcc aggatttaat cattttcccc ttagctcagg
     2941 ttatttagat attatacaag gaattcaaag ttattttttt attcttcatt gctaattttt
     3001 gtcatttaat ttacctccat gcccggtact gcaaacctgt ggttttgaag aatctaaata
     3061 cctcagtcac ttttaagaat ctctgccata atttggctca atgtttaagg ttagattttt
     3121 aaagaaattt ttattgagct aaaggatatc attttagggt atcgtttatt tacaaattct
     3181 tttggctgaa acatgatctc atattaatat tttaatattt cttttcaaaa taaaacagaa
     3241 aagcaagtag aatgttggca aattttatct gatttgacct tgttttgagg gaatagtcat
     3301 aatttctttg aaagaagtta tttctcactg attttggcta aacagtattc atatttcttc
     3361 atctctgtta ctgaccactt ttcagtagac tgtttccaaa atgtgtattc acattgactt
     3421 tctccctgat gtgaattccg tgtgggtttt agataatagt aagagagaag agattgctct
     3481 cctatattca gtgaatgaga agggaacttt tttctgaaga gcaaaattgg tgcccaaaaa
     3541 tattggacat ctgttttttg tttttttttt tttttttttt tttttttgag acggagtctc
     3601 gctctgtcac ccaggctgga gtgcagtggc gtgatcttgg ctcactgcaa cctctgcctc
     3661 ctgggttcac accattctcc tgcctcagcc tcccaagtag ctgggactac aggcacccgc
     3721 aaccacaccc ggctaatttt ttttgtattt ttagtagaga tggggtttca ccatgttagc
     3781 caggattgtc tccatctcct gacctcgtga tccacccgcc ttggcctccc aaagagctgg
     3841 gattactggt gtgagccacc gtgcccggcc tggacatctg gttttaacta gatggaaggg
     3901 aagaacatta tgaatcttta aaatacggct gttgccattt ttctctcttc ttaacatgca
     3961 gcataggtga caagcttttc tgtcatcatc atggagcatt ctgaatcatg acatttttgt
     4021 ttgagagttc attcttgaat tttcagttca aaatattgtt tgaactatta ttccacattc
     4081 aaagattata taaggtcctg tgcttttgaa tctttttcaa aacatttatt tctgcctgct
     4141 taaaaaaaat acttttattt ccccacagag agttcaggac ttcagattag tttgtgttca
     4201 gctcacttaa ctggatagac aattttgcgt tttgcaacac catcctgtag gttttcttta
     4261 ctagtcaaag tgtaggtctt tttaaaattt ttaatcttta tttttatttt tattttgaaa
     4321 cagagtctca ctctgttgcc caggctggag tgcagtggtg tgatctgtgc tcactgcaac
     4381 ctctgtcacc cgggtttaag cgattcttct gcctgagcct cccaagtagc tgggattaca
     4441 agttcctgcc accgtgcctg gctaattttt gcagttttag tagaggcagg gttccaccac
     4501 cttggccagg ctggtcttga actcctgacc tcatgatcca cccaccttgt cctctcaaaa
     4561 tgcttacagg catgaaccac tgtgaccggc caggtctttt tttttttaaa gagtctatcc
     4621 taggcttggt acagatggcg cctgtggtaa atctgtgtta acatggtggt agaccatgga
     4681 gaatgggtag atggagcttc tagactccaa aacaacaaaa ccacagtgtg agtacactgt
     4741 cccattaggt tgactgaagt ctgagtacat tttctggcct gcgtgccgtg acttatccaa
     4801 cctgtgaact gattgtgatc tgcttggtaa cttggtttgg tgtaaactgc tcttaaccct
     4861 ttgctgatga agaaaataat catataagtg gaacta
//
