LOCUS       NM_152574              10339 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 39B (TTC39B),
            transcript variant 1, mRNA.
ACCESSION   NM_152574
VERSION     NM_152574.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10339)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 10339)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 10339)
  AUTHORS   Steinthorsdottir,V., Thorleifsson,G., Aradottir,K., Feenstra,B.,
            Sigurdsson,A., Stefansdottir,L., Kristinsdottir,A.M., Zink,F.,
            Halldorsson,G.H., Munk Nielsen,N., Geller,F., Melbye,M.,
            Gudbjartsson,D.F., Geirsson,R.T., Thorsteinsdottir,U. and
            Stefansson,K.
  TITLE     Common variants upstream of KDR encoding VEGFR2 and in TTC39B
            associate with endometriosis
  JOURNAL   Nat Commun 7, 12350 (2016)
   PUBMED   27453397
  REMARK    GeneRIF: association of rs519664[T] in TTC39B on 9p22 with
            endometriosis, is reported.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10339)
  AUTHORS   Rodriguez,S., Gaunt,T.R., Guo,Y., Zheng,J., Barnes,M.R., Tang,W.,
            Danish,F., Johnson,A., Castillo,B.A., Li,Y.R., Hakonarson,H.,
            Buxbaum,S.G., Palmer,T., Tsai,M.Y., Lange,L.A., Ebrahim,S., Davey
            Smith,G., Lawlor,D.A., Folsom,A.R., Hoogeveen,R., Reiner,A.,
            Keating,B. and Day,I.N.
  TITLE     Lipids, obesity and gallbladder disease in women: insights from
            genetic studies using the cardiovascular gene-centric 50K SNP array
  JOURNAL   Eur J Hum Genet 24 (1), 106-112 (2016)
   PUBMED   25920552
  REMARK    GeneRIF: Two new polymorphisms associated with gall bladder disease
            and obesity in women have been identified, GCKR rs1260326, and
            TTC39B rs686030.
REFERENCE   5  (bases 1 to 10339)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   6  (bases 1 to 10339)
  AUTHORS   O'Seaghdha,C.M., Yang,Q., Glazer,N.L., Leak,T.S., Dehghan,A.,
            Smith,A.V., Kao,W.H., Lohman,K., Hwang,S.J., Johnson,A.D.,
            Hofman,A., Uitterlinden,A.G., Chen,Y.D., Brown,E.M.,
            Siscovick,D.S., Harris,T.B., Psaty,B.M., Coresh,J., Gudnason,V.,
            Witteman,J.C., Liu,Y.M., Kestenbaum,B.R., Fox,C.S. and Kottgen,A.
  CONSRTM   GEFOS Consortium
  TITLE     Common variants in the calcium-sensing receptor gene are associated
            with total serum calcium levels
  JOURNAL   Hum Mol Genet 19 (21), 4296-4303 (2010)
   PUBMED   20705733
REFERENCE   7  (bases 1 to 10339)
  AUTHORS   Waterworth,D.M., Ricketts,S.L., Song,K., Chen,L., Zhao,J.H.,
            Ripatti,S., Aulchenko,Y.S., Zhang,W., Yuan,X., Lim,N., Luan,J.,
            Ashford,S., Wheeler,E., Young,E.H., Hadley,D., Thompson,J.R.,
            Braund,P.S., Johnson,T., Struchalin,M., Surakka,I., Luben,R.,
            Khaw,K.T., Rodwell,S.A., Loos,R.J., Boekholdt,S.M., Inouye,M.,
            Deloukas,P., Elliott,P., Schlessinger,D., Sanna,S., Scuteri,A.,
            Jackson,A., Mohlke,K.L., Tuomilehto,J., Roberts,R., Stewart,A.,
            Kesaniemi,Y.A., Mahley,R.W., Grundy,S.M., McArdle,W., Cardon,L.,
            Waeber,G., Vollenweider,P., Chambers,J.C., Boehnke,M.,
            Abecasis,G.R., Salomaa,V., Jarvelin,M.R., Ruokonen,A., Barroso,I.,
            Epstein,S.E., Hakonarson,H.H., Rader,D.J., Reilly,M.P.,
            Witteman,J.C., Hall,A.S., Samani,N.J., Strachan,D.P., Barter,P.,
            van Duijn,C.M., Kooner,J.S., Peltonen,L., Wareham,N.J.,
            McPherson,R., Mooser,V. and Sandhu,M.S.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genetic variants influencing circulating lipid levels and risk of
            coronary artery disease
  JOURNAL   Arterioscler Thromb Vasc Biol 30 (11), 2264-2276 (2010)
   PUBMED   20864672
REFERENCE   8  (bases 1 to 10339)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 10339)
  AUTHORS   Kathiresan,S., Willer,C.J., Peloso,G.M., Demissie,S., Musunuru,K.,
            Schadt,E.E., Kaplan,L., Bennett,D., Li,Y., Tanaka,T., Voight,B.F.,
            Bonnycastle,L.L., Jackson,A.U., Crawford,G., Surti,A., Guiducci,C.,
            Burtt,N.P., Parish,S., Clarke,R., Zelenika,D., Kubalanza,K.A.,
            Morken,M.A., Scott,L.J., Stringham,H.M., Galan,P., Swift,A.J.,
            Kuusisto,J., Bergman,R.N., Sundvall,J., Laakso,M., Ferrucci,L.,
            Scheet,P., Sanna,S., Uda,M., Yang,Q., Lunetta,K.L., Dupuis,J., de
            Bakker,P.I., O'Donnell,C.J., Chambers,J.C., Kooner,J.S.,
            Hercberg,S., Meneton,P., Lakatta,E.G., Scuteri,A., Schlessinger,D.,
            Tuomilehto,J., Collins,F.S., Groop,L., Altshuler,D., Collins,R.,
            Lathrop,G.M., Melander,O., Salomaa,V., Peltonen,L.,
            Orho-Melander,M., Ordovas,J.M., Boehnke,M., Abecasis,G.R.,
            Mohlke,K.L. and Cupples,L.A.
  TITLE     Common variants at 30 loci contribute to polygenic dyslipidemia
  JOURNAL   Nat Genet 41 (1), 56-65 (2009)
   PUBMED   19060906
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 10339)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591393.10.
            
            On May 26, 2021 this sequence version replaced NM_152574.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2745566.1,
                                           SRR11853564.26971.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512701.7/ ENSP00000422496.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL591393.10        171755-171887       c
            134-168             AL591393.10        132585-132619       c
            169-264             AL591393.10        90588-90683         c
            265-375             AL591393.10        78810-78920         c
            376-507             AL591393.10        75937-76068         c
            508-584             AL591393.10        74759-74835         c
            585-652             AL591393.10        68494-68561         c
            653-717             AL591393.10        64532-64596         c
            718-823             AL591393.10        57261-57366         c
            824-889             AL591393.10        55861-55926         c
            890-998             AL591393.10        55225-55333         c
            999-1066            AL591393.10        54396-54463         c
            1067-1126           AL591393.10        54245-54304         c
            1127-1288           AL591393.10        52642-52803         c
            1289-1380           AL591393.10        51615-51706         c
            1381-1507           AL591393.10        49951-50077         c
            1508-1616           AL591393.10        46978-47086         c
            1617-1734           AL591393.10        42368-42485         c
            1735-1851           AL591393.10        39690-39806         c
            1852-10339          AL591393.10        28293-36780         c
FEATURES             Location/Qualifiers
     source          1..10339
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.3"
     gene            1..10339
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /note="tetratricopeptide repeat domain 39B"
                     /db_xref="GeneID:158219"
                     /db_xref="HGNC:HGNC:23704"
                     /db_xref="MIM:613574"
     exon            1..133
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1942
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 39B; TPR repeat protein
                     39B"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 39B isoform 1"
                     /protein_id="NP_689787.3"
                     /db_xref="CCDS:CCDS6477.3"
                     /db_xref="GeneID:158219"
                     /db_xref="HGNC:HGNC:23704"
                     /db_xref="MIM:613574"
                     /translation="MALLGSRAELEADEDVFEDALETISISSHSDMATSSLHFASCDT
                     QQAPRQRGASTVSSSSSTKVDLKSGLEECAVALNLFLSNKFTDALELLRPWAKESMYH
                     ALGYSTIVVLQAVLTFEQQDIQNGISAMKDALQTCQKYRKKYTVVESFSSLLSRGSLE
                     QLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHEI
                     QKNKLQQEFFYEFEGGVKLGSGAFNLMLSLLPARIIRLLEFIGFSGNRELGLLQLREG
                     ASGRSMRSALCCLTILAFHTYISLILGTGEVNVAEAERLLAPFLQQFPNGSLVLFYHA
                     RIELLKGNLEEAQEVFQKCISVQEEWKQFHHLCYWELMWINVFQQNWMQAYYYSDLLC
                     KESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSIPTEKFA
                     VRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQ
                     NFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLFEL
                     ASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD"
     exon            134..168
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            169..264
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            265..375
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            376..507
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            508..584
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            585..652
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            653..717
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            718..823
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            824..889
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            890..998
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1066
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1126
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1288
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1380
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1507
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1616
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1734
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1851
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..10339
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10319..10324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /note="hexamer: AATAAA"
     polyA_site      10339
                     /gene="TTC39B"
                     /gene_synonym="C9orf52"
                     /note="major polyA site"
ORIGIN      
        1 cctttgcgct gggctgagcc cagagccgag agcaggagtc ggctctgagt tccctgcttg
       61 gtttttgggt ggcagcagcc agaggaggaa tatggcgctc ttaggcagcc gagcggagct
      121 ggaagcggac gaggacgttt tcgaagatgc cttggaaacc atctcaatat cttctcactc
      181 agatatggca acaagcagcc ttcactttgc atcatgtgat acacaacagg cgcccagaca
      241 gcgcggagcg tctactgtca gcagttcatc atcaaccaag gtggatctca agagtggcct
      301 cgaagaatgt gctgtggcat tgaacttatt tctaagcaac aaatttacag acgccttaga
      361 attgcttcgc ccctgggcta aggagagtat gtaccatgcc ttgggctaca gtaccattgt
      421 ggtgttgcag gctgtcctga ccttcgagca acaggacatc cagaacggca tttctgccat
      481 gaaggacgct ttacaaacct gccaaaaata caggaaaaaa tacacagttg tagaatcttt
      541 ctcaagtctt ctttctagag gatccctgga gcaactgagt gaagaggaaa tgcatgctga
      601 aatctgttat gccgagtgtc tcctacagaa agctgcactc acgtttgtgc aggatgaaaa
      661 tatgatcaac ttcatcaaag gtggactcaa aattagaaca agttaccaaa tatataaaga
      721 atgtctttct atcctgcatg aaattcagaa gaacaaactt cagcaggaat tcttctatga
      781 gtttgaaggg ggtgtcaagc ttggcagtgg ggcctttaat ttgatgctgt cccttttacc
      841 agcaaggatt atcagactac tagaatttat tggattttct gggaataggg agttgggcct
      901 cctgcagtta cgtgaaggtg cttcaggaag gagcatgagg tctgcactgt gctgcttaac
      961 catcttagct tttcatactt acatctccct aatacttggt acaggagaag tgaatgttgc
     1021 ggaagcagag cgtctcctgg cacccttcct ccagcagttt ccaaatggct cactcgtgtt
     1081 gttttatcat gcccgaatag agttgctgaa agggaatctt gaagaggcac aagaagtatt
     1141 tcaaaaatgc atttcagttc aagaagaatg gaaacagttt caccatctct gctactggga
     1201 gctaatgtgg attaatgttt tccaacaaaa ctggatgcag gcatattact attcagatct
     1261 gctttgcaaa gagagtaaat ggtccaaggc aacttatgtg ttcttgaaag cagcaatttt
     1321 gagtatgctt ccagaggagg atgtagtagc aacgaatgag aatgtggtaa ctttattcag
     1381 acaggtggac agcttgaagc agagaattgc cgggaaatct atccctactg agaagtttgc
     1441 tgtgaggaag gctcggcgtt actccgcctc cttacctgca cctgtgaagc tcatcttacc
     1501 tgccctggaa atgatgtatg tctggaatgg tttttcaata gtgagcaaaa gaaaagacct
     1561 ttctgaaaat ctgttagtaa ctgttgaaaa agctgaggca gctttacaaa gtcaaaattt
     1621 taacagcttc tctgtggatg atgagtgctt agtgaagtta cttaaaggat gttgcctcaa
     1681 gaacttacag cggcccttgc aagctgaact atgttacaat catgttgtgg aaagtgaaaa
     1741 gctactgaag tatgaccact acctagtgcc gttcactcta tttgaattgg catctttgta
     1801 taaaagccag ggggaaattg acaaggccat aaagttccta gaaactgcaa ggaacaacta
     1861 caaagattac tccctggagt ccagactaca cttcagaatt caggcagctc ttcacctctg
     1921 gagaaaacct tcctcagatt gatcagaact tgaaggatgg aatttttcct caattagcat
     1981 cggcatctgc tatagattca accttatatt aaagtggaaa aatgatcttg tgaataagag
     2041 acaaaaaaac agtttttttg gtcaatattt tctatcatct gagagattta ctgttggtct
     2101 acataatttt ttttcctatg gaatggcatt ctatattatc tagaaaattc ttatattttg
     2161 cctcccccaa aagaatttca tattatttga attagggggc gaagaagtct tttgaaagac
     2221 ttgcagatgc aatagtctaa ttagattatt tattttttta atgtgaaaat taatattgtt
     2281 tagcaaatag cttacaagtt gagccaattt tggatttgtt gggtagttaa acttcagaga
     2341 tattttgttg cctgtattta aatttcagaa gataaataaa tatcattgca tttaaaatag
     2401 cttaacagtg accttcagaa gacttctgaa aaagacagtc tgagaacatg aacacggatc
     2461 gatataatgt acttcatggg ttgaagagac ctttctctat aaaggatgat gcagtattca
     2521 gttagtggtt ttttactctt catttgatta aaggtggtga cgttttggag agactgattt
     2581 tgaatgtact taagtctatt ataataacaa aattcaaaac ccctgtgtat ctaaagggaa
     2641 ggaagtgtca tattttagga atttttctta accttagcaa tgagagccta aaatacatac
     2701 atggattatt tttcttctag gaagtaaatt tcctgctgct ttaaatgata tgtaaaatat
     2761 caataatttt tacacttaag atgttggtaa gacctagttt tctaatctct ctagcactgt
     2821 gatgtctcct tgtagataat ctggaccttg cttagtcctt tagttgggaa acagaatcag
     2881 ggcatagagc agaagagagc ttgacactcc atatggtcct ggttctgcta cccattagcg
     2941 attagtgagg agacctttag ggagtccact gtgccctgtg tgtcaccaca ttttcttctg
     3001 tgaaatcaag attaaagaac agatgacttt caaggtcttt ttcagtttta taactgtgag
     3061 tctatgtatt aggtatttat tttcaacaaa tgactttaaa atgtcgaatg caaaccattc
     3121 ccacttggag tgttttattt ttcaatcatc atcattgccc ccaactcccc acatgtatgt
     3181 gttgtggcat ccagagtgag aaaagacaat ttatgagttg atgaatctgg gccttatttc
     3241 tatttccatt ttgaagaata acttgtcata gaagcctctg cagtttaaca gaaggagcca
     3301 catattggga gtcacgagtt catctctgtg ggttaatagt tccatgacac ggagtacgta
     3361 gctcagcttt tcaggggttc agttgcccca ctatggatag cggtgtggta tttggtactt
     3421 gtgagggctc aattagataa aacatatgat agctttttgt aaactgtaaa aggctataca
     3481 aaagtatgaa ttattataat aattatggtt ttttatgtct ggattacagt atcaacacaa
     3541 aagtattggc tgatactgtg gtttgtgttg taaaatgaaa gaagtgtaga aattcaaata
     3601 ccttactgtg tattcatgtg tttgatgttg acagtaggct acccaggtta tatgaacctg
     3661 ctcctgccgt tccctgccac atggacctgt atcaagcagt gtgtggcttg ttttcttcaa
     3721 ggtactgatt cttgaccaac actgaggatg tatatccaat gaaagataga tatcaatggc
     3781 ggtagatatc aatgtgttat tagtaataca actttaggta cagacaaaat agaaaataaa
     3841 attaactgtc attataatta gtagtggaaa atacattaaa aattatttgt gtatagcttt
     3901 ggaaaaaagt tttccaaaaa aagctttttg gaaaaaagct cttagaagag ctttggtaac
     3961 attatttttg aaagcgcaca ctcacattgt gactgtgggt atactgagca tatattctta
     4021 cattgttact gtgagaagct gcaagtcagt gctgcaagtc agtaacaaat tctcttttgg
     4081 ggataaaatg aaacagtttt aagcttagag tggccatttt tattttaact ctgcattact
     4141 aaacaaatat aaaagaaatt catctccatt taaaaatctt ttttgttatt tatattttgt
     4201 tttatttttg tttcctattc tttatgcagt tacctgatac tatggacagt atatccagtg
     4261 gatcttttag tactgtaata tcaaaatgct acaaatattt atgtttcctg ctatgttcaa
     4321 gatattgtag tggcaccaac ttcttgggca tcagctaata ttgcattttg gagtcattag
     4381 ggtgttctgt gaagaatgaa tactgaagtg acagttttat ctagtttttt gaggggcatt
     4441 tatgatgggg ttgggttgcc attgtgtctg acagtgcaat tcatgtagtt cctggcataa
     4501 ttgccttttt tttttcctta atggagaggc agggttctga ttggtgctgt ataaatttaa
     4561 gtaactttgt gctttgtagg aatggtgaca aggaaggcat gatttccccc tgacaaggaa
     4621 tgaaaggtga actgtatcag ctcttatctg gacatatatg ttaatgtttt ctatgctccc
     4681 tgatacaaga agtttccaag ttatatagga aaattaagtc cattgatcct gtctttatcc
     4741 tcagagggca gaaatgagac aagtggataa aggctgtagg aagctgaatt ccagattaat
     4801 cagtgccgag gaagattttt cattatcgga aaacccaaca gtctaaaatc aataaccagt
     4861 tcttctgcaa aggggtgagt ttaagcaggg ctaatgtgac tgtcatttct gcctgtcctg
     4921 caagcttaga ctagttgaac tttgaggtca ctctatgatt cttttattag ggcttcaaat
     4981 cagcagggag tgtgtaaaga aaaaatgctc cccccctacc atttcaaata aaagtgaatg
     5041 ttttctcttt caaagctact attagaggta gttgtgatag acactaacaa tccccggtgt
     5101 taatactttc cactcctttt attttatttt aatttaatat tattttattg agacagagtc
     5161 tcgctctgtc acccaggctg gagtgcagtg gcgtaatctc tgctcactgc aagctcctcc
     5221 tcccaggttc acgccattct cctgcctcag cctcccgagt agctgggact acaggcgccc
     5281 gccaccacgc ctggctaatt ttttgtattt tgagtagaga cggggtttca ccgtgttagc
     5341 caggatggtc tcgatctcct gaactcgtga tccactcctt tttaaagtga gtctagtctg
     5401 ttgatcttca taaataggag ggttttcctc cagcttggac attaaaaata atttttaaaa
     5461 agatctttgt ggctaactgg aaaatcttct ggaattatct aatgcttcat tcatttccct
     5521 ccatttctgt tttttttttt tgtatttata ctctgcatat ttagaaatct taaattcaaa
     5581 tacatttagt taaaatgagt tgacgaagac tccagtgatg ttttaatacc ctaagatttt
     5641 gtgattcctt gggcctggaa tggatcttag aaaattacct tgccctcatg agcctgtaaa
     5701 ccgtgttgtt tcccctcagt cttgctctgt ccagtacagt agcccctcgc cacacatggc
     5761 tgcggagcac ccggaatggc ttacagcaca tgtgggaatg gtgctgaatg ctgaggaagc
     5821 attcactcat acgtgctgca cttcttaaag gcctcccaat agcctgcttt gcggagttct
     5881 ggcttttact tgctgtctac tatgatcacc tgatttgtgc ttcacataca tatctgtgaa
     5941 gtttgctttt tctatttaaa gtgcccttaa actttcattt gatcgtgttt atctgcagat
     6001 ggtcagtgtc attggcatat ttgaacatta ttctgccctc cctccgccaa actccttatg
     6061 tactagatta agaaatttta tttttgagat gatgatttta atttgatttt acagacattc
     6121 ttttttacaa agtacagttg ttagagttat agaagagtga ttcacatctt tgagaagata
     6181 gatttcatga ttaatatata tattttttga gacagagttt cgctcttgtt gcccaggctg
     6241 gagtgcaatt gcacgatcta ggctcactgc aacctctgcc tcccaggttc aagcaattct
     6301 cctgcctcag cctcccaagt agctgggatt acaggcatgt gccaccatgc ccagctaatt
     6361 ttgtattttt agtagagatg gggtttctcc atgttggtca gtctggtctc gaactcccaa
     6421 cttcaggtga tctggccgcc ttggcctccc aaagtgctgg gattacaggc gtgagccacc
     6481 atgcctggcc caatattttc taagataaaa ttattctgag aaatctagtg gaatcttttc
     6541 cattgctttg ttattaatgt ttcaacactg actttctcaa ctaggccagt attactattt
     6601 aaaggttttt agaggctggc aatggtggct cacgcctgta atcctaaaac tttgggaagc
     6661 caaagttggg gggcgtcact tgggaccagg ggtttgaggc cagcctgggc aatacagtga
     6721 gaacctgtct ttacaaaaaa aaaaaaaaaa aaaaaaatga gccgtgcatg gtggagtgca
     6781 cttgtagtcc tagctactag ggagacttag gtgggataat tgcttgatcc caggagtttg
     6841 aggctacagt gagctaagat catgccactg cactccaccc caggtgacag agtgagaccc
     6901 tgtctcaaaa aaaaaaaaaa aaaaaaaaaa aatatatata tatatatata tatatatata
     6961 tatatatata tatatataaa ataaaggttt gtggacacat gttacccatt tagagaataa
     7021 tttatttttg aatgtgtatg atacctaagt gatatgcata tatataatta agacatttta
     7081 aatctcttca gatatttctt cataagatac atgtatctat agatagctat atacaaaact
     7141 acttacaaat aataaataga cattgtttta tacagttctt tccaaagaaa tgcaggattt
     7201 cttatcctag tccttcctcc ccgagtccag ttatttacat atttttgtct ttaagtgtta
     7261 gattgcttgt ttctgctgcc tattgttggt agttttgtct tttacacatt tgctgttaga
     7321 tttagttatt ttgaaatgtt gaacttgaaa tgtaatgaaa aggacacatc agaatttatc
     7381 atcagggaag atatctttta tgttgagcag ctgctatctg atcttgacag actgtcctct
     7441 tagaggactg ttgaagtcca ttctagtcat tttgtaactt cataactgca gaaagaaatg
     7501 atgcaaggac tgtttagtgg actgagatgg ctgagcaggt tcttggcctg aattatccag
     7561 aggagatagg tggatctagc ttcagaggaa gtctacaccc cattcccttc tgcttacaat
     7621 gtacccatga tatgtgttta gcacagtaat actgtaacag gacatcacat ggaaaaatca
     7681 aagcagctgg ctcactgtat ttaactgaaa agaatgccta cagattggat atttaatagg
     7741 gaaaattaag gcactttaat aacaaacttc attatgtgaa acttgttgaa tattaacata
     7801 caatatacct tgtatattaa tgccatagtt tttagaaaca ctaatttaaa caacaaattt
     7861 aaggggtgct ggcatatccc agtgacacct tcagttttat tgctgcttag tattttctag
     7921 taaattagtt ttaattattg gtagtctgtt gggcaccatt tgggaaagaa ataaattggt
     7981 ctcagtgtag cagacttgta gccaaaaact ttgaataaaa aataagtata ataaagaata
     8041 ttatttcatt tttaaaggaa ttgtattatt ttgaagtgct gtgtggttga tatggtttgg
     8101 ttgtgtctct acccaaatct cttattgaat tgtagttccc ataatcccca catgggaggg
     8161 acccagtggg aggtgactga atcatggggg cagttttccc catgctattc tcatgatagt
     8221 gattgagttc tcacgagatt tgatggtttt ataaggggct tttccccctt tgctcagcac
     8281 ttctctttcc tgccgccctg tgaagaagaa ggtgcctttc tttccctttg ccttccgcca
     8341 ttattctaag tttcctgagg ccttctcagc catgcagaat tgtgagtcaa ttatacctct
     8401 tttttaaata aattatccag tctcagatat ttcttcatag cagtgtgaga atggactaat
     8461 acaatggtct taatcaattt gaaggtatga cactctttgc tttggaaatc atgtagacat
     8521 tttaagtcat tcctattttt aatgtagaca aacgtccagg tagcaatttt ggggataata
     8581 aatgagttca cccttttttt ttcttttttt ccctgagaca gagtttgctc ttgttgccca
     8641 ggctggagtt taatggcacg atcttggctt accacaacct ctgcctcctg ggttcaagca
     8701 attctcctgc ctcaggctcc caagtagctg ggattacagg catgtgccat cacacccggc
     8761 taatttttgt atttttagta gagacagggt atctccatgt tggtcaggct ggtctcgaac
     8821 tcctgacctc aggtgatccg cccacttcag cctcccaaag tgctgggatt acaggcgtga
     8881 gccatcatgc ctggccgagt tcagctttta ttcacatttt ttccccaaag tgatttattc
     8941 ttcaaagtag acagttatgt tctatagagt gttttgtttt ttctttaaga aaataattta
     9001 cataaacaga gattatggta aacattttaa atcttaggct gttggttaaa tttaatggtt
     9061 taagcactgt tgggttctct ttaattaata tttgcagaag gagaacatat gtgtttcact
     9121 gatatgtatg gtccagaaaa attacttaat tctcaaaaat atgttgcatt ctcatattgt
     9181 gttagggaaa attccataag tagtctattt ttttttttct tttgctgact gttaacatcc
     9241 aaacacctga atgaaaactg actcatttct gtattggtgt ttaaaaatat tgatttgcag
     9301 atgttcacag aacacttgca ttttttgatt cacattgcta aatcaaatgt aaaggcaaat
     9361 atgtatattt aataaatgag aagtattttt ttattactga aatttattct caaagcaaat
     9421 gtattttgta gatgtttcat ttgggagatt ttgctttgcc ttaaaacata caaaataaac
     9481 ctgtcttgtg gtctgcccac ctcaaaacct ctgttaactt gacatgtaga aggagttcag
     9541 aattctttga taatgtgtgg ttttcacttt tgtttggatt aaacaaaaat aaaattagag
     9601 tccatagcac tttgtaaact aatgtgaagt ttcttgttga atcataaaag ctacctgtat
     9661 gtactttata atttaatgtt ctgttagtaa aaattgtcag cattttatct ttttctcttc
     9721 tcattacatt ttagtctcca atctttccca ctctcagcag tcacagtttt gcagagcaaa
     9781 acatttttag aaactgaata tgtgtgagtt ctatataaaa tgaatgtgtt agtaacatcc
     9841 atctgctgat caaggaggca ttggatctgg tactagaagg tgaaattgat tgtagctatc
     9901 aaagcatttt atcaatgtaa gtcaagaaaa aagaagaaaa ctgtgaacct ctgatatttt
     9961 taacataaaa actgttccca atgagtgttc tcttgctgat tttgtgttaa tgttattgtc
    10021 tatgattttt aagctaatgc taatataaaa tctaaaattt caacatgatg acaacaattc
    10081 ctgtagcctg tttttaccat taggatgttt ttgaaaacag atgtcatctt agaaattata
    10141 tttttaagtg caaataaatc atcctgactt gaaagtcaac acattttatt tttcattccg
    10201 tagtatcaca gaatatgctg catttagata caggtttaat ttgccagatt ttctcaaaat
    10261 tctgtatttt tatattgcta caactggttt acttaacatg caattgaatt gttatttaaa
    10321 taaattacat ttgatggaa
//
