LOCUS       NM_017931               2566 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 38 (TTC38), mRNA.
ACCESSION   NM_017931
VERSION     NM_017931.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2566)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2566)
  AUTHORS   Wang,H., Guo,J., Jiang,J., Wu,W., Chang,X., Zhou,H., Li,Z. and
            Zhao,J.
  TITLE     New genes associated with rheumatoid arthritis identified by gene
            expression profiling
  JOURNAL   Int J Immunogenet 44 (3), 107-113 (2017)
   PUBMED   28371410
  REMARK    GeneRIF: we proposed that four newly identified peripheral blood
            mononuclear cells-derived genes( DHRS3, TTC38, SAP30BP and LPIN2
            )could be integrated with previously reported rheumatoid arthritis
            (RA)-associated genes to monitor and/or diagnose RA.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z93024.1.
            
            On May 21, 2020 this sequence version replaced NM_017931.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000706.1, BC018918.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381031.8/ ENSP00000370419.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                Z93024.1           34008-34072         c
            66-143              Z93024.1           33489-33566         c
            144-225             Z93024.1           29664-29745         c
            226-397             Z93024.1           28011-28182         c
            398-571             Z93024.1           26659-26832         c
            572-647             Z93024.1           23419-23494         c
            648-767             Z93024.1           20362-20481         c
            768-827             Z93024.1           18048-18107         c
            828-866             Z93024.1           16801-16839         c
            867-948             Z93024.1           14926-15007         c
            949-1114            Z93024.1           13492-13657         c
            1115-1274           Z93024.1           12519-12678         c
            1275-1348           Z93024.1           12181-12254         c
            1349-2566           Z93024.1           8072-9289           c
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..2566
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /note="tetratricopeptide repeat domain 38"
                     /db_xref="GeneID:55020"
                     /db_xref="HGNC:HGNC:26082"
     exon            1..65
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1442
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /note="TPR repeat protein 38"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 38"
                     /protein_id="NP_060401.3"
                     /db_xref="CCDS:CCDS43030.1"
                     /db_xref="GeneID:55020"
                     /db_xref="HGNC:HGNC:26082"
                     /translation="MAAASPLRDCQAWKDARLPLSTTSNEACKLFDATLTQYVKWTND
                     KSLGGIEGCLSKLKAADPTFVMGHAMATGLVLIGTGSSVKLDKELDLAVKTMVEISRT
                     QPLTRREQLHVSAVETFANGNFPKACELWEQILQDHPTDMLALKFSHDAYFYLGYQEQ
                     MRDSVARIYPFWTPDIPLSSYVKGIYSFGLMETNFYDQAEKLAKEALSINPTDAWSVH
                     TVAHIHEMKAEIKDGLEFMQHSETFWKDSDMLACHNYWHWALYLIEKGEYEAALTIYD
                     THILPSLQANDAMLDVVDSCSMLYRLQMEGVSVGQRWQDVLPVARKHSRDHILLFNDA
                     HFLMASLGAHDPQTTQELLTTLRDASESPGENCQHLLARDVGLPLCQALVEAEDGNPD
                     RVLELLLPIRYRIVQLGGSNAQRDVFNQLLIHAALNCTSSVHKNVARSLLMERDALKP
                     NSPLTERLIRKAATVHLMQ"
     exon            66..143
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            144..225
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            226..397
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            398..571
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            572..647
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            648..767
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            768..827
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            828..866
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            867..948
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1114
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1274
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1348
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..2566
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2544..2549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /note="hexamer: AATGAA"
     polyA_site      2566
                     /gene="TTC38"
                     /gene_synonym="LL22NC03-5H6.5"
                     /note="major polyA site"
ORIGIN      
        1 agagctcgcg gtggactccg acccggcgca acatggccgc agcctcgcct ctgcgcgact
       61 gccaggcctg gaaggatgcg aggctcccgc tctccaccac aagcaacgaa gcctgcaagc
      121 tgttcgatgc cacgctgacc cagtatgtaa aatggaccaa tgacaagagt ctcggtggca
      181 tcgagggctg cctgtcaaag ctcaaagcag cagatccaac ctttgtgatg ggccacgcca
      241 tggctactgg ccttgtgctg attggcactg gaagctccgt gaagctggac aaagagctgg
      301 acctggctgt gaagacaatg gtggagattt caagaaccca gccgctgaca aggcgggagc
      361 agctgcacgt gtctgcagta gagacatttg ccaatgggaa ctttccgaaa gcctgtgaac
      421 tatgggaaca gattctccag gaccacccga cagacatgtt ggccctgaaa ttttcccatg
      481 atgcttattt ttacctgggc tatcaggaac agatgagaga ttctgttgct cgaatttacc
      541 ccttctggac acctgacatc cccctaagca gctatgtgaa aggcatctac tcttttggct
      601 tgatggaaac caacttctac gaccaggcag aaaaactcgc caaagaggct ttatctatta
      661 acccgacaga cgcatggtcg gtgcacaccg tcgctcacat ccacgagatg aaagcagaga
      721 tcaaggatgg gttggaattc atgcagcact cagagacctt ctggaaggac tctgatatgt
      781 tggcttgtca taactattgg cactgggctt tatatctgat tgagaagggc gaatatgagg
      841 ccgcgctgac catctacgat acccacatcc ttcccagcct gcaggccaac gatgcaatgc
      901 tggacgtggt ggacagctgc tccatgctct accgcctgca gatggaagga gtgtctgtgg
      961 gccagcggtg gcaggatgtc ctgcctgtgg cccggaagca cagccgagac cacatcctgc
     1021 tgttcaatga cgcacacttc ctgatggcat ccctgggtgc acacgacccc cagaccacac
     1081 aggagctgct gaccaccctg cgggacgcca gcgaatcccc aggggagaac tgccagcacc
     1141 tcctggcccg agacgtgggg ctgcccctgt gccaggccct ggtggaggct gaggacggga
     1201 accctgaccg cgtcctggag ctgctcctgc ccatccgcta ccggatcgtc cagctcggtg
     1261 ggagcaatgc ccagagagac gtcttcaacc agctgctgat tcacgcggcc ttaaactgca
     1321 cctccagcgt ccataagaac gtagcccgga gccttctgat ggagcgtgat gccttgaagc
     1381 ccaactcgcc cctgaccgag cggctcatcc gcaaggcagc taccgtccac ctcatgcagt
     1441 gagccagcct ggccgcctcc accctgcaga acctcagtgg tggcgtcact gcgtccagtc
     1501 agctgctcca ccgggttagg gtcaggagac ggccagagcc tgtttgttag ggctgttaga
     1561 gggtgatctt cagttttaca ggaagtgggt cacgggttaa ttttaaatgt gattccgaat
     1621 ctcctttcag tcctcgagaa gggccaatga gcatttttca gcagtcacag ccagtgtgag
     1681 tgctgctctt tccacctgcc ttgcaaattc tgtttcccag gggaatgtgt ctactgcctg
     1741 gtggttcaaa ggttggaagg cagggcagag gtgggggctg attctgctgg gacaggtctt
     1801 ccagaggcag cctcccccca ctgcctgtcc ccgtccccac caggctgccc ttgggatgga
     1861 ccttttcatt cttttcttta tattctagac agtctctgtt gtctcattgt gttgctgtcc
     1921 catttttcag gtgagggtac cggggtaggg gagtggcctg cccagggtca cactatgaga
     1981 ggcccccacc tgctgccttt ggacgcagcc ccctgctgct gcatccacca cccttcttac
     2041 agatcagcgc gcacatgggg tccttctgct gtctctgggg cgagtcttgg agccccctgg
     2101 ggggctctgt tggtgctgat ttggacccgt ttctcttttt aaactgcaca tcataacagg
     2161 gcttcatgtc gagcatgatt ttaatcataa atgcacttct gaggtgcaag gattgagctc
     2221 agagctgctc tgttgtggca aaacccaaag tgctgtgatg tgtggctgtg acaagcctgg
     2281 agcgggtcct gtgagcgccg cctctgtctc ctgcttcccc actgaacgcc tgctgaatgt
     2341 gccgctgact cagctgtgct gctttcagcc ctcctgtgag gggcggtccc agtgcacaga
     2401 tgtttttcaa gttcctcagt ttgtactgaa attagggatt catcagggca ggaagcaggc
     2461 aggcctctca gaagggagag gaggcctcca aatctattga gtccccacag tttgctcaag
     2521 cccaggcaaa tttctgtgat taaaatgaat tcatcagttc ctccaa
//
