LOCUS       NM_001080441             668 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 36 (TTC36), transcript
            variant 1, mRNA.
ACCESSION   NM_001080441 XM_084672
VERSION     NM_001080441.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 668)
  AUTHORS   Xu,Y., Yang,Q., Xue,B., Wang,X., Tian,R., Deng,R., Chen,S.,
            Wang,X., Wang,L., Wang,C., Chen,J., You,R., Liu,Q., Li,H., Wang,J.,
            Li,X., Liu,S., Yang,D., Tang,S. and Zhu,H.
  TITLE     Heat Shock-Binding Protein 21 Regulates the Innate Immune Response
            to Viral Infection
  JOURNAL   J Virol 96 (7), e0000122 (2022)
   PUBMED   35254105
  REMARK    GeneRIF: Heat Shock-Binding Protein 21 Regulates the Innate Immune
            Response to Viral Infection.
REFERENCE   2  (bases 1 to 668)
  AUTHORS   Xie,Y., Lv,X., Ni,D., Liu,J., Hu,Y., Liu,Y., Liu,Y., Liu,R.,
            Zhao,H., Lu,Z. and Zhou,Q.
  TITLE     HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis
            induces tyrosinemia and neurological damage
  JOURNAL   Nat Commun 10 (1), 4266 (2019)
   PUBMED   31537781
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 668)
  AUTHORS   Jiang,L., Kwong,D.L., Li,Y., Liu,M., Yuan,Y.F., Li,Y., Fu,L. and
            Guan,X.Y.
  TITLE     HBP21, a chaperone of heat shock protein 70, functions as a tumor
            suppressor in hepatocellular carcinoma
  JOURNAL   Carcinogenesis 36 (10), 1111-1120 (2015)
   PUBMED   26246424
  REMARK    GeneRIF: As a chaperone of heat shock protein 70 (HSP70), HBP21
            could inhibit interaction between HSP70 and Bax, increased Bax
            protein translocation from cytoplasm to mitochondria.
REFERENCE   4  (bases 1 to 668)
  AUTHORS   Liu,Q., Gao,J., Chen,X., Chen,Y., Chen,J., Wang,S., Liu,J., Liu,X.
            and Li,J.
  TITLE     HBP21: a novel member of TPR motif family, as a potential chaperone
            of heat shock protein 70 in proliferative vitreoretinopathy (PVR)
            and breast cancer
  JOURNAL   Mol Biotechnol 40 (3), 231-240 (2008)
   PUBMED   18587674
  REMARK    GeneRIF: The newly discovered interaction between HBP21 and Hsp70
            suggests that HBP21 may be involved in the inhibition of
            progression and metastasis of tumor cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EU489483.1 and BC146916.1.
            
            On Jan 9, 2020 this sequence version replaced NM_001080441.3.
            
            Summary: The protein encoded by this gene has three
            tetratricopeptide repeats and is a chaperone for heat shock protein
            70. The encoded protein may function as a tumor suppressor in
            hepatocellular carcinoma (HCC) since it promotes apoptosis but is
            downregulated in HCC. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146921.1, EU489483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302783.10/ ENSP00000307640.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-650               EU489483.1         42-691
            651-668             BC146916.1         653-670
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..668
                     /gene="TTC36"
                     /gene_synonym="HBP21"
                     /note="tetratricopeptide repeat domain 36"
                     /db_xref="GeneID:143941"
                     /db_xref="HGNC:HGNC:33708"
                     /db_xref="MIM:620701"
     exon            1..139
                     /gene="TTC36"
                     /gene_synonym="HBP21"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..591
                     /gene="TTC36"
                     /gene_synonym="HBP21"
                     /note="isoform a is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 36; HSP70 binding protein
                     21; TPR repeat protein 36"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 36 isoform a"
                     /protein_id="NP_001073910.1"
                     /db_xref="CCDS:CCDS31687.1"
                     /db_xref="GeneID:143941"
                     /db_xref="HGNC:HGNC:33708"
                     /db_xref="MIM:620701"
                     /translation="MGTPNDQAVLQAIFNPDTPFGDIVGLDLGEEAEKEEREEDEVFP
                     QAQLEQSKALELQGVMAAEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVA
                     GALEDLERAVELSGGRGRAARQSFVQRGLLARLQGRDDDARRDFERAARLGSPFARRQ
                     LVLLNPYAALCNRMLADMMGQLRRPRDSR"
     exon            140..328
                     /gene="TTC36"
                     /gene_synonym="HBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            329..668
                     /gene="TTC36"
                     /gene_synonym="HBP21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      645..650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC36"
                     /gene_synonym="HBP21"
                     /note="hexamer: AATAAA"
     polyA_site      668
                     /gene="TTC36"
                     /gene_synonym="HBP21"
                     /note="major polyA site"
ORIGIN      
        1 gggattttgg agttgagcac catggggact ccaaatgatc aggcagtgct gcaggccatc
       61 ttcaaccctg acaccccatt tggagacatt gttggattgg acctcggaga ggaagcagaa
      121 aaggaagaac gagaagaaga tgaagttttc cctcaagcac agctggaaca gtccaaggcc
      181 ctggagctgc agggggtgat ggcagcagag gctggggacc tcagcacagc cctggagagg
      241 tttggccaag ccatctgcct gctgcctgag agggcttcag cctacaacaa ccgtgcccag
      301 gcccggcgac tccagggaga cgtggcaggc gccctggagg atctggaacg cgcggtggag
      361 ctgagcggcg gccggggccg cgccgcccgc cagagctttg tgcagcgcgg actcctggcg
      421 cggctgcagg gccgagacga cgacgcccgc agggacttcg agagggcggc acggctgggc
      481 agccccttcg cgcggcgcca gctggtgctg ctcaacccct acgccgcgct gtgcaaccgc
      541 atgctggccg acatgatggg gcagctgcgc cgcccccgtg acagccgctg agcgccgcgg
      601 acccgggcgt ccgcgggcga ggggacggga ctgggccctg aaccaataaa gccgtcgggc
      661 ctcaccga
//
