LOCUS       NM_012382               5497 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 33 (TTC33), mRNA.
ACCESSION   NM_012382
VERSION     NM_012382.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5497)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5497)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5497)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA518274.1, BC015701.1, BC036536.1, AI174764.1, DA652008.1,
            BE869916.1, AC093264.2, BQ922097.1, BM543635.1, BM689740.1,
            BF509085.1 and CR738110.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012382.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.167682.1,
                                           SRR1660803.73795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337702.5/ ENSP00000338533.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA518274.1         10-30
            22-2485             BC015701.1         1-2464
            2486-2598           BC036536.1         2444-2556
            2599-2995           AI174764.1         1-397               c
            2996-3472           DA652008.1         75-551
            3473-3508           BE869916.1         244-279
            3509-3510           AC093264.2         37327-37328
            3511-3781           BE869916.1         282-552
            3782-4160           BQ922097.1         110-488
            4161-4669           BM543635.1         177-685
            4670-4905           BM689740.1         174-409
            4906-5479           BF509085.1         125-698
            5480-5497           CR738110.1         596-613
FEATURES             Location/Qualifiers
     source          1..5497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..5497
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /note="tetratricopeptide repeat domain 33"
                     /db_xref="GeneID:23548"
                     /db_xref="HGNC:HGNC:29959"
     exon            1..138
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /inference="alignment:Splign:2.1.0"
     exon            139..360
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..928
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /note="osmosis responsive factor; TPR repeat protein 33"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 33"
                     /protein_id="NP_036514.1"
                     /db_xref="CCDS:CCDS3931.1"
                     /db_xref="GeneID:23548"
                     /db_xref="HGNC:HGNC:29959"
                     /translation="MASFGWKRKIGEKVSKVTSQQFEAEAADEKDVVDNDEGNWLHAI
                     KRRKEILLEGCAEKSKQLKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQV
                     LMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMN
                     PEIWKEDLSWARTLQEQQKVAQRIKKSEAPAEVTHFSPKSIPDYDFESDEIVAVCAAI
                     AEKEKTVSANKTMVIVSASGAIETVTEKEDGATPPDGSVFIKAR"
     exon            361..442
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /inference="alignment:Splign:2.1.0"
     exon            443..574
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /inference="alignment:Splign:2.1.0"
     exon            575..5497
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /note="hexamer: AATAAA"
     polyA_site      2598
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /note="major polyA site"
     regulatory      5469..5474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /note="hexamer: AATAAA"
     polyA_site      5497
                     /gene="TTC33"
                     /gene_synonym="OSRF"
                     /note="major polyA site"
ORIGIN      
        1 gatttgtggt cccggagaag agattggcgg aggggaaaga ctgagtcgtc tttcctttgc
       61 ccgcttctgt ggactgttcg aacgcccagg ggtgggccaa acccgtttct taggaaacca
      121 ggaatccagg gaaggcagaa tggcttcctt tgggtggaag aggaaaattg gtgagaaggt
      181 ctcaaaggtc acttcccagc agtttgaagc tgaagctgct gatgagaagg atgtagttga
      241 caacgatgaa gggaactggc ttcatgccat taaacgtagg aaagaaattc ttcttgaagg
      301 ctgtgctgag aaaagtaaac agctgaagga tgaaggagcc agtttggctg aaaataaaag
      361 atatcgggag gcaattcaga agtgggatga agcactacag ttaactccaa atgatgctac
      421 cctatacgag atgaaatcac aggtgctaat gtctcttcat gaaatgttcc cagcagtaca
      481 tgcagcagaa atggccgtcc agcaaaatcc acattcatgg gagtcttggc agactttggg
      541 acgtgctcaa cttggtttag gagagataat cctggcaatt cgaagttttc aagtagccct
      601 tcacatctat ccaatgaacc ctgaaatatg gaaagaagac ctctcttggg caagaacgct
      661 ccaggagcag cagaaggtag cacagaggat taaaaaaagt gaagcaccag ctgaagtaac
      721 acacttttca ccaaagtcaa ttccagacta tgactttgaa agtgatgaga ttgttgctgt
      781 ttgtgcagct attgctgaga aagagaagac agtttcagca aataaaacaa tggttattgt
      841 gtctgcttct ggggccatag agactgtaac tgaaaaggag gatggtgcta caccaccaga
      901 tggctctgtt tttatcaaag cccgatgaag cagtatgcat aggattattt gaatctgtct
      961 ttttgattgc ctcttgaagt tttgacatag agacatttac tctggagata gataggagaa
     1021 cgcctggttg taaaatatgt ttttcagatg aggcatataa aaactaaaat ggcaggatta
     1081 ttgtatagtg tttggaatat gctttgataa gttatgattt atatttctca aggttaaaat
     1141 tctgagtaaa atggtctttg attaataaac ttagtttaat ctgaatatgt aaatgaatac
     1201 attttaaaga caaaacttga aaaatgtatt cttgaatagt gaataatttg atcaatgtta
     1261 ctgaaatgct gtctcaactt ttgttttatg ataaaggaag tgtgtgattt ccctccctct
     1321 gagaaatata ctgcgcttaa tatttgctgt ctttttcttg cttcattaga gtaagtctgt
     1381 cagaaagctt gaatattttt gacattcatt ttgattcaaa gttgtcattt ggttatatgt
     1441 ggaatctttg aaagtttggc tgaaaatgca cacaaatgtg tacattctga acattttctg
     1501 aagtttctct taattctgat ttgtgtttct gttttgactt tgaagttgta acaatgatag
     1561 ttgtctcctt cagtatttgg taaaagtgta aagtattgat aaatatgaga atgatggttt
     1621 tattttttaa ttgttacagt aagtaatcct taccacaaat gagtcatttt taaaatatgc
     1681 atttttaaat gaatggcttt tacagatagg ttaatgacaa ttgtactgct atattatccc
     1741 agtcaaaacc aatactttct tttctttatt ttacaaagct ttaaaaaccc tggaaacaac
     1801 ttacttcttg cttgtgtctt tccatttgat gactgggaat tacttttcta gataactttt
     1861 tttgaaacta ctcagtgaaa tgaaaaataa ttacaatttt aaatagctaa ttatatcttt
     1921 ctaaaaataa aaaagtaggg ctgttattag agtgccaatg aataaataac ttaagcacaa
     1981 aatacataga aattggaatg tgatttatag tacaatctca tgagtatgaa aaggctatat
     2041 taaaaaaaat tttattgaaa gtccacagtc atattcacaa accaatactg tcattgctaa
     2101 tctgaactat tatttttata ctatatattg tagtacaata atatagaact gttgggttct
     2161 gttacttctg acactcagga agatactatt ggtgtattaa ttttatcttt gttagagatg
     2221 aaagtagccc actttatgtt aaagatctta ctactgttgg agcttataag taatgatcta
     2281 cattttttat gaagatggtt tttaaaactt ttgttttatt ggaatgcata tctcttttca
     2341 gggttggaga aattagcact tgccttgaaa agaatattct ttccttaagt tatatcatca
     2401 gaaaattagc tctggttaga gaggttagtt tcagagtgct ccaaaaaata tgttaattat
     2461 tttattttgt ttaataaaga acattctcaa aacgtaaata ggtatctaga gaagtgagta
     2521 ctcaacattt ggtatattgt tttgagtaat ggatgtttgt tttttgtgta atttgtgaat
     2581 aaatagtttt tttctgcatt ttgaagattt tcctattatt ttatgttgtt agcttttgaa
     2641 aaattagatt gatctactta gtgtctttct tatatgaact taatatattt aaagtacctt
     2701 gcatggtgcc tcacacatga agtaatgcca gctatttcag taaatgctag ctatttctat
     2761 gaagaacttg agttagtttg gagatattta acctcaattt cctctgattt taaaaaagga
     2821 gaactttttt tgtaatcctt tccttatctg aaagtaagaa gtctctgatt ccagtattat
     2881 aggagagata gtgggatttt tcttgacagg gtctatagct caagtcccaa agaggcaaga
     2941 ctcaggatgg aatgcatgtg gccactaggc cctgttataa gaacctagtg tttcctctgt
     3001 actggcatgg taggccaagt tagtctcttt cttacccaga tataagacat aaaatagttt
     3061 agacataaga cagaggagaa aaagaaacag taagttatgg agaaggaagg cagctcattt
     3121 ctgcaggccc ctcaaaatgc ttattttagc tcatactctt ctatgcgtga agagaaaaat
     3181 gcacccatta ttttacaagg atgtgaatac tgatatacaa acatagacta agcttgttaa
     3241 ttttaataac aaatctttat gaatctgaag agaattgatg ttcatgataa tgatatagat
     3301 gtttaatata ctttctgaaa taacactgtt tactgttcaa gttatattga ctataattta
     3361 cattattctt gtttgagaat tgtatggcat agacactcat tagtcagagt gtctagacat
     3421 ccagaccatg cctgataaca caagaatcat atatcattct ctagaaaaca ggctgtttgg
     3481 ttatagagta tttatcttaa atatattaac agacactaca taaacattga aaagccatgc
     3541 aagttatagc tcacaggagc cagatctact gcaactgggg cctacataca aaattttatg
     3601 gcagtggttt cagtatgaca atcttttgaa ttgatgccgt atggtaaaac tataaagatt
     3661 ttttaaaagc tctgtctcag ctagaatttt taagattata actgaacagt atagcccttt
     3721 tagttgtttg aaaattacat aatgattcaa aagcttgttt cactgccttt cccagcacta
     3781 agaaaattaa caatcatttc ttttaatttc cttgaatcag agccattcta aagtgactct
     3841 ggaccagcaa ttctgagcta tgatttcatg atacatgtat taatatctaa atgagttgtg
     3901 agttgacata agaaccatag ttccataata attatcttca aatcaatgga tatcttaaat
     3961 gtgttttttt cttccttaga gattattatt aaactgatgt atttgataat aaagaatttt
     4021 aggactgaga aagttaagtt tttcttacca ataataagat attgaaatat ataaattata
     4081 aaacagaaat aaaatgaaat aaaggaggtt atccctaaag tcatttacct tagtcacttg
     4141 caattaaata tggttacttc ggaagaagaa gtgtggccct aaagctactg taacatgaat
     4201 catgccctaa tgtgcactat atatgaacta ctttggtcag aaggcagcgg cgggtaagga
     4261 tggcttcctc tcacagtgct tcttaggcta tccatttacc aaggaattct aatctctttc
     4321 tctcacttca ccaggaaagg agggagttta agatatagaa ctgggcatgc tagcctcttt
     4381 tttccctttt gtggatttgt cataactgca gagaaccgat gttgtggtct cttgccagct
     4441 acattgtgaa ccttgcagtg aaagttcttt gcctctgcaa agggagattt gtgcttgtgc
     4501 agaactgccc atgccttagt aagcaggtct gtctaattct aagttcaata tctggtggct
     4561 attgttggca taaacttaaa gtacatcctc taacctagcc tttttcagca gtaaacttaa
     4621 aatattgaat ctccatctgt ctgtgtctca agtggttcag aggtcaggag aggagaggga
     4681 cattatttta tgactccctc aaactttaac aaagactagt gcagattata tttcgaagta
     4741 agcatgagat atattaaaaa ccacatgtgg gaattctttc ctaattttag aggttttttt
     4801 taaataatgg aaattctatt gaaattgagt agtgttaatt acaaggcaac aggtaaacat
     4861 ttgttcagga tatttaaaag gtctgctgag ttggaattgt gacagaccac attgttgact
     4921 ctagattgaa ttggaaggga agaatgtgaa atgaattagg atatcctctg ttcacctcta
     4981 ttaactttct taaatgagta taacttagaa ataataaaat gcaagtattt taacgttata
     5041 gttgggagag ttttgacaaa tgtaaacacc cacttcacca ccactaccat cctgatatag
     5101 tgtgtgtcca tcacccaaaa agttctctaa agcccttttg cagttggttc ccctccacct
     5161 gaacagccat ccctagtcaa ctacttttct gctttctgtg gctatacgtt agatttgact
     5221 tcagaattct agagtttgaa ataaataggc catataatat gcactctttt tgtgtctgac
     5281 tttttttttg cttaacatga tgcttttgaa acccatccat gttgagattc atccatgtta
     5341 tcatgtgtat caataataag ttccttttta ttgctgaata gtattctagt atatagatat
     5401 accacaattt gtttagctgt tcacctattg atggacattt aggttgtttc aagttttgat
     5461 ctattatgaa taaagctgct atatatataa atcacaa
//
