LOCUS       NM_001008237             941 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 32 (TTC32), mRNA.
ACCESSION   NM_001008237 XM_059438
VERSION     NM_001008237.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 941)
  AUTHORS   Xu,Y., Zhuo,Y., Ye,M., Li,M., Tang,X. and Zhou,L.
  TITLE     Association study of genetic variants at TTC32-WDR35 gene cluster
            with coronary artery disease in Chinese Han population
  JOURNAL   J Clin Lab Anal 35 (2), e23594 (2021)
   PUBMED   33009702
  REMARK    GeneRIF: Association study of genetic variants at TTC32-WDR35 gene
            cluster with coronary artery disease in Chinese Han population.
REFERENCE   2  (bases 1 to 941)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 941)
  AUTHORS   Lu,X., Wang,L., Chen,S., He,L., Yang,X., Shi,Y., Cheng,J.,
            Zhang,L., Gu,C.C., Huang,J., Wu,T., Ma,Y., Li,J., Cao,J., Chen,J.,
            Ge,D., Fan,Z., Li,Y., Zhao,L., Li,H., Zhou,X., Chen,L., Liu,D.,
            Chen,J., Duan,X., Hao,Y., Wang,L., Lu,F., Liu,Z., Yao,C., Shen,C.,
            Pu,X., Yu,L., Fang,X., Xu,L., Mu,J., Wu,X., Zheng,R., Wu,N.,
            Zhao,Q., Li,Y., Liu,X., Wang,M., Yu,D., Hu,D., Ji,X., Guo,D.,
            Sun,D., Wang,Q., Yang,Y., Liu,F., Mao,Q., Liang,X., Ji,J., Chen,P.,
            Mo,X., Li,D., Chai,G., Tang,Y., Li,X., Du,Z., Liu,X., Dou,C.,
            Yang,Z., Meng,Q., Wang,D., Wang,R., Yang,J., Schunkert,H.,
            Samani,N.J., Kathiresan,S., Reilly,M.P., Erdmann,J., Peng,X.,
            Wu,X., Liu,D., Yang,Y., Chen,R., Qiang,B. and Gu,D.
  CONSRTM   Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis
            (CARDIoGRAM) Consortium
  TITLE     Genome-wide association study in Han Chinese identifies four new
            susceptibility loci for coronary artery disease
  JOURNAL   Nat Genet 44 (8), 890-894 (2012)
   PUBMED   22751097
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057850.1, BC070381.1 and AI366807.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001008237.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.969.1, SRR1660809.16281.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333610.4/ ENSP00000333018.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BC057850.1         4-129
            127-812             BC070381.1         1-686
            813-941             AI366807.1         5-133               c
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..941
                     /gene="TTC32"
                     /note="tetratricopeptide repeat domain 32"
                     /db_xref="GeneID:130502"
                     /db_xref="HGNC:HGNC:32954"
     exon            1..278
                     /gene="TTC32"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..585
                     /gene="TTC32"
                     /note="TPR repeat protein 32"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 32"
                     /protein_id="NP_001008238.1"
                     /db_xref="CCDS:CCDS33151.1"
                     /db_xref="GeneID:130502"
                     /db_xref="HGNC:HGNC:32954"
                     /translation="MEGQRQESHATLTLAQAHFNNGEYAEAEALYSAYIRRCACAASS
                     DESPGSKCSPEDLATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLIL
                     YRLGYFDDALEDFKKVLDLNPGFQDATLSLKQTILDKEEKQRRNVAKNY"
     exon            279..445
                     /gene="TTC32"
                     /inference="alignment:Splign:2.1.0"
     exon            446..941
                     /gene="TTC32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      799..804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC32"
                     /note="hexamer: ATTAAA"
     regulatory      806..811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC32"
                     /note="hexamer: ATTATA"
     polyA_site      818
                     /gene="TTC32"
                     /note="major polyA site"
     polyA_site      822
                     /gene="TTC32"
                     /note="major polyA site"
     regulatory      919..924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC32"
                     /note="hexamer: AATAAA"
     polyA_site      941
                     /gene="TTC32"
ORIGIN      
        1 aggcacaaac ctagcgccaa ggttggctgt caaggtagat tccagggtgt ggaagtggct
       61 ttgtggtgcc acctctaacc gctcggaggt caacccccat tctacaccga aaactaggcc
      121 ttggctgcta tggaaggaca gcggcaagaa agccacgcaa ccctaacact cgcccaggct
      181 catttcaaca atggagagta cgcggaggcc gaggcactgt actccgctta cattcgccgg
      241 tgcgcttgcg cggcctccag cgacgagagt cccgggagca aatgcagccc tgaggatttg
      301 gctactgcat ataacaacag ggggcaaatc aagtacttca gggttgattt ttatgaagcc
      361 atggatgact acacatctgc catagaagtc caacccaatt ttgaagttcc atattacaac
      421 agagggttga tactgtatag gctgggatat tttgatgatg ctttggaaga tttcaagaag
      481 gtcttagact taaatcctgg atttcaagat gctactttga gcttaaaaca gactattcta
      541 gacaaagaag aaaaacaaag aagaaatgtt gcaaaaaatt attgatattt ttaacttaat
      601 ggaagtattg attcatgatc cttacatctg catctagtta tcagtaattt agatattgag
      661 ctattttgat ttatatttaa gaaattaata cattagcact gaaagttaaa tagtgtgttt
      721 aaggtagtta atttcaggtt gaatgggttt tttttaatga agtgtaaata ataccaatgt
      781 ataagtgtat attattatat taaatattat agtaaaaagg aatgtgtggt attttcttca
      841 gcaaaactat ttttgtgatt tttttattct caacttttta tttaaaaaat gttacatctg
      901 cagaaaagtt gaaagtataa taaactcttc agttaaattc a
//
