LOCUS       NM_022492               2916 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 31 (TTC31), transcript
            variant 1, mRNA.
ACCESSION   NM_022492
VERSION     NM_022492.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2916)
  AUTHORS   Orekhova,A.S., Sverdlova,P.S., Spirin,P.V., Leonova,O.G.,
            Popenko,V.I., Prasolov,V.S. and Rubtsov,P.M.
  TITLE     [Novel bidirectional promoter from human genome]
  JOURNAL   Mol Biol (Mosk) 45 (3), 486-495 (2011)
   PUBMED   21790010
  REMARK    GeneRIF: A fragment of the CCDC142-TTC31 intergenic region was
            cloned; this fragment functions as bidirectional promoter.
REFERENCE   2  (bases 1 to 2916)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005041.2.
            
            On Nov 14, 2019 this sequence version replaced NM_022492.5.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036017.1, SRR14038196.3352522.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233623.11/ ENSP00000233623.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC005041.2         52164-52218         c
            56-144              AC005041.2         51889-51977         c
            145-247             AC005041.2         45172-45274         c
            248-477             AC005041.2         44826-45055         c
            478-561             AC005041.2         44560-44643         c
            562-618             AC005041.2         44115-44171         c
            619-699             AC005041.2         43924-44004         c
            700-891             AC005041.2         43627-43818         c
            892-943             AC005041.2         43244-43295         c
            944-1034            AC005041.2         43070-43160         c
            1035-1176           AC005041.2         42854-42995         c
            1177-1278           AC005041.2         42552-42653         c
            1279-2916           AC005041.2         40740-42377         c
FEATURES             Location/Qualifiers
     source          1..2916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..2916
                     /gene="TTC31"
                     /note="tetratricopeptide repeat domain 31"
                     /db_xref="GeneID:64427"
                     /db_xref="HGNC:HGNC:25759"
     exon            1..55
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1575
                     /gene="TTC31"
                     /note="isoform a is encoded by transcript variant 1; TPR
                     repeat protein 31; tetratricopeptide repeat protein 31"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 31 isoform a"
                     /protein_id="NP_071937.4"
                     /db_xref="CCDS:CCDS42701.1"
                     /db_xref="GeneID:64427"
                     /db_xref="HGNC:HGNC:25759"
                     /translation="MAPIPKTVGRIKLDCSLRPSCPLEVAAAPKLCKEFGPEDYGEED
                     IVDFLRRLVESDPQGLHRIHVDGSSGRLQLWHHDYLLGHLDDEGKSTGQSDRGKGAEG
                     LGTYCGLRKSFLYPPQESEPCPQSPSASATFPSVSDSLLQVAMPQKLLVTEEEANRLA
                     EELVAEEERMKQKAEKKRLKKKRQKERKRQERLEQYCGEPKASTTSDGDESPPSSPGN
                     PVQGQCGEEEDSLDLSSTFVSLALRKVGDWPLSARREKGLNQEPQGRGLALQKMGQEE
                     ESPPREERPQQSPKVQASPGLLAAALQQSQELAKLGTSFAQNGFYHEAVVLFTQALKL
                     NPQDHRLFGNRSFCHERLGQPAWALADAQVALTLRPGWPRGLFRLGKALMGLQRFREA
                     AAVFQETLRGGSQPDAARELRSCLLHLTLQGQRGGICAPPLSPGALQPLPHAELAPSG
                     LPSLRCPRSTALRSPGLSPLLHYPSCHRSHPNQPLSQTQSRRPHPLKPQDPSKGWDIL
                     GLGLQHLSQAR"
     exon            56..144
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            145..247
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            248..477
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            478..561
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            562..618
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            619..699
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            700..891
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            892..943
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1034
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1176
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1278
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..2916
                     /gene="TTC31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2894..2899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC31"
                     /note="hexamer: AATAAA"
     polyA_site      2916
                     /gene="TTC31"
                     /note="major polyA site"
ORIGIN      
        1 gtcactgtag atgcgatggc gccgattcca aagactgtgg ggcggatcaa gctagactgc
       61 tctctacggc ccagctgccc actggaggtc gctgctgcac ccaaactttg caaggaattc
      121 ggtccagagg attacggcga agaggacata gtggattttc ttcgacggct tgtggagagt
      181 gatccccagg gcctgcaccg gatccatgtg gatgggagca gcgggcggct gcagctgtgg
      241 caccatgatt acctcctggg ccacttggat gatgaaggga aatcaactgg acagagtgac
      301 aggggcaagg gggctgaggg actgggcacc tactgtggtc tccgcaagtc cttcctgtat
      361 cctccccaag agtctgagcc ctgccctcaa agcccctctg cctctgccac cttccccagt
      421 gtctcagaca gcctgcttca ggtggccatg ccccagaagc tcctggtgac agaagaggaa
      481 gccaatcgcc tggctgagga gctggtggct gaggaggagc gcatgaaaca gaaagcagag
      541 aaaaagcgac tcaagaagaa gcgtcaaaag gaacggaagc gacaggagcg tttggagcag
      601 tactgtgggg agcccaaggc cagcactacc tcagatggag atgagagccc cccatccagc
      661 cctggaaacc cagttcaggg acagtgtggt gaagaagagg actcactgga tctatctagc
      721 acttttgtgt ctctggcttt gcgcaaggtt ggggattggc ccctcagtgc ccgcagagag
      781 aagggactga accaggagcc ccaaggcagg ggtctggccc tccagaagat gggtcaagag
      841 gaagagagcc ctccaagaga ggagaggccc cagcagagtc caaaggtaca ggcatctccg
      901 ggactgctgg cagctgcctt acaacagagc caggaactgg caaagttggg taccagcttt
      961 gctcaaaatg gtttctacca tgaggccgtg gtcctcttca cccaggcctt gaagctcaac
     1021 ccccaggacc accggttatt tggaaatcgt tccttctgcc atgagcggtt gggtcagcca
     1081 gcgtgggccc tggctgatgc ccaggtggcc cttaccctac ggcctggctg gccccggggc
     1141 ctcttccgcc tgggcaaggc cttgatggga ctacagcgct tcagagaggc agctgctgtg
     1201 tttcaggaaa ctctgagagg tgggtcccag cctgacgcag cccgagagct ccgctcttgc
     1261 cttctccacc tcacactgca gggtcagcga ggaggaatct gtgcaccacc tctgtcacct
     1321 ggggccctcc agccacttcc ccatgctgag ctggcaccct caggcctacc ttccctcagg
     1381 tgccctcgaa gcactgcttt gaggtcccct ggcctgtctc cactcttgca ttatccttca
     1441 tgtcaccgaa gccaccccaa ccagcccctc tcccagactc agagtagaag gccccatcct
     1501 ctcaagcccc aggacccttc aaagggctgg gacatcctgg gacttgggct ccagcatctg
     1561 tctcaggcca gatgaggggg caccggtccc tcatagggca gggccatgta tatatccctt
     1621 ggtgggggac atagtgtggt gacagttcac tgcatatttt gagaccttat tctctagatc
     1681 catagttaat gatgccctgg cagtcattcc tcttgccatg gggaagcttc tgatgagaga
     1741 aaggagcccc acatccactg aaacatcctt tggttctcaa gcttcttctg gaggcagtaa
     1801 ggaaaaataa aacccaccaa ggctcaagaa gggaactata gaaaagttca ggtttttagg
     1861 ctatagcaga gacagtgaga aagcatctgg gcctttctct tcctcttggt ccaggggacc
     1921 tcattcacca actagagctt ggtgtacagg aacggggtca cagtgctgag ggggcttgag
     1981 tcccaccttt cagcttgatg gatgctcacc tcttctcagc cccagctcgt gccctgtttt
     2041 tctagccata gcccccagat tactcacagc tcctcatgcc atttcctgtc cagattgcta
     2101 tgtatgactc tgacctctct tgtccagtgg tctggtgctc acctcctctc actgctagaa
     2161 tattcaccaa gggtttgcat ttgggaagtc ccttaccagc tcctgcttag agctggtagg
     2221 gccatacatg tccacactcc caactggtgg ctctcccgct gaatggggcc tcagcaggtg
     2281 cccaagctgc tacaaccttg gccactctgt ttctccaccc cagcactggg catggtaatt
     2341 agcctttccc catgttaatt tattcagttt tttcaagggt caactgaatt ccccacttcc
     2401 tgggtaagaa gcatgatctc cttttaattt cacgtctaag atcctggcag cttcccctag
     2461 ctggttcctc tgtagtcctg ctgggactgt cagctcattt aaatgtgggt ctgcagaagg
     2521 ctttaggtct cccccaaccc ccttaccttt cacagaggaa cctttcatca ggataaatga
     2581 ttattgctgc cctgtgggtc ttgctcaata ctgttcatac ctggagagag aaggtattga
     2641 aacatctcct ttatgtgtga ctttcccaaa tttttaaaaa ttgtttatgg tttaggcccc
     2701 ttaaatactg tgtagcagga tgaagtctac cattaccagc tgggtcacct tggatgggtc
     2761 tgtcaacatc taagcctcag ttccctcacc tgtaaaaatg agggtagtcc ctacctcata
     2821 agggatattg tgaggatgga aagcgaaagt gtgagaaaat acctcccaag tgcctggtac
     2881 atagtgggtg ctaaataaac cactttttgt ctgcaa
//
