LOCUS       NM_001353937            7668 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 3 (TTC3), transcript
            variant 9, mRNA.
ACCESSION   NM_001353937
VERSION     NM_001353937.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7668)
  AUTHORS   Cukier,H.N., Duarte,C.L., Laverde-Paz,M.J., Simon,S.A., Van
            Booven,D.J., Miyares,A.T., Whitehead,P.L., Hamilton-Nelson,K.L.,
            Adams,L.D., Carney,R.M., Cuccaro,M.L., Vance,J.M.,
            Pericak-Vance,M.A., Griswold,A.J. and Dykxhoorn,D.M.
  TITLE     An Alzheimer's disease risk variant in TTC3 modifies the actin
            cytoskeleton organization and the PI3K-Akt signaling pathway in
            iPSC-derived forebrain neurons
  JOURNAL   Neurobiol Aging 131, 182-195 (2023)
   PUBMED   37677864
  REMARK    GeneRIF: An Alzheimer's disease risk variant in TTC3 modifies the
            actin cytoskeleton organization and the PI3K-Akt signaling pathway
            in iPSC-derived forebrain neurons.
REFERENCE   2  (bases 1 to 7668)
  AUTHORS   Zhou,X., Chen,X., Hong,T., Zhang,M., Cai,Y. and Cui,L.
  TITLE     TTC3-Mediated Protein Quality Control, A Potential Mechanism for
            Cognitive Impairment
  JOURNAL   Cell Mol Neurobiol 42 (6), 1659-1669 (2022)
   PUBMED   33638766
  REMARK    GeneRIF: TTC3-Mediated Protein Quality Control, A Potential
            Mechanism for Cognitive Impairment.
            Review article
REFERENCE   3  (bases 1 to 7668)
  AUTHORS   Laverde-Paz,M.J., Nuytemans,K., Wang,L., Vance,J.M.,
            Pericak-Vance,M.A., Dykxhoorn,D.M. and Cukier,H.N.
  TITLE     Derivation of stem cell line UMi028-A-2 containing a CRISPR/Cas9
            induced Alzheimer's disease risk variant p.S1038C in the TTC3 gene
  JOURNAL   Stem Cell Res 52, 102258 (2021)
   PUBMED   33626494
  REMARK    GeneRIF: Derivation of stem cell line UMi028-A-2 containing a
            CRISPR/Cas9 induced Alzheimer's disease risk variant p.S1038C in
            the TTC3 gene.
REFERENCE   4  (bases 1 to 7668)
  AUTHORS   Gong,Y., Wang,K., Xiao,S.P., Mi,P., Li,W., Shang,Y. and Dou,F.
  TITLE     Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and
            Form Aggregates in the Nucleus
  JOURNAL   Neuromolecular Med 21 (1), 85-96 (2019)
   PUBMED   30203323
  REMARK    GeneRIF: Overexpressed TTC3 Protein Tends to be Cleaved into
            Fragments and Form Aggregates in the Nucleus.
REFERENCE   5  (bases 1 to 7668)
  AUTHORS   Kim,J.H., Ham,S., Lee,Y., Suh,G.Y. and Lee,Y.S.
  TITLE     TTC3 contributes to TGF-beta1-induced epithelial-mesenchymal
            transition and myofibroblast differentiation, potentially through
            SMURF2 ubiquitylation and degradation
  JOURNAL   Cell Death Dis 10 (2), 92 (2019)
   PUBMED   30696809
  REMARK    GeneRIF: Data suggest that TTC3 may contribute to TGF-beta1-induced
            EMT and myofibroblast differentiation, potentially through SMURF2
            ubiquitylation/proteasomal degradation and subsequent inhibition of
            SMURF2-mediated suppression of SMAD2 and SMAD3, which in turn
            induces TTC3 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7668)
  AUTHORS   Rachidi,M., Lopes,C., Gassanova,S., Sinet,P.M., Vekemans,M.,
            Attie,T., Delezoide,A.L. and Delabar,J.M.
  TITLE     Regional and cellular specificity of the expression of TPRD, the
            tetratricopeptide Down syndrome gene, during human embryonic
            development
  JOURNAL   Mech Dev 93 (1-2), 189-193 (2000)
   PUBMED   10781955
REFERENCE   7  (bases 1 to 7668)
  AUTHORS   Dahmane,N., Ghezala,G.A., Gosset,P., Chamoun,Z.,
            Dufresne-Zacharia,M.C., Lopes,C., Rabatel,N.,
            Gassanova-Maugenre,S., Chettouh,Z., Abramowski,V., Fayet,E.,
            Yaspo,M.L., Korn,B., Blouin,J.L., Lehrach,H., Poutska,A.,
            Antonarakis,S.E., Sinet,P.M., Creau,N. and Delabar,J.M.
  TITLE     Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21
            involved in Down syndrome
  JOURNAL   Genomics 48 (1), 12-23 (1998)
   PUBMED   9503011
REFERENCE   8  (bases 1 to 7668)
  AUTHORS   Eki,T., Abe,M., Naitou,M., Sasanuma,S.I., Nohata,J., Kawashima,K.,
            Ahmad,I., Hanaoka,F. and Murakami,Y.
  TITLE     Cloning and characterization of novel gene, DCRR1, expressed from
            Down's syndrome critical region of human chromosome 21q22.2
  JOURNAL   DNA Seq 7 (3-4), 153-164 (1997)
   PUBMED   9254009
REFERENCE   9  (bases 1 to 7668)
  AUTHORS   Tsukahara,F., Hattori,M., Muraki,T. and Sakaki,Y.
  TITLE     Identification and cloning of a novel cDNA belonging to
            tetratricopeptide repeat gene family from Down syndrome-critical
            region 21q22.2
  JOURNAL   J Biochem 120 (4), 820-827 (1996)
   PUBMED   8947847
REFERENCE   10 (bases 1 to 7668)
  AUTHORS   Ohira,M., Ootsuyama,A., Suzuki,E., Ichikawa,H., Seki,N., Nagase,T.,
            Nomura,N. and Ohki,M.
  TITLE     Identification of a novel human gene containing the
            tetratricopeptide repeat domain from the Down syndrome region of
            chromosome 21
  JOURNAL   DNA Res 3 (1), 9-16 (1996)
   PUBMED   8724848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001429.2, AP001432.2 and KF510554.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001353937.1.
            
            Transcript Variant: This variant (9), as well as variant 10,
            encodes isoform 5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1990001.1,
                                           SRR1660807.38716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AP001429.2         4517-4627
            112-266             AP001429.2         18510-18664
            267-309             AP001429.2         19096-19138
            310-460             AP001429.2         19459-19609
            461-548             AP001429.2         20062-20149
            549-602             AP001429.2         21496-21549
            603-723             AP001429.2         22556-22676
            724-809             AP001429.2         25268-25353
            810-904             AP001429.2         26613-26707
            905-967             AP001429.2         27844-27906
            968-1022            AP001429.2         39655-39709
            1023-1185           AP001429.2         53080-53242
            1186-1231           AP001429.2         54246-54291
            1232-1355           AP001429.2         55882-56005
            1356-1419           AP001429.2         57343-57406
            1420-1480           AP001429.2         60266-60326
            1481-1565           AP001429.2         63945-64029
            1566-1700           AP001429.2         66643-66777
            1701-1781           AP001429.2         69897-69977
            1782-1894           AP001429.2         71824-71936
            1895-2015           AP001429.2         75788-75908
            2016-2138           AP001429.2         78744-78866
            2139-2240           AP001429.2         79809-79910
            2241-2333           AP001429.2         81341-81433
            2334-2470           AP001429.2         83156-83292
            2471-2797           AP001432.2         168-494
            2798-2884           KF510554.1         1-87                c
            2885-3049           AP001432.2         3961-4125
            3050-3096           AP001432.2         6918-6964
            3097-3153           AP001432.2         8021-8077
            3154-3227           AP001432.2         9209-9282
            3228-3392           AP001432.2         11270-11434
            3393-4458           AP001432.2         12769-13834
            4459-4524           AP001432.2         14774-14839
            4525-4674           AP001432.2         19814-19963
            4675-4814           AP001432.2         29993-30132
            4815-4883           AP001432.2         32924-32992
            4884-4980           AP001432.2         34267-34363
            4981-5081           AP001432.2         35713-35813
            5082-5172           AP001432.2         38552-38642
            5173-5274           AP001432.2         39330-39431
            5275-5636           AP001432.2         42893-43254
            5637-5763           AP001432.2         44788-44914
            5764-5907           AP001432.2         45100-45243
            5908-6000           AP001432.2         47450-47542
            6001-7668           AP001432.2         48658-50325
FEATURES             Location/Qualifiers
     source          1..7668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.13"
     gene            1..7668
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /note="tetratricopeptide repeat domain 3"
                     /db_xref="GeneID:7267"
                     /db_xref="HGNC:HGNC:12393"
                     /db_xref="MIM:602259"
     exon            1..111
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            112..266
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            267..309
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            310..460
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            461..548
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            549..602
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            603..723
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            724..809
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            810..904
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            905..967
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1022
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1185
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1231
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1355
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1419
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1480
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1565
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1700
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1781
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1894
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2015
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2138
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2240
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             2224..6135
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /EC_number="2.3.2.27"
                     /note="isoform 5 is encoded by transcript variant 9; TPR
                     repeat protein D; E3 ubiquitin-protein ligase TTC3; TPR
                     repeat protein 3; RING finger protein 105;
                     tetratricopeptide repeat protein 3; RING-type E3 ubiquitin
                     transferase TTC3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TTC3 isoform 5"
                     /protein_id="NP_001340866.1"
                     /db_xref="GeneID:7267"
                     /db_xref="HGNC:HGNC:12393"
                     /db_xref="MIM:602259"
                     /translation="MIKLTRIFYKEYVLPLTVKVSFLRLSSSAVVVKLNVNLEKLRLK
                     EDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETVDNVQRCQFLDDRILQCI
                     KQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENN
                     RVKTRIFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFL
                     WNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALHSALDEFFDIMD
                     SRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDH
                     SNRNSDSAGPFAVPDHLRQDVEEFEALYDQHSNEYVVRNKKLWDMNPKQKCSTLYDYF
                     SQFLEEHGPLDMSNKMFSAEYEFFPEETRQILEKAGGLKPFLLGCPRFVVIDNCIALK
                     KVASRLKKKRKKKNIKTKVEEISKAGEYVRVKLQLNPAAREFKPDVKSKPVSDSSSAP
                     AFENVKPKPVSANSPKPACEDVKAKPVSDNSSRQVSEDGQPKGVSSNSPKPGSEDANY
                     KRVSCNSPKPVLEDVKPTYWAQSHLVTGYCTYLPFQRFDITQTPPAYINVLPGLPQYT
                     SIYTPLASLSPEYQLPRSVPVVPSFVANDRADKNAAAYFEGHHLNAENVAGHQIASET
                     QILEGSLGISVKSHCSTGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQ
                     MVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIEKEHQVLQDQLQEVYENYEQIKLKG
                     LEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIK
                     KVSNASEMYTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQR
                     AVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRDPAAYPDMESDIRSWELFL
                     SNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDD
                     GQGLVTSASDVTGNHAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRA
                     GQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFPCYNSTELAGFIK
                     KVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQG
                     SPSVVVAPSPKTKGQKAEDVPVRIALGASSCEICHEVFKSKNVRVLKCGHKYHKGCFK
                     QWLKGQSACPACQGRDLLTEESPSGRGWPSQNQELPSCSSR"
     exon            2241..2333
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2470
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2797
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..3049
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3096
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3153
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3227
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3392
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..4458
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4524
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4674
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4814
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..4883
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4884..4980
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4981..5081
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5172
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5173..5274
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5636
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5637..5763
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5764..5907
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5908..6000
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            6001..7668
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7644..7649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /note="hexamer: AATAAA"
     polyA_site      7668
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /note="major polyA site"
ORIGIN      
        1 acccgctccc tcccgccgtc ggctgacgtg gagggccgga ggtggcggcg gcggcggcgg
       61 cggctgctgc tgctgctgcc cgcgtccgag gctcgcgggc ggcgggcccg gacttgtgca
      121 ccatggacaa ttttgctgag ggagatttca ctgtggcgga ttatgccttg ttagaagatt
      181 gccctcacgt ggatgattgt gtctttgctg ctgaatttat gagcaatgat tatgttcgtg
      241 tgactcagct ttactgtgat ggggtgggtg tgcaatataa agattatatc caaagtgaga
      301 ggaatttgga atttgacatc tgcagtatat ggtgtagtaa accaatttct gtcctgcaag
      361 attattgcga tgccattaaa ataaacatct tctggccact tctgtttcaa catcaaaaca
      421 gttccgtaat atcacgattg catccctgtg tggacgccaa caattcacgt gcttctgaga
      481 taaatttgaa gaaactacaa catcttgagt tgatggaaga tattgtggat ttggcaaaga
      541 aagttgctaa tgattcattc cttattggag gcttattgag aattggttgt aaaatagaaa
      601 ataaaatctt ggcaatggaa gaagctctga attggataaa atatgcaggc gatgtaacaa
      661 ttctaactaa attaggatca attgacaatt gttggcctat gttaagtatt ttctttactg
      721 aatacaagta ccacataact aaaattgtaa tggaagactg caatttgctt gaagaactta
      781 aaactcaaag ttgtatggat tgtatagagg aaggagaact aatgaaaatg aaaggaaatg
      841 aagagttttc caaagaaaga tttgatatag ctattatcta ttacaccaga gccattgaat
      901 atagacctga aaactacctt ctttatggta accgagctct ttgttttctt cgtactggac
      961 agtttagaaa tgcactcggt gatggaaaga gagccactat tctgaagaac acttggccaa
     1021 agggtcatta tcgttattgt gatgctcttt ctatgctggg ggaatatgac tgggccctgc
     1081 aagcaaacat aaaagctcaa aaactctgta aaaatgaccc tgagggaatc aaggatctaa
     1141 ttcagcagca tgtaaagtta caaaaacaaa tagaagacct acaaggtcga acagcaaata
     1201 aggatccaat taaagccttt tatgaaaaca gggcctacac acctaggagt ttatcagcac
     1261 ctatatttac tacttcactt aactttgtgg agaaggaaag agatttcaga aaaattaatc
     1321 acgaaatggc caacggtggt aatcagaatc taaaggtggc ggatgaggcg ttgaaggtag
     1381 atgattgtga ctgtcatcct gaattttcac caccatcaag tcagcctcca aaacataaag
     1441 gaaaacaaaa atctcgaaac aatgaatcag aaaagttcag ttctagttca ccattgactt
     1501 taccagcaga tttgaagaac atcttggaga aacagttttc taaatcttcc agagctgcac
     1561 accaggattt tgctaatata atgaaaatgc tgagaagctt aattcaagat ggctatatgg
     1621 ccttattgga gcagcgttgc cgcagcgctg cacaggcctt tacagagttg ctgaacggtt
     1681 tagatcctca aaaaataaag caattgaacc tggccatgat taactatgtt ttggtcgtct
     1741 atggacttgc catttctctc cttggaatag gacagcctga ggaattatct gaagccgaaa
     1801 accagtttaa gaggattatt gaacactacc ccagtgaggg ccttgattgc ttggcctact
     1861 gtggaattgg aaaagtatat ttgaaaaaaa acagatttct agaagctctc aatcactttg
     1921 agaaagcaag aaccttgatt tatcgtcttc ctggagtgtt aacttggccc acgagtaatg
     1981 tgattattga agagtctcag ccacaaaaaa taaagatgct gttagagaaa tttgttgaag
     2041 aatgcaagtt ccctccagtg ccagatgcca tttgttgcta tcagaagtgc catggatatt
     2101 ctaagatcca gatatacata actgatccag actttaaggg ttttatacgc atcagctgtt
     2161 gccagtactg taaaatagaa tttcacatga attgctggaa gaagttaaaa actacaacct
     2221 ttaatgataa aattgacaag gattttctac aaggaatatg tcttacccct gactgtgaag
     2281 gtgtcatttc taagattatc atcttcagca gtggtggtga agttaaatgt gaacctagag
     2341 aaactaagac tgaaagaaga caaaaaattg aagagaaaga tccaaaaaaa agaagcaaaa
     2401 aagttagcac aagaaagaat ggaggaggac ttaagagaaa gtaatccacc caaaaatgaa
     2461 gagcagaaag aaactgtaga caatgttcag cgttgtcagt tccttgatga cagaattcta
     2521 cagtgtataa agcagtatgc tgacaagatt aaatccggca tacagaatac agccatgctt
     2581 ctcaaagaat tgctttcttg gaaagttttg agcacagaag actatacaac ctgtttttct
     2641 agcagaaatt ttctaaatga agcagtggac tatgttattc gccacttgat tcaagaaaat
     2701 aacagagtaa agacaagaat atttctgcat gttttgagtg agcttaaaga agtggagccc
     2761 aaattagccg cctggatcca aaaacttaat agctttggct tagatgccac aggaactttc
     2821 ttttctcgtt atggagcatc tcttaaactg cttgatttta gtatcatgac tttcctctgg
     2881 aatgagaaat atggtcacaa actagactct atagaaggaa agcaacttga ttatttctct
     2941 gagccagcat cattgaagga agcccgttgt ttaatatggc tgctagaaga acacagagac
     3001 aagttcccag cattgcatag tgctttagat gaattctttg atataatgga cagccgctgt
     3061 actgtgttaa ggaaacaaga tagtggtgaa gcaccgttta gttcaaccaa ggtgaaaaac
     3121 aaaagcaaga aaaagaagcc aaaggattca aagcctatgt tagttgggtc tggaacaact
     3181 tcagtaactt caaataatga gatcatcact tcaagtgaag accatagcaa tcgaaattca
     3241 gattctgcag gcccatttgc agtgcctgac catcttcggc aagatgtaga agaattcgaa
     3301 gctctctatg accaacacag taacgaatat gttgtccgca ataagaagct atgggacatg
     3361 aacccaaaac aaaaatgttc aactctatat gattacttct ctcagttttt ggaggaacat
     3421 ggtcccttgg acatgagtaa caagatgttc tctgcagaat atgagttttt cccagaagaa
     3481 actcgacaga tactagaaaa agcaggaggt ttaaaacctt ttctcttggg atgccctcgt
     3541 tttgttgtga ttgacaactg tattgcactg aagaaggttg catcacggct caagaaaaaa
     3601 aggaagaaga aaaacattaa aacaaaagta gaagaaattt caaaagcagg ggagtatgta
     3661 cgagttaaac tacaactgaa tccagctgct agggaattta aaccagatgt aaagtctaaa
     3721 ccagtgtcag attcatcttc agcaccagct tttgaaaatg tgaaacccaa acctgtgtct
     3781 gcaaattctc ccaagccagc ttgtgaagat gtgaaggcca aaccagtatc cgacaattct
     3841 tctagacaag tttctgagga tgggcaaccc aaaggggtct cttctaattc tcctaaacca
     3901 ggctctgagg atgcaaatta caagcgagtc tcctgtaatt cccccaaacc ggttcttgag
     3961 gatgtgaaac caacttattg ggctcaatcc catttggtca caggatactg tacgtatctt
     4021 cctttccaga gatttgatat cacccagaca ccgccagcat acataaacgt gttaccaggt
     4081 ttgccccagt acaccagcat atatacaccc ttggccagcc tttctcctga atatcagcta
     4141 ccaagatcag taccagtggt gccgtctttt gtagccaatg acagagcaga taaaaatgct
     4201 gctgcctatt ttgagggtca tcatttgaat gctgagaatg ttgctggtca ccagattgcc
     4261 tctgaaacac agatccttga gggctctttg ggaatatctg taaagtcaca ctgcagcaca
     4321 ggtgatgctc atacagtcct gagtgagtct aacagaaatg atgagcactg tggaaattct
     4381 aacaacaaat gtgaagtaat tccagaaagc accagtgcag taacaaacat tccacacgtg
     4441 cagatggttg ccatacaggt atcttggaac ataatacacc aagaagtcaa tactgagcca
     4501 tataatcctt ttgaggaacg acaaggggaa atttcacgga ttgaaaagga gcaccaagta
     4561 ttacaagacc aacttcaaga agtgtatgaa aattatgagc agataaaact taagggctta
     4621 gaagagacca gggacctgga agagaagttg aaaaggcact tagaagaaaa caagatctca
     4681 aagacggaat tagattggtt ccttcaagat ttggaaagag aaattaaaaa atggcaacag
     4741 gaaaaaaaag aaatccaaga aagactaaaa tcactgaaga agaaaattaa aaaggtttca
     4801 aatgccagtg aaatgtatac ccagaaaaat gatggaaagg aaaaggaaca tgaattacat
     4861 ctggatcagt cccttgaaat cagcaacaca cttacaaatg agaaaatgaa aatagaagag
     4921 tatataaaga aagggaaaga ggattatgaa gagagtcatc agagagctgt ggctgcagag
     4981 gtatccgtac ttgaaaactg gaaggagagt gaagtgtata agctacagat catggagtca
     5041 caagcagaag cctttctgaa gaagctgggg ctgattagcc gtgatcctgc agcatatcct
     5101 gacatggagt ctgatatacg ttcatgggaa ttgtttcttt ctaatgttac aaaagaaatt
     5161 gagaaagcaa agtctcagtt tgaagaacaa attaaggcaa ttaaaaatgg ttctcggctc
     5221 agtgaacttt ctaaagtgca gatttctgag ctttcatttc ctgcctgtaa cacggttcat
     5281 cccgagttac tccctgagtc ttcaggcgac gatggccaag ggcttgtgac ttctgcaagc
     5341 gacgtgactg gaaaccacgc agcacttcac agggatccta gtgtgttctc tgctggtgat
     5401 tccccagggg aggctccttc tgcgctgttg ccagggccac cccctggtca gcctgaagcc
     5461 actcagctga cagggccaaa acgggctggc caggcagctc tgtcagaacg aagccctgtg
     5521 gctgatcgga agcagcctgt tcctccagga cgtgctgcgc gttcaagcca gtctccaaaa
     5581 aagccgttca atagtattat tgagcacctg tcagtggtat tcccatgtta caacagcact
     5641 gagcttgctg gttttattaa aaaagtgcga agcaaaaaca agaactcact ctcaggattg
     5701 agtattgatg aaattgtcca aagagtgaca gaacacattc tagatgaaca gaaaaagaaa
     5761 aagccaaacc caggaaagga caagaggact tatgagccca gctctgccac ccccgtgacc
     5821 aggtcctccc agggctcacc ctcggtggtt gttgcaccat cacccaaaac caaggggcag
     5881 aaagcagaag atgtccctgt gaggattgca ctgggtgcaa gttcctgtga aatatgccac
     5941 gaggtgttca aatcaaaaaa cgtgcgtgtg ctcaaatgtg ggcacaagta tcacaaaggg
     6001 tgctttaagc agtggcttaa agggcagagc gcttgcccgg cctgccaggg tcgtgatctc
     6061 ctgacagaag agtcaccttc tggaagaggc tggcccagtc agaatcagga gctgccttcc
     6121 tgctcttcta ggtagtcaca cttcactaaa gtgtcatcca ccagtgtgtt gaatccgaag
     6181 aatgacaatt ttctaccact ggtgtaaaaa acaaacattt gaagaccctt gtgcattgtg
     6241 tgtcacaaag ctaaatacat ggaaatcgtt aatatcgctg atattaagta atttccccac
     6301 tctgagtgaa tactttgatg attgccaaca gtggctaata aaatgacggc taccacactc
     6361 atgggtcact ggggctgcgc agggctcttt gaggtgggtg gcttcttttg gaaagtacta
     6421 tgaacgtctc gaagcagtat tctagtgata agaattctta acatagccaa gcgccccacg
     6481 tttgttcccc acgtttgttc cccttttctg tttgaaaaac ctgttctggt agctccacaa
     6541 gagagatgat actgactttt taaatttttt acaagagtct gtattcctga tatgcctata
     6601 tttttcctca aagattctgc attttaagga tgggcataag caaactatat tttaataatt
     6661 tatagttaat gttaaaatat tggctgattt agaccaaaag attcaaatct cctctttgtg
     6721 aaatcccatc tgcatttgat tttttattat tttatgttcc cccgttagat tgttttaagt
     6781 gtttgctttt catcttttat agatgtaatc tgattttcaa aaatcattaa cactttttaa
     6841 ttagtatcga ctaagacttt ttccccctgg aatcgaggct gtgtgtccgt catcccagcc
     6901 cccggttgga gcctgctctt tgaactccgc tgccttcctt agcagcttct gtcctcttct
     6961 gtgagtcagt cagcgagtgc ttgggatccg catccagccg tgctgagcac acaacaggct
     7021 gtgtgtggaa atggccacca ccattctcct tccccacccc accacaaaaa gagaagctgt
     7081 gtctttagac aaccctgagg tatctgtgtt acaatcgttc tgtgtttgat atttgtgtaa
     7141 agtatgcatg cagtcttgta ctgtgaccta agaacaaaac tgtaactgca ttagaaacca
     7201 tgaaaaaatt agatattgtt ttgtgacttt tagacagtgg taaatataga accatgaatt
     7261 ctggtcacat tccatttctc tccaacatga aggatcaaaa aatgtttttc aatgtgttct
     7321 ttgttccact ggaaacttag agtcatgagt ttatgagctg atttggtcac cttcctctgc
     7381 ctttgttcac tgtgagttct gatgtcttag tgacttagtt cttagaagct cacgccttag
     7441 tttgaaacag attctccacg gtggtcccca aaacactgtc tgcatatcca taagaattga
     7501 gcgctatggg tgttaacgtg catgaggatc agtttgcagc agcaagtaca aaaggagaag
     7561 aggaacatcc gttgaatgag tgtgttttgt acataacttc agatacttgt gaacatgcct
     7621 tatatttgtc caacaactgt cagaataaag aacattctaa aatgagaa
//
