LOCUS       NM_001330683            7842 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 3 (TTC3), transcript
            variant 7, mRNA.
ACCESSION   NM_001330683 XM_017028463
VERSION     NM_001330683.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7842)
  AUTHORS   Cukier,H.N., Duarte,C.L., Laverde-Paz,M.J., Simon,S.A., Van
            Booven,D.J., Miyares,A.T., Whitehead,P.L., Hamilton-Nelson,K.L.,
            Adams,L.D., Carney,R.M., Cuccaro,M.L., Vance,J.M.,
            Pericak-Vance,M.A., Griswold,A.J. and Dykxhoorn,D.M.
  TITLE     An Alzheimer's disease risk variant in TTC3 modifies the actin
            cytoskeleton organization and the PI3K-Akt signaling pathway in
            iPSC-derived forebrain neurons
  JOURNAL   Neurobiol Aging 131, 182-195 (2023)
   PUBMED   37677864
  REMARK    GeneRIF: An Alzheimer's disease risk variant in TTC3 modifies the
            actin cytoskeleton organization and the PI3K-Akt signaling pathway
            in iPSC-derived forebrain neurons.
REFERENCE   2  (bases 1 to 7842)
  AUTHORS   Zhou,X., Chen,X., Hong,T., Zhang,M., Cai,Y. and Cui,L.
  TITLE     TTC3-Mediated Protein Quality Control, A Potential Mechanism for
            Cognitive Impairment
  JOURNAL   Cell Mol Neurobiol 42 (6), 1659-1669 (2022)
   PUBMED   33638766
  REMARK    GeneRIF: TTC3-Mediated Protein Quality Control, A Potential
            Mechanism for Cognitive Impairment.
            Review article
REFERENCE   3  (bases 1 to 7842)
  AUTHORS   Laverde-Paz,M.J., Nuytemans,K., Wang,L., Vance,J.M.,
            Pericak-Vance,M.A., Dykxhoorn,D.M. and Cukier,H.N.
  TITLE     Derivation of stem cell line UMi028-A-2 containing a CRISPR/Cas9
            induced Alzheimer's disease risk variant p.S1038C in the TTC3 gene
  JOURNAL   Stem Cell Res 52, 102258 (2021)
   PUBMED   33626494
  REMARK    GeneRIF: Derivation of stem cell line UMi028-A-2 containing a
            CRISPR/Cas9 induced Alzheimer's disease risk variant p.S1038C in
            the TTC3 gene.
REFERENCE   4  (bases 1 to 7842)
  AUTHORS   Gong,Y., Wang,K., Xiao,S.P., Mi,P., Li,W., Shang,Y. and Dou,F.
  TITLE     Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and
            Form Aggregates in the Nucleus
  JOURNAL   Neuromolecular Med 21 (1), 85-96 (2019)
   PUBMED   30203323
  REMARK    GeneRIF: Overexpressed TTC3 Protein Tends to be Cleaved into
            Fragments and Form Aggregates in the Nucleus.
REFERENCE   5  (bases 1 to 7842)
  AUTHORS   Kim,J.H., Ham,S., Lee,Y., Suh,G.Y. and Lee,Y.S.
  TITLE     TTC3 contributes to TGF-beta1-induced epithelial-mesenchymal
            transition and myofibroblast differentiation, potentially through
            SMURF2 ubiquitylation and degradation
  JOURNAL   Cell Death Dis 10 (2), 92 (2019)
   PUBMED   30696809
  REMARK    GeneRIF: Data suggest that TTC3 may contribute to TGF-beta1-induced
            EMT and myofibroblast differentiation, potentially through SMURF2
            ubiquitylation/proteasomal degradation and subsequent inhibition of
            SMURF2-mediated suppression of SMAD2 and SMAD3, which in turn
            induces TTC3 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7842)
  AUTHORS   Rachidi,M., Lopes,C., Gassanova,S., Sinet,P.M., Vekemans,M.,
            Attie,T., Delezoide,A.L. and Delabar,J.M.
  TITLE     Regional and cellular specificity of the expression of TPRD, the
            tetratricopeptide Down syndrome gene, during human embryonic
            development
  JOURNAL   Mech Dev 93 (1-2), 189-193 (2000)
   PUBMED   10781955
REFERENCE   7  (bases 1 to 7842)
  AUTHORS   Dahmane,N., Ghezala,G.A., Gosset,P., Chamoun,Z.,
            Dufresne-Zacharia,M.C., Lopes,C., Rabatel,N.,
            Gassanova-Maugenre,S., Chettouh,Z., Abramowski,V., Fayet,E.,
            Yaspo,M.L., Korn,B., Blouin,J.L., Lehrach,H., Poutska,A.,
            Antonarakis,S.E., Sinet,P.M., Creau,N. and Delabar,J.M.
  TITLE     Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21
            involved in Down syndrome
  JOURNAL   Genomics 48 (1), 12-23 (1998)
   PUBMED   9503011
REFERENCE   8  (bases 1 to 7842)
  AUTHORS   Eki,T., Abe,M., Naitou,M., Sasanuma,S.I., Nohata,J., Kawashima,K.,
            Ahmad,I., Hanaoka,F. and Murakami,Y.
  TITLE     Cloning and characterization of novel gene, DCRR1, expressed from
            Down's syndrome critical region of human chromosome 21q22.2
  JOURNAL   DNA Seq 7 (3-4), 153-164 (1997)
   PUBMED   9254009
REFERENCE   9  (bases 1 to 7842)
  AUTHORS   Tsukahara,F., Hattori,M., Muraki,T. and Sakaki,Y.
  TITLE     Identification and cloning of a novel cDNA belonging to
            tetratricopeptide repeat gene family from Down syndrome-critical
            region 21q22.2
  JOURNAL   J Biochem 120 (4), 820-827 (1996)
   PUBMED   8947847
REFERENCE   10 (bases 1 to 7842)
  AUTHORS   Ohira,M., Ootsuyama,A., Suzuki,E., Ichikawa,H., Seki,N., Nagase,T.,
            Nomura,N. and Ohki,M.
  TITLE     Identification of a novel human gene containing the
            tetratricopeptide repeat domain from the Down syndrome region of
            chromosome 21
  JOURNAL   DNA Res 3 (1), 9-16 (1996)
   PUBMED   8724848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001429.2, AP001432.2 and KF510554.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001330683.1.
            
            Transcript Variant: This variant (7), as well as variants 1 and 2,
            encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.110257.1,
                                           SRR1803612.72585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418766.6/ ENSP00000403943.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AP001429.2         4517-4736
            221-375             AP001429.2         18510-18664
            376-418             AP001429.2         19096-19138
            419-569             AP001429.2         19459-19609
            570-657             AP001429.2         20062-20149
            658-711             AP001429.2         21496-21549
            712-832             AP001429.2         22556-22676
            833-918             AP001429.2         25268-25353
            919-1013            AP001429.2         26613-26707
            1014-1076           AP001429.2         27844-27906
            1077-1131           AP001429.2         39655-39709
            1132-1294           AP001429.2         53080-53242
            1295-1340           AP001429.2         54246-54291
            1341-1464           AP001429.2         55882-56005
            1465-1528           AP001429.2         57343-57406
            1529-1589           AP001429.2         60266-60326
            1590-1674           AP001429.2         63945-64029
            1675-1809           AP001429.2         66643-66777
            1810-1890           AP001429.2         69897-69977
            1891-2003           AP001429.2         71824-71936
            2004-2124           AP001429.2         75788-75908
            2125-2247           AP001429.2         78744-78866
            2248-2349           AP001429.2         79809-79910
            2350-2442           AP001429.2         81341-81433
            2443-2507           AP001429.2         82083-82147
            2508-2644           AP001429.2         83156-83292
            2645-2971           AP001432.2         168-494
            2972-3058           KF510554.1         1-87                c
            3059-3223           AP001432.2         3961-4125
            3224-3270           AP001432.2         6918-6964
            3271-3327           AP001432.2         8021-8077
            3328-3401           AP001432.2         9209-9282
            3402-3566           AP001432.2         11270-11434
            3567-4632           AP001432.2         12769-13834
            4633-4698           AP001432.2         14774-14839
            4699-4848           AP001432.2         19814-19963
            4849-4988           AP001432.2         29993-30132
            4989-5057           AP001432.2         32924-32992
            5058-5154           AP001432.2         34267-34363
            5155-5255           AP001432.2         35713-35813
            5256-5346           AP001432.2         38552-38642
            5347-5448           AP001432.2         39330-39431
            5449-5810           AP001432.2         42893-43254
            5811-5937           AP001432.2         44788-44914
            5938-6081           AP001432.2         45100-45243
            6082-6174           AP001432.2         47450-47542
            6175-7842           AP001432.2         48658-50325
FEATURES             Location/Qualifiers
     source          1..7842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.13"
     gene            1..7842
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /note="tetratricopeptide repeat domain 3"
                     /db_xref="GeneID:7267"
                     /db_xref="HGNC:HGNC:12393"
                     /db_xref="MIM:602259"
     exon            1..220
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            221..375
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..6309
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 7; TPR
                     repeat protein D; E3 ubiquitin-protein ligase TTC3; TPR
                     repeat protein 3; RING finger protein 105;
                     tetratricopeptide repeat protein 3; RING-type E3 ubiquitin
                     transferase TTC3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TTC3 isoform 1"
                     /protein_id="NP_001317612.1"
                     /db_xref="CCDS:CCDS13651.1"
                     /db_xref="GeneID:7267"
                     /db_xref="HGNC:HGNC:12393"
                     /db_xref="MIM:602259"
                     /translation="MDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLY
                     CDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKINIFWPLLFQHQNSSV
                     ISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIEN
                     KILAMEEALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEE
                     LKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCFL
                     RTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPE
                     GIKDLIQQHVKLQKQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKE
                     RDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNNESE
                     KFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRS
                     AAQAFTELLNGLDPQKIKQLNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRII
                     EHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEE
                     SQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQY
                     CKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPDCEGVISKIIIFSSGGEVKCEFEH
                     KVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPP
                     KNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDY
                     TTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELKEVEPKLAAWIQKLNSFG
                     LDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCL
                     IWLLEEHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKD
                     SKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDVEEFEALYDQHS
                     NEYVVRNKKLWDMNPKQKCSTLYDYFSQFLEEHGPLDMSNKMFSAEYEFFPEETRQIL
                     EKAGGLKPFLLGCPRFVVIDNCIALKKVASRLKKKRKKKNIKTKVEEISKAGEYVRVK
                     LQLNPAAREFKPDVKSKPVSDSSSAPAFENVKPKPVSANSPKPACEDVKAKPVSDNSS
                     RQVSEDGQPKGVSSNSPKPGSEDANYKRVSCNSPKPVLEDVKPTYWAQSHLVTGYCTY
                     LPFQRFDITQTPPAYINVLPGLPQYTSIYTPLASLSPEYQLPRSVPVVPSFVANDRAD
                     KNAAAYFEGHHLNAENVAGHQIASETQILEGSLGISVKSHCSTGDAHTVLSESNRNDE
                     HCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISR
                     IEKEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDL
                     EREIKKWQQEKKEIQERLKSLKKKIKKVSNASEMYTQKNDGKEKEHELHLDQSLEISN
                     TLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLK
                     KLGLISRDPAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSK
                     VQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGNHAALHRDPSVFSAGDSPG
                     EAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKK
                     PFNSIIEHLSVVFPCYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKK
                     KKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDVPVRIALGASSCE
                     ICHEVFKSKNVRVLKCGHKYHKGCFKQWLKGQSACPACQGRDLLTEESPSGRGWPSQN
                     QELPSCSSR"
     exon            376..418
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            419..569
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            570..657
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            658..711
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            712..832
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            833..918
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1013
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1076
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1131
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1294
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1340
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1464
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1528
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1589
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1674
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1809
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1890
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2003
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2124
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2247
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2349
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2442
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2507
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2644
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2971
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3223
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3270
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3327
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3401
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3566
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..4632
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4698
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4699..4848
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..4988
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            4989..5057
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5154
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5155..5255
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5256..5346
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5347..5448
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5449..5810
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5811..5937
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            5938..6081
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            6082..6174
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     exon            6175..7842
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7818..7823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /note="hexamer: AATAAA"
     polyA_site      7842
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /note="major polyA site"
ORIGIN      
        1 acccgctccc tcccgccgtc ggctgacgtg gagggccgga ggtggcggcg gcggcggcgg
       61 cggctgctgc tgctgctgcc cgcgtccgag gctcgcgggc ggcgggcccg ggtgagtgca
      121 cacccggcgc gctgccgggc tcccggatgt gtcaccttgt cccgctgcag ccgagatgcc
      181 gggggagcgg ggccttccac accccctccg tgggtgtgtg acttgtgcac catggacaat
      241 tttgctgagg gagatttcac tgtggcggat tatgccttgt tagaagattg ccctcacgtg
      301 gatgattgtg tctttgctgc tgaatttatg agcaatgatt atgttcgtgt gactcagctt
      361 tactgtgatg gggtgggtgt gcaatataaa gattatatcc aaagtgagag gaatttggaa
      421 tttgacatct gcagtatatg gtgtagtaaa ccaatttctg tcctgcaaga ttattgcgat
      481 gccattaaaa taaacatctt ctggccactt ctgtttcaac atcaaaacag ttccgtaata
      541 tcacgattgc atccctgtgt ggacgccaac aattcacgtg cttctgagat aaatttgaag
      601 aaactacaac atcttgagtt gatggaagat attgtggatt tggcaaagaa agttgctaat
      661 gattcattcc ttattggagg cttattgaga attggttgta aaatagaaaa taaaatcttg
      721 gcaatggaag aagctctgaa ttggataaaa tatgcaggcg atgtaacaat tctaactaaa
      781 ttaggatcaa ttgacaattg ttggcctatg ttaagtattt tctttactga atacaagtac
      841 cacataacta aaattgtaat ggaagactgc aatttgcttg aagaacttaa aactcaaagt
      901 tgtatggatt gtatagagga aggagaacta atgaaaatga aaggaaatga agagttttcc
      961 aaagaaagat ttgatatagc tattatctat tacaccagag ccattgaata tagacctgaa
     1021 aactaccttc tttatggtaa ccgagctctt tgttttcttc gtactggaca gtttagaaat
     1081 gcactcggtg atggaaagag agccactatt ctgaagaaca cttggccaaa gggtcattat
     1141 cgttattgtg atgctctttc tatgctgggg gaatatgact gggccctgca agcaaacata
     1201 aaagctcaaa aactctgtaa aaatgaccct gagggaatca aggatctaat tcagcagcat
     1261 gtaaagttac aaaaacaaat agaagaccta caaggtcgaa cagcaaataa ggatccaatt
     1321 aaagcctttt atgaaaacag ggcctacaca cctaggagtt tatcagcacc tatatttact
     1381 acttcactta actttgtgga gaaggaaaga gatttcagaa aaattaatca cgaaatggcc
     1441 aacggtggta atcagaatct aaaggtggcg gatgaggcgt tgaaggtaga tgattgtgac
     1501 tgtcatcctg aattttcacc accatcaagt cagcctccaa aacataaagg aaaacaaaaa
     1561 tctcgaaaca atgaatcaga aaagttcagt tctagttcac cattgacttt accagcagat
     1621 ttgaagaaca tcttggagaa acagttttct aaatcttcca gagctgcaca ccaggatttt
     1681 gctaatataa tgaaaatgct gagaagctta attcaagatg gctatatggc cttattggag
     1741 cagcgttgcc gcagcgctgc acaggccttt acagagttgc tgaacggttt agatcctcaa
     1801 aaaataaagc aattgaacct ggccatgatt aactatgttt tggtcgtcta tggacttgcc
     1861 atttctctcc ttggaatagg acagcctgag gaattatctg aagccgaaaa ccagtttaag
     1921 aggattattg aacactaccc cagtgagggc cttgattgct tggcctactg tggaattgga
     1981 aaagtatatt tgaaaaaaaa cagatttcta gaagctctca atcactttga gaaagcaaga
     2041 accttgattt atcgtcttcc tggagtgtta acttggccca cgagtaatgt gattattgaa
     2101 gagtctcagc cacaaaaaat aaagatgctg ttagagaaat ttgttgaaga atgcaagttc
     2161 cctccagtgc cagatgccat ttgttgctat cagaagtgcc atggatattc taagatccag
     2221 atatacataa ctgatccaga ctttaagggt tttatacgca tcagctgttg ccagtactgt
     2281 aaaatagaat ttcacatgaa ttgctggaag aagttaaaaa ctacaacctt taatgataaa
     2341 attgacaagg attttctaca aggaatatgt cttacccctg actgtgaagg tgtcatttct
     2401 aagattatca tcttcagcag tggtggtgaa gttaaatgtg aatttgaaca caaggtcata
     2461 aaagaaaagg ttcctccaag acctattctg aaacagaaat gttctagcct agagaaacta
     2521 agactgaaag aagacaaaaa attgaagaga aagatccaaa aaaaagaagc aaaaaagtta
     2581 gcacaagaaa gaatggagga ggacttaaga gaaagtaatc cacccaaaaa tgaagagcag
     2641 aaagaaactg tagacaatgt tcagcgttgt cagttccttg atgacagaat tctacagtgt
     2701 ataaagcagt atgctgacaa gattaaatcc ggcatacaga atacagccat gcttctcaaa
     2761 gaattgcttt cttggaaagt tttgagcaca gaagactata caacctgttt ttctagcaga
     2821 aattttctaa atgaagcagt ggactatgtt attcgccact tgattcaaga aaataacaga
     2881 gtaaagacaa gaatatttct gcatgttttg agtgagctta aagaagtgga gcccaaatta
     2941 gccgcctgga tccaaaaact taatagcttt ggcttagatg ccacaggaac tttcttttct
     3001 cgttatggag catctcttaa actgcttgat tttagtatca tgactttcct ctggaatgag
     3061 aaatatggtc acaaactaga ctctatagaa ggaaagcaac ttgattattt ctctgagcca
     3121 gcatcattga aggaagcccg ttgtttaata tggctgctag aagaacacag agacaagttc
     3181 ccagcattgc atagtgcttt agatgaattc tttgatataa tggacagccg ctgtactgtg
     3241 ttaaggaaac aagatagtgg tgaagcaccg tttagttcaa ccaaggtgaa aaacaaaagc
     3301 aagaaaaaga agccaaagga ttcaaagcct atgttagttg ggtctggaac aacttcagta
     3361 acttcaaata atgagatcat cacttcaagt gaagaccata gcaatcgaaa ttcagattct
     3421 gcaggcccat ttgcagtgcc tgaccatctt cggcaagatg tagaagaatt cgaagctctc
     3481 tatgaccaac acagtaacga atatgttgtc cgcaataaga agctatggga catgaaccca
     3541 aaacaaaaat gttcaactct atatgattac ttctctcagt ttttggagga acatggtccc
     3601 ttggacatga gtaacaagat gttctctgca gaatatgagt ttttcccaga agaaactcga
     3661 cagatactag aaaaagcagg aggtttaaaa ccttttctct tgggatgccc tcgttttgtt
     3721 gtgattgaca actgtattgc actgaagaag gttgcatcac ggctcaagaa aaaaaggaag
     3781 aagaaaaaca ttaaaacaaa agtagaagaa atttcaaaag caggggagta tgtacgagtt
     3841 aaactacaac tgaatccagc tgctagggaa tttaaaccag atgtaaagtc taaaccagtg
     3901 tcagattcat cttcagcacc agcttttgaa aatgtgaaac ccaaacctgt gtctgcaaat
     3961 tctcccaagc cagcttgtga agatgtgaag gccaaaccag tatccgacaa ttcttctaga
     4021 caagtttctg aggatgggca acccaaaggg gtctcttcta attctcctaa accaggctct
     4081 gaggatgcaa attacaagcg agtctcctgt aattccccca aaccggttct tgaggatgtg
     4141 aaaccaactt attgggctca atcccatttg gtcacaggat actgtacgta tcttcctttc
     4201 cagagatttg atatcaccca gacaccgcca gcatacataa acgtgttacc aggtttgccc
     4261 cagtacacca gcatatatac acccttggcc agcctttctc ctgaatatca gctaccaaga
     4321 tcagtaccag tggtgccgtc ttttgtagcc aatgacagag cagataaaaa tgctgctgcc
     4381 tattttgagg gtcatcattt gaatgctgag aatgttgctg gtcaccagat tgcctctgaa
     4441 acacagatcc ttgagggctc tttgggaata tctgtaaagt cacactgcag cacaggtgat
     4501 gctcatacag tcctgagtga gtctaacaga aatgatgagc actgtggaaa ttctaacaac
     4561 aaatgtgaag taattccaga aagcaccagt gcagtaacaa acattccaca cgtgcagatg
     4621 gttgccatac aggtatcttg gaacataata caccaagaag tcaatactga gccatataat
     4681 ccttttgagg aacgacaagg ggaaatttca cggattgaaa aggagcacca agtattacaa
     4741 gaccaacttc aagaagtgta tgaaaattat gagcagataa aacttaaggg cttagaagag
     4801 accagggacc tggaagagaa gttgaaaagg cacttagaag aaaacaagat ctcaaagacg
     4861 gaattagatt ggttccttca agatttggaa agagaaatta aaaaatggca acaggaaaaa
     4921 aaagaaatcc aagaaagact aaaatcactg aagaagaaaa ttaaaaaggt ttcaaatgcc
     4981 agtgaaatgt atacccagaa aaatgatgga aaggaaaagg aacatgaatt acatctggat
     5041 cagtcccttg aaatcagcaa cacacttaca aatgagaaaa tgaaaataga agagtatata
     5101 aagaaaggga aagaggatta tgaagagagt catcagagag ctgtggctgc agaggtatcc
     5161 gtacttgaaa actggaagga gagtgaagtg tataagctac agatcatgga gtcacaagca
     5221 gaagcctttc tgaagaagct ggggctgatt agccgtgatc ctgcagcata tcctgacatg
     5281 gagtctgata tacgttcatg ggaattgttt ctttctaatg ttacaaaaga aattgagaaa
     5341 gcaaagtctc agtttgaaga acaaattaag gcaattaaaa atggttctcg gctcagtgaa
     5401 ctttctaaag tgcagatttc tgagctttca tttcctgcct gtaacacggt tcatcccgag
     5461 ttactccctg agtcttcagg cgacgatggc caagggcttg tgacttctgc aagcgacgtg
     5521 actggaaacc acgcagcact tcacagggat cctagtgtgt tctctgctgg tgattcccca
     5581 ggggaggctc cttctgcgct gttgccaggg ccaccccctg gtcagcctga agccactcag
     5641 ctgacagggc caaaacgggc tggccaggca gctctgtcag aacgaagccc tgtggctgat
     5701 cggaagcagc ctgttcctcc aggacgtgct gcgcgttcaa gccagtctcc aaaaaagccg
     5761 ttcaatagta ttattgagca cctgtcagtg gtattcccat gttacaacag cactgagctt
     5821 gctggtttta ttaaaaaagt gcgaagcaaa aacaagaact cactctcagg attgagtatt
     5881 gatgaaattg tccaaagagt gacagaacac attctagatg aacagaaaaa gaaaaagcca
     5941 aacccaggaa aggacaagag gacttatgag cccagctctg ccacccccgt gaccaggtcc
     6001 tcccagggct caccctcggt ggttgttgca ccatcaccca aaaccaaggg gcagaaagca
     6061 gaagatgtcc ctgtgaggat tgcactgggt gcaagttcct gtgaaatatg ccacgaggtg
     6121 ttcaaatcaa aaaacgtgcg tgtgctcaaa tgtgggcaca agtatcacaa agggtgcttt
     6181 aagcagtggc ttaaagggca gagcgcttgc ccggcctgcc agggtcgtga tctcctgaca
     6241 gaagagtcac cttctggaag aggctggccc agtcagaatc aggagctgcc ttcctgctct
     6301 tctaggtagt cacacttcac taaagtgtca tccaccagtg tgttgaatcc gaagaatgac
     6361 aattttctac cactggtgta aaaaacaaac atttgaagac ccttgtgcat tgtgtgtcac
     6421 aaagctaaat acatggaaat cgttaatatc gctgatatta agtaatttcc ccactctgag
     6481 tgaatacttt gatgattgcc aacagtggct aataaaatga cggctaccac actcatgggt
     6541 cactggggct gcgcagggct ctttgaggtg ggtggcttct tttggaaagt actatgaacg
     6601 tctcgaagca gtattctagt gataagaatt cttaacatag ccaagcgccc cacgtttgtt
     6661 ccccacgttt gttccccttt tctgtttgaa aaacctgttc tggtagctcc acaagagaga
     6721 tgatactgac tttttaaatt ttttacaaga gtctgtattc ctgatatgcc tatatttttc
     6781 ctcaaagatt ctgcatttta aggatgggca taagcaaact atattttaat aatttatagt
     6841 taatgttaaa atattggctg atttagacca aaagattcaa atctcctctt tgtgaaatcc
     6901 catctgcatt tgatttttta ttattttatg ttcccccgtt agattgtttt aagtgtttgc
     6961 ttttcatctt ttatagatgt aatctgattt tcaaaaatca ttaacacttt ttaattagta
     7021 tcgactaaga ctttttcccc ctggaatcga ggctgtgtgt ccgtcatccc agcccccggt
     7081 tggagcctgc tctttgaact ccgctgcctt ccttagcagc ttctgtcctc ttctgtgagt
     7141 cagtcagcga gtgcttggga tccgcatcca gccgtgctga gcacacaaca ggctgtgtgt
     7201 ggaaatggcc accaccattc tccttcccca ccccaccaca aaaagagaag ctgtgtcttt
     7261 agacaaccct gaggtatctg tgttacaatc gttctgtgtt tgatatttgt gtaaagtatg
     7321 catgcagtct tgtactgtga cctaagaaca aaactgtaac tgcattagaa accatgaaaa
     7381 aattagatat tgttttgtga cttttagaca gtggtaaata tagaaccatg aattctggtc
     7441 acattccatt tctctccaac atgaaggatc aaaaaatgtt tttcaatgtg ttctttgttc
     7501 cactggaaac ttagagtcat gagtttatga gctgatttgg tcaccttcct ctgcctttgt
     7561 tcactgtgag ttctgatgtc ttagtgactt agttcttaga agctcacgcc ttagtttgaa
     7621 acagattctc cacggtggtc cccaaaacac tgtctgcata tccataagaa ttgagcgcta
     7681 tgggtgttaa cgtgcatgag gatcagtttg cagcagcaag tacaaaagga gaagaggaac
     7741 atccgttgaa tgagtgtgtt ttgtacataa cttcagatac ttgtgaacat gccttatatt
     7801 tgtccaacaa ctgtcagaat aaagaacatt ctaaaatgag aa
//
