LOCUS       NM_031956               2178 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 29 (TTC29), transcript
            variant 2, mRNA.
ACCESSION   NM_031956
VERSION     NM_031956.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Dacheux,D., Martinez,G., Broster Reix,C.E., Beurois,J., Lores,P.,
            Tounkara,M., Dupuy,J.W., Robinson,D.R., Loeuillet,C., Lambert,E.,
            Wehbe,Z., Escoffier,J., Amiri-Yekta,A., Daneshipour,A.,
            Hosseini,S.H., Zouari,R., Mustapha,S.F.B., Halouani,L., Jiang,X.,
            Shen,Y., Liu,C., Thierry-Mieg,N., Septier,A., Bidart,M., Satre,V.,
            Cazin,C., Kherraf,Z.E., Arnoult,C., Ray,P.F., Toure,A.,
            Bonhivers,M. and Coutton,C.
  TITLE     Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and
            is required for male fertility and flagellum function
  JOURNAL   Elife 12, 87698 (2023)
   PUBMED   37934199
  REMARK    GeneRIF: Novel axonemal protein ZMYND12 interacts with TTC29 and
            DNAH1, and is required for male fertility and flagellum function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Liu,C., He,X., Liu,W., Yang,S., Wang,L., Li,W., Wu,H., Tang,S.,
            Ni,X., Wang,J., Gao,Y., Tian,S., Zhang,L., Cong,J., Zhang,Z.,
            Tan,Q., Zhang,J., Li,H., Zhong,Y., Lv,M., Li,J., Jin,L., Cao,Y. and
            Zhang,F.
  TITLE     Bi-allelic Mutations in TTC29 Cause Male Subfertility with
            Asthenoteratospermia in Humans and Mice
  JOURNAL   Am J Hum Genet 105 (6), 1168-1181 (2019)
   PUBMED   31735294
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Lores,P., Dacheux,D., Kherraf,Z.E., Nsota Mbango,J.F., Coutton,C.,
            Stouvenel,L., Ialy-Radio,C., Amiri-Yekta,A., Whitfield,M.,
            Schmitt,A., Cazin,C., Givelet,M., Ferreux,L., Fourati Ben
            Mustapha,S., Halouani,L., Marrakchi,O., Daneshipour,A., El
            Khouri,E., Do Cruzeiro,M., Favier,M., Guillonneau,F., Chaudhry,M.,
            Sakheli,Z., Wolf,J.P., Patrat,C., Gacon,G., Savinov,S.N.,
            Hosseini,S.H., Robinson,D.R., Zouari,R., Ziyyat,A., Arnoult,C.,
            Dulioust,E., Bonhivers,M., Ray,P.F. and Toure,A.
  TITLE     Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal
            Protein, Result in Asthenozoospermia and Male Infertility
  JOURNAL   Am J Hum Genet 105 (6), 1148-1167 (2019)
   PUBMED   31735292
  REMARK    GeneRIF: Mutations in TTC29 results in Asthenozoospermia and Male
            Infertility.
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: TTC29 expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Chouraki,V., De Bruijn,R.F., Chapuis,J., Bis,J.C., Reitz,C.,
            Schraen,S., Ibrahim-Verbaas,C.A., Grenier-Boley,B., Delay,C.,
            Rogers,R., Demiautte,F., Mounier,A., Fitzpatrick,A.L., Berr,C.,
            Dartigues,J.F., Uitterlinden,A.G., Hofman,A., Breteler,M.,
            Becker,J.T., Lathrop,M., Schupf,N., Alperovitch,A., Mayeux,R., van
            Duijn,C.M., Buee,L., Amouyel,P., Lopez,O.L., Ikram,M.A., Tzourio,C.
            and Lambert,J.C.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     A genome-wide association meta-analysis of plasma Abeta peptides
            concentrations in the elderly
  JOURNAL   Mol Psychiatry 19 (12), 1326-1335 (2014)
   PUBMED   24535457
REFERENCE   6  (bases 1 to 2178)
  AUTHORS   Ohta,M., Ohyama,K., Asano,A., Yokota,S., Khalid,A.M. and Yamano,Y.
  TITLE     Regulation of rat tetratricopeptide repeat domain 29 gene
            expression by follicle-stimulating hormone
  JOURNAL   Biosci Biotechnol Biochem 76 (8), 1540-1543 (2012)
   PUBMED   22878202
REFERENCE   7  (bases 1 to 2178)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB034049.1, BC024193.2, AK093145.1, AF345910.1, BG208860.1 and
            AC093887.3.
            
            On Aug 13, 2020 this sequence version replaced NM_031956.3.
            
            Transcript Variant: This variant (2) differs in its 5' UTR and uses
            a downstream start codon, compared to variant 1. The encoded
            isoform (2) has a shorter N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005602.1, AK301807.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325106.9/ ENSP00000316740.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DB034049.1         19-54
            37-626              BC024193.2         1-590
            627-925             AK093145.1         696-994
            926-926             AF345910.1         899-899
            927-1539            AK093145.1         996-1608
            1540-2053           BG208860.1         1-514
            2054-2178           AC093887.3         172654-172778       c
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.22"
     gene            1..2178
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="tetratricopeptide repeat domain 29"
                     /db_xref="GeneID:83894"
                     /db_xref="HGNC:HGNC:29936"
                     /db_xref="MIM:618735"
     exon            1..156
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            157..203
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            204..301
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1637
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tetratricopeptide repeat protein 29; TPR repeat protein
                     29; testis development protein NYD-SP14; testicular
                     secretory protein Li 62"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 29 isoform 2"
                     /protein_id="NP_114162.2"
                     /db_xref="CCDS:CCDS47141.1"
                     /db_xref="GeneID:83894"
                     /db_xref="HGNC:HGNC:29936"
                     /db_xref="MIM:618735"
                     /translation="MTTLPPLPMTRPKLTALARQKLPCSSRKIPRSQLIKEKDDIDHY
                     LEVNFKGLSKEEVAAYRNSYKKNICVDMLRDGYHKSFTELFALMERWDALREAARVRS
                     LFWLQKPLEEQPDKLDYLYHYLTRAEDAERKESFEDVHNNLYALACYFNNSEDKWVRN
                     HFYERCFKIAQLIKIDCGKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRIWK
                     DETGRSLNLLACESLLRTYRLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEAEA
                     SYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAI
                     KYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKGYYNKASECFQQAFDTTVELMSMPL
                     MDETKVHYGIAKAHQMMLTVNNYIESADLTSLNYLLSWKESRGNIEPDPVTEEFRGST
                     VEAVSQNSERLEELSRFPGDQKNET"
     exon            302..385
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            386..609
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            610..795
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1008
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1094
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1186
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1310
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1539
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1606
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..2178
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1626..1631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="hexamer: AATGAA"
     polyA_site      1665
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="major polyA site"
     regulatory      1725..1730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="hexamer: AATATA"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="hexamer: AATAAA"
     polyA_site      1748
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="major polyA site"
     polyA_site      1768
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="major polyA site"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="hexamer: AATATA"
     polyA_site      1850
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
     regulatory      2150..2155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
                     /note="hexamer: AATAAA"
     polyA_site      2178
                     /gene="TTC29"
                     /gene_synonym="NYD-SP14; SPGF42; TBPP2A"
ORIGIN      
        1 gctctcggcg tcccctgtct ccgctccggc ggagccaggc ttcggaatca ctgagagagg
       61 agggggcagc gccaacgccc agcacctgcc gccggtgggg gactgacttc ggcggaacgg
      121 aaaactggag ttgtttccct gggccagtgc accgaggctg aagtctataa gcctggagag
      181 accatcagca gtaatctgca aattccgaaa tgaccaccct gcccccactg cccatgacac
      241 gcccgaagct tacagcctta gccagacaga agctgccttg ctcctccaga aaaattccaa
      301 ggtctcaatt gatcaaagaa aaagatgaca tagatcatta tctagaggta aatttcaaag
      361 gattatcaaa agaggaagtt gctgcttata ggaactccta caagaagaat atctgtgtgg
      421 acatgctgcg agatggttat cataagtcct tcaccgagct cttcgctctg atggagcggt
      481 gggatgccct gagggaggct gcgagagtca ggtccctctt ctggctgcag aagcccctgg
      541 aggagcagcc tgataaactg gattacctgt accattacct gaccagggct gaggacgctg
      601 agaggaaaga atccttcgaa gatgtacata ataacttgta tgctctggcc tgttacttca
      661 ataattctga agacaagtgg gtaaggaacc acttctatga acgatgtttt aagattgctc
      721 agctgatcaa aattgactgt gggaagaaag aagccgaggc acacatgcat atgggtcttc
      781 tctacgagga agatggtcag cttctggaag ctgctgagca ttatgaagca ttccatcaat
      841 tgacacaggg gcggatatgg aaggatgaga caggccgctc tctcaacttg ttggcctgtg
      901 agagtctcct gaggacttac agattactct cagacaaaat gctagaaaat aaagaataca
      961 aacaggccat caaaattcta ataaaagctt ctgaaatagc caaagaagga agtgacaaaa
     1021 agatggaagc ggaagcctct tactacttgg gcttagcaca cttagctgct gaggaatatg
     1081 aaacagcatt aacagtcctt gacacttact gtaaaatctc cacagacctg gatgatgatc
     1141 tcagtctggg gagaggctat gaagccatag ccaaggtcct gcagagccaa ggagagatga
     1201 cagaagcaat taaatacttg aaaaaatttg tgaaaattgc aagaaacaat tttcaaagcc
     1261 tagatttggt gagagcaagt acaatgcttg gggacatcta caatgaaaaa ggatactaca
     1321 acaaagcttc tgaatgcttt cagcaagctt ttgacacaac agtagagcta atgagcatgc
     1381 ctctgatgga tgagacaaaa gttcactatg gaatagcaaa agctcatcag atgatgctta
     1441 cagtgaacaa ctatatagag tctgcagatc tcaccagcct caactacctg ctgtcatgga
     1501 aggagagcag aggtaacatt gaacctgatc cagttactga agagtttaga ggatccacag
     1561 tggaagctgt atctcaaaac tcagaacgtt tggaagaact cagtaggttt ccaggtgatc
     1621 aaaaaaatga aacttaaagc agcttttcac ttaacatcaa agcaagaaga aatccatcat
     1681 gtcaccttag acttcaatac ttgtaatagg agcatgttac agataatata gagttataat
     1741 aaaacggact atgactcttt tcattggatt ttgcatttca gtgtgttact ataaatttaa
     1801 tccaaaacat ctaaatccat gaaaataaaa tatattccaa ttcttagaaa tatcagcaat
     1861 catccatgaa ataaatgatt tcctcttatc cactattcca caagaaatag tgataccatg
     1921 aaaccaaaat aagaaaatat tttctaatga gaaaataatt acaagcttaa gaaaatcttt
     1981 catgctgaat tcatgtagga aaatatttgc taaaactcta gggaaacttc tcaacataga
     2041 taaaaggagt ataagcaatt aagcctacca tactgataag tcttgtttga aacagttttc
     2101 tttacctgtg taacagtata ttttatgata cttttagctg atagcacata ataaaactta
     2161 tccatgtcaa cttaaaaa
//
