LOCUS       NM_001145418           11770 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 28 (TTC28), transcript
            variant 1, mRNA.
ACCESSION   NM_001145418 XM_929318
VERSION     NM_001145418.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11770)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   2  (bases 1 to 11770)
  AUTHORS   Izumiyama,T., Minoshima,S., Yoshida,T. and Shimizu,N.
  TITLE     A novel big protein TPRBK possessing 25 units of TPR motif is
            essential for the progress of mitosis and cytokinesis
  JOURNAL   Gene 511 (2), 202-217 (2012)
   PUBMED   23036704
  REMARK    GeneRIF: observations indicated that a novel big protein TPRBK is
            essential for the formation and integrity of the midbody, hence we
            postulated that TPRBK plays a critical role in the progress of
            mitosis and cytokinesis during mammalian cell cycle
REFERENCE   3  (bases 1 to 11770)
  AUTHORS   Wang,K., Li,W.D., Zhang,C.K., Wang,Z., Glessner,J.T., Grant,S.F.,
            Zhao,H., Hakonarson,H. and Price,R.A.
  TITLE     A genome-wide association study on obesity and obesity-related
            traits
  JOURNAL   PLoS One 6 (4), e18939 (2011)
   PUBMED   21552555
  REMARK    Erratum:[PLoS One. 2012;7(2). doi:
            10.1371/annotation/a34ee94e-3e6a-48bd-a19e-398a4bb88580]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11770)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121825.19, AL023281.1, AL035397.4, AL050313.6, AL035453.4 and
            AL033538.1.
            
            On Feb 9, 2021 this sequence version replaced NM_001145418.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB665284.1, SRR14038192.2713350.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397906.7/ ENSP00000381003.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AL121825.19        88018-88236         c
            220-498             AL121825.19        37948-38226         c
            499-646             AL023281.1         96000-96147         c
            647-919             AL023281.1         87084-87356         c
            920-1050            AL023281.1         85702-85832         c
            1051-1558           AL035397.4         30093-30600         c
            1559-2601           AL050313.6         101-1143            c
            2602-2900           AL035453.4         31606-31904         c
            2901-3424           AL035453.4         29823-30346         c
            3425-3534           AL035453.4         25715-25824         c
            3535-3664           AL035453.4         23459-23588         c
            3665-3883           AL035453.4         20734-20952         c
            3884-4049           AL035453.4         18624-18789         c
            4050-4190           AL033538.1         69270-69410         c
            4191-4335           AL033538.1         53292-53436         c
            4336-4515           AL033538.1         40418-40597         c
            4516-5236           AL033538.1         37584-38304         c
            5237-5361           AL033538.1         35179-35303         c
            5362-5593           AL033538.1         32331-32562         c
            5594-5670           AL033538.1         31631-31707         c
            5671-5694           AL033538.1         29833-29856         c
            5695-5824           AL033538.1         28922-29051         c
            5825-5932           AL033538.1         24293-24400         c
            5933-11770          AL033538.1         17058-22895         c
FEATURES             Location/Qualifiers
     source          1..11770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..11770
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="tetratricopeptide repeat domain 28"
                     /db_xref="GeneID:23331"
                     /db_xref="HGNC:HGNC:29179"
                     /db_xref="MIM:615098"
     exon            1..219
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..7563
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 28; TPR repeat protein
                     28; TPR-containing big gene cloned at Keio; TPR
                     repeat-containing big gene cloned at Keio"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 28 isoform 1"
                     /protein_id="NP_001138890.1"
                     /db_xref="CCDS:CCDS46678.1"
                     /db_xref="GeneID:23331"
                     /db_xref="HGNC:HGNC:29179"
                     /db_xref="MIM:615098"
                     /translation="MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIG
                     QRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAY
                     MKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSL
                     QLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVV
                     LEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRA
                     HGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNAL
                     ASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKRE
                     EARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDL
                     ERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELS
                     DYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQA
                     LGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLA
                     PDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGL
                     AFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQ
                     LGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHG
                     HLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGY
                     FEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQ
                     DQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGN
                     YEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEET
                     NNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHH
                     ALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASAL
                     FETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLL
                     VERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHE
                     HYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETES
                     EAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGT
                     SSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFAL
                     LKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSA
                     VMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWK
                     LSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAAD
                     VLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMF
                     IHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQ
                     ALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQAL
                     LTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITAS
                     ETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLA
                     ALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESL
                     ASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGG
                     PGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENR
                     NTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSD
                     TGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKS
                     NNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSG
                     YSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNM
                     SPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFW
                     QSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHD
                     GAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLRLPSGNGYKFLSPGRFFPSSK
                     C"
     exon            220..498
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            499..646
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            647..919
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1050
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1558
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..2900
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3424
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3534
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3664
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3883
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..4049
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            4050..4190
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4335
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            4336..4515
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..5236
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            5237..5361
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            5362..5593
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            5594..5670
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            5671..5694
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            5695..5824
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            5825..5932
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     exon            5933..11770
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11743..11748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="hexamer: ATTAAA"
     polyA_site      11770
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="major polyA site"
ORIGIN      
        1 agtgaggggc gccgcggcgg cgcgcagcac ggcgggaaca tggcgcgcgg aaccggcgcg
       61 cgcgcctagc tggcgggacc gttagctcga ggcggacgcg gcccgggccc cgtggggatg
      121 gagcagtcgc cgccgccggc gcccgagccg acccaagggc cgacccccgc aaggagccga
      181 aggcggcggg agccagagtc gccgccggcg tcggcgccga ttcctctctt tggtgctgac
      241 actattggcc agagaagtcc tgatggaccg gtactgagca aagctgaatt tgttgagaaa
      301 gttcgtcaga gtaatcaggc ctgtcatgat ggagatttcc acacagctat tgttctgtat
      361 aatgaagccc tggctgttga ccctcagaac tgcatcttat acagcaatag atctgcagcc
      421 tacatgaaaa tccagcagta tgacaaggca ctggatgatg caatcaaagc tcgacttctc
      481 aatcccaagt ggccaaaggc atacttccga cagggtgttg ccctccagta ccttggacgt
      541 catgccgatg ccctggcagc ctttgcatct ggactggctc aagaccccaa gagtctccag
      601 cttctggtgg ggatggtgga agccgccatg aaatctccca tgagagactc cctcgagccc
      661 acttatcagc agcttcagaa aatgaaactg gacaagagtc cctttgtggt cgtgtctgtg
      721 gttgggcagg aactcctgac agctggccat catggggcct ctgtggttgt cttagaagcc
      781 gcactgaaga ttggcacctg cagcctcaaa ctgagaggtt ctgttttctc tgccctgagc
      841 agtgcttact ggtctcttgg aaatacagag aagagcaccg gatatatgca gcaggacttg
      901 gatgtagcca agaccttagg tgaccagaca ggagaatgcc gagctcatgg gaatctgggc
      961 tctgcattct tctccaaagg aaattaccgg gaggctctca ctaaccacag gcatcagttg
     1021 gtactcgcca tgaaactcaa agatcgagag gcagcttcat cagccttgag cagtctgggc
     1081 cacgtgtaca cagccattgg agactacccc aatgcactgg ccagtcacaa acagtgtgtt
     1141 cttcttgcca agcaatccaa agatgaactt tctgaagccc gagaacttgg caacatggga
     1201 gctgtgtata ttgccatggg tgactttgag aatgctgtgc agtgccatga gcagcatctg
     1261 aagatagcca aggacctggg gaacaagcga gaagaggccc gggcttatag caacctgggc
     1321 agtgcctatc actaccggag gaactttgac aaggccatgt cttaccataa ctatgtcctg
     1381 gagctggcac aggagttgat ggagaaggct attgagatgc gggcctatgc tggactaggc
     1441 catgctgcca ggtgcatgca ggatttggag agagctaaac aataccatga gcagcagctg
     1501 ggcattgctg aggatctcaa ggaccgggct gcagaggggc gagcatcctc caatctagga
     1561 atcatacacc agatgaaagg tgattatgac actgcactga aactccacaa gacccacctg
     1621 tgcattgccc aggagctgag tgattatgct gcccagggcc gtgcctatgg gaatatgggc
     1681 aatgcctaca atgccctggg catgtacgac caggcggtca aataccatcg gcaggagctg
     1741 cagatctcca tggaagtgaa tgaccgcgcc tcacaggcct ccacacatgg gaaccttgcc
     1801 gtggcctacc aggccctggg tgcccatgac cgggccctgc aacactatca gaaccacttg
     1861 aacatcgccc gggagctacg agacatccag agcgaggccc gggccctcag caacctgggc
     1921 aatttccact gctctcgggg agagtatgtc caggctgccc cctattatga acagtacctc
     1981 cggcttgctc ccgaccttca agacatggaa ggagaaggga aggtctgcca caatcttggc
     2041 tatgcccatt actgccttgg aaactatcag gaggcagtga agtactacga acaggatctg
     2101 gcactggcta aagaccttca cgacaagttg agccaagcaa aagcctactg caacttgggc
     2161 ctagcattca aggctctgct gaatttcagt aaagctgaag agtgtcagaa gtacctactg
     2221 tccctagccc agtctctgaa taattcccag gctaaatttc gagccctagg aaacctgggc
     2281 gatatattca tctgtaaaaa agatataaat ggtgcaataa aattctatga gcagcaactg
     2341 ggcttagctc accaggtaaa ggacagaaga ttagaagcca gtgcatatgc agccctgggc
     2401 actgcatacc gaatgatcca gaagtatgac aaggccctgg gttatcacac acaggaactg
     2461 gaggtatatc aggagctgag tgacttgcca ggggagtgca gagctcatgg gcacctggct
     2521 gctgtctaca tggcccttgg gaaatacaca atggcattca agtgttatga agagcaactg
     2581 gatctagggc aaaagctgaa ggatccgagt ctggaagccc aggtctatgg caacatgggc
     2641 atcacaaaga tgaacatgaa tgtgatggaa gaagccattg gctactttga gcagcaattg
     2701 gccatgctgc agcagctaag tggaaatgag tctgtgctcg acaggggccg ggcctatggc
     2761 aacctggggg attgctacga agccctgggt gactatgagg aagctatcaa atactatgaa
     2821 caatatttat ctgtcgcgca gagtctgaat cgcatgcaag accaagccaa ggcttaccgg
     2881 ggcctgggaa atggacacag ggcaatgggg agcttgcagc aagcccttgt gtgctttgaa
     2941 aagaggctcg tggttgctca tgaacttgga gaggccttca ataaagccca ggcctatgga
     3001 gagctgggaa gtctgcacag ccaattaggg aattacgaac aagccatttc ctgccttgaa
     3061 cgccagctga acattgctag agatatgaaa gaccgagccc tggagagtga cgcagcctgt
     3121 ggcctggggg gcgtttacca gcagatgggg gagtatgaca cagccctgca gtaccaccag
     3181 cttgatctac agatagcaga ggaaaccaac aaccccacgt gccagggccg agcctatggg
     3241 aacctgggcc tgacttatga atccctgggc accttcgaga gggctgtggt ctatcaagaa
     3301 cagcacttga gcattgctgc acagatgaat gacttggcgg ccaagacggt gtcatatagt
     3361 agccttggaa ggacccatca tgccttgcag aactattccc aagcagtcat gtacttacag
     3421 gaaggtttaa ggttagctga gcaactgggc cgaagagaag atgaggcaaa aattcgccat
     3481 ggccttggcc tctccctttg ggctagtgga aacttggagg aggcccaaca ccagctttat
     3541 agggcatcag ccttgtttga aacaatccga catgaggcac agctgagcac ggactacaaa
     3601 ctctccctct ttgacctgca gacatcatcc taccaggcct tgcagcgggt gctcgtcagc
     3661 ctaggccatc atgatgaagc cctggctgtg gcagaaaggg gacggacaag ggcatttgct
     3721 gatcttctgg tggaacgaca aacaggacaa caagactccg acccctactc cccagtcact
     3781 attgatcaga tcttagagat ggtaaatggc cagaggggac tagtgcttta ctattccctg
     3841 gctgcaggct atctgtatag ctggctgctg gctcctgggg caggaattgt gaagtttcat
     3901 gaacactacc tgggtgagaa cacagtggaa aactcaagtg acttccaggc cagcagcagt
     3961 gtaacccttc caacagcaac cggctcagcc ctggagcagc acattgccag tgtccgggag
     4021 gccctggggg tggagtctca ctactcaagg gcctgtgcca gcagtgagac agagagtgaa
     4081 gcgggagaca tcatggacca gcaatttgaa gagatgaaca acaaactcaa ctcggtcact
     4141 gaccccactg gctttctgcg gatggttcgc cgcaataacc tgtttaacag gagctgccag
     4201 agcatgacga gcctgttcag taacactgtg tcaccgaccc aggacgggac ctcctctctt
     4261 cccaggaggc agagctcgtt tgccaagccc ccgctccgtg ccctgtatga cctgctcatc
     4321 gcgcccatgg aagggggcct gatgcactcc agcggccccg tgggccggca ccggcagctc
     4381 atcctggttc tggaggggga gctctacctc attcctttcg ccctcctgaa gggaagctcc
     4441 tccaatgagt acctctacga gcgcttcggc ctccttgctg tcccttccat ccgctccctc
     4501 agcgtgcagt ccaagtctca cttacggaag aacccgccca catactccag ctccacatcc
     4561 atggcggctg tcatcggcaa ccccaagcta ccatcggccg tgatggacag gtggctgtgg
     4621 gggcccatgc catcggccga ggaagaggcc tacatggtgt ccgagctgct gggctgccag
     4681 cccctagtgg gcagtgtggc caccaaggag agggtcatga gtgccctgac ccaggctgaa
     4741 tgcgtccact ttgccaccca catctcctgg aagctgtcgg ccttggtcct cacgcccagc
     4801 atggacggca accctgccag cagcaagagc tccttcggcc acccctacac gatccctgag
     4861 tccttgcggg tgcaggacga tgccagtgat ggggagagca tctcggactg cccgcccctg
     4921 caggagctgc tgcttactgc cgccgacgtc ctggacctgc agctgcctgt gaagctggtg
     4981 gtgcttggct cctcccagga gtccaacagc aaagtcacag ccgacggggt catcgcgctg
     5041 acaagggcct tcctggctgc cggcgctcag tgtgtcctcg tgtctctgtg gcctgtgcca
     5101 gtggctgctt ctaagatgtt catccatgcc ttctactcat ccctgctgaa cggcctgaaa
     5161 gccagcgccg ccctggggga ggccatgaag gtggtgcaga gcagcaaggc cttctcgcac
     5221 ccctccaact gggcagggtt catgctcatc gggagtgacg ttaagctgaa cagcccctca
     5281 tcactcatcg gccaggccct cacagagatc ctgcagcacc cggagcgtgc gcgggacgcc
     5341 ctgcgagtgc tgctgcacct ggtggagaaa tccctgcagc gcatccagaa tgggcagcgc
     5401 aatgccatgt acacatccca gcagagtgtg gagaacaaag tgggcggcat ccctggctgg
     5461 caggccctcc tcaccgctgt gggcttccgg ctggaccccc caaccagtgg cctgccagcg
     5521 gctgtcttct tcccaacctc cgacccgggc gaccggctcc agcagtgcag cagcacactc
     5581 cagtccctgc tgggtctgcc caatcctgcc ctccaagccc tttgcaaact catcactgcc
     5641 tccgagacgg gcgagcagct catcagccgg gctgttaaaa atatggttgg aatgctccac
     5701 caggtgctgg ttcagctcca ggctggcgag aaggagcagg acttggcatc agctcccatt
     5761 caggtctcca tcagcgtcca gctgtggcgg ctcccgggat gccacgagtt cctggcagct
     5821 ctaggttttg atctctgtga agttggtcag gaggaagtaa tcctgaaaac cgggaagcaa
     5881 gctaatcgac ggactgtgca cttcgcgctc cagtccctgc tgtctctgtt tgattctact
     5941 gagctaccca agcgcctcag ccttgacagc tcctcctccc tcgagtctct tgcttctgct
     6001 cagtctgttt ccaacgccct gcccttgggt taccagcaac cccccttctc tcccaccggt
     6061 gcggacagca tcgcctcaga tgccatctct gtgtacagtc tgagctccat tgcctcctca
     6121 atgagctttg tctccaaacc cgagggtgga tcagagggtg gaggccccgg aggacggcag
     6181 gaccatgacc ggtccaagaa cgcttacctg cagagatcca ccctgcctag gagccagctg
     6241 cctccccaga cccgccctgc aggcaacaaa gatgaagaag aatatgaagg gttttctatc
     6301 atcagtaacg agcccttggc gacctaccaa gaaaaccgaa acacatgctt ctcaccagac
     6361 cacaaacaac cccaacctgg gacagccgga ggcatgagag tctcggtgag ctccaaaggg
     6421 agcatcagca ctccaaattc tccagtgaaa atgactctga ttcccagccc caactcaccc
     6481 ttccaaaagg tgggaaaact agcaagctca gatacaggag aatcagacca gtctagcaca
     6541 gaaacggaca gtaccgtgaa atcccaagaa gaaagcaacc caaaactgga tccacaagag
     6601 ttagcccaga aaattctgga ggagacacag agtcatctca ttgcggtgga gcgtcttcag
     6661 aggagcggcg gccaggtgag caagagtaat aaccctgaag acggcgttca ggcgcccagc
     6721 agcactgctg tcttcagagc gtcagaaacc agtgcgttca gcaggcctgt tctctcccat
     6781 cagaagagtc agccatcacc agtcactgtt aaaccaaagc ccccagccag gagctcctcc
     6841 ctgcccaagg tgagttccgg atatagcagc cccaccacct cagagatgtc catcaaagac
     6901 agcccgagcc agcacagtgg ccggccatcg cccggctgcg actcacagac ttcccagctg
     6961 gaccagcctc tctttaaact gaagtacccc agctctcctt acagcgctca catttccaaa
     7021 tcaccaagga acatgtcccc aagctccggc caccagtctc ctgctggcag tgcaccctcc
     7081 ccagctctct cctactcctc agctggatct gctcgctcaa gtccagcaga cgctcccgac
     7141 atagacaaac tgaaaatggc agccattgat gaaaaggtgc aggctgtcca taacctgaag
     7201 atgttctggc agagcacacc ccagcattcc acagggccaa tgaagatctt ccggggggct
     7261 cctggcacga tgacttccaa aagggatgtc ctcagtctgt tgaatttgtc accacggcac
     7321 aataagaagg aggagggagt ggataagctt gaactgaagg agctgtccct gcagcagcat
     7381 gacggagctc caccgaaagc ccctcccaac ggacactggc gcaccgagac cacctcgctg
     7441 ggctcactgc cgctgcccgc cggccctccc gccacagccc ccgcgcgccc tttgaggctt
     7501 ccttctggaa atggctacaa gttcctgtct ccaggaagat ttttcccttc ttccaaatgc
     7561 taaagcatct tttataccca ctgactctga gcagcctgca gatgggggcc tggcgtttgc
     7621 ttcagccctt ccctgagtgc agtcccccca cagccaccag caccctcatg atgctgtgct
     7681 ctgcaggcga ggggcaccac cacgtccaaa ggctgccaca cacactggtg gcttttctgg
     7741 gccacattca ccaaaagcca ggacttctgt ggggctggta caggaggctc atggaatttc
     7801 ctacacactt caccaaatgt ttgtttacct ttgaactccc tgcttctcat ctttgatatg
     7861 attcttcacc aggattttgt acaaaaatga tcatggttct ggggtgggga gaggaaaggg
     7921 agcacatatt ttgctaagag gtatatatgc agtacctttt atacacagaa atacaaatag
     7981 agctttttct aaggctttcg gttgctggtt gggggtggga tatatgaaat ttcagttgaa
     8041 ttctacagga aagtgttata ttagccaaaa acagaaaaat ggtttttaaa atgccaatga
     8101 tttgtaatta aattgtagca attttggtct catgatagtg taatatctca gcaacaatgc
     8161 aataattcac attgaaacag cgcttccatt ctgaactctg ctctgcaaat gtcttttggg
     8221 tcccgctgtc aaccaaactt gaattttctt aaaaaaaaaa ttatgtaact cttatccagg
     8281 cattttagaa ctatgcaatt gtgatttaaa atgcaacttt gtgcttttaa aacattattg
     8341 accttttttg tatatggata aacaacttgg ttttattatc aatagtactt tgcatttata
     8401 gctattattt ttaaaagctc aaaaagtttt ttaaaatgtc aaattttgaa tagtcatcaa
     8461 taagtaatta tcaagtttgg aaggaaaggt tgaaatgact ccgtttcctt ataagcaaaa
     8521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaatttccat ggctaactag atttaaccag
     8581 aatcccgcct tccaggctcc tgttcccttt tattagctgc tgaattttat tcccttttcc
     8641 caactccagg tccctcagtt gtcttatatc taaatccttt gccaggtccc cacaatccca
     8701 gcacctgcct ctgtgagctg cccccaggcc ctcaccttgg ccctggccag cctcctgtgc
     8761 tcctgctgtc tgaaggactg gcccctcccc cactgctgaa gccacacgta cagatcctaa
     8821 gcaacagggc cttttgctgg gacgtatgcc tggattatgg ccaaccggga agagagagat
     8881 gtatcttaaa aagtggaggt ggacttctcc tacagctctg acggtaactt aaattgttgc
     8941 cagcttgagg caagacaagg gaatcatcta gttaggggta accattaatt tattttataa
     9001 agaaaggaaa tgctgaaagt cgtattagta ctgagtttag ttggagaatt tagataagta
     9061 agtatctttt aggtaattct aaaattaaaa tcctacccac ctcactacag ggttcctcat
     9121 gaaggtgggc ggccacctgg cctgggccac cagcagcaca tggagcagac ctgaggggcc
     9181 tggcaggggg cactgacctc aggatcccca ggtgggggtt ttaaccatgg gtgggatctc
     9241 agcttctgcg catacactga caatctcacc tgttcctcag tgtactcctc tgaaaagaag
     9301 aaaggataat atttatccaa tctgtgttct cctgagctcc atcctagggg tttttaattt
     9361 aaccaacagc catgttgaca aaagccaaca ataagcatgt cttattctag ccctgatccc
     9421 aacactgaaa gcgaagtact ttataaagaa gccagcaatt atgagggttt ctttatgtta
     9481 gtaggggaaa aaatggtaat aaaagtacca gtgtagcaag tgaagaccaa atttatagca
     9541 ctgtgcatta gatagcaaaa tcaggttctt aacaatgaaa agtaaacctc aagtttctaa
     9601 atccatatgc agatggttag gctgtccctc tcttagcaaa tctctcagcc tccttctttc
     9661 ccaagtgcca aggatccctg gagtaaagct ctggggtctg tgctctcttt ctgtgagggg
     9721 aaggctgcgg ccctatttgc ccctctctag caaacacccc caccaccctg ccgcttcctg
     9781 tggttattga gccagctagg agttactcat ggactctaac ctggttttag tcccatgtac
     9841 atcgttgttt taggtttcat actgaagagc caatggttta tgtggtttta ttctgtctta
     9901 aatataagtt tcaaggaagg gaaaacaaaa gtgataaaat gatagaacag tctagaggcc
     9961 actgtaaagt caccgccact ttacgtgtat gtcagtcttg gtgttcttgt atgagtaaaa
    10021 tggatgtaaa atcataaaat cacagtgaat gtttcaggct acactggaaa aagtatgcac
    10081 ttagaattaa aggaaattgt ataattcacc aagatttctt tgtgtagatc aggggttggc
    10141 aactatgacc cacaggctaa gactggtcag cggtctggtt tttcacagcc atgagctaag
    10201 ttaccttttt aaagggttat ataagtaatt acatcatatt tttgattttg cctttggccc
    10261 acaccacata aaatattcaa tacctggcct tttttttttt ttttgagaca gagtctcgct
    10321 ctgtcaccca ggatagagtg cactggtgcg attttggctc actgcaacct cttcctcctg
    10381 ggttcaagca attctccctg cctcagcctc taagtagctg ggactacagg cacccactac
    10441 catgccttgc taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct
    10501 ggtctcgaac tcctgacctc aggggatccg cccgccttgg cctcccaaac tgctgggatt
    10561 acaggtgagc cactgcgccc agccaatacc tggcctttta agaagtttgc tgactcctgg
    10621 tatggatgac agaaaatgga ataacgtttt gtttctccag tctaggaaaa gcaagtcagg
    10681 tagtggatag actgactggc gtccggggag cccagggtat gtgagggcca cgtggatgga
    10741 agcaaatgcc tcctgcatag cccttggctc tttgtcccac ttgggaggag tccatggatg
    10801 taatatttac aaaacaattt tttccttacc atttgcagaa agcattgcat atatttcctt
    10861 ttagctcagg aaactggcat gccccaccct ctgctactcc atcagatgta aatacaatga
    10921 ctataagccg tacaactccc ctctcttaga aacctcagca ggaccacaga gcaagggagt
    10981 caaagctttc ttaattctct ccagtaaatg actcaactaa tttgattttt ttaattaagt
    11041 caaaatatca agagaaaaat tgctactaaa acttacattt tgatccacac tgatgtgcaa
    11101 cacaaaatga aagttttcac ctccattcca ttttttaaaa attcacggtc cacactgaaa
    11161 cttgctgggt tttagcagga gacaaaggtg tcacccacgc tgtcctcatc ctgctctctc
    11221 tgtcccagtg acgctccagc atatgatcac tgcagccggt ccctggcccg tgccgattct
    11281 gccacctccc agccacacac atttgcagac ccacaagaag aactgtagcc ttgataattt
    11341 cagttcaggc tggaaaaatg ccatgcaata atctggtttg ctttcagtaa gtaggcaaca
    11401 agtgaaaact gtataatttt catcacctat tctgctgttc tatctaaaat gagtgtacct
    11461 gtggtttgtg aactgggccc ttgtttgtgc cagatccttc aaagatgttc cctgtcagga
    11521 cacctgtggc cctgcccctc ctcagacacc ttcccactgg cattcacgtt ccttatatgc
    11581 agtgttagcc atctttggcc tacgtggact ttttttgtaa attacaccat ttccagacat
    11641 taaacttttt atattatgaa atttaccatg taaaaagaac ttcatatttt tattgagatt
    11701 gctaaggcac ttggccttcc tcctttgtga ttttcagtgt ctattaaagc atgagttccc
    11761 tcagttttaa
//
