LOCUS       NM_017735               2888 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 27 (TTC27), transcript
            variant 1, mRNA.
ACCESSION   NM_017735
VERSION     NM_017735.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Tomkins,J.E., Dihanich,S., Beilina,A., Ferrari,R., Ilacqua,N.,
            Cookson,M.R., Lewis,P.A. and Manzoni,C.
  TITLE     Comparative Protein Interaction Network Analysis Identifies Shared
            and Distinct Functions for the Human ROCO Proteins
  JOURNAL   Proteomics 18 (10), e1700444 (2018)
   PUBMED   29513927
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Melville,S.A., Buros,J., Parrado,A.R., Vardarajan,B., Logue,M.W.,
            Shen,L., Risacher,S.L., Kim,S., Jun,G., DeCarli,C., Lunetta,K.L.,
            Baldwin,C.T., Saykin,A.J. and Farrer,L.A.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Multiple loci influencing hippocampal degeneration identified by
            genome scan
  JOURNAL   Ann Neurol 72 (1), 65-75 (2012)
   PUBMED   22745009
REFERENCE   4  (bases 1 to 2888)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133246.3 and AL121656.2.
            
            On Nov 23, 2018 this sequence version replaced NM_017735.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063791.1, SRR1803611.59378.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317907.9/ ENSP00000313953.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               AL133246.3         54391-54721
            332-509             AL133246.3         56864-57041
            510-639             AL133246.3         60217-60346
            640-780             AL133246.3         66611-66751
            781-883             AL133246.3         76472-76574
            884-1048            AL133246.3         90644-90808
            1049-1182           AL133246.3         92976-93109
            1183-1295           AL133246.3         98613-98725
            1296-1362           AL133246.3         105197-105263
            1363-1476           AL133246.3         129148-129261
            1477-1572           AL133246.3         160169-160264
            1573-1695           AL133246.3         163035-163157
            1696-1923           AL133246.3         184633-184860
            1924-2022           AL133246.3         204223-204321
            2023-2075           AL121656.2         3815-3867
            2076-2241           AL121656.2         8173-8338
            2242-2439           AL121656.2         32213-32410
            2440-2551           AL121656.2         33693-33804
            2552-2652           AL121656.2         38646-38746
            2653-2888           AL121656.2         42005-42240
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..2888
                     /gene="TTC27"
                     /note="tetratricopeptide repeat domain 27"
                     /db_xref="GeneID:55622"
                     /db_xref="HGNC:HGNC:25986"
     exon            1..331
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2775
                     /gene="TTC27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 27; TPR repeat protein
                     27"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 27 isoform 1"
                     /protein_id="NP_060205.3"
                     /db_xref="CCDS:CCDS33176.1"
                     /db_xref="GeneID:55622"
                     /db_xref="HGNC:HGNC:25986"
                     /translation="MWTPELAILRGFPTEAERQQWKQEGVVGSESGSFLQLLLEGNYE
                     AIFLNSMTQNIFNSTTTAEEKIDSYLEKQVVTFLDYSTDLDTTERQQLIFLLGVSSLQ
                     LFVQSNWTGPPVDLHPQDFLSSVLFQQFSEVKGLDAFVLSLLTLDGESIYSLTSKPIL
                     LLLARIILVNVRHKLTAIQSLPWWTLRCVNIHQHLLEERSPLLFTLAENCIDQVMKLQ
                     NLFVDDSGRYLAIQFHLECAYVFLYYYEYRKAKDQLDIAKDISQLQIDLTGALGKRTR
                     FQENYVAQLILDVRREGDVLSNCEFTPAPTPQEHLTKNLELNDDTILNDIKLADCEQF
                     QMPDLCAEEIAIILGICTNFQKNNPVHTLTEVELLAFTSCLLSQPKFWAIQTSALILR
                     TKLEKGSTRRVERAMRQTQALADQFEDKTTSVLERLKIFYCCQVPPHWAIQRQLASLL
                     FELGCTSSALQIFEKLEMWEDVVICYERAGQHGKAEEILRQELEKKETPSLYCLLGDV
                     LGDHSCYDKAWELSRYRSARAQRSKALLHLRNKEFQECVECFERSVKINPMQLGVWFS
                     LGCAYLALEDYQGSAKAFQRCVTLEPDNAEAWNNLSTSYIRLKQKVKAFRTLQEALKC
                     NYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKYKDVQVLKILVRAVIDGMTDR
                     SGDVATGLKGKLQELFGRVTSRVTNDGEIWRLYAHVYGNGQSEKPDENEKAFQCLSKA
                     YKCDTQSNCWEKDITSFKEVVQRALGLAHVAIKCSKNKSSSQEAVQMLSSVRLNLRGL
                     LSKAKQLFTDVATGEMSRELADDITAMDTLVTELQDLSNQFRNQY"
     exon            332..509
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            510..639
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            640..780
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            781..883
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1048
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1182
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1295
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1362
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1476
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1572
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1695
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1923
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2022
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2075
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2241
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2439
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2551
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2652
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2888
                     /gene="TTC27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2866..2871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC27"
                     /note="hexamer: AATAAA"
     polyA_site      2888
                     /gene="TTC27"
                     /note="major polyA site"
ORIGIN      
        1 cttctcctag gcggaagcca gaccagagag cgtgcgtgtt tttcccaggg tgccccgcgc
       61 tgctgttatg gccgcctcct tgaggtagta tccgcacatg gaattctagg gccgcaggtg
      121 tatttacggt aactgtcgcc actagatttc agcgcctttg gactctcctg ttttcacttt
      181 cttttgttga ctcccgtgtg gccctcgtgg gagcctgttt tggctgcagc ggtgtctggg
      241 gtgatgtgga ccccggagct ggcaattctg aggggattcc ccactgaggc tgagcggcag
      301 caatggaaac aggagggggt cgtcggttca gagagtggat ctttcctaca attgctactg
      361 gaagggaact atgaagccat attcttaaat tcaatgactc aaaatatttt taattcaaca
      421 acaaccgctg aagaaaagat tgatagctac ctggagaagc aggtagtaac attcctggat
      481 tactcaacag atttggacac aacggaaaga caacagttga tatttctact tggtgtgagc
      541 agtttgcaac tttttgttca gagcaactgg acggggcccc ctgttgactt acaccctcag
      601 gactttttgt catctgtttt gttccagcaa ttcagtgagg ttaaaggact ggatgcattt
      661 gttctgagcc tgctcactct agatggtgaa tcaatctaca gcctgacctc gaagcctata
      721 ctactgttat tagcacgcat tatcctagtg aatgtaagac ataaactgac agctattcag
      781 agcttgccat ggtggacttt gagatgtgtg aatattcatc agcatttgct tgaggaacgc
      841 tcacctctgc tttttactct tgccgaaaac tgtattgatc aagtgatgaa actacagaat
      901 ctgtttgtag atgattcagg tcgatatttg gctattcaat tccatctgga atgtgcatat
      961 gtgtttttat attattatga gtacagaaaa gcaaaagatc agttggatat tgctaaggac
     1021 atcagccaat tacaaattga tttgacaggt gctttgggaa aaagaacacg gttccaggaa
     1081 aattatgtgg cacaactgat tctagatgta agaagggaag gggatgtcct ttcaaattgt
     1141 gaattcactc cagcacccac tcctcaggaa catttaacca agaatcttga gctcaatgat
     1201 gacaccattc tgaatgacat aaagttagca gattgtgaac agttccagat gccggatctg
     1261 tgtgctgaag agatcgctat tattcttgga atctgcacta attttcaaaa gaataaccca
     1321 gtgcacacat taactgaagt ggagcttctg gcatttacat catgtttgct ttcacaacca
     1381 aagttctggg ccattcagac atcagccttg atcctccgga caaaacttga gaaaggaagt
     1441 actcgccgag tggaacgggc aatgaggcag acacaggctc ttgcagacca atttgaagat
     1501 aaaactacat ctgtattgga acgcctgaag attttctatt gctgtcaagt accacctcac
     1561 tgggccattc agcgccaact tgcaagtttg ctctttgagt tgggatgtac cagttcagcc
     1621 cttcagatat ttgaaaagct agaaatgtgg gaagatgttg tcatttgtta tgaaagagcc
     1681 gggcagcacg gaaaggcaga agaaatcctt agacaagagc tggagaaaaa agaaacgcct
     1741 agtttatact gcttgcttgg agatgtcctc ggagaccatt cttgctatga caaggcctgg
     1801 gagttgtccc ggtaccgcag tgctcgtgct cagcgctcca aagccctcct tcatcttcgg
     1861 aacaaggagt ttcaagagtg tgtagagtgc ttcgaacgct cggttaagat taatcccatg
     1921 cagctcgggg tgtggttttc tctcggttgt gcctatttgg ccttggaaga ctatcaaggt
     1981 tcagcaaagg catttcagcg ctgtgtgact ctagaacccg ataatgctga agcttggaac
     2041 aatttgtcaa cttcctatat ccgattaaaa caaaaagtaa aagcttttag aactttacaa
     2101 gaagctctca agtgtaacta tgaacactgg cagatttggg aaaactacat cctcaccagc
     2161 actgacgttg gggaattttc agaagccatt aaagcttatc accggctctt ggacttacgt
     2221 gacaaataca aagatgttca ggtccttaaa attctagtca gggcagtgat tgatgggatg
     2281 actgatcgaa gtggagatgt tgcaactggc ctcaaaggaa agctgcagga gttatttggc
     2341 agagtgactt caagagtgac aaatgatgga gaaatctgga ggctgtatgc ccacgtatat
     2401 ggaaatgggc agagtgaaaa gcctgatgaa aatgaaaagg cattccagtg cctctcaaag
     2461 gcatacaagt gtgacaccca gtccaattgt tgggagaaag atattacatc atttaaggaa
     2521 gttgttcaaa gagccttagg acttgcacat gtggccataa aatgcagtaa aaacaaatcc
     2581 agttcccaag aagctgtaca aatgctttct tctgttcgac tcaatttacg gggcttgtta
     2641 tctaaagcaa agcaactttt tacagatgtg gcaactggag aaatgtccag ggaattagct
     2701 gatgacataa cagctatgga caccttagtg acagagctcc aagacctaag caaccagttt
     2761 cgaaatcagt attgattctg ctggaagcag attctggaaa aggtgctttc acctgctggt
     2821 aaaagataca tctgtatatc tgaaatgcaa gatattgatt tttaaaataa atttgtttta
     2881 tgacttaa
//
