LOCUS       NM_144725               2408 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens tetratricopeptide repeat domain 23 like (TTC23L),
            transcript variant 2, mRNA.
ACCESSION   NM_144725
VERSION     NM_144725.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2408)
  AUTHORS   Pan,T.L., Hsu,S.Y., Wang,P.W., Cheng,Y.T., Chang,Y.C., Saha,S.,
            Hu,J. and Ouyang,P.
  TITLE     FLJ25439, a novel cytokinesis-associated protein, induces
            tetraploidization and maintains chromosomal stability via enhancing
            expression of endoplasmic reticulum stress chaperones
  JOURNAL   Cell Cycle 14 (8), 1174-1187 (2015)
   PUBMED   25751302
  REMARK    GeneRIF: FLJ25439 is involved in pathways related to
            anti-apoptosis, protein folding, the cell cycle, and cytoskeleton
            regulation.
REFERENCE   5  (bases 1 to 2408)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK058168.1, BC057775.1, BX088767.1 and AC026801.7.
            
            On Jun 2, 2019 this sequence version replaced NM_144725.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, initiates translation at a
            downstream start site, and contains a shorter 3' UTR, compared to
            variant 1. The encoded isoform (2) has a shorter N-terminus than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK058168.1, BC057775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505624.6/ ENSP00000422188.1
            NMD candidate          :: PMID: 25751302
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-446               AK058168.1         1-446
            447-1352            BC057775.1         419-1324
            1353-1359           BX088767.1         630-636
            1360-2408           AC026801.7         141601-142649
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..2408
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /note="tetratricopeptide repeat domain 23 like"
                     /db_xref="GeneID:153657"
                     /db_xref="HGNC:HGNC:26355"
                     /db_xref="MIM:616344"
     exon            1..96
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..171
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1189
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tetratricopeptide repeat protein 23-like"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 23-like isoform
                     2"
                     /protein_id="NP_653326.3"
                     /db_xref="CCDS:CCDS54840.1"
                     /db_xref="GeneID:153657"
                     /db_xref="HGNC:HGNC:26355"
                     /db_xref="MIM:616344"
                     /translation="MQASPIRIPTVSNDIDWDFCFHMSQQTEIPAHQQTDELYPTGGC
                     GESEEETKAKEKEKAIDCMSHPKEKLAQSQKKVAQLIKEKMNTQANKELIRCVILSRI
                     IFGDHHWKCARALANLAYGYLTLRGLPVQAKKHATSAKNTLLTWKANTTSNKEKEEIL
                     EALVKLYYTLGVAWLLQNRGREAYFNLQKAERNMKELKELYKGGVCELQVSENDLTLA
                     LGRASLAIHRLNLALAYFEKAIGDVIAAKGDRTSDLISLYEEAAQIEQLRRNHNQAIQ
                     YLQQAHSVCVSLFTEVSPKTAEMSALLAKAYAMSGEAQHRDAVEIYFIRSINAYRATL
                     GSEDFETLSTTEEFCKWLVQNGEKQDK"
     exon            172..358
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..482
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..639
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..765
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..943
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1052
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1180
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1286
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..2408
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1331..1336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /note="hexamer: AATAAA"
     polyA_site      1359
                     /gene="TTC23L"
                     /gene_synonym="MC25-1"
                     /note="major polyA site"
ORIGIN      
        1 attgtctcct tggccggacc tgggctgcgg aaggtaactg gggacgtcgc aggctgtgca
       61 gctttcgcga ggcaccgctt tggcgcccgg accgaggaag aagatgcaag ccagccccat
      121 ccgtatccca actgttagca atgacatcga ctgggatttc tgcttccata tgtcacagca
      181 aaccgagatc ccagctcacc agcaaacaga tgagttgtat cccactggtg ggtgtggaga
      241 gagtgaagag gaaactaaag ctaaagagaa ggagaaggcc atagactgta tgtctcatcc
      301 caaagagaaa ttagcccaat cccagaagaa agtagctcag ctgattaagg aaaaaatgaa
      361 tactcaagca aacaaggagc tgattcgatg tgtcatcctt tctcggatta tttttgggga
      421 ccatcactgg aaatgtgcac gagctctggc caacctagct tatggctact tgacactgag
      481 aggcctccca gttcaggcca agaaacatgc tacatcagcc aagaatacac tgttgacctg
      541 gaaggcaaat acgacctcaa ataaggagaa agaggaaatc ctggaagctc tggtcaagct
      601 gtactacact ctgggcgtgg cctggctcct gcagaaccgt ggcagagaag cctatttcaa
      661 cctgcagaag gcagagagaa acatgaagga gctgaaagaa ttatataaag gaggtgtttg
      721 tgaattacaa gtctctgaga acgacctaac acttgctttg ggcagagcct ccttggccat
      781 ccacagactg aacctagctc tggcatactt tgaaaaggca attggcgatg ttattgctgc
      841 caagggtgat aggacgtcag atctgatcag cctgtacgag gaagctgctc agatagagca
      901 gctgaggagg aaccacaacc aggccatcca gtacttgcag caggctcatt ctgtctgtgt
      961 ttctttgttc actgaagtca gccccaaaac tgcagaaatg agtgcgttac tggccaaagc
     1021 ttatgccatg tctggagagg cccagcacag ggatgctgtt gagatatatt tcataagaag
     1081 tatcaatgca tatcgagcaa cattgggctc agaggatttt gaaacactga gcaccactga
     1141 agaattttgc aaatggcttg tccaaaatgg agaaaaacag gacaagtagc agttcatcca
     1201 gatggagaag agaagccatt cctggaagaa ggaactctac atacaaaggc acagaagcat
     1261 gacagagggc agtgtatgga ggaatggtct tctgttatca aattgaaaac ctctatacag
     1321 gatagccaac aataaagaca accttgttga tgataaaaat tctcgaccac aaaatgtttc
     1381 tcaacactga tagcagtggc agatctaaaa caacggtttt ttattaagga ctctgggaaa
     1441 aaaaggtcca cttagcagca gcattccagg tgaaataccc aagagccatt agaaactagg
     1501 atcctggctg ggcgcggtgg ctcatgccta taatcccagc actttgggag gccgaggcag
     1561 gccaatcatg aagtcaggag attgagacca tcctggtcaa cacggtgaaa ccccatctct
     1621 actaaaaata caaaaaaaat tagctgggcg tggtgacaca tgcctgtaaa cctagctact
     1681 cgggaggctg aggcagaaga atcacttgaa ccggggtcgg aggttgcagt gaactgggat
     1741 catgccactg cactccagcc tggcgacaga tagagactgc gtctcaaaaa aaacaaacaa
     1801 aaaacaaaca aacaaaccca actaggatcc tgatctatga cttgggggaa agaaatcttt
     1861 tagtcacatg ctttaagtta gttttttgtg tcactggaac tccattacct tccatttccc
     1921 tttttctaac tctattcctt tcagttctga ctttttaaaa aattctgcga tacctaagga
     1981 gtttattggt gaacactttc atgtactaca gttgaccact gaacaatgca ggggctaggg
     2041 ctgccaatgc cttgtgcagt caaaaatctt tgtataactt tggattcccc caaaacttaa
     2101 ctgctaatag cctactgtta actgggagcc ttactgataa gcttaacagt tgattaacac
     2161 atattttgta tgttatatgt atagtatata atatattctt acaataagta aactagagaa
     2221 aggcaaaggt tattaagaaa atgataaggg gccaagtgtg gtggctcatt gcctgtaatc
     2281 ctagcactct gggaggcaga ggaaggcaga ctgcttgagc ccaggaggtc gaggctgcag
     2341 tgagctgaga ttgtgccact gcactccagc ctggatgaga aagtgagacc ctgttcaaaa
     2401 aaaaaaaa
//
