LOCUS       NM_001288615            3872 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tetratricopeptide repeat domain 23 (TTC23), transcript
            variant 8, mRNA.
ACCESSION   NM_001288615 XM_005254974
VERSION     NM_001288615.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3872)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3872)
  AUTHORS   Shamseldin,H.E., Shaheen,R., Ewida,N., Bubshait,D.K., Alkuraya,H.,
            Almardawi,E., Howaidi,A., Sabr,Y., Abdalla,E.M., Alfaifi,A.Y.,
            Alghamdi,J.M., Alsagheir,A., Alfares,A., Morsy,H., Hussein,M.H.,
            Al-Muhaizea,M.A., Shagrani,M., Al Sabban,E., Salih,M.A., Meriki,N.,
            Khan,R., Almugbel,M., Qari,A., Tulba,M., Mahnashi,M., Alhazmi,K.,
            Alsalamah,A.K., Nowilaty,S.R., Alhashem,A., Hashem,M.,
            Abdulwahab,F., Ibrahim,N., Alshidi,T., AlObeid,E., Alenazi,M.M.,
            Alzaidan,H., Rahbeeni,Z., Al-Owain,M., Sogaty,S., Seidahmed,M.Z.
            and Alkuraya,F.S.
  TITLE     The morbid genome of ciliopathies: an update
  JOURNAL   Genet Med 22 (6), 1051-1060 (2020)
   PUBMED   32055034
  REMARK    Erratum:[Genet Med. 2022 Apr;24(4):966. doi:
            10.1016/j.gim.2022.01.019.. PMID: 35394428]
REFERENCE   3  (bases 1 to 3872)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3872)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3872)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3872)
  AUTHORS   Karasik,D., Hsu,Y.H., Zhou,Y., Cupples,L.A., Kiel,D.P. and
            Demissie,S.
  TITLE     Genome-wide pleiotropy of osteoporosis-related phenotypes: the
            Framingham Study
  JOURNAL   J Bone Miner Res 25 (7), 1555-1563 (2010)
   PUBMED   20200953
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 3872)
  AUTHORS   Blatch,G.L. and Lassle,M.
  TITLE     The tetratricopeptide repeat: a structural motif mediating
            protein-protein interactions
  JOURNAL   Bioessays 21 (11), 932-939 (1999)
   PUBMED   10517866
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB014606.1, DA448674.1, AF411456.1, AC022819.8 and BC015728.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001288615.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF411456.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394132.7/ ENSP00000377690.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DB014606.1         39-82
            45-45               DA448674.1         335-335
            46-1608             AF411456.1         55-1617
            1609-1609           AC022819.8         162817-162817
            1610-3439           AF411456.1         1619-3448
            3440-3872           BC015728.1         3109-3541
FEATURES             Location/Qualifiers
     source          1..3872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..3872
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /note="tetratricopeptide repeat domain 23"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
     exon            1..411
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            412..533
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            534..728
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            729..821
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1021
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             842..2185
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /note="TPR repeat protein 23; cervical cancer
                     proto-oncogene 8 protein"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 23"
                     /protein_id="NP_001275544.1"
                     /db_xref="CCDS:CCDS10379.2"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
                     /translation="MQESQETHISNHLDEVVAAVSITHRKKFQNKLLQTALFQPPREK
                     LHLCEEKAKSYSNSHEYKQAVHELVRCVALTRICYGDSHWKLAEAHVNLAQGYLQLKG
                     LSLQAKQHAEKARQILANSIVPPYSENTDVFKFSIELFHTMGRALLSLQKFKEAAENL
                     TKAERLSKELLQCGRIIKEEWIEIEARIRLSFAQVYQGQKKSKEALSHYQAALEYVEI
                     SKGETSRECVPILRELAGVEQALGLHDVSINHFLQAHLIILSRSPSQVEAADSAHIVA
                     HAAVASGRHEHHDVAEQYFQESMAHLKDSEGMGRTKFLSIQDEFCHFLQMTGQKERAT
                     SILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKCLQIQTLLYGP
                     QDKRTLATQQAMGMLSTAPKVASKPRQASKAKVAFCTSIPQDTLLGKARPGTTAD"
     exon            1022..1145
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1296
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1422
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1600
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1706
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1834
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1984
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2067
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..3872
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3850..3855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /note="hexamer: AATAAA"
     polyA_site      3872
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /note="major polyA site"
ORIGIN      
        1 gaggtacccg cttgctttat gggaaaaggc tgctccggaa ctgccctact ttagactttt
       61 tcatggttat caatctgtac aaagaatcac caaactgata aagcaggaac cagagggcaa
      121 atcacgctgc caagacaact gtgtaattcg ctcgaaaaag aaacggtgag cctctccagc
      181 agactgggta aactggcaag ggattttacg acatagttgg agattggaga gttacagaaa
      241 cttttccggt tttttacaag ttttaaagga gtgattgagt gtcaaaggaa aagcagagaa
      301 aatacaggca caatttaaag acagcaggaa gaagagtgtt cagagagcat ttttctcttt
      361 agggtgaagt ttgaaagcat catgcccaga ttatcagtgg atttttgaaa gatggagtct
      421 cgctctgtca cccaggctgg agtatagtgg tgtgatcttg gctcactgca acctctgcct
      481 cccaggttca agcgattctc ctgcctcagc ctctcgagta gctggaatta caggtctggc
      541 agaaggaaca gtatcaactg actgagtagg tctcattggc agttgtgatt cagagaccta
      601 gaaagctgaa cccacggctg gcaagaagag gatggtttgt gggacctggg ctgatgtctg
      661 atgaaatttt aagccccagc tatagctact acaaagaaaa gtggctgatg ataagcatgt
      721 aactcaaaag acagagtttt gccatgttgc ccaggctggt cccaaactcc tgagctgagg
      781 tgaccctccc gcctccacct cccagagtgc tgggattaca gaagacaatg tatataaaaa
      841 tatgcaagaa tcacaggaaa cccacatatc caaccaccta gatgaagttg ttgctgctgt
      901 tagcatcact catagaaaga agttccaaaa caagctgctt cagacagcac tattccagcc
      961 tcctcgagag aaactccacc tctgtgaaga gaaagcaaag tcctattcca acagtcatga
     1021 gtacaaacag gccgtccatg agcttgtgcg ttgcgtagca ctgacaagaa tttgctatgg
     1081 agactcacat tggaaactag cagaggcaca tgttaatctg gctcaaggct acctccagct
     1141 gaaaggactg tcactgcaag caaaacaaca tgcagaaaaa gccagacaaa tcctcgccaa
     1201 ctccattgtg cctccctata gtgagaatac agatgttttc aagttttcca ttgagctttt
     1261 ccataccatg ggcagagctt tactctccct tcaaaaattt aaggaagctg cagagaattt
     1321 gacaaaagca gagagacttt caaaggagct gctacaatgt ggaagaatta taaaggaaga
     1381 atggatagaa attgaagcac ggatcagatt atcatttgca caggtgtatc aaggtcagaa
     1441 gaagtcaaaa gaagctttgt cccactatca agcagctttg gaatatgttg agatcagtaa
     1501 aggtgaaaca agtcgtgagt gtgtacccat attgagagaa ttagcaggtg tagagcaagc
     1561 cctgggactc cacgatgtat ccatcaacca cttcctccag gcacatctta tcatcctgag
     1621 tagaagcccc tctcaagtgg aggcagcaga ctcggcacac atcgtcgccc atgctgctgt
     1681 cgcttcaggg agacacgagc accatgatgt agctgagcag tattttcaag agagcatggc
     1741 tcatcttaag gattctgaag ggatgggaag aaccaaattt ctttcaattc aagatgaatt
     1801 ttgccatttt ctacaaatga ctggacaaaa agagagagca acctcgatcc tgagagagtc
     1861 cctggaagcc aaagtggaag catttggcga tttcagtccc gaggtggcag agacataccg
     1921 gctcctggga ggagcagacc tggcgcaggg gaaccacagt ggggcccgca agaaactgaa
     1981 gaagtgtctc cagatccaga ccctcttata tggaccgcag gacaaaagga ctctggccac
     2041 ccagcaggcc atgggcatgc tgtccacggc ccccaaggtt gcttcgaagc caaggcaggc
     2101 atcaaaagcc aaagtggcct tctgcaccag catccctcag gacaccctgc tggggaaggc
     2161 ccggcccggc acaacagcag actgaggccc ccaccctgaa aaagcctagg acattcctgg
     2221 gcactgtcat ttagggtgct gtacaaatca cctccgccta gaaaatggaa ttcaacagtc
     2281 aggatacaga tttccaaggc caactgttgg ccccaacatg caacagtgag accataagcc
     2341 tcccgtgggc cacattttga cagtggatgc ccttcagggt gatatatgct ataaagcagt
     2401 tttctatcac ctaagtggtt tttcttgcca acaagaattt ttacccatca gcactactgt
     2461 ggctgaaaaa cttctcttca acagttcagt gcgccctgtg caggagtcag cccggcatct
     2521 gcttgtacac acagctcctt gcataggtgt ggagttagat ctggacagtg aacttcagga
     2581 agtcctttct tataggaggc taatagggat tgagaataac atgagaagaa aacgctaata
     2641 aagggaaacc tgaacacgct gctgtcagca tgtgttttca aagtgcagcc tgcctcagag
     2701 ttcttcggag cctgaaaagg ggtttgagaa agagcccagt aggaggggca ggaggccgac
     2761 acacctgact tggcctgggg cccaggaggc aggtgtaagg gagtgaaaag aaaggctagc
     2821 cggaggctgc ggggggaaga ccgcagactc cctgctgctt cgcatccctc ctgtggcctc
     2881 cactgcaggc aggacaaacc tggatgccac ctggagctgc ttcctgagtt ggcacactat
     2941 cgtgtacaca gcagtcttca gccccctgga aggaggccat agtcgtgtga ggatggcaaa
     3001 gtcgaacagg aagctttgag tgccttcctc cacgatgtca acgaggagat ccagtgccag
     3061 atcgaggtgg atggaacacc caggggtagg ggtgcaggtg tgggcagtga tgtcccttcc
     3121 cctccctccc ctggtcccac agactgtggc catgaggctg caggctggtg ctatgacagc
     3181 agattgcagc acagggccct cccctccagc ccccagtggg acatcaaaac caccctgggg
     3241 ccatttgtgc agggcaccac ctccagtatt gatggggaaa ataaactcag tagagccacg
     3301 acagggtgga gagaagcagg gaccattgtc ttcctcagga gcgtgacagc tgaccccaca
     3361 gaccatgctt gctggtacac actggtccca gacccaggcc tgtcggacat cagcagtgtg
     3421 ctaaaaacgt gtaagatgtc actactcacc gtgtgtccta tctagttgac atgggtggag
     3481 tcagctaagg ggtgaatgtt catatgctcc caattcacgt tgaagcccta atccccaaag
     3541 ggatggtatt gggggtgggg tcttggagag gtgattaggt tatgagggtg gagccctgat
     3601 gaatgggatt agtgctttat aaggagagac accagagaga tgatctctct ctccaccatg
     3661 tgaggacaca gtgagaagac agccgtctgc aggcccggaa gagagccctc accaggaaat
     3721 gaaactgttg gcaccttgag acttcccagc ttccagaact gtaagaaata aatgtttgtt
     3781 gtttaagcct ttcaggctac ggctttctgt tacagcagcc tgaactgaga gtccatgccg
     3841 agtttttgaa ataaatgtga attctgatgt ta
//
