LOCUS       NM_001114108            3401 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 22 (TTC22), transcript
            variant 1, mRNA.
ACCESSION   NM_001114108
VERSION     NM_001114108.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3401)
  AUTHORS   Xu,Q., Zhang,J., Zhao,Z., Chu,Y. and Fang,J.
  TITLE     Revealing PACMA 31 as a new chemical type TrxR inhibitor to promote
            cancer cell apoptosis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1869 (10), 119323 (2022)
   PUBMED   35793738
  REMARK    GeneRIF: Revealing PACMA 31 as a new chemical type TrxR inhibitor
            to promote cancer cell apoptosis.
REFERENCE   2  (bases 1 to 3401)
  AUTHORS   Tian,W., Du,Y., Ma,Y., Zhang,B., Gu,L., Zhou,J. and Deng,D.
  TITLE     miR663a-TTC22V1 axis inhibits colon cancer metastasis
  JOURNAL   Oncol Rep 41 (3), 1718-1728 (2019)
   PUBMED   30664167
  REMARK    GeneRIF: Study results suggest that TTC22 variant 1 (TTC22V1) mRNA
            is a crucial miR663a target that directly promotes colon cancer
            cell migration/invasion. High TTC22V1 expression is a significant
            poor survival factor for patients with colon cancer.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096536.2 and AL139244.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001114108.1.
            
            Summary: This gene encodes a protein with seven tetratricopeptide
            (TPR) repeats. Tetratricopeptide repeat containing motifs are found
            in a variety of proteins and may mediate protein-protein
            interactions and chaperone activity. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138507.35203.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371276.9/ ENSP00000360323.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-727               AC096536.2         17310-18036         c
            728-783             AC096536.2         4755-4810           c
            784-899             AC096536.2         4424-4539           c
            900-1018            AC096536.2         3670-3788           c
            1019-1180           AC096536.2         2696-2857           c
            1181-1333           AL139244.21        126194-126346       c
            1334-3401           AL139244.21        123581-125648       c
FEATURES             Location/Qualifiers
     source          1..3401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..3401
                     /gene="TTC22"
                     /note="tetratricopeptide repeat domain 22"
                     /db_xref="GeneID:55001"
                     /db_xref="HGNC:HGNC:26067"
     exon            1..727
                     /gene="TTC22"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1870
                     /gene="TTC22"
                     /note="isoform 1 is encoded by transcript variant 1; TPR
                     repeat protein 22"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 22 isoform 1"
                     /protein_id="NP_001107580.1"
                     /db_xref="CCDS:CCDS44152.1"
                     /db_xref="GeneID:55001"
                     /db_xref="HGNC:HGNC:26067"
                     /translation="MAELEAVADDLDALIDDLDYLPGHFHLEMQLNFEPRSPAPQRAR
                     DLKLQREGLRQELQLAAAPQRPAVRHLLGAFAFYLEELDEARECFLEVAHEHPGNLNA
                     WANLAHVYGRLGQEEEEEACAARLADLMGLAEEPEAAGDPQLRAARCLAEQGYAHGFD
                     VGCASPEERARGLAAGIALYDKALGYGQQIPMEEKRGWYFTMATLYIRLDGIFLELGS
                     EEQKRLPAFNRTLALLRQVLKSEDPRHRALAWCYLGMLLERKDTFSTTPMGVHDCGYS
                     GTDPLDCFGKAIEIAKNQPPILNRLAKIFYFLGKQDMAIGTCNMALDVLRDPELNWQA
                     YCTRAKIHIRAYLHDLKRAKMGLGGMPDRNHLACAKADLEEVVRVCPGFKAYLDIGQV
                     YYYMGVDAVQELLAVDEAALNQALVFLAKAGESELGATLPELQLLRGKCLRIKGEDAN
                     AAACFKRAVELDDAGSSHTDGFGCLLEALLAQWSQAQLSDGELGREVDAWLRRAQDKY
                     PAARLRQELQRVWRGHTDEVLGLARALVAQGRPALVRLLFETMEREGEGASAPRDRRA
                     VSF"
     exon            728..783
                     /gene="TTC22"
                     /inference="alignment:Splign:2.1.0"
     exon            784..899
                     /gene="TTC22"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1018
                     /gene="TTC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1180
                     /gene="TTC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1333
                     /gene="TTC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..3401
                     /gene="TTC22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3381..3386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC22"
                     /note="hexamer: AATAAA"
     polyA_site      3401
                     /gene="TTC22"
                     /note="major polyA site"
ORIGIN      
        1 acctgcggga ggcgccctga gaccgagagg ccgcagcgcc cggggcctct gccggctgcc
       61 cctcgcctcc cgcacggagc tcgctcgggg aacgccccca tccactgccc tccacagcct
      121 cagggacaag ggtgaggcca ggggagcaga gggagcagtc atggcggagc tggaggctgt
      181 ggccgacgat ctagacgccc tcatcgacga cctggactac ctcccgggcc actttcacct
      241 ggagatgcag ttgaacttcg agccgcgctc gccggcccca cagcgcgccc gggacctgaa
      301 gctgcagcgg gagggtctgc ggcaggagct ccagctggcg gccgccccgc agcgccccgc
      361 tgtgcgtcac ctcctgggcg ctttcgcatt ctacctggag gagctggacg aggcccgcga
      421 gtgcttcctc gaggtggccc acgagcaccc gggcaacctc aatgcctggg ccaatctggc
      481 acacgtgtac gggcggctgg gccaggaaga agaggaggag gcgtgcgccg cacggctggc
      541 cgacctcatg ggcctggcag aggagcccga ggccgccggg gacccccagc tccgcgccgc
      601 tcgctgcctg gccgagcagg gctacgcgca tggcttcgac gtcggctgcg ccagcccaga
      661 ggagcgtgcg cgggggctgg cggcaggcat cgcgctctac gacaaggcgc taggctacgg
      721 gcagcagatc ccgatggagg agaaaagggg ctggtatttc accatggcaa cactctacat
      781 caggctagat ggcatcttcc tggagctggg cagtgaggag cagaagagac tgcctgcctt
      841 caaccgcacg ctggccctac tccggcaagt gctgaagtcc gaggaccccc gccaccgagc
      901 cctggcctgg tgctacctcg ggatgctgct ggagcggaag gacaccttct ccaccacccc
      961 catgggcgtc catgactgcg ggtactcagg gaccgaccct ctagactgct tcggcaaggc
     1021 cattgagatt gccaagaacc aacctcccat cctgaatcgc ctggcaaaaa tcttctactt
     1081 cctgggaaag caggatatgg ccattggaac ctgcaacatg gccctggatg tcctacgaga
     1141 tccagaactc aactggcagg cgtactgcac aagggccaag atccacatca gagcctacct
     1201 gcatgacctc aagcgggcca agatgggtct cgggggcatg cctgacagga accacctggc
     1261 ctgtgccaag gctgaccttg aggaagtggt cagggtgtgc ccaggcttca aggcgtacct
     1321 ggacatcggc caggtctact actatatggg cgtggacgcg gtgcaggagc tgctggcggt
     1381 ggacgaggcg gcgctgaacc aggcgctggt gttcctggcc aaggcgggcg agtcggagct
     1441 gggtgccacg ctgcccgagc tgcagctgct gcgcggcaag tgcctgcgca tcaagggcga
     1501 ggacgccaac gcggccgcct gcttcaagcg cgcagtggag ctggacgacg cgggctccag
     1561 ccacaccgac ggcttcggct gcctgctcga ggcgctgctg gcgcagtgga gccaggcaca
     1621 gctgagcgac ggggagctgg gccgcgaggt ggacgcctgg ctgcgccgcg cccaggacaa
     1681 gtaccccgcg gcgcgcctgc gccaggagct gcagcgcgtg tggcgcgggc acacggacga
     1741 ggtgttgggg ctggcccggg ccctggtggc ccagggacgg ccggcgctgg tgcggctgct
     1801 cttcgagacc atggagcgcg agggcgaggg cgccagcgcg ccgcgggacc gccgggctgt
     1861 ctcattctag ggctcaggtg cccaggccgg aggctccctg ggaccccgcc caggccccgc
     1921 ccagctgatg ggaccaggtc cggatggact ccctgcctta ggctgacctg ggagcggagc
     1981 cagttcgatt cttggtcggg aattgtgaat ggggatgttg cgacacccgc gcggtttgaa
     2041 acgcccaccc agactggaag gcctgattcc cgagagcaga agaggctggg agcagaggtg
     2101 agaaaacact gggaagctgc caattaaggg acagaatttt ctagacatac aggtaaaata
     2161 agatggttgt gaggcttctg agagaaacag aagacagcta cctcagtgtg gcagttttct
     2221 agtccgggcg ctcaatccct caggcctgag tgcctgtctt tggactccgg taggccacac
     2281 tctatcctta tgagaaagcc ccgtttactt tagttgactg gagtgtggtc tcagctcctg
     2341 cagccagaaa agccctgact aaagcagagg gcagggtggc acggcgagtg agttacggga
     2401 cagggcccta gcctaagcct cgtgctcagg gctcattcct gcctctctgc tacttttcta
     2461 gtaggcctcc ttcttggtcc gcttggccca aaaggcctcc caaatgctct gaaatagagc
     2521 tcatcaatag aaccttcact tgatttccct cttcttgggg gaaactaagg gcgccaccca
     2581 ttaggaggtg ccacctgccc cccccctttt tttttttttt ttttgagagg gagtttcgct
     2641 cttgttgccc atgctggagt gcaatggcac gatcttggcc cactgcaacc tccatctcct
     2701 gggttcaagc gatcttcccg cctcagcctt ccaagtagct gggattacag acgtgtgcca
     2761 tcaggcctgg ctaattttgt atttttagta gagacagggt ttcgccatgt tggtcaggat
     2821 ggtctcgaac tcctgacctc aactgatcca cccgcctcag cctcccaaag tgctaggatt
     2881 acaggtgtga gccactgcac ccggccctgc ccccagtctt gaccattcta ctaattttaa
     2941 agaacatctt ggaattttac actcttggaa tcatagtcgt agaatccttt ttttgagaca
     3001 gagtctcact ctgtcgccca ggctggagtg cagtggccag atctcagctc actgaaacct
     3061 cagcctccca agttcaagtg attctcgtac ctcagcctcc tgagtagctg gaattccagg
     3121 ctgtactcac tgctttgctc atatcctcgc tcattaccag ggacaggcca gcacccctgc
     3181 attgcatctc acatatccac tgatggatgg agaacagact gaaattcagt gccttagaga
     3241 ccacacactc caaccccctc attgtgcaga tgggaaaact gagagccata gaagggaagt
     3301 ggcttgccca aagccacact tactgttttc cccacactgt accacaaact ttcaccattc
     3361 ttcaggtttg gaaaaatact aataaactga tcaacactaa a
//
