LOCUS       NM_018259               4488 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 17 (TTC17), transcript
            variant 1, mRNA.
ACCESSION   NM_018259
VERSION     NM_018259.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4488)
  AUTHORS   Canniff,N.P., Graham,J.B., Guay,K.P., Lubicki,D.A., Eyles,S.J.,
            Rauch,J.N. and Hebert,D.N.
  TITLE     TTC17 is an endoplasmic reticulum resident TPR-containing adaptor
            protein
  JOURNAL   J Biol Chem 299 (12), 105450 (2023)
   PUBMED   37949225
  REMARK    GeneRIF: TTC17 is an endoplasmic reticulum resident TPR-containing
            adaptor protein.
REFERENCE   2  (bases 1 to 4488)
  AUTHORS   Bassaganyas,L., Popa,S.J., Horlbeck,M., Puri,C., Stewart,S.E.,
            Campelo,F., Ashok,A., Butnaru,C.M., Brouwers,N., Heydari,K.,
            Ripoche,J., Weissman,J., Rubinsztein,D.C., Schekman,R.,
            Malhotra,V., Moreau,K. and Villeneuve,J.
  TITLE     New factors for protein transport identified by a genome-wide
            CRISPRi screen in mammalian cells
  JOURNAL   J Cell Biol 218 (11), 3861-3879 (2019)
   PUBMED   31488582
  REMARK    GeneRIF: TTC17 is localized along the secretory pathway and was
            found to interact with resident proteins of ER-Golgi membranes.
REFERENCE   3  (bases 1 to 4488)
  AUTHORS   van der Valk,R.J., Kreiner-Moller,E., Kooijman,M.N., Guxens,M.,
            Stergiakouli,E., Saaf,A., Bradfield,J.P., Geller,F., Hayes,M.G.,
            Cousminer,D.L., Korner,A., Thiering,E., Curtin,J.A., Myhre,R.,
            Huikari,V., Joro,R., Kerkhof,M., Warrington,N.M., Pitkanen,N.,
            Ntalla,I., Horikoshi,M., Veijola,R., Freathy,R.M., Teo,Y.Y.,
            Barton,S.J., Evans,D.M., Kemp,J.P., St Pourcain,B., Ring,S.M.,
            Davey Smith,G., Bergstrom,A., Kull,I., Hakonarson,H., Mentch,F.D.,
            Bisgaard,H., Chawes,B., Stokholm,J., Waage,J., Eriksen,P.,
            Sevelsted,A., Melbye,M., van Duijn,C.M., Medina-Gomez,C.,
            Hofman,A., de Jongste,J.C., Taal,H.R., Uitterlinden,A.G.,
            Armstrong,L.L., Eriksson,J., Palotie,A., Bustamante,M.,
            Estivill,X., Gonzalez,J.R., Llop,S., Kiess,W., Mahajan,A.,
            Flexeder,C., Tiesler,C.M., Murray,C.S., Simpson,A., Magnus,P.,
            Sengpiel,V., Hartikainen,A.L., Keinanen-Kiukaanniemi,S., Lewin,A.,
            Da Silva Couto Alves,A., Blakemore,A.I., Buxton,J.L., Kaakinen,M.,
            Rodriguez,A., Sebert,S., Vaarasmaki,M., Lakka,T., Lindi,V.,
            Gehring,U., Postma,D.S., Ang,W., Newnham,J.P., Lyytikainen,L.P.,
            Pahkala,K., Raitakari,O.T., Panoutsopoulou,K., Zeggini,E.,
            Boomsma,D.I., Groen-Blokhuis,M., Ilonen,J., Franke,L.,
            Hirschhorn,J.N., Pers,T.H., Liang,L., Huang,J., Hocher,B., Knip,M.,
            Saw,S.M., Holloway,J.W., Melen,E., Grant,S.F., Feenstra,B.,
            Lowe,W.L., Widen,E., Sergeyev,E., Grallert,H., Custovic,A.,
            Jacobsson,B., Jarvelin,M.R., Atalay,M., Koppelman,G.H.,
            Pennell,C.E., Niinikoski,H., Dedoussis,G.V., Mccarthy,M.I.,
            Frayling,T.M., Sunyer,J., Timpson,N.J., Rivadeneira,F.,
            Bonnelykke,K. and Jaddoe,V.W.
  CONSRTM   Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium;
            Genetic Investigation of ANthropometric Traits (GIANT) Consortium;
            Early Growth Genetics (EGG) Consortium
  TITLE     A novel common variant in DCST2 is associated with length in early
            life and height in adulthood
  JOURNAL   Hum Mol Genet 24 (4), 1155-1168 (2015)
   PUBMED   25281659
REFERENCE   4  (bases 1 to 4488)
  AUTHORS   Bontems,F., Fish,R.J., Borlat,I., Lembo,F., Chocu,S., Chalmel,F.,
            Borg,J.P., Pineau,C., Neerman-Arbez,M., Bairoch,A. and Lane,L.
  TITLE     C2orf62 and TTC17 are involved in actin organization and
            ciliogenesis in zebrafish and human
  JOURNAL   PLoS One 9 (1), e86476 (2014)
   PUBMED   24475127
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4488)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA106610.1, BC017238.2, BC041893.1 and AW070863.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018259.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.37739.1,
                                           SRR1803613.145556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000039989.9/ ENSP00000039989.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA106610.1         36-56
            22-3509             BC017238.2         6-3493
            3510-4484           BC041893.1         1627-2601
            4485-4488           AW070863.1         3-6                 c
FEATURES             Location/Qualifiers
     source          1..4488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p12-p11.2"
     gene            1..4488
                     /gene="TTC17"
                     /note="tetratricopeptide repeat domain 17"
                     /db_xref="GeneID:55761"
                     /db_xref="HGNC:HGNC:25596"
                     /db_xref="MIM:619388"
     exon            1..194
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..3461
                     /gene="TTC17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tetratricopeptide repeat protein 17; TPR repeat
                     protein 17"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 17 isoform 1
                     precursor"
                     /protein_id="NP_060729.2"
                     /db_xref="CCDS:CCDS31466.1"
                     /db_xref="GeneID:55761"
                     /db_xref="HGNC:HGNC:25596"
                     /db_xref="MIM:619388"
                     /translation="MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVV
                     TEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQKIHIEENEDRDTG
                     LEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDC
                     TKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEG
                     LQKNTSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAH
                     FSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKR
                     KHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILR
                     NIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGEDSS
                     TSSMMSVNFDVQSNQSDINDSVKSSPVAHSILWIWGRDSDAYRDKQHILWPKRADCTE
                     SYPRVPVGGELPTYFLPPENKGLRIHELSSDDYSTEEEAQTPDCSITDFRKSHTLSYL
                     VKELEVRMDLKAKMPDDHARKILLSRINNYTIPEEEIGSFLFHAINKPNAPIWLILNE
                     AGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQAL
                     AINSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPF
                     LYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMK
                     GRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTP
                     GKKVETGQIENGHRYQANLEITGPKVASPGPQGKKRDYQRLGWPSPDECLKLRWVELT
                     AIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASL
                     HYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQ
                     GKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNH
                     FTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP"
     exon            195..284
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            285..454
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            455..566
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            567..698
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            699..808
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            809..953
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1093
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1254
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1367
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1514
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1630
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1796
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1874
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2099
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2286
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2546
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2700
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2821
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2981
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3065
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3185
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3329
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..4488
                     /gene="TTC17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4466..4471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC17"
                     /note="hexamer: AATAAA"
     polyA_site      4488
                     /gene="TTC17"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggtg tgagcggccc ggccgggggg gcaagatggc ggcggcagta ggggttcgtg
       61 gccggtacga gctgccgcct tgctccggcc caggctggct cctcagcctt tccgccttgc
      121 tgagtgtggc ggcacgaggg gccttcgcca ccacgcactg ggtcgtcacg gaggacggga
      181 aaatccagca gcaggtggat tcaccaatga acttgaagca tcctcatgac ctagtcatat
      241 taatgagaca agaagcaaca gttaactacc tcaaagaatt agagaaacaa ttagttgctc
      301 aaaaaattca catagaagag aatgaggaca gagacacagg actggaacag agacataata
      361 aagaagaccc agactgcatc aaagccaagg tgcccttagg ggacctggat ctatatgatg
      421 gcacatacat aactttggag agcaaagaca tcagtcctga agattatata gacacagaat
      481 ctcctgtccc tccagaccca gagcaacctg attgtactaa aattctagaa cttccatata
      541 gtatacatgc ttttcagcac ttgagaggtg tacaggagag agttaatctt tctgcacctc
      601 tgctacctaa agaagaccca atcttcacat atttatctaa acggttagga aggagtatag
      661 atgacatagg tcacctcatt catgaaggcc tacagaagaa cacttcctcg tgggtactgt
      721 ataacatggc ttcattttac tggagaatta agaatgagcc atatcaggta gtagaatgtg
      781 ccatgcgagc acttcacttc tcttccaggc acaataaaga cattgccctg gtcaacctgg
      841 caaacgttct acacagagca cacttctctg ctgatgctgc tgtcgtggtc catgcagctc
      901 tggatgacag tgacttcttc accagctatt acactttggg gaatatatat gcaatgcttg
      961 gggaatataa ccactcagtg ctctgttatg accacgcttt gcaggccaga cctgggtttg
     1021 agcaagctat aaagaggaag catgctgtcc tatgtcagca aaaactggag cagaaattgg
     1081 aggctcagca tagatctctc cagcgaacac tgaatgagtt aaaagagtat caaaagcagc
     1141 atgaccacta cctgagacag caggaaatcc tagaaaaaca taaactgatt caggaggagc
     1201 aaatcttaag aaatatcatt catgagactc agatggcaaa agaggcacaa ttaggaaatc
     1261 atcagatatg ccgactggtc aaccagcagc atagtttaca ttgccagtgg gaccagcctg
     1321 tacgctatca tcgtggagat atctttgaaa atgtggacta tgttcagttt ggtgaggatt
     1381 catcaacctc cagtatgatg tctgtgaact ttgatgttca atcaaatcag agtgatatca
     1441 atgattcggt caagtcttct cccgtagccc attctattct ctggatttgg ggcagggact
     1501 ctgatgcata tagggacaaa cagcatattc tatggcctaa aagagcagat tgtacagaaa
     1561 gctaccctag agtccctgtt ggtggggaat tgccaacgta ttttctgcct ccggaaaaca
     1621 aaggactcag gatccacgaa ctcagcagtg atgattattc tacagaagaa gaggcccaaa
     1681 cccctgactg ttccataact gacttcagaa aaagccacac tctgtcctac ttagtcaaag
     1741 aattagaggt tcgcatggat ctgaaagcca aaatgccaga tgaccatgca cgaaaaattt
     1801 tgctttcccg tattaataac tatactatcc cagaagaaga aattgggtct ttcttatttc
     1861 atgctattaa taagccaaat gctcctatct ggctcatact caatgaagct ggactatact
     1921 ggagagcagt aggaaatagc acttttgcta ttgcctgtct tcagagggct ttgaatttag
     1981 ctccacttca ataccaagat gttcctcttg tcaacttggc caaccttttg attcattacg
     2041 gccttcatct tgatgccact aagctgctac ttcaagcttt ggccatcaat agctctgagc
     2101 ctctgacctt tttgagcctg ggaaatgctt accttgctct gaagaatatc agtggggcac
     2161 ttgaggcctt tagacaggcc ttgaaattaa ccaccaaatg tccagagtgt gaaaacagcc
     2221 tgaagttgat ccgctgtatg cagttttatc cttttctgta caacatcact tcttctgttt
     2281 gcagtggtac ggtggttgag gagagcaatg gttctgatga gatggagaat tcagatgaaa
     2341 ccaaaatgtc agaagaaata ctggctttgg tggatgaatt tcaacaggca tggcctttgg
     2401 aaggctttgg gggtgcacta gagatgaaag ggcggcgtct agacttacaa ggaatacggg
     2461 tgctgaagaa aggtccccag gatggagtgg ccagaagctc ttgctatgga gactgcagaa
     2521 gtgaagatga tgaagcaaca gaatggatta cattccaggt caaacgtgta aagaaaccca
     2581 aaggagatca taagaaaact cctgggaaaa aagtagaaac aggtcagata gaaaatggac
     2641 atcgttacca agcaaaccta gagatcactg gccccaaggt ggcatctcct gggccacaag
     2701 gaaaaaaacg tgactaccag cgtctgggat ggcccagccc ggacgaatgc ctcaaactcc
     2761 gctgggtaga gctgactgcc atcgtgagta cctggcttgc agtttcttca aaaaacattg
     2821 acatcacaga acacatagat tttgccaccc ctatacagca gccagcaatg gagcctcttt
     2881 gcaatggcaa tctccccacg agtatgcata ccctggacca cttgcatggg gtttccaacc
     2941 gagccagcct gcactacaca ggggagagtc agttaacaga ggtattacaa aatctcggca
     3001 aagaccaata tccacaacag tcgcttgaac agattggcac ccgaattgcc aaagttttgg
     3061 aaaagaacca gacgtcctgg gtcctctcca gcatggcagc cctctactgg agggtgaaag
     3121 gccaaggaaa gaaggcaatc gactgcctcc gccaggctct gcactatgcg ccacaccaga
     3181 tgaaggatgt gcccctgatt agcctggcca acatcttgca caatgccaag ctctggaatg
     3241 acgccgtcat agtagccacc atggcagtag agatcgcacc acactttgct gtgaaccact
     3301 tcactctggg caatgtctac gtggcaatgg aagaatttga aaaagcactg gtgtggtatg
     3361 aatccacatt gaagcttcag cccgagtttg tcccagccaa gaaccgaatc cagaccatcc
     3421 agtgtcactt aatgctgaag aagggacggc gctctcctta gtgcacttct tccttctctc
     3481 tttctcttta ctcatgctct aaaaaaaaag aataagaaaa gaaaccaatc attgtcagta
     3541 tctactatta atgatgtgtg tgaaaataac taagacttat aacaggactt ttacatatgt
     3601 gggaattggt ttgtttttgt ttttacgttt ctcctttccc ccaaccaacc tcagaagagg
     3661 caccttcaga aacacacatt tcttaaaagg aaagtgcagc ttcaagatat tgtgtaaata
     3721 ctgagccaag acatttctgg agctgtgctc tgtctccaaa aacctcaatg cctttagggc
     3781 ttttctcagt ggtccagcta gccttctctt tggaggagga tgaagccgca ttgcacattc
     3841 tctgcttcct gtcgtagcct ctgttgtcaa tggaaatgcg gaagcccatc tggtgcccgt
     3901 cagtgagaag caacgttctg cgctctctcc gttagacctc catgctgtcc ccagtcttgt
     3961 ccattccatg ctgctgtgtt acaaactctc agaggtagtt tgcaggggag gaaggggaat
     4021 atgattttaa aaacaaaata tttacaacaa caaaaattct taggatcacc tgacctttgt
     4081 aatgttattt atgttgggga gggagggggg ctgagaaggg gaaatcagca gtgtgcaaca
     4141 tctttataat ttgtacttta attacaaatc acaaggaaac caataagttg aaatcctata
     4201 taacaggttt atatatatag aatatgtata tttgaagccc tctacagact gagtctatgt
     4261 tttactaatt ctttgttcac tgtgttaccc atcttggaat aagttgtgaa tgtcagctcc
     4321 ctctctctga ggcctccaga cttagctcct caggagggta atgagccaag gttgagtgtt
     4381 tccatacaat gcttttacct ttgatcccag gagaatcaga aactccaaca ttttggaatc
     4441 ttcaagggca catactgaga aaaaaaataa aattgtttat gagcaaaa
//
