LOCUS       NM_144965               2874 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 16 (TTC16), transcript
            variant 1, mRNA.
ACCESSION   NM_144965
VERSION     NM_144965.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057342.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144965.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057342.1, SRR1803615.76959.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373289.4/ ENSP00000362386.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2874              AK057342.1         1-2874
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2874
                     /gene="TTC16"
                     /note="tetratricopeptide repeat domain 16"
                     /db_xref="GeneID:158248"
                     /db_xref="HGNC:HGNC:26536"
     exon            1..85
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2689
                     /gene="TTC16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 16; TPR repeat protein
                     16"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 16 isoform 1"
                     /protein_id="NP_659402.1"
                     /db_xref="CCDS:CCDS6875.1"
                     /db_xref="GeneID:158248"
                     /db_xref="HGNC:HGNC:26536"
                     /translation="MTDSDEDALKVDQGPSRDIPKPWVIPAPKGILQHIFGTSHVFQS
                     ICDVKPKVTGLTVPLKVREYYSRGQQCLEQADWETAVLLFSRALHLDPQLVDFYALRA
                     EAYLQLCDFSSAAQNLRRAYSLQQDNCKHLERLTFVLYLQGQCLFEQCAFLDALNVFS
                     HAAELQPEKPCFRYRCMACLLALKQHQACLTLITNELKQDTTNADVYIFRARLYNFLQ
                     KPHLCYRDLHSALLLNPKHPQARMLLQKMVAQAQQARQDAGILAVQGKLQHALQRINR
                     AIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQEDMVRQAQRQLLLTY
                     NDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGDCFFQLGNLAFAEADYQQAL
                     ALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRAKSR
                     QLLQNIFGARQDVATVLLLNPKQPKLSLLMTNLFPGMSVEEVLSTQIAHLARLQLEQM
                     VEGSLQAGSPQGIVGMLKRHELERQKALALQHSWKQGEPLIATSEELKATPEIPQVKP
                     GSSEGEAEAPEEEEEKEKEKKEEKKSELIPSKVASLSDSYLDQTSSASSMSFRTTGTS
                     ETEMSAICQEYRSTSATAVTFSDSSLLKTQSSDSGNNREALSHGPRKIKATQGQRQSL
                     SKTEPTQSQRRNSSKTKATIHKRNSSKTKATQSQRRNSSKTRATQGQGQSSSKTEATQ
                     GQRQSSSEIEATQGPRQEPSKTKTTRSPRQRPRKVKAARGRSWRPSKVDATQGRSRGL
                     LRSSTKTEAFYDSNWSLSKTEYAQGQGQRSSKAEGAQGKSQGMSSTSSKAESTWGPSP
                     SLSKTEVDQDLTYYEAV"
     exon            86..258
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            259..349
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            350..493
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            494..594
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            595..724
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            725..939
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1184
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1326
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1492
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1635
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1831
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1919
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2874
                     /gene="TTC16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2785..2790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC16"
                     /note="hexamer: ATTAAA"
     polyA_site      2806
                     /gene="TTC16"
                     /note="major polyA site"
     regulatory      2853..2858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC16"
                     /note="hexamer: ATTAAA"
     polyA_site      2874
                     /gene="TTC16"
                     /note="major polyA site"
ORIGIN      
        1 agcaacgtca gggccagggc cgcgaggtag ttggcagagg cctcggggtc ctcctggaag
       61 gggcctcatg acagattcgg acgaggatgc cctgaaggtt gaccagggcc cctcacggga
      121 catcccaaag ccatgggtga ttccagcccc caaagggatc ctgcagcaca tctttgggac
      181 cagccacgtg ttccaaagca tctgtgatgt aaaaccaaag gtcacagggt taacagtgcc
      241 cctcaaagtc agggaatact actccagagg ccagcagtgc ttggagcagg cagactggga
      301 gacagctgtg ctgctcttct cccgcgcact ccacctggac ccacagctgg tggacttcta
      361 tgccttacgg gctgaggcct acctccagct ctgtgacttc tcctcggccg cccagaacct
      421 gcgaagggcc tactcattac agcaggacaa ctgcaagcac ctggagcgcc tcacctttgt
      481 gctctaccta cagggacaat gcctttttga gcagtgtgcc ttcctggatg ccctgaatgt
      541 cttctcacat gctgctgagc tccagcctga gaaaccatgc ttccgttacc gatgcatggc
      601 ctgtctcctg gccctcaagc agcatcaggc ctgcctcacg ctcatcacca acgagctgaa
      661 gcaggacacc accaacgccg atgtctacat cttccgggcc agactctaca actttctcca
      721 gaagccccac ctctgctacc gggacctgca cagcgccttg ctgttgaatc ccaagcaccc
      781 gcaggccagg atgctgctcc agaagatggt ggcccaggcc cagcaggcgc gccaagatgc
      841 ggggatcctg gctgtgcagg gcaagctgca gcacgcactg cagcggatca accgtgccat
      901 cgagaacaac cctctggacc ccagtctctt cctcttccgg ggcaccatgt accgacggct
      961 ccaggagttc gatggggcag tggaggactt cctgaaggtg ctggacatgg tgaccgagga
     1021 ccaggaggac atggtgcggc aggcacagcg ccagctgttg ctgacctaca acgactttgc
     1081 cgtgcactgc tacaggcagg gcgcctacca ggagggcgtg ctgctgctga acaaggccct
     1141 ccgggacgag cagcaggaga aaggactcta catcaaccga ggcgattgct tcttccagct
     1201 gggcaacctg gcctttgccg aggcggacta ccagcaggcg ctggcgctga gccctcagga
     1261 cgagggcgcc aacacgcgca tgggcctgct gcaggagaag atgggcttct gcgagcagag
     1321 gcgcaagcag ttccagaagg cagagaacca cttctccacg gccatccggc acaaccccca
     1381 gaaggcccag tactacctgt accgggccaa gagccggcag ctgctgcaga acatttttgg
     1441 ggcccgccag gatgtggcca ctgtcctgct cctcaacccc aagcaaccaa agctgtccct
     1501 gctgatgacc aacctcttcc cgggcatgtc ggtggaggag gtgcttagca cccagatagc
     1561 ccacctggcc aggctgcagc tggagcagat ggtggagggc agcctgcagg ccggcagccc
     1621 acaaggcatt gtggggatgc ttaaacggca cgagttggag cgccagaagg ccttggccct
     1681 gcagcactca tggaagcagg gggagccttt gattgcgacc tccgaggagc tgaaggccac
     1741 ccctgagatt ccgcaggtaa aaccgggaag ctcagaggga gaggctgagg cccctgagga
     1801 ggaggaagaa aaggagaagg agaaaaaaga ggagaaaaaa tcagagctca tacctagcaa
     1861 ggtggcgtcc ctgtctgaca gctaccttga ccagacctct tcagcctcca gcatgagctt
     1921 caggaccaca ggcacctcag agactgagat gtcggctatc tgccaggaat acaggagcac
     1981 ctcagccacc gccgtgacat tctctgactc gtcactgttg aagacgcaat cctcggactc
     2041 tgggaacaac agggaggcac taagccatgg tcccagaaaa atcaaggcca cccagggcca
     2101 gaggcagagc cttagcaaga ctgagcccac ccagagccag aggcggaact ccagcaagac
     2161 caaggccact atacacaaga ggaactccag caagaccaag gccacccaaa gccagaggcg
     2221 gaactccagc aagaccaggg ccacccaggg ccaggggcag agctccagca agactgaggc
     2281 cactcagggc cagaggcaga gctccagcga gattgaggcc acccagggcc caaggcagga
     2341 gcccagcaag accaagacca cccggagccc aaggcagagg cccagaaagg tcaaggctgc
     2401 tcgtggccgg agctggagac ccagcaaggt tgatgccacc cagggccgaa gcaggggact
     2461 gctccgaagt tccaccaaga ctgaggcttt ctatgactca aactggagcc tcagcaaaac
     2521 tgagtatgcc caaggccagg gccagaggtc cagcaaggct gagggtgccc agggcaagag
     2581 ccagggcatg agctcaactt ccagcaaggc cgagtccacc tggggaccca gcccaagtct
     2641 cagcaaaact gaggttgatc aggacctcac ctactatgaa gctgtctgaa gggaccatcc
     2701 agaccctccc ttcttgctgg ggaggggacg agttctaccc acctccccac actggcactc
     2761 agccagctgc ctccttccag agcaattaaa agtcttagca acagtcctct ggtcccacag
     2821 ctgagtttat tatacttgtt ttcttttaca aaattaaaaa catctaaaac cagg
//
