LOCUS       NM_133462               3000 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 14 (TTC14), transcript
            variant 1, mRNA.
ACCESSION   NM_133462
VERSION     NM_133462.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX474122.1, AK055984.1, AB075860.2, AI742462.1 and AI811067.1.
            
            On Nov 23, 2018 this sequence version replaced NM_133462.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.123968.1,
                                           SRR1660803.90011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296015.9/ ENSP00000296015.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BX474122.1         35-65
            32-429              AK055984.1         23-420
            430-2848            AB075860.2         1-2419
            2849-2996           AI742462.1         11-158              c
            2997-3000           AI811067.1         27-30               c
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.33"
     gene            1..3000
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /note="tetratricopeptide repeat domain 14"
                     /db_xref="GeneID:151613"
                     /db_xref="HGNC:HGNC:24697"
     exon            1..260
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2412
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /note="isoform a is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 14; TPR repeat protein
                     14"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 14 isoform a"
                     /protein_id="NP_597719.1"
                     /db_xref="CCDS:CCDS3237.1"
                     /db_xref="GeneID:151613"
                     /db_xref="HGNC:HGNC:24697"
                     /translation="MDRDLLRQSLNCHGSSLLSLLRSEQQDNPHFRSLLGSAAEPARG
                     PPPQHPLQGRKEKRVDNIEIQKFISKKADLLFALSWKSDAPATSEINEDSEDHYAIMP
                     PLEQFMEIPSMDRRELFFRDIERGDIVIGRISSIREFGFFMVLICLGSGIMRDIAHLE
                     ITALCPLRDVPSHSNHGDPLSYYQTGDIIRAGIKDIDRYHEKLAVSLYSSSLPPHLSG
                     IKLGVISSEELPLYYRRSVELNSNSLESYENVMQSSLGFVNPGVVEFLLEKLGIDESN
                     PPSLMRGLQSKNFSEDDFASALRKKQSASWALKCVKIGVDYFKVGRHVDAMNEYNKAL
                     EIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGGQL
                     EEEEKFLNAESYYKKALALDETFKDAEDALQKLHKYMQKSLELREKQAEKEEKQKTKK
                     IETSAEKLRKLLKEEKRLKKKRRKSTSSSSVSSADESVSSSSSSSSSGHKRHKKHKRN
                     RSESSRSSRRHSSRASSNQIDQNRKDECYPVPANTSASFLNHKQEVEKLLGKQDRLQY
                     EKTQIKEKDRCPLSSSSLEIPDDFGGRSEDPRDFYNSYKTQAGSSKTEKPYKSERHFS
                     SRRNSSDSFCRNSEDKIYGYRRFEKDIEGRKEHYRRWEPGSVRHSTSPASSEYSWKSV
                     EKYKKYAHSGSRDFSRHEQRYRLNTNQGEYEREDNYGEDIKTEVPEEDALSSKEHSES
                     SVKKNLPQNLLNIFNQIAEFEKEKGNKSKN"
     exon            261..385
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            386..585
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            586..670
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            671..800
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            801..956
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1028
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1148
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1271
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1389
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1499
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..3000
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2821..2826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /note="hexamer: ATTAAA"
     polyA_site      2849
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /note="major polyA site"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
                     /note="hexamer: ATTAAA"
     polyA_site      3000
                     /gene="TTC14"
                     /gene_synonym="DRDL5813; PRO19630"
ORIGIN      
        1 agacagtttc ttccgcttcc tgtaccaccc ggctcaagta gcggacacgg aacagggaac
       61 tatcagcccg tcggcctccg ggccctgcat tctctagcca tggaccggga ccttttgcgg
      121 cagtcgctaa attgccacgg gtcgtctttg ctctctctac ttcggagcga acagcaggac
      181 aatccacact tccgtagcct cctggggtcg gccgccgagc cagcccgggg cccgccgccc
      241 cagcacccgt tgcagggcag aaaagagaag agagttgaca acatcgagat acagaaattc
      301 atctccaaaa aagcggatct gctttttgca ctttcctgga aatcagatgc acctgcaact
      361 tctgaaatta atgaagacag tgaagatcat tatgcaatca tgccaccttt agagcaattc
      421 atggagatac ctagtatgga tcggagagag ctgtttttcc gagatattga gcgtggtgat
      481 atagtgattg gaagaattag ttctattcgg gaattcggtt ttttcatggt gttgatctgt
      541 ttaggaagtg gtatcatgag agatatagcc cacttagaaa tcacagctct ttgtccctta
      601 agagatgtgc cttctcacag taaccatggg gatcctttat catattacca aactggtgac
      661 atcattcgag ctggaatcaa ggatattgac agataccatg aaaagctagc agtatctctg
      721 tatagctctt ctcttccacc acacctatct ggtattaaat taggtgtaat tagctctgaa
      781 gagcttcctt tatactacag gagaagtgtt gagctaaata gcaattcttt ggagtcctat
      841 gaaaatgtca tgcagagttc cttgggattt gttaatccag gagtagttga attccttcta
      901 gaaaaactag gaatagatga atctaatcca ccatctttaa tgagaggcct acaaagcaaa
      961 aatttctctg aagatgattt tgcttctgca ttgagaaaaa aacaatccgc atcttgggct
     1021 ttaaaatgtg tgaagatcgg agttgactat tttaaagttg gacgccatgt ggatgctatg
     1081 aatgaataca ataaagcttt ggaaatagac aaacaaaacg tggaagcttt ggtagctcgt
     1141 ggagcattat atgcgacaaa aggaagtttg aacaaagcaa tagaagattt tgagcttgca
     1201 ttagaaaact gtccaactca cagaaatgca agaaaatacc tctgccagac acttgtagag
     1261 agaggaggac agttagaaga agaagaaaag tttttaaatg ctgaaagtta ctataagaaa
     1321 gctttggctt tggatgagac ttttaaagat gcagaggatg ctttgcagaa acttcataaa
     1381 tatatgcaga aatctttgga attaagagaa aaacaagctg aaaaggaaga aaagcagaaa
     1441 acaaagaaaa tagaaacaag tgcagaaaag ttgcgtaagc tcttaaaaga agagaagagg
     1501 ctaaagaaga aaagaagaaa atcaacttct tcttcaagtg tttcttctgc tgatgaatca
     1561 gtgtcttcat catcatcctc ttcctcttct ggtcacaaaa ggcataagaa acataagagg
     1621 aaccgttcag agtcttctcg cagttccaga aggcattcat ctagggcatc ctcaaatcag
     1681 atagatcaga ataggaaaga tgagtgctac ccagttccag ctaatacttc agcatctttt
     1741 cttaaccata aacaagaagt ggagaaacta ctggggaagc aggataggtt acagtatgaa
     1801 aagacacaga taaaagagaa agatagatgc cctctctctt catcttcact tgaaataccg
     1861 gatgattttg gaggtaggtc tgaagatcca agagattttt ataacagcta taaaacccaa
     1921 gcaggtagta gcaaaacaga aaagccatat aaatcagaaa gacatttttc cagtagaaga
     1981 aattcctcag attccttctg taggaattca gaggacaaga tttatggtta taggagattt
     2041 gaaaaggata tagagggaag aaaagagcac tatagaaggt gggaaccagg ttctgtgagg
     2101 cattctacct caccagcaag ctcagaatac tcttggaagt cagttgagaa atacaaaaaa
     2161 tacgctcact ctggatcacg tgatttcagt agacatgagc aaagataccg tttaaataca
     2221 aatcaaggag aatatgaaag agaggacaat tatggggagg atatcaaaac agaggttcca
     2281 gaagaagatg cactaagtag caaagaacac tcagaaagca gtgttaagaa aaatttacct
     2341 cagaatttac tgaatatatt taatcagata gctgaatttg aaaaagaaaa aggaaataag
     2401 tcaaaaaatt aatacaccaa ggatatcggc accattacac aaaatgccat taagtgaagt
     2461 ttttggttgt attagtcata acagttgagt gcagaaatct ctgcttctaa aattatttgt
     2521 agagattaca ggaaacaaat gcttttaagt aagtttttct caaattttgt ttcagttcta
     2581 ggtcccttgt cacagcttgg tttttagact ttttatgtat atgtttatgt acagtatatt
     2641 actcttgaca gtttgaattt cttcacctaa agataattct ctgaaagtac tgtttcttca
     2701 ttctattgcg gtatatgaga attcctgggt gcatcttatt ctgctgtttg agagaaaaat
     2761 ttgtgcattg aacacttgga tcatttttat aaaaattaat ttcattttct tttctgttaa
     2821 attaaaaatc gtcagctttt gaaagattat atgttcgaat gtttcttgaa cacttttata
     2881 tttatcagtt taaatattac attttttgcc caattttttt taaaattttt aaatggtaga
     2941 ttatatgtct taattttcct ctaaagccca atttgattaa aagtggtttg tgaacagtca
//
