LOCUS       NM_024525               3276 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 13 (TTC13), transcript
            variant 1, mRNA.
ACCESSION   NM_024525 XM_939087
VERSION     NM_024525.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3276)
  AUTHORS   Xie,L., Fang,Y., Chen,J., Meng,W., Guan,Y. and Gong,W.
  TITLE     TTC13 expression and STAT3 activation may form a positive feedback
            loop to promote ccRCC progression
  JOURNAL   PeerJ 11, e16316 (2023)
   PUBMED   37927783
  REMARK    GeneRIF: TTC13 expression and STAT3 activation may form a positive
            feedback loop to promote ccRCC progression.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA741498.1, DA468037.1, AK075386.1, AK074365.1, AK075561.1 and
            EL946523.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024525.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075386.1, SRR1803617.207690.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366661.9/ ENSP00000355621.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DA741498.1         12-47
            37-142              DA468037.1         30-135
            143-1335            AK075386.1         120-1312
            1336-1343           AK074365.1         255-262
            1344-2532           AK075386.1         1321-2509
            2533-3252           AK075561.1         2361-3080
            3253-3276           EL946523.1         514-537
FEATURES             Location/Qualifiers
     source          1..3276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..3276
                     /gene="TTC13"
                     /note="tetratricopeptide repeat domain 13"
                     /db_xref="GeneID:79573"
                     /db_xref="HGNC:HGNC:26204"
     exon            1..302
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2614
                     /gene="TTC13"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; TPR repeat protein 13; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 13 isoform a
                     precursor"
                     /protein_id="NP_078801.3"
                     /db_xref="CCDS:CCDS1588.1"
                     /db_xref="GeneID:79573"
                     /db_xref="HGNC:HGNC:26204"
                     /translation="MAPAGCCCCCCFWGGAVAAAGAARRVLLLLLLGVLSAGLRPGAL
                     ATEHYSPLSLLKQELQHRQQQEAPAGGGGCSPQSGDWGDQYSAECGESSFLNFHDSDC
                     EPKGSSPCDSLLSLNTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYD
                     EAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEV
                     FEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSL
                     ELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFE
                     AATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKG
                     LSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEY
                     NIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIKDVLHQNFESYKPEVQELICVAD
                     RLGSLMQYETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMF
                     DIAVKWRRIADPDQPVLWLDQMPARSLSRGFNNHINLIRGQVINMRYLEYFEKILHFI
                     KDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIMKQFNTKTKDGFTVNTKVPSLKD
                     QGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHAEIDALYKDLTAKGKVLILSS
                     EFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGALMASGKEVAGKIPKGKLV
                     DFEAMTAPGSEAFSKVAKSWMNLKSISPSYKTLPSVSETFPTLRSMIEVLNTDSSPRC
                     LKKL"
     exon            303..397
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            398..473
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            474..544
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            545..610
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            611..703
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            704..820
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            821..931
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1014
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1156
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1331
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1488
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1619
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1752
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1845
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1929
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2014
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2124
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2260
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2340
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2419
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2499
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..3276
                     /gene="TTC13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3231..3236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC13"
                     /note="hexamer: AATAAA"
     polyA_site      3276
                     /gene="TTC13"
                     /note="major polyA site"
ORIGIN      
        1 aagggctgtc gcgcatgcgc cttgagggaa gatggcacct gccggctgct gctgctgctg
       61 ctgcttctgg ggcggcgctg tggccgccgc gggcgccgcc cggcgtgtcc tgctgctgct
      121 gctgctgggg gtcctgtccg ccgggctgcg gccaggcgcc ctggccaccg agcactactc
      181 gccgctctcc ctgctcaagc aggagctgca gcaccggcag cagcaggagg ccccggcggg
      241 cggcggcggc tgcagcccgc agtccgggga ctggggggac cagtactctg ccgagtgcgg
      301 cgagtcatcc tttttgaact tccatgactc agactgcgaa cccaagggat catcaccctg
      361 tgactccttg ctttccctca acactgagaa gattctgagc caggccaagt ctattgcaga
      421 acagaagaga ttcccgtttg ccactgataa tgacagcaca aatgaagagt tagctattgc
      481 ttatgtcttg attggcagtg gtctgtatga tgaagcaata cggcattttt caacaatgct
      541 tcaggaggag cctgatctgg ttagtgcaat ttatggccga gggatagcct atggaaagaa
      601 gggactacat gacattaaga atgctgagct tgctctgttc gaactgagcc gagtaattac
      661 cttggaacca gatcgtccag aggtatttga gcagcgagca gaaattctgt cccctctggg
      721 acgaattaat gaagcagtga atgacctcac taaagctatc caactgcagc cctcagcacg
      781 gctgtacaga catcggggaa ccctgtactt catatcagag gactatgcaa cagcccatga
      841 agactttcag cagtccttag aactgaacaa aaaccagcct atagctatgc tatacaaagg
      901 tttaactttc tttcacagag gacttctgaa ggaagctatt gaatccttca aagaagcttt
      961 gaagcagaaa gttgacttta ttgatgcata taaaagtcta gggcaggcat atagagaact
     1021 gggcaatttt gaagcagcca ctgagagctt tcaaaaggca ctgttgctca accaaaatca
     1081 tgtgcaaacc ctccagctcc ggggaatgat gctctaccac cacggcagct tacaggaagc
     1141 ccttaagaac tttaagcggt gtctgcagct agagccatat aatgaagtgt gccagtatat
     1201 gaaagggctc agccatgttg ccatgggaca gttttatgaa gggataaaag cacaaacaaa
     1261 agttatgctg aatgatcctc tcccaggcca gaaggctagc cctgagtatc ttaaagtaaa
     1321 gtatctccga gagtattctc gatatcttca tgcacacctt gatacccccc ttacggaata
     1381 taacattgat gtggatctgc ctggaagctt taaggaccac tgggctaaaa atttgccttt
     1441 cctcatagaa gactacgaag agcagccagg gttgcaaccc cacataaaag atgtgttaca
     1501 tcagaatttt gagagttata agcctgaagt acaggagctg atttgtgtgg ctgatcgttt
     1561 gggatccctg atgcaatatg aaacacctgg tttcctgcca aacaagagaa tacacagagc
     1621 tatgggtttg gccgcattgg aggtcatgca agccgtgcag cgtacatgga ccaactcgaa
     1681 agttcgaatg aatgggaaga cacggttgat gcagtggaga gacatgtttg acattgcagt
     1741 taaatggaga aggattgctg acccagacca gcccgtgctg tggttagatc aaatgccagc
     1801 acgaagtctt agcagaggtt ttaacaacca cattaattta atcaggggtc aggtgatcaa
     1861 catgagatac ctagaatatt ttgagaaaat acttcatttt attaaagaca gaattcttgt
     1921 ttatcatgga gctaataatc ctaaaggatt gctggaagtt cgggaagccc tggaaaaggt
     1981 acacaaagta gaagaccttc ttccgattat gaagcagttt aatactaaaa cgaaggatgg
     2041 gttcaccgtg aacacaaaag ttcccagcct taaagaccaa gggaaggaat atgatggatt
     2101 cacaatcacg attacaggag acaaagttgg caatatatta ttttctgtgg aaactcaaac
     2161 cacggaagaa aggacacaat tatatcatgc tgaaatagat gcactttata aagatttgac
     2221 agcaaaagga aaagtattga ttctttcatc agaatttggg gaggctgatg ctgtctgcaa
     2281 cttaatctta tccttagttt attactttta taatttaatg ccactctctc gaggatccag
     2341 tgtaattgct tactcggtca tcgtgggagc actgatggca agtggaaaag aagtagcagg
     2401 aaaaattccc aaagggaagt tagtcgactt tgaagctatg acagcccctg gttcagaggc
     2461 ctttagcaaa gtcgccaaaa gctggatgaa cttgaaaagt atttcacctt cttataagac
     2521 tcttccatca gtatcagaaa cgtttccaac gttaagatcg atgattgagg tgctaaacac
     2581 agactcttct ccacgttgtc ttaagaaact ctagttctgc tgctgtattt atacaagtaa
     2641 agggccggac ctcttgcttc ttaagttatt ttttaaaaca tggaattata aagaaattag
     2701 gtcctctatt acttttgata ccaattttta taggaattga atacttgaaa tcattttctt
     2761 tacttttctg aaccataatg aaaatcatga aagaggcttt cggggggaaa aagctacttg
     2821 acttggaggg aaagcgtatg tattagccgg cagcctgttg gttcccactt ataaagtcat
     2881 ataactcctt ccttacagta aaaaaaattt tcctcaacaa ctaaaatata atactgaaga
     2941 tgaacaaaaa caaaaccaaa taggagtgtt tgtattcctt tagagatctg gatatttttc
     3001 aaagacttgc tttttacgca cattgtgata gagcatcttt tgttgactca cgtaacctcc
     3061 atgtgtgggt cctttgtttt attagaacca tggaagaagg ttcctgggcc atcagtatgt
     3121 gttgcagagc tcacagccag gaacacttat tttgaacaat gcagacagta cttgccagag
     3181 tcccaaatgc tgaattattg aaccatgttt ttttttcctt tgttgaaaaa aataaaccag
     3241 ggtgatttct ataaatcacc agtttttggc attgga
//
