LOCUS       NM_003314               1441 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript
            variant 1, mRNA.
ACCESSION   NM_003314 XM_001717166 XM_001722976 XM_001725128
VERSION     NM_003314.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1441)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1441)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1441)
  AUTHORS   Kwan,D.H., Yung,L.Y., Ye,R.D. and Wong,Y.H.
  TITLE     Activation of Ras-dependent signaling pathways by G(14) -coupled
            receptors requires the adaptor protein TPR1
  JOURNAL   J Cell Biochem 113 (11), 3486-3497 (2012)
   PUBMED   22711498
  REMARK    GeneRIF: TPR1 is required for Galpha14 to stimulate Ras-dependent
            signaling pathways, but not for the propagation of signals along
            Ras-independent pathways.
REFERENCE   5  (bases 1 to 1441)
  AUTHORS   Liu,A.M., Lo,R.Kh., Guo,E.X., Ho,M.K., Ye,R.D. and Wong,Y.H.
  TITLE     Galpha16 interacts with tetratricopeptide repeat 1 (TPR1) through
            its beta3 region to activate Ras independently of phospholipase
            Cbeta signaling
  JOURNAL   BMC Struct Biol 11, 17 (2011)
   PUBMED   21486497
  REMARK    GeneRIF: beta3 region of Galpha16 is essential for interaction with
            TPR1 and the subsequent activation of Ras
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1441)
  AUTHORS   Ligon,L.A., Tokito,M., Finklestein,J.M., Grossman,F.E. and
            Holzbaur,E.L.
  TITLE     A direct interaction between cytoplasmic dynein and kinesin I may
            coordinate motor activity
  JOURNAL   J Biol Chem 279 (18), 19201-19208 (2004)
   PUBMED   14985359
REFERENCE   7  (bases 1 to 1441)
  AUTHORS   Oh,W.K. and Song,J.
  TITLE     Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses
            Hsp70-HspBp1 complex formation
  JOURNAL   Mol Cells 16 (1), 84-91 (2003)
   PUBMED   14503850
  REMARK    GeneRIF: Results report cooperative interactions involving Hsp70,
            Hsp40, and TPR1 that enhance Hsp70-dependent folding of chemically
            denatured substrates.
REFERENCE   8  (bases 1 to 1441)
  AUTHORS   Marty,C., Browning,D.D. and Ye,R.D.
  TITLE     Identification of tetratricopeptide repeat 1 as an adaptor protein
            that interacts with heterotrimeric G proteins and the small GTPase
            Ras
  JOURNAL   Mol Cell Biol 23 (11), 3847-3858 (2003)
   PUBMED   12748287
  REMARK    GeneRIF: Data show that tetratricopeptide repeat 1 is a novel
            adaptor protein for Ras and selected Galpha proteins that may be
            involved in protein-protein interaction relating to G-protein
            signaling.
REFERENCE   9  (bases 1 to 1441)
  AUTHORS   Zhao,S. and Sancar,A.
  TITLE     Human blue-light photoreceptor hCRY2 specifically interacts with
            protein serine/threonine phosphatase 5 and modulates its activity
  JOURNAL   Photochem Photobiol 66 (5), 727-731 (1997)
   PUBMED   9383998
REFERENCE   10 (bases 1 to 1441)
  AUTHORS   Murthy,A.E., Bernards,A., Church,D., Wasmuth,J. and Gusella,J.F.
  TITLE     Identification and characterization of two novel tetratricopeptide
            repeat-containing genes
  JOURNAL   DNA Cell Biol 15 (9), 727-735 (1996)
   PUBMED   8836031
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP245572.1 and U46570.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003314.2.
            
            Summary: This gene encodes a protein that belongs to the tetratrico
            peptide repeat superfamily of proteins. The encoded protein plays a
            role in protein-protein interactions, and binds to the Galpha
            subunit of G protein-coupled receptors to activate the Ras
            signaling pathway. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1063557.1,
                                           SRR3476690.281072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231238.10/ ENSP00000231238.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BP245572.1         40-73
            35-1441             U46570.1           1-1407
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..1441
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /note="tetratricopeptide repeat domain 1"
                     /db_xref="GeneID:7265"
                     /db_xref="HGNC:HGNC:12391"
                     /db_xref="MIM:601963"
     exon            1..55
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            56..414
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..963
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /note="TPR repeat protein 1"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 1"
                     /protein_id="NP_003305.1"
                     /db_xref="CCDS:CCDS4348.1"
                     /db_xref="GeneID:7265"
                     /db_xref="HGNC:HGNC:12391"
                     /db_xref="MIM:601963"
                     /translation="MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSK
                     LLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEK
                     NMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSN
                     RAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEK
                     DPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSS
                     TGSYSINFVQNPNNNR"
     exon            415..475
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..588
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..625
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..774
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..829
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1441
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1421..1426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /note="hexamer: AATAAA"
     polyA_site      1441
                     /gene="TTC1"
                     /gene_synonym="TPR1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtagga gctctcagag gctaagaagg tggagaccgg agaagctgtg aggttcttta
       61 gcgtcacctc cctcactggg cagcatgggg gagaagtcag agaactgtgg ggttccagag
      121 gatctgttaa atggtttgaa ggttacagat actcaggaag ccgagtgtgc tggccctcca
      181 gttcctgatc ccaaaaatca gcattcccag agtaagctgc tcagggatga tgaggcccat
      241 ctccaggagg accagggaga agaggagtgt tttcatgact gcagtgcctc atttgaggag
      301 gagccaggag cggacaaggt tgagaacaaa tctaatgaag atgtgaattc ctctgaacta
      361 gatgaagaat acctaataga actggaaaaa aacatgtcgg atgaagagaa acagaaaaga
      421 agagaagaga gcactagact aaaggaggag ggaaatgaac agtttaagaa aggagattat
      481 atagaagctg aaagttctta tagtcgagcc ctcgaaatgt gcccatcctg cttccaaaag
      541 gagaggtcga ttctattttc aaatagagct gcagcaagga tgaaacagga caagaaagaa
      601 atggccatca atgactgcag caaagcaatt caattaaacc ccagctatat cagggcaata
      661 ttgaggagag cagagttgta tgagaagacg gacaagctag atgaagccct ggaagactat
      721 aaatctatat tagaaaaaga tccatcaata catcaagcaa gagaagcttg tatgagatta
      781 cctaagcaaa ttgaagaacg taatgaaaga ctaaaagaag agatgttagg taaattaaaa
      841 gatcttggga acttggttct ccgacctttt gggctctcca cggaaaattt ccagatcaaa
      901 caggattcct ctaccggctc gtactccatc aatttcgttc aaaatccaaa taataacaga
      961 taacaaagat aacaaaagct ttacaagctg acttggaatt gtgtgctgct tgctgttagc
     1021 taggggaaag gccctgccaa tgtttaactt ttaaaagcat cttatctaaa agaaaggcta
     1081 tccagtagag cccagtgctc ccttgtccct cttttatgat cagggtgaaa tgtacttcct
     1141 gatgtaatga acctaatttg atttccattt taaggtggtg tctgtgcagc tggtgtcccc
     1201 gattctggct gtcctatgtc caggaagaag cccatttgtt gaggctgacc ttcctgatca
     1261 tacacacaca cagcccagca aaagcctctc ctgaaccaaa caaacctgtt ggttgggaga
     1321 ctgcccagac atgattgatg acgggttccc gcctgctgtc ccctccctga tcacacagct
     1381 aacgaggctg cctccagcat ttcctgattt cctctgtggt aataaaagct ttctgtgctt
     1441 a
//
