LOCUS       NM_139246               4116 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens thiosulfate sulfurtransferase like domain containing 2
            (TSTD2), mRNA.
ACCESSION   NM_139246
VERSION     NM_139246.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Kubota,M., Zhang,B.S., Li,S.Y., Yoshida,Y., Wang,H., Adachi,A.,
            Matsutani,T., Mine,S., Machida,T., Kamitsukasa,I., Wada,T.,
            Aotsuka,A., Kitamura,K., Takizawa,H., Kuroda,H., Iwadate,Y. and
            Hiwasa,T.
  TITLE     Serum anti-TSTD2 antibody as a biomarker for
            atherosclerosis-induced ischemic stroke and chronic kidney disease
  JOURNAL   Med Int (Lond) 3 (1), 4 (2022)
   PUBMED   36699658
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4116)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4116)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4116)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 4116)
  AUTHORS   Takahashi,M., Saenko,V.A., Rogounovitch,T.I., Kawaguchi,T.,
            Drozd,V.M., Takigawa-Imamura,H., Akulevich,N.M., Ratanajaraya,C.,
            Mitsutake,N., Takamura,N., Danilova,L.I., Lushchik,M.L.,
            Demidchik,Y.E., Heath,S., Yamada,R., Lathrop,M., Matsuda,F. and
            Yamashita,S.
  TITLE     The FOXE1 locus is a major genetic determinant for
            radiation-related thyroid carcinoma in Chernobyl
  JOURNAL   Hum Mol Genet 19 (12), 2516-2523 (2010)
   PUBMED   20350937
REFERENCE   6  (bases 1 to 4116)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   7  (bases 1 to 4116)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA735730.1, CN298691.1, BC035604.1, AL162385.16 and BU625565.1.
            
            On Nov 23, 2018 this sequence version replaced NM_139246.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.104497.1,
                                           SRR1803616.257999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341170.5/ ENSP00000342499.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA735730.1         313-335
            24-51               CN298691.1         199-226
            52-423              BC035604.1         11-382
            424-424             CN298691.1         600-600
            425-1555            BC035604.1         384-1514
            1556-3394           AL162385.16        105748-107586       c
            3395-4116           BU625565.1         18-739              c
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..4116
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:158427"
                     /db_xref="HGNC:HGNC:30087"
     exon            1..126
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            127..341
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1727
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /note="PP4189; rhodanese domain-containing protein 2;
                     thiosulfate sulfurtransferase (rhodanese)-like domain
                     containing 2; rhodanese like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2"
                     /protein_id="NP_640339.4"
                     /db_xref="CCDS:CCDS6727.2"
                     /db_xref="GeneID:158427"
                     /db_xref="HGNC:HGNC:30087"
                     /translation="MPSSTSPDQGDDLENCILRFSDLDLKDMSLINPSSSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKEVPTKRSFECKEKLWKCCRQLFTDQTSIHRHVATQHAD
                     EIYHQTASILKQLAVTLSTSKSLSSADEKNPLKECLPHSHDVSAWLPDISCFNPDELI
                     SGQGSEEGEVLLYYCYHDLEDPQWICAWQTALCQHLHLTGKIRIAAEGINGTVGGSKL
                     ATRLYVEVMLSFPLFKDDLCKDDFKTSKGGAHCFPELRVGVFEEIVPMGISPKKISYK
                     KPGIHLSPGEFHKEVEKFLSQANQEQSDTILLDCRNFYESKIGRFQGCLAPDIRKFSY
                     FPSYVDKNLELFREKRVLMYCTGGIRCERGSAYLKAKGVCKEVFQLKGGIHKYLEEFP
                     DGFYKGKLFVFDERYALSYNSDVVSECSYCGARWDQYKLCSTPQCRQLVLTCPACQGQ
                     GFTACCVTCQDKGSRKVSGPMQDSFKEECECTARRPRIPRELLQHVRQPVSPEPGPDA
                     DEDGPVLM"
     exon            342..658
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            659..779
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            780..905
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1011
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1130
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1289
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1428
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..4116
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4087..4092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /note="hexamer: AATAAA"
     polyA_site      4116
                     /gene="TSTD2"
                     /gene_synonym="C9orf97"
                     /note="major polyA site"
ORIGIN      
        1 gtcacgagcg agcttttcta cccaaatacg cggcggggga ataggctcga gggcggtgag
       61 cagtgacaat tgctaggcgg agacagtgca gggaagagag accttagaaa ggatcaggac
      121 tggcgggagg tatttaactg aaaggaatat ctgcttcact gttgcaacca aaccagatgc
      181 cttcttccac ttcaccagac caaggagatg acctggagaa ctgcatttta agattttctg
      241 acctggattt aaaagatatg agtcttatta atcccagcag cagtcttaaa gcagaattag
      301 atggcagtac aaaaaagaaa tactcgtttg caaagaaaaa ggcctttgcc ctttttgtca
      361 aaaccaaaga agttccaaca aaaaggagtt ttgaatgtaa agaaaaattg tggaaatgct
      421 gtcggcagct attcacagac caaaccagca tccatagaca tgtggcaaca caacatgctg
      481 atgaaattta tcaccagaca gcttctattt taaagcaact ggctgtgaca ttgagcacct
      541 caaagagtct ttcgtctgca gatgaaaaga accctttaaa agagtgcctt ccacatagcc
      601 atgacgtgtc tgcttggctc cctgatataa gctgctttaa ccctgatgag ctgataagtg
      661 gccagggcag tgaagaaggg gaggtgctcc tttattactg ctaccatgac ctggaggatc
      721 cccaatggat ctgtgcctgg cagacagctc tgtgtcagca cctgcacctc acaggcaaga
      781 ttcgaattgc tgcagaagga atcaatggga cagttggtgg aagcaaattg gctaccagac
      841 tttatgtgga agtcatgctt tccttcccat tgtttaagga tgacctgtgt aaagatgatt
      901 ttaagaccag caaaggagga gctcactgtt ttccagaatt gcgtgttggt gtatttgaag
      961 aaatcgtgcc catggggatc agccccaaaa agatctccta caagaagcct ggaatccatt
     1021 tatccccagg tgaatttcat aaagaagtag aaaagttttt atctcaggca aatcaagaac
     1081 aaagtgatac tatccttctt gattgcagaa acttctatga aagcaaaata ggacgattcc
     1141 aaggctgctt agccccagac atcaggaaat tcagttactt ccctagctac gttgacaaaa
     1201 atctagaact tttcagagag aagagagtgc tgatgtactg taccgggggc atccgctgtg
     1261 agcggggttc agcctacctc aaagccaagg gagtgtgcaa ggaggtgttc cagctcaagg
     1321 gtggcatcca caagtacctg gaagagtttc ctgatggctt ttacaaaggg aagttgtttg
     1381 tttttgatga acgctatgct ctgtcctaca acagtgatgt ggtgtcagag tgttcatact
     1441 gtggagcccg ctgggaccag tataaactct gctctactcc ccagtgccgc cagctcgttt
     1501 tgacctgccc tgcctgtcaa ggacaaggat tcacagcctg ttgtgtcaca tgtcaagaca
     1561 aggggagcag gaaagtttca ggccctatgc aagacagctt taaagaggaa tgcgagtgca
     1621 cagcccgacg gccacgcata cctagggaac tcttgcagca tgtgcgacag cctgtgagcc
     1681 cagagccagg gcctgatgct gatgaggatg ggccagtgct tatgtgagca gcacctttgg
     1741 cattttccca ggccctcggt aaaagtaggt ttggggtgac tatacagaga aagcatggca
     1801 agactgcaga aacagagaaa tcgggaactt cagttctggc cgctgccacc gtggcagccg
     1861 tctacacttc acagcgggag gggaggagtc acgttgtcta ccacttacct gagacattct
     1921 gatttggatg atgctagagc acagaaaata ggtgagctgc atgggatccc aaagctgctg
     1981 agggatagag cctgagcctg gtggccacag catatgccct ttctgttcca tgcagctggg
     2041 gctgttagta gtcattgccc ttgtcagcag accttctacc ctggtggcaa acacatgaaa
     2101 gctgtggccc tgggagtggc ctcctaaaac aagccactta ggtcatctgc catctaccct
     2161 taacctctgt ctctcgcctg aggggaatct gcaagctgtg cattgggctt acctcctgct
     2221 tttgtagaaa taaccatcct ttggtataca tggaggatag ttccagaacg cctgagtata
     2281 caaaaaccca atgcatactc aagtcccaca gtgggcccta cagaacccac gtatgtgata
     2341 aatcagccct ccatgtacgc aggtttcgcc ccctgccaat actgtatttt caacctgtat
     2401 ggttgaaaaa aatccatata taagtgcagc catgcagttc aaacccatat tgttcaaggg
     2461 tcaactgtat agtttattga acagccacac ccattccttt acacatgatc tatggcagag
     2521 ttgaatagtt gcaacagaca ctatgtggcc tgcaaaatcg gaaattttta ctgtctggcc
     2581 ttttacagaa aagtttgcca gcccctgatc tagaccagca gctcatctga tagaggcaga
     2641 ggtggcctta aagatgtggc cttcttcatt ttctgttggt ttggtttcgt ttctatgaga
     2701 gatttcctct gatagctctg ctttccccag cacttactct ctgagctttt aaatgttctc
     2761 tctgggagct tcatataagc tcggtgacat ttgagccaca gtttttagat cagcacctgg
     2821 aatacatgac acattcttac tgaggtcatc cagcactgcc atggtggctg cccagtcttc
     2881 tggccagtgt gccaggcaca tgtccctgtc acacaggttc caagaaacac atacgcagcc
     2941 atgcatagac caacagattt aatattatat tgcagttttc agcgatgcag aatgcagctg
     3001 caattgtgtt ttaaggagaa gccaaatggg gatggttgtc cctgcaacat ggtgccactc
     3061 ctgggccatg tgcagcctca gtggacactc ttccatagcg ctgaggccct ggccccgcct
     3121 ccagttaccc tgtactgccc actgccttac agttcagtgc gcaggccttc accttttcat
     3181 caccagcctc tctgctcagt gctctggagt tcttgacctt gtcctttatc atgagatttg
     3241 ctgaaatcac taatgaaaat aactcccaaa agcaacaaac aaaaatatta gtttaactgg
     3301 cactgtggta tattaaaagg cacaagggca ttgtggctta acacttttgc tggatcccaa
     3361 gagacgcaca tgatgttaaa aagagatctg gcagcagtac taatactaca tttcagtgta
     3421 atcatcttgg ggtggtttgg ccaggatttc ccaattcctt gatatctgga gtttcttcac
     3481 cattgtccgg catcctgcgg aggcttaata tacaggcgta aggtcagcag caatttgtct
     3541 aataagtgat gagatcagta gctgaagtct ctaagctggg ccattactaa ataccatagc
     3601 catgttgatc tggaaattta tccctctagt gtcttacctc acataagcca tttgcccact
     3661 gtgcaatata gaaaggtgtt ttcaaaagta tttggccgta gattttcaca tccatcataa
     3721 ggttggcatt caataaggaa aaagttctaa ctccagtatt aaattgtaca taaatcccaa
     3781 atgttcttaa agaacactca gggacatgtt tgttgcctgg gattggtaat gaaaggttgg
     3841 tttttgaaac ttgaaatttc accattggtt tttttcctat catttctgca tatccagcaa
     3901 aaggaatctc atgttgactc ctggcagagt tcagtggctt cagtctgtct atctgttctg
     3961 aggggaaaat tgtgttctgg atccagtaat caatttggca actttaatcg aggttttcaa
     4021 aattccaagg agggttaata aagaatgata atcagtttta tttgctaata gctaagacaa
     4081 atttgtaata aagtgtttta taatacttca aaagca
//
