LOCUS       NM_001113207             567 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens thiosulfate sulfurtransferase like domain containing 1
            (TSTD1), transcript variant 1, mRNA.
ACCESSION   NM_001113207 NM_001126312 XM_001722251 XM_001725725 XM_001725726
VERSION     NM_001113207.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Libiad,M., Motl,N., Akey,D.L., Sakamoto,N., Fearon,E.R., Smith,J.L.
            and Banerjee,R.
  TITLE     Thiosulfate sulfurtransferase-like domain-containing 1 protein
            interacts with thioredoxin
  JOURNAL   J Biol Chem 293 (8), 2675-2686 (2018)
   PUBMED   29348167
  REMARK    GeneRIF: Data suggest that TSTD1 can utilize thioredoxin as an
            acceptor in the presence of thioredoxin reductase and NADPH.
REFERENCE   2  (bases 1 to 567)
  AUTHORS   Schlittler,M., Goiny,M., Agudelo,L.Z., Venckunas,T., Brazaitis,M.,
            Skurvydas,A., Kamandulis,S., Ruas,J.L., Erhardt,S., Westerblad,H.
            and Andersson,D.C.
  TITLE     Endurance exercise increases skeletal muscle kynurenine
            aminotransferases and plasma kynurenic acid in humans
  JOURNAL   Am J Physiol Cell Physiol 310 (10), C836-C840 (2016)
   PUBMED   27030575
  REMARK    GeneRIF: Endurance exercise caused an increase in plasma KYNA
            within the first hour after exercise. In contrast, a bout of
            high-intensity eccentric exercise did not lead to increased plasma
            KYNA concentration. Our results show that regular endurance
            exercise causes adaptations in kynurenine metabolism which can have
            implications for exercise recommendations for patients with
            depressive disorder.
REFERENCE   3  (bases 1 to 567)
  AUTHORS   Melideo,S.L., Jackson,M.R. and Jorns,M.S.
  TITLE     Biosynthesis of a central intermediate in hydrogen sulfide
            metabolism by a novel human sulfurtransferase and its yeast
            ortholog
  JOURNAL   Biochemistry 53 (28), 4739-4753 (2014)
   PUBMED   24981631
  REMARK    GeneRIF: Biosynthesis of a central intermediate in hydrogen sulfide
            metabolism by a novel human sulfurtransferase and its yeast
            ortholog.
REFERENCE   4  (bases 1 to 567)
  AUTHORS   Rejdak,R., Rummelt,C., Zrenner,E., Grieb,P., Rejdak,K., Okuno,E.,
            Thaler,S., Nowomiejska,K., Kruse,F., Turski,W. and Junemann,A.G.
  TITLE     Presence of L-kynurenine aminotransferase III in retinal ganglion
            cells and corpora amylacea in the human retina and optic nerve
  JOURNAL   Folia Neuropathol 49 (2), 132-137 (2011)
   PUBMED   21845542
  REMARK    GeneRIF: The presence of kynurenine aminotransferase III in Corpora
            amylacea in the human retina and optic nerve indicates that this
            enzyme may be relevant in mechanisms of neurodegeneration leading
            to Corpora amylaceaformation.
REFERENCE   5  (bases 1 to 567)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 567)
  AUTHORS   Wenzel,K., Felix,S.B., Flachmeier,C., Heere,P., Schulze,W.,
            Grunewald,I., Pankow,H., Hewelt,A., Scherneck,S., Bauer,D. and
            Hoehe,M.R.
  TITLE     Identification and characterization of KAT, a novel gene
            preferentially expressed in several human cancer cell lines
  JOURNAL   Biol Chem 384 (5), 763-775 (2003)
   PUBMED   12817473
REFERENCE   7  (bases 1 to 567)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   8  (bases 1 to 567)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 567)
  AUTHORS   Gupta,S.K., Pillarisetti,K. and Ohlstein,E.H.
  TITLE     Platelet agonist F11 receptor is a member of the immunoglobulin
            superfamily and identical with junctional adhesion molecule (JAM):
            regulation of expression in human endothelial cells and macrophages
  JOURNAL   IUBMB Life 50 (1), 51-56 (2000)
   PUBMED   11087121
REFERENCE   10 (bases 1 to 567)
  AUTHORS   Ozaki,H., Ishii,K., Horiuchi,H., Arai,H., Kawamoto,T., Okawa,K.,
            Iwamatsu,A. and Kita,T.
  TITLE     Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes
            redistribution of junctional adhesion molecule in human endothelial
            cells
  JOURNAL   J Immunol 163 (2), 553-557 (1999)
   PUBMED   10395639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD675389.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001113207.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.486518.1, CB994352.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence (PMID:
                                                12665801)
            MANE Ensembl match               :: ENST00000423014.3/
                                                ENSP00000388293.2
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               CD675389.1         16-582
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..567
                     /gene="TSTD1"
                     /gene_synonym="KAT; TST"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 1"
                     /db_xref="GeneID:100131187"
                     /db_xref="HGNC:HGNC:35410"
                     /db_xref="MIM:616041"
     exon            1..85
                     /gene="TSTD1"
                     /gene_synonym="KAT; TST"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..423
                     /gene="TSTD1"
                     /gene_synonym="KAT; TST"
                     /EC_number="2.8.1.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative thiosulfate sulfurtransferase KAT; thiosulfate
                     sulfurtransferase/rhodanese-like domain-containing protein
                     1; thiosulfate sulfurtransferase (rhodanese)-like domain
                     containing 1; thiosulfate:glutathione sulfurtransferase"
                     /codon_start=1
                     /product="thiosulfate:glutathione sulfurtransferase
                     isoform 1"
                     /protein_id="NP_001106678.1"
                     /db_xref="CCDS:CCDS53400.1"
                     /db_xref="GeneID:100131187"
                     /db_xref="HGNC:HGNC:35410"
                     /db_xref="MIM:616041"
                     /translation="MAGAPTVSLPELRSLLASGRARLFDVRSREEAAAGTIPGALNIP
                     VSELESALQMEPAAFQALYSAEKPKLEDEHLVFFCQMGKRGLQATQLARSLGYTGARN
                     YAGAYREWLEKES"
     exon            86..208
                     /gene="TSTD1"
                     /gene_synonym="KAT; TST"
                     /inference="alignment:Splign:2.1.0"
     exon            209..371
                     /gene="TSTD1"
                     /gene_synonym="KAT; TST"
                     /inference="alignment:Splign:2.1.0"
     exon            372..567
                     /gene="TSTD1"
                     /gene_synonym="KAT; TST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      547..552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSTD1"
                     /gene_synonym="KAT; TST"
                     /note="hexamer: AATAAA"
     polyA_site      567
                     /gene="TSTD1"
                     /gene_synonym="KAT; TST"
                     /note="major polyA site"
ORIGIN      
        1 gaacgggaga tgttgcaggc gccgagaggg cgggccaggg ccgcactccg gagactcgcg
       61 gttgctacgc gcaccatggc tggagcgccc acggtctcgc ttcctgaact ccgttcactc
      121 ctagcctccg gacgggcccg gctcttcgac gtgcgctctc gcgaggaggc ggcagctggg
      181 accatcccag gggcgctcaa catcccggtg tccgagttgg agagtgctct gcagatggag
      241 ccagctgcct tccaggcttt atattctgct gagaagccaa agctggaaga tgagcatctc
      301 gttttcttct gtcagatggg caagcggggc ctccaggcca cgcagctggc ccggagtctt
      361 ggatacactg gggctcgcaa ctacgctgga gcctatagag aatggttgga gaaagagagt
      421 taggcaggag gcagcttact gattgccacc ccctggcccc ttaatggcca ccttaactaa
      481 gggtgtgaac gggctgactt ggtgaattgg gcaactcctt atagtgttgt gcacacaaaa
      541 gcatcaaata aagaacattt aatcaaa
//
