LOCUS       NM_032037               1330 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens testis specific serine kinase 6 (TSSK6), mRNA.
ACCESSION   NM_032037
VERSION     NM_032037.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1330)
  AUTHORS   Delgado,M., Gallegos,Z., Stippec,S., McGlynn,K., Cobb,M.H. and
            Whitehurst,A.W.
  TITLE     Testis-specific serine kinase 6 (TSSK6) is abnormally expressed in
            colorectal cancer and promotes oncogenic behaviors
  JOURNAL   J Biol Chem 300 (6), 107380 (2024)
   PUBMED   38762178
  REMARK    GeneRIF: Testis-specific serine kinase 6 (TSSK6) is abnormally
            expressed in colorectal cancer and promotes oncogenic behaviors.
REFERENCE   2  (bases 1 to 1330)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1330)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 1330)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   5  (bases 1 to 1330)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   6  (bases 1 to 1330)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   7  (bases 1 to 1330)
  AUTHORS   Jha,K.N., Wong,L., Zerfas,P.M., De Silva,R.S., Fan,Y.X.,
            Spiridonov,N.A. and Johnson,G.R.
  TITLE     Identification of a novel HSP70-binding cochaperone critical to
            HSP90-mediated activation of small serine/threonine kinase
  JOURNAL   J Biol Chem 285 (45), 35180-35187 (2010)
   PUBMED   20829357
REFERENCE   8  (bases 1 to 1330)
  AUTHORS   Su,D., Zhang,W., Yang,Y., Zhang,H., Liu,Y.Q., Bai,G., Ma,Y.X.,
            Peng,Y. and Zhang,S.Z.
  TITLE     c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene
            associated with spermatogenic impairment in a Chinese population
  JOURNAL   Asian J Androl 12 (2), 234-239 (2010)
   PUBMED   20037600
  REMARK    GeneRIF: findings, for the first time, suggested an association of
            c.822+126T>G/C in TSSK6 with spermatogenic impairment in humans in
            which allele T may be a risk factor for male infertility, while
            alleles C and G may decrease susceptibility to male infertility
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1330)
  AUTHORS   Spiridonov,N.A., Wong,L., Zerfas,P.M., Starost,M.F., Pack,S.D.,
            Paweletz,C.P. and Johnson,G.R.
  TITLE     Identification and characterization of SSTK, a serine/threonine
            protein kinase essential for male fertility
  JOURNAL   Mol Cell Biol 25 (10), 4250-4261 (2005)
   PUBMED   15870294
  REMARK    GeneRIF: results demonstrate that SSTK is required for proper
            postmeiotic chromatin remodeling and male fertility
REFERENCE   10 (bases 1 to 1330)
  AUTHORS   Hao,Z., Jha,K.N., Kim,Y.H., Vemuganti,S., Westbrook,V.A.,
            Chertihin,O., Markgraf,K., Flickinger,C.J., Coppola,M., Herr,J.C.
            and Visconti,P.E.
  TITLE     Expression analysis of the human testis-specific serine/threonine
            kinase (TSSK) homologues. A TSSK member is present in the
            equatorial segment of human sperm
  JOURNAL   Mol Hum Reprod 10 (6), 433-444 (2004)
   PUBMED   15044604
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF348077.1 and AA608857.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_032037.3.
            
            Summary: This intronless gene encodes a member of the CAMK
            (calcium/calmodulin-dependent) serine/threonine protein kinase
            family. The encoded kinase has a broad expression pattern but is
            described as testis-specific due to effects on fertility. Male mice
            which lack the gene encoding a highly similar protein are sterile
            and have morphologically abnormal sperm. [provided by RefSeq, Jan
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF348077.1, HM005618.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585580.4/ ENSP00000466477.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1308              AF348077.1         138-1445
            1309-1330           AA608857.1         18-39               c
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1330
                     /gene="TSSK6"
                     /gene_synonym="CT72; FKSG82; SSTK; TSSK4"
                     /note="testis specific serine kinase 6"
                     /db_xref="GeneID:83983"
                     /db_xref="HGNC:HGNC:30410"
                     /db_xref="MIM:610712"
     exon            1..1330
                     /gene="TSSK6"
                     /gene_synonym="CT72; FKSG82; SSTK; TSSK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..943
                     /gene="TSSK6"
                     /gene_synonym="CT72; FKSG82; SSTK; TSSK4"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine protein kinase SSTK; cancer/testis
                     antigen 72; small serine/threonine kinase; TSK-6; testis
                     secretory sperm-binding protein Li 205a"
                     /codon_start=1
                     /product="testis-specific serine/threonine-protein kinase
                     6"
                     /protein_id="NP_114426.1"
                     /db_xref="CCDS:CCDS12403.1"
                     /db_xref="GeneID:83983"
                     /db_xref="HGNC:HGNC:30410"
                     /db_xref="MIM:610712"
                     /translation="MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVD
                     RRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQ
                     RNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQ
                     AHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIA
                     GLPRRQKRGVLYPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG"
     regulatory      1309..1314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSSK6"
                     /gene_synonym="CT72; FKSG82; SSTK; TSSK4"
                     /note="hexamer: AATAAA"
     polyA_site      1330
                     /gene="TSSK6"
                     /gene_synonym="CT72; FKSG82; SSTK; TSSK4"
                     /note="major polyA site"
ORIGIN      
        1 agtgggcaca tgggggtgcg ggggtgtagg tgccaagcgc catggcttag acccgagatt
       61 ggagtccggc cgccccccga cagcagccgc ctcctgcccc ccgtgcgccc taggcgccac
      121 catgtcggga gacaaacttc tgagcgaact cggttataag ctgggccgca caattggaga
      181 gggcagctac tccaaggtga aggtggccac atccaagaag tacaagggta ccgtggccat
      241 caaggtggtg gaccggcggc gagcgccccc ggacttcgtc aacaagttcc tgccgcgaga
      301 gctgtccatc ctgcggggcg tgcgacaccc gcacatcgtg cacgtcttcg agttcatcga
      361 ggtgtgcaac gggaaactgt acatcgtgat ggaagcggcc gccaccgacc tgctgcaagc
      421 cgtgcagcgc aacgggcgca tccccggagt tcaggcgcgc gacctctttg cgcagatcgc
      481 cggcgccgtg cgctacctgc acgatcatca cctggtgcac cgcgacctca agtgcgaaaa
      541 cgtgctgctg agcccggacg agcgccgcgt caagctcacc gacttcggct tcggccgcca
      601 ggcccatggc tacccagacc tgagcaccac ctactgcggc tcagccgcct acgcgtcacc
      661 cgaggtgctc ctgggcatcc cctacgaccc caagaagtac gatgtgtgga gcatgggcgt
      721 cgtgctctac gtcatggtca ccgggtgcat gcccttcgac gactcggaca tcgccggcct
      781 gccccggcgc cagaaacgcg gcgtgctcta tcccgaaggc ctcgagctgt ccgagcgctg
      841 caaggccctg atcgccgagc tgctgcagtt cagcccgtcc gccaggccct ccgcgggcca
      901 ggtagcgcgc aactgctggc tgcgcgccgg ggactccggc tagaagccgg gtggttccag
      961 ccattcctgc agccaagggc actgggccag ggcggcgcac gcgcaagagg cgcgcttcga
     1021 gggaatatgc gaagctgccg cgtgctgctg cacatgcgct ttttcccttc cgcttccctc
     1081 cctttcttcc cacgggggag tccgcagttg cccttgttcg gaatccacgt tccccgcgat
     1141 cccgggagct ggaggcgcat gcgcatccgc gattccctgc gaccaggccc cgagagggcg
     1201 agaccagagg ggacggaagc attgcgcctg cgcggaactc tcagcctctg cgcggagggc
     1261 gtcccttccc aaccagccgt gggtgccagg ttcccggttg gaacctgcaa taaactcgct
     1321 gttcctcgca
//
