LOCUS       NM_052841               1026 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens testis specific serine kinase 3 (TSSK3), mRNA.
ACCESSION   NM_052841
VERSION     NM_052841.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1026)
  AUTHORS   Nayyab,S., Gervasi,M.G., Tourzani,D.A., Caraballo,D.A., Jha,K.N.,
            Teves,M.E., Cui,W., Georg,G.I., Visconti,P.E. and Salicioni,A.M.
  TITLE     TSSK3, a novel target for male contraception, is required for
            spermiogenesis
  JOURNAL   Mol Reprod Dev 88 (11), 718-730 (2021)
   PUBMED   34623009
  REMARK    GeneRIF: TSSK3, a novel target for male contraception, is required
            for spermiogenesis.
REFERENCE   2  (bases 1 to 1026)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1026)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 1026)
  AUTHORS   Bucko-Justyna,M., Lipinski,L., Burgering,B.M. and Trzeciak,L.
  TITLE     Characterization of testis-specific serine-threonine kinase 3 and
            its activation by phosphoinositide-dependent kinase-1-dependent
            signalling
  JOURNAL   FEBS J 272 (24), 6310-6323 (2005)
   PUBMED   16336268
  REMARK    GeneRIF: PDK1-induced phosphorylation increased in vitro TSSK3
            kinase activity, suggesting that TSSK3 can be regulated in the same
            way as AGC kinase family members. The peptide sequence RRSSSY
            containing Ser5 is identified as a target for TSSK3 phosphorylation
REFERENCE   5  (bases 1 to 1026)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   6  (bases 1 to 1026)
  AUTHORS   Visconti,P.E., Hao,Z., Purdon,M.A., Stein,P., Balsara,B.R.,
            Testa,J.R., Herr,J.C., Moss,S.B. and Kopf,G.S.
  TITLE     Cloning and chromosomal localization of a gene encoding a novel
            serine/threonine kinase belonging to the subfamily of
            testis-specific kinases
  JOURNAL   Genomics 77 (3), 163-170 (2001)
   PUBMED   11597141
  REMARK    GeneRIF: human homolog of mouse stk22d; It was cloned and found it
            to be expressed exclusively in the testis.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035354.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052841.3.
            
            Summary: This gene encodes a kinase expressed exclusively in the
            testis that is thought to play a role in either germ cell
            differentiation or mature sperm function. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035354.1, SRR5189667.54114.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373534.4/ ENSP00000362634.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1026              BC035354.1         343-1368
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..1026
                     /gene="TSSK3"
                     /gene_synonym="SPOGA3; STK22C; STK22D; TSK3"
                     /note="testis specific serine kinase 3"
                     /db_xref="GeneID:81629"
                     /db_xref="HGNC:HGNC:15473"
                     /db_xref="MIM:607660"
     exon            1..308
                     /gene="TSSK3"
                     /gene_synonym="SPOGA3; STK22C; STK22D; TSK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..970
                     /gene="TSSK3"
                     /gene_synonym="SPOGA3; STK22C; STK22D; TSK3"
                     /EC_number="2.7.11.1"
                     /note="spermiogenesis associated 3; testis-specific
                     serine/threonine kinase 22C; TSK-3; TSSK-3;
                     testis-specific kinase 3; serine/threonine-protein kinase
                     22C"
                     /codon_start=1
                     /product="testis-specific serine/threonine-protein kinase
                     3"
                     /protein_id="NP_443073.1"
                     /db_xref="CCDS:CCDS362.1"
                     /db_xref="GeneID:81629"
                     /db_xref="HGNC:HGNC:15473"
                     /db_xref="MIM:607660"
                     /translation="MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKM
                     GGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLN
                     GGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPK
                     SHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKM
                     LWQQQKGVSFPTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST"
     exon            309..1026
                     /gene="TSSK3"
                     /gene_synonym="SPOGA3; STK22C; STK22D; TSK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      995..1000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSSK3"
                     /gene_synonym="SPOGA3; STK22C; STK22D; TSK3"
                     /note="hexamer: AATAAA"
     polyA_site      1026
                     /gene="TSSK3"
                     /gene_synonym="SPOGA3; STK22C; STK22D; TSK3"
                     /note="major polyA site"
ORIGIN      
        1 ccacccgccg ctgtgtccag acagagaatg ttctaacgct gggggcggct gcggatgaag
       61 tccttgggga gaaaaggagc aggccaaggg cgatggtgga gtagagctgc ctctcagagg
      121 cagcatgagc tgagagggtg ataggaaggc ggcgctagac agcatggagg actttctgct
      181 ctccaatggg taccagctgg gcaagaccat tggggaaggg acctactcaa aagtcaaaga
      241 agcattttcc aaaaaacacc aaagaaaagt ggcaattaaa gttatagaca agatgggagg
      301 gccagaagag tttatccaga gattcctccc tcgggagctc caaatcgtcc gtaccctgga
      361 ccacaagaac atcatccagg tgtatgagat gctggagtct gccgacggga aaatctgcct
      421 ggtgatggag ctcgctgagg gaggggatgt ctttgactgc gtgctgaatg gggggccact
      481 gcctgaaagc cgggccaagg ccctcttccg tcagatggtt gaggccatcc gctactgcca
      541 tggctgtggt gtggcccacc gggacctcaa atgtgagaac gccttgttgc agggcttcaa
      601 cctgaagctg actgactttg gctttgccaa ggtgttgccc aagtcacacc gggagctgag
      661 ccagaccttc tgcggcagta cagcctatgc tgcccccgag gtgctgcagg gcattcccca
      721 cgatagcaaa aaaggtgatg tctggagcat gggtgtggtc ctgtatgtca tgctctgtgc
      781 cagcctacct tttgacgaca cagacatccc caagatgctg tggcagcagc agaagggggt
      841 gtccttcccc actcatctga gcatctcggc cgattgccag gacctgctca agaggctcct
      901 ggaacccgat atgatcctcc ggccttcaat tgaagaagtt agttggcatc catggctagc
      961 aagcacttga taaaagcaat ggcaagtgct ctccaataaa gtagggggag aaagcaaacc
     1021 caaaaa
//
