LOCUS       NM_032028               2437 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens testis specific serine kinase 1B (TSSK1B), mRNA.
ACCESSION   NM_032028
VERSION     NM_032028.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2437)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2437)
  AUTHORS   Kadiyska,T., Tourtourikov,I., Dabchev,K., Madzharova,D.,
            Tincheva,S., Spandidos,D.A. and Zoumpourlis,V.
  TITLE     Role of testis-specific serine kinase 1B in undiagnosed male
            infertility
  JOURNAL   Mol Med Rep 25 (6) (2022)
   PUBMED   35485285
  REMARK    GeneRIF: Role of testisspecific serine kinase 1B in undiagnosed
            male infertility.
REFERENCE   3  (bases 1 to 2437)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 2437)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2437)
  AUTHORS   Shang,P., Hoogerbrugge,J., Baarends,W.M. and Grootegoed,J.A.
  TITLE     Evolution of testis-specific kinases TSSK1B and TSSK2 in primates
  JOURNAL   Andrology 1 (1), 160-168 (2013)
   PUBMED   23258646
  REMARK    GeneRIF: Report evolution of testis-specific kinases TSSK1B and
            TSSK2 in primates.
REFERENCE   6  (bases 1 to 2437)
  AUTHORS   Zhang,L., Yan,Y., Liu,Z., Abliz,Z. and Liu,G.
  TITLE     Identification of peptide substrate and small molecule inhibitors
            of testis-specific serine/threonine kinase1 (TSSK1) by the
            developed assays
  JOURNAL   J Med Chem 52 (14), 4419-4428 (2009)
   PUBMED   19530700
REFERENCE   7  (bases 1 to 2437)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 2437)
  AUTHORS   Jaleel,M., McBride,A., Lizcano,J.M., Deak,M., Toth,R., Morrice,N.A.
            and Alessi,D.R.
  TITLE     Identification of the sucrose non-fermenting related kinase SNRK,
            as a novel LKB1 substrate
  JOURNAL   FEBS Lett 579 (6), 1417-1423 (2005)
   PUBMED   15733851
REFERENCE   9  (bases 1 to 2437)
  AUTHORS   Hao,Z., Jha,K.N., Kim,Y.H., Vemuganti,S., Westbrook,V.A.,
            Chertihin,O., Markgraf,K., Flickinger,C.J., Coppola,M., Herr,J.C.
            and Visconti,P.E.
  TITLE     Expression analysis of the human testis-specific serine/threonine
            kinase (TSSK) homologues. A TSSK member is present in the
            equatorial segment of human sperm
  JOURNAL   Mol Hum Reprod 10 (6), 433-444 (2004)
   PUBMED   15044604
REFERENCE   10 (bases 1 to 2437)
  AUTHORS   Bashkirov,V.I., Bashkirova,E.V., Haghnazari,E. and Heyer,W.D.
  TITLE     Direct kinase-to-kinase signaling mediated by the FHA
            phosphoprotein recognition domain of the Dun1 DNA damage checkpoint
            kinase
  JOURNAL   Mol Cell Biol 23 (4), 1441-1452 (2003)
   PUBMED   12556502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB025324.1, BC022515.1, AK122904.1, DB527624.1 and AC010431.7.
            
            On May 17, 2019 this sequence version replaced NM_032028.3.
            
            Summary: TSSK1 belongs to a family of serine/threonine kinases
            highly expressed in testis (Hao et al., 2004 [PubMed
            15044604]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK122904.1, HM005678.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390666.4/ ENSP00000375081.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB025324.1         43-66
            25-1247             BC022515.1         5-1227
            1248-2377           AK122904.1         1248-2377
            2378-2388           DB527624.1         396-406
            2389-2436           AK122904.1         2389-2436
            2437-2437           AC010431.7         79851-79851
FEATURES             Location/Qualifiers
     source          1..2437
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.2"
     gene            1..2437
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /note="testis specific serine kinase 1B"
                     /db_xref="GeneID:83942"
                     /db_xref="HGNC:HGNC:14968"
                     /db_xref="MIM:610709"
     exon            1..2437
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1254
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 22D (spermiogenesis
                     associated); testis-specific serine kinase 1;
                     spermiogenesis associated 4; serine/threonine kinase
                     FKSG81; TSK-1; TSSK-1; testis-specific kinase 1;
                     serine/threonine-protein kinase 22A; testis tissue
                     sperm-binding protein Li 55e"
                     /codon_start=1
                     /product="testis-specific serine/threonine-protein kinase
                     1"
                     /protein_id="NP_114417.1"
                     /db_xref="CCDS:CCDS4112.1"
                     /db_xref="GeneID:83942"
                     /db_xref="HGNC:HGNC:14968"
                     /db_xref="MIM:610709"
                     /translation="MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIID
                     RKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELI
                     KTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKR
                     CLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDD
                     SNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKA
                     RGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQ
                     MSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /note="hexamer: AATAGA"
     polyA_site      2016
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /note="major polyA site"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /note="hexamer: ATTATA"
     polyA_site      2137
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
     regulatory      2190..2195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /note="hexamer: AAGAAA"
     polyA_site      2211
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /note="major polyA site"
     regulatory      2412..2417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
                     /note="hexamer: TATAAA"
     polyA_site      2437
                     /gene="TSSK1B"
                     /gene_synonym="FKSG81; SPOGA4; STK22D; TSK1; TSSK1"
ORIGIN      
        1 actccagagt cttggcctct aggaggcagg aacagcaggc ctggccagcc caaaggactc
       61 tctatccagg atgtaaatga gcacactgct ggcccatgcg cctcggggct gtagagggca
      121 gcctcagagg cactgggcat tcctggcacc atggatgacg ctgctgtcct caagcgacga
      181 ggctacctcc tggggataaa tttaggagag ggctcctatg caaaagtaaa atctgcttac
      241 tctgagcgcc tgaagttcaa tgtggcgatc aagatcatcg accgcaagaa ggcccccgca
      301 gacttcttgg agaaattcct tccccgggaa attgagattc tggccatgtt aaaccactgc
      361 tccatcatta agacctacga gatctttgag acatcacatg gcaaggtcta catcgtcatg
      421 gagctcgcgg tccagggcga cctcctcgag ttaatcaaaa cccggggagc cctgcatgag
      481 gacgaagctc gcaagaagtt ccaccagctt tccttggcca tcaagtactg ccacgacctg
      541 gacgtcgtcc accgggacct caagtgtgac aaccttctcc ttgacaagga cttcaacatc
      601 aagctgtccg acttcagctt ctccaagcgc tgcctgcggg atgacagtgg tcgaatggca
      661 ttaagcaaga ccttctgtgg gtcaccagcg tatgcggccc cagaggtgct gcagggcatt
      721 ccctaccagc ccaaggtgta cgacatctgg agcctaggcg tgatcctcta catcatggtc
      781 tgcggctcca tgccctacga cgactccaac atcaagaaga tgctgcgtat ccagaaggag
      841 caccgcgtca acttcccacg ctccaagcac ctgacaggcg agtgcaagga cctcatctac
      901 cacatgctgc agcccgacgt caaccggcgg ctccacatcg acgagatcct cagccactgc
      961 tggatgcagc ccaaggcacg gggatctccc tctgtggcca tcaacaagga gggggagagt
     1021 tcccggggaa ctgaaccctt gtggaccccc gaacctggct ctgacaagaa gtctgccacc
     1081 aagctggagc ctgagggaga ggcacagccc caggcacagc ctgagacaaa acccgagggg
     1141 acagcaatgc aaatgtccag gcagtcggag atcctgggtt tccccagcaa gccgtcgact
     1201 atggagacag aggaagggcc cccccaacag cctccagaga cgcgggccca gtgagcttct
     1261 tgcggcccag ggaatgagat ggagctcacg gcttaaagcc caagctctga agaagtcaag
     1321 ggtggagcca gagaaggaag gcagtcccag atgagcctct attttcatca gcttcttctc
     1381 tctccccttg aacttggtaa cccacatggt tctcccgtgg cccctaggtg gatgaggcca
     1441 aagtcaaatc caaggctgag acagtcgtgc gactcctact cccccagagc gtgacccgga
     1501 gcaggtgctg gacacagagc ctgtctcagc agagggtccc cactggccgc aacggctcag
     1561 tgacagcaag agcaggaaga gcagcaggaa ggcaccgctg tccaccttgg gcaccattta
     1621 tcctcctttc atcgtccccg gggcagttgc gtgaccctgc tgggaggcca gaccgggcca
     1681 gactgagggt caggggacca ggctgggttg ggggttgggt ggggctggac ggggacgagg
     1741 cgcggagagg cggcgggaaa gagcttcggc tgggccacgg gctcgcgggc actctcggcg
     1801 gcagcctcgg gggctccgac tccagctctg ggcaagatcc ataaactttt aaagaagcct
     1861 caaaacatac ttttaaagca ttaagcttta aagtgctaga aatcttgtgc cccatatgtg
     1921 cttctttcag tattatccta gatcctcagg agtagcatgg caactggaga aaatgggagg
     1981 aaagacaaga agaaatagaa gctgatttaa catcaagttt attcagtttt gatttttctt
     2041 atctctactg gctttctcct gttcaaacct tgcagcgata atatttggaa aagagcactt
     2101 ggaaattata ttcctgtttt taactcttta tatttaatca ttctccttgt aattgatttt
     2161 gtagctaatt tactccccag cacccccaga agaaaatttt acaaaggaaa atgttttatt
     2221 tttatttttt ccttatcaac tttttattta aatgctaata tccaattaat ggacaaacga
     2281 atcagctaat actggaaaca atgtaacaat agtgaaaagc atgaactttt gatttctata
     2341 gaccgaattt gactctgcta ctaaatgatc ttgggcaagt tggttaatct atatgtctca
     2401 gtttctttat ctataaaatg agaataatac aacttca
//
