LOCUS       NM_001001410            1210 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TSR3 ribosome maturation factor (TSR3), mRNA.
ACCESSION   NM_001001410
VERSION     NM_001001410.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1210)
  AUTHORS   Meyer,B., Wurm,J.P., Sharma,S., Immer,C., Pogoryelov,D., Kotter,P.,
            Lafontaine,D.L., Wohnert,J. and Entian,K.D.
  TITLE     Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl
            transferase responsible for 18S rRNA hypermodification in yeast and
            humans
  JOURNAL   Nucleic Acids Res 44 (9), 4304-4316 (2016)
   PUBMED   27084949
  REMARK    GeneRIF: Structurally, Tsr3 represents a novel class of acp
            transferase enzymes.
REFERENCE   2  (bases 1 to 1210)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   3  (bases 1 to 1210)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031709.12, BC016699.1 and BC017325.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001001410.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017325.2, BC013943.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000007390.3/ ENSP00000007390.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL031709.12        19944-19949         c
            7-1206              BC016699.1         5-1204
            1207-1210           BC017325.2         1185-1188
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1210
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /note="TSR3 ribosome maturation factor"
                     /db_xref="GeneID:115939"
                     /db_xref="HGNC:HGNC:14175"
                     /db_xref="MIM:617058"
     exon            1..186
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1013
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /EC_number="2.5.1.157"
                     /note="probable ribosome biogenesis protein C16orf42;
                     ribosome biogenesis protein TSR3 homolog; TSR3, 20S rRNA
                     accumulation, homolog; TSR3, acp transferase ribosome
                     maturation factor; 20S S rRNA accumulation protein 3
                     homolog"
                     /codon_start=1
                     /product="18S rRNA aminocarboxypropyltransferase"
                     /protein_id="NP_001001410.1"
                     /db_xref="CCDS:CCDS10435.1"
                     /db_xref="GeneID:115939"
                     /db_xref="HGNC:HGNC:14175"
                     /db_xref="MIM:617058"
                     /translation="MGRRRAARGPGAEGGRPRHLPTRSLEAFAEEVGAALQASVEPGA
                     ADGEGGPGPAALPCTLAMWELGHCDPRRCTGRKLARLGLVRCLRLGHRFGGLVLSPVG
                     KQYASPADRQLVAQSGVAVIDCSWARLDETPFGKMRGSHLRLLPYLVAANPVNYGRPY
                     RLSCVEAFAATFCIVGFPDLAVILLRKFKWGKGFLDLNRQLLDKYAACGSPEEVLQAE
                     QEFLANAKESPQEEEIDPFDVDSGREFGNPNRPVASTRLPSDTDDSDASEDPGPGAER
                     GGASSSCCEEEQTQGRGAEARAPAEVWKGIKKRQRD"
     exon            187..406
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            407..600
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..777
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..841
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1210
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1190..1195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /note="hexamer: AATGAA"
     polyA_site      1210
                     /gene="TSR3"
                     /gene_synonym="C16orf42; HsTsr3"
                     /note="major polyA site"
ORIGIN      
        1 agccgcacag cccattggga ggccgagggg cgcggccgtg gggtggggag tccccggcac
       61 cccaggtccg cgccatgggc cgcaggaggg cagcgcgcgg gccgggggcg gaaggcggcc
      121 gccctcggca cctcccgacg cgctccctgg aggccttcgc cgaggaggtc ggcgccgcgc
      181 tgcaggcttc cgtggagcca ggggcggctg acggcgaggg cggcccgggc ccggcggcgc
      241 tgccctgcac gctggccatg tgggagttgg gccactgcga cccccggcgc tgcacgggcc
      301 gcaagctggc ccgcctgggg ctggtgcgct gcctgcgcct gggccacaga ttcggcggtc
      361 tggtgctgag ccccgtgggc aagcagtacg cgtcccccgc agacagacag ctggtggcgc
      421 agtctggggt cgccgtcatc gactgctcct gggccaggct ggacgagaca ccgtttggga
      481 agatgcgagg gagccacttg cgcctgttgc cctacctggt ggccgccaac cccgtgaact
      541 atggccggcc ctacagactt tcctgcgtgg aagcgtttgc tgccaccttc tgcatcgtag
      601 gctttccaga ccttgctgtc attttgctgc ggaagtttaa atggggcaag ggcttcttgg
      661 acctgaaccg ccagctcctg gacaagtacg cggcctgcgg cagcccggag gaggtgctgc
      721 aggcggagca ggagttcttg gccaatgcca aggagagccc ccaggaggag gagatcgatc
      781 ccttcgatgt ggattcaggg agagagtttg gaaaccccaa caggcctgtg gccagcaccc
      841 ggctgccctc ggacactgat gacagtgatg cgtctgagga cccagggcct ggcgccgagc
      901 gcggaggagc cagcagcagc tgctgtgaag aggagcagac gcagggacgg ggggctgagg
      961 ccagggcccc ggctgaggtt tggaaaggaa tcaagaaacg gcagagagac tgagggttgc
     1021 agacacatat atttttgagg ctgggtgacg agaaaatcta gagacatgag ggacataaat
     1081 gggcctggca gcctcggctc tttgcggctg ctggcaggac tgagctgtcc gggttctccc
     1141 cacacttcca gcacagctgt gctctgtgtc ctgcctcggc gctctcgcaa atgaagctgc
     1201 aggccaagaa
//
