LOCUS       NM_033512               4441 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TSPY like 5 (TSPYL5), mRNA.
ACCESSION   NM_033512
VERSION     NM_033512.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4441)
  AUTHORS   Dalui,S., Dasgupta,A., Adhikari,S., Das,C. and Roy,S.
  TITLE     Human testis-specific Y-encoded protein-like protein 5 is a histone
            H3/H4-specific chaperone that facilitates histone deposition in
            vitro
  JOURNAL   J Biol Chem 298 (8), 102200 (2022)
   PUBMED   35772497
  REMARK    GeneRIF: Human testis-specific Y-encoded protein-like protein 5 is
            a histone H3/H4-specific chaperone that facilitates histone
            deposition in vitro.
REFERENCE   2  (bases 1 to 4441)
  AUTHORS   Huang,C., He,C., Ruan,P. and Zhou,R.
  TITLE     TSPYL5 activates endoplasmic reticulum stress to inhibit cell
            proliferation, migration and invasion in colorectal cancer
  JOURNAL   Oncol Rep 44 (2), 449-456 (2020)
   PUBMED   32627024
  REMARK    GeneRIF: TSPYL5 activates endoplasmic reticulum stress to inhibit
            cell proliferation, migration and invasion in colorectal cancer.
REFERENCE   3  (bases 1 to 4441)
  AUTHORS   Episkopou,H., Diman,A., Claude,E., Viceconte,N. and Decottignies,A.
  TITLE     TSPYL5 Depletion Induces Specific Death of ALT Cells through
            USP7-Dependent Proteasomal Degradation of POT1
  JOURNAL   Mol Cell 75 (3), 469-482 (2019)
   PUBMED   31278054
  REMARK    GeneRIF: PML depletion suppressed POT1 poly-ubiquitination,
            suggesting an interplay between USP7 and PML to trigger POT1
            degradation in TSPYL5-depleted ALT(+) cells. We demonstrate that
            ALT telomeres need to be protected from POT1 degradation in
            ALT-associated PML bodies and identify TSPYL5 as an ALT(+)
            cancer-specific therapeutic target.
REFERENCE   4  (bases 1 to 4441)
  AUTHORS   Na,H.J., Yeum,C.E., Kim,H.S., Lee,J., Kim,J.Y. and Cho,Y.S.
  TITLE     TSPYL5-mediated inhibition of p53 promotes human endothelial cell
            function
  JOURNAL   Angiogenesis 22 (2), 281-293 (2019)
   PUBMED   30471052
  REMARK    GeneRIF: TSPYL5, a novel angiogenic regulator, plays a key role in
            maintaining endothelial integrity and function.
REFERENCE   5  (bases 1 to 4441)
  AUTHORS   Huang,C. and Luo,H.
  TITLE     miR-19-5p Enhances Tumorigenesis in Human Colorectal Cancer Cells
            by Targeting TSPYL5
  JOURNAL   DNA Cell Biol 37 (1), 23-30 (2018)
   PUBMED   29240449
  REMARK    GeneRIF: Increasing the expression of TSPYL5 in HT29 cells or
            inhibiting miR-19-5p promotes apoptosis of HT29 cells.
            Erratum:[DNA Cell Biol. 2018 Apr;37(4):416. doi:
            10.1089/dna.2017.3804.correx.. PMID: 29634419]
REFERENCE   6  (bases 1 to 4441)
  AUTHORS   Qiu,X., Hu,B., Huang,Y., Deng,Y., Wang,X. and Zheng,F.
  TITLE     Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular
            Carcinoma and Their Potential Clinical Significance
  JOURNAL   Dig Dis Sci 61 (1), 149-157 (2016)
   PUBMED   26386860
  REMARK    GeneRIF: Suggest that hypermethylation of ACP1, BMP4, and TSPYL5
            are common events in HCC and could be used as potentially
            detectable biomarkers in HCC tissues.
REFERENCE   7  (bases 1 to 4441)
  AUTHORS   Liu,M., Ingle,J.N., Fridley,B.L., Buzdar,A.U., Robson,M.E.,
            Kubo,M., Wang,L., Batzler,A., Jenkins,G.D., Pietrzak,T.L.,
            Carlson,E.E., Goetz,M.P., Northfelt,D.W., Perez,E.A.,
            Williard,C.V., Schaid,D.J., Nakamura,Y. and Weinshilboum,R.M.
  TITLE     TSPYL5 SNPs: association with plasma estradiol concentrations and
            aromatase expression
  JOURNAL   Mol Endocrinol 27 (4), 657-670 (2013)
   PUBMED   23518928
  REMARK    GeneRIF: TSPYL5 knockdown decreased, and overexpression increased
            aromatase (CYP19A1) expression through the skin/adipose (I.4)
            promoter.
REFERENCE   8  (bases 1 to 4441)
  AUTHORS   Epping,M.T., Meijer,L.A., Krijgsman,O., Bos,J.L., Pandolfi,P.P. and
            Bernards,R.
  TITLE     TSPYL5 suppresses p53 levels and function by physical interaction
            with USP7
  JOURNAL   Nat Cell Biol 13 (1), 102-108 (2011)
   PUBMED   21170034
  REMARK    GeneRIF: Data identify TSPYL5 as a suppressor of p53 function
            through its interaction with USP7.
REFERENCE   9  (bases 1 to 4441)
  AUTHORS   Kim,E.J., Lee,S.Y., Kim,T.R., Choi,S.I., Cho,E.W., Kim,K.C. and
            Kim,I.G.
  TITLE     TSPYL5 is involved in cell growth and the resistance to radiation
            in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT
            pathway
  JOURNAL   Biochem Biophys Res Commun 392 (3), 448-453 (2010)
   PUBMED   20079711
  REMARK    GeneRIF: This study provides the first demonstration that TSPYL5
            modulates cell growth and sensitization of cells to the detrimental
            effects of damaging agents via regulation of p21(WAF1/Cip1) and
            PTEN/AKT pathway.
REFERENCE   10 (bases 1 to 4441)
  AUTHORS   Jung,Y., Park,J., Bang,Y.J. and Kim,T.Y.
  TITLE     Gene silencing of TSPYL5 mediated by aberrant promoter methylation
            in gastric cancers
  JOURNAL   Lab Invest 88 (2), 153-160 (2008)
   PUBMED   18059362
  REMARK    GeneRIF: aberrant methylation at a CpG island of TSPYL5 may play an
            important role in development of gastric cancers
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC045630.1, AB051537.1 and AK091445.1.
            
            On May 17, 2019 this sequence version replaced NM_033512.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB051537.1, SRR1803615.227473.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322128.5/ ENSP00000322802.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1176              BC045630.1         21-1196
            1177-1992           AB051537.1         1136-1951
            1993-2015           BC045630.1         2013-2035
            2016-2210           AK091445.1         2052-2246
            2211-2326           BC045630.1         2231-2346
            2327-3616           AB051537.1         2286-3575
            3617-4441           BC045630.1         3636-4460
FEATURES             Location/Qualifiers
     source          1..4441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..4441
                     /gene="TSPYL5"
                     /note="TSPY like 5"
                     /db_xref="GeneID:85453"
                     /db_xref="HGNC:HGNC:29367"
                     /db_xref="MIM:614721"
     exon            1..4441
                     /gene="TSPYL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1338
                     /gene="TSPYL5"
                     /note="TSPY-like protein 5"
                     /codon_start=1
                     /product="testis-specific Y-encoded-like protein 5"
                     /protein_id="NP_277047.2"
                     /db_xref="CCDS:CCDS34927.1"
                     /db_xref="GeneID:85453"
                     /db_xref="HGNC:HGNC:29367"
                     /db_xref="MIM:614721"
                     /translation="MSGRSRGRKSSRAKNRGKGRAKARVRPAPDDAPRDPDPSQYQSL
                     GEDTQAAQVQAGAGWGGLEAAASAQLLRLGEEAACRLPLDCGLALRARAAGDHGQAAA
                     RPGPGKAASLSERLAADTVFVGTAGTVGRPKNAPRVGNRRGPAGKKAPETCSTAGRGP
                     QVIAGGRQKKGAAGENTSVSAGEEKKEERDAGSGPPATEGSMDTLENVQLKLENMNAQ
                     ADRAYLRLSRKFGQLRLQHLERRNHLIQNIPGFWGQAFQNHPQLASFLNSQEKEVLSY
                     LNSLEVEELGLARLGYKIKFYFDRNPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGH
                     DLQSLSQGNPENNRSFFGWFSNHSSIESDKIVEIINEELWPNPLQFYLLSEGARVEKG
                     KEKEGRQGPGKQPMETTQPGVSQSN"
     regulatory      4419..4424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPYL5"
                     /note="hexamer: AATAAA"
     polyA_site      4441
                     /gene="TSPYL5"
                     /note="major polyA site"
ORIGIN      
        1 agagacccgc tcggtcccga ccgagagctg gcgtcaggag ccgcagggtc acagcgtgtc
       61 tttgaagctg cctccgccgc caccatgagc ggccgaagtc ggggtcgaaa gtcctcccgc
      121 gccaaaaacc ggggcaaagg ccgcgccaaa gcccgagtcc gccctgctcc ggacgacgcc
      181 ccgcgcgacc cggacccttc acagtaccag agtctcgggg aagacaccca ggcggcacag
      241 gtgcaggctg gcgcggggtg gggtggcctg gaagccgctg cgtccgcgca gctcctccgg
      301 ctcggggagg aggccgcctg ccggctcccc ctggactgtg gcctcgcgct gcgggcccga
      361 gctgcggggg accacgggca ggccgcggcc aggcccggcc cggggaaggc cgcatctctc
      421 tcggagcgcc tggccgcaga cactgtcttc gtgggaacag cgggaaccgt gggaaggccg
      481 aaaaatgccc cccgcgttgg aaaccggcgt ggccctgccg ggaagaaggc cccagaaacc
      541 tgtagcaccg cggggagggg gcctcaggtc atagctggtg ggaggcagaa gaaaggggcg
      601 gcaggggaga atacctcggt gtcagctggg gaggaaaaga aggaagagag ggatgcaggg
      661 tcggggcccc cagcgacgga aggcagcatg gatacgctgg agaacgtgca gctgaagctg
      721 gagaacatga acgcccaggc ggacagggcc taccttcggc tctccaggaa gtttgggcag
      781 ttgcgactgc agcacttgga gcgcaggaac cacctcatcc aaaatatccc gggcttctgg
      841 gggcaagcat ttcagaacca tccccagcta gcatcctttc tgaatagcca agagaaagag
      901 gtactgagct acttaaacag cttggaagtg gaagagctcg gccttgccag attgggctac
      961 aaaatcaagt tctacttcga tcgcaacccg tatttccaaa ataaggtgct catcaaggaa
     1021 tatgggtgtg gtccttctgg ccaggtggtg tctcgttcta ctccaatcca gtggctccca
     1081 gggcatgatc tccagtccct aagccaggga aacccagaaa acaaccgtag tttctttggg
     1141 tggttttcaa accacagctc cattgagtct gacaagattg tggagataat caacgaagaa
     1201 ttgtggccca atcccttgca gttctacctt ttgagtgaag gggctcgtgt agagaaagga
     1261 aaggaaaaag aaggcaggca aggtccagga aagcagccaa tggagactac tcagcctggg
     1321 gtgagccaat ccaactgatc ctgcacaagt ctccctgcta cctcctgctg ggctgctcct
     1381 ggttgactac atatttggct ctctgccttc tcttcatgtt ggcctctgtg tactatagac
     1441 cctttggact ttagttacaa gaatatggca tttatgatca tgttcttttg cctcccatag
     1501 cctcttgctt ttctacgtta gtgtcacatg ttatgtgatc gcacccggac tgttcatatg
     1561 ttaagcacac atactttaga tgtgtgctcc ctgttatcta cattgcctgg accttgttct
     1621 tggctctggc ctttcctact tgtctttaac atggacactc atgagtcatc ctccaggacg
     1681 accagtgcat cctcaagctc tgctccttca gggccagtga cttgctgggc ttcgtgttca
     1741 tgctggccat gcatgtcatc tatgcaagcg tttccattgc cactgcagaa tgaagccagt
     1801 gcacatggta ttagtcatca gccagaactt cctgttctgt gggtctgggg tcaccagctg
     1861 agatgtcacc tgctttattt ctggctttgg cctgtggtct gtgataccca tcctgcttga
     1921 tgttctgcag aatggcactt gactgctggg catgcatgaa gttaagggca agaaacagta
     1981 tgccatgtgt tctgtaccat catgtgtctc ttcttgcttc tgggcccttc tactggtgaa
     2041 ctttcatcaa gatctgcgcc atgccgtgtc actatcaagc cattaagttt tgtctgggtt
     2101 gctgtcagcc ccagttggct tcctggtcaa caaggacctc aagaactgcc tgtggaccga
     2161 ggccccctac cagtgcatga gacacacacc taccctcccc agctttccag gaaccctact
     2221 ggctgccaga ctgatgggcg ggctggtatg tgtggacatg tgttcactgt cattatgctg
     2281 tggctccagg tgagggtgag gactgggcct atatagaatc cagataccat tgtcaacttc
     2341 ccttattccc gtctaagatg tgagcagagt gccatagtag gggttctggg aagaggtatt
     2401 tctgatttgt gggcctctgc ttgcttgact tcaggtcact tatacttctt attttgcttg
     2461 cctgccttca tccctcattt cctccctctc attcttcttt cctccctccc tttcctggta
     2521 gcctcctttc ctccccttct gccttcccct tccttctttc cttattcttt tttattttgt
     2581 ttaaatagta ccacagagaa aacaactgaa aaaccacatt tttctacata cagctgggga
     2641 ggtagctgag aacttggcac tgcgcacaca tactaggttg aaagagagtt gaggaaacca
     2701 gaaggccaag tggatctgct ggcaaaccct gaacctgtct cctgcgcttg ctctacagtt
     2761 ctgaagttga aaatcctttt catgcctagc atctgcttga gttataaacc ccaaggcagc
     2821 catgtcatag actagtgttt actcttgttt tgactttgtt ttaatgcttc ctaagaccca
     2881 agtgcctcct gctgtttcct cctttgtggt agcctctggc catctggacc tcaatcccca
     2941 gctttcccac tttcagcagt cctttgctct ctttgcttct acctcaaata gccccaggag
     3001 tgggctttag tctccaatat ggagcatctc aagcttctcc tgggggatgg ggattgggat
     3061 gggcagaatc tgttttggat ctccgggtta tttccagtgg gtgtaaaagc agagctgggc
     3121 ctttccctct cttatccctg agggtgggta agaaggactg tatctacacc tgttcttccc
     3181 taccttctct tttgttaggg aggcctcatt ctaagttcct caagagagtc cttggcttaa
     3241 agctgtagca agggtgtgct aggtggggga tttggagcaa aaccgtcgag taggcatgat
     3301 actggtatgg agtgggcctg caaaatcaga cagaaatggc ttgagaagcc gcagggggag
     3361 catgcctgtc tctcagtgat agagtatggg agggacctcc ctagcttgga aaatgagaat
     3421 tgaaggggtt atgaacaaat aggatgccta gttgaggatg ttcccaaagt tttgtccaat
     3481 cttatcatta gtagatttta taagccacag agacaaacca gaaacggaat aatgttactt
     3541 tggatgcttt atttttttgt tctaggtgtg gctttgtaca tgcagaagaa tgctatatgc
     3601 tgcacatttt gcctttaaag tcttacgact ttccccattt tagtctaatg ggaagataca
     3661 gatgtgcaag tctgcttttt tgttttttgt tattattttt ttttttttgc tctgtgttat
     3721 ggacattttc agacatgcac agaagtggag aggatggtcc ttggacccca tgtgtccatc
     3781 acctagctgc atcacttatc agctatggtc aacctggttt catctgtatc tctctctttt
     3841 cacctgtatt gtttattgaa aatccaagac actatgccaa tgcaaccgtg actactttgg
     3901 gagattggta gtctcttttg atggtgatag tgatggggtg cactatcata atcacatcag
     3961 gtctgctttt tgcttttaat gttaactaat gaagttccag agatgggcct tagaaatgtg
     4021 ttttaagaat taacaaggag tctcaaaaag aaatgagagg gatgcttcct ttcccttgca
     4081 tctacaaaac aagagagaga ctgttctgtt gtaaaactct ttcaaaaatt ctgatatggt
     4141 aaggtacttg agacccttca ccagaatgtc aatctttttt tctgtgtaac atggaaactt
     4201 gtgtgaccat tagcattgtt atcagcttgt actggtctca taactctggt tttggaagaa
     4261 taatttggaa attgttgctg tgttctgtga aaataacctc cccaaaataa ttagtaactg
     4321 gttgttctac ttggtaattt gacaccctgt taataacgca attatttctg tgttcttaaa
     4381 cagtataaat agttgtaagt ttgcatgcat gatggaaaaa taaaaacctg tatctctgtt
     4441 a
//
