LOCUS       NM_022117               2815 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens TSPY like 2 (TSPYL2), mRNA.
ACCESSION   NM_022117 XM_939609 XM_944226 XM_944229 XM_944231
VERSION     NM_022117.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2815)
  AUTHORS   Tan,H., Miao,M.X., Luo,R.X., So,J., Peng,L., Zhu,X., Leung,E.H.W.,
            Zhu,L., Chan,K.M., Cheung,M. and Chan,S.Y.
  TITLE     TSPYL1 as a Critical Regulator of TGFbeta Signaling through
            Repression of TGFBR1 and TSPYL2
  JOURNAL   Adv Sci (Weinh) 11 (21), e2306486 (2024)
   PUBMED   38588050
  REMARK    GeneRIF: TSPYL1 as a Critical Regulator of TGFbeta Signaling
            through Repression of TGFBR1 and TSPYL2.
REFERENCE   2  (bases 1 to 2815)
  AUTHORS   Huang,D., Zhao,Q., Yang,K., Lei,J., Jing,Y., Li,H., Zhang,C.,
            Ma,S., Sun,S., Cai,Y., Wang,G., Qu,J., Zhang,W., Wang,S. and
            Liu,G.H.
  TITLE     CRL2APPBP2-mediated TSPYL2 degradation counteracts human
            mesenchymal stem cell senescence
  JOURNAL   Sci China Life Sci 67 (3), 460-474 (2024)
   PUBMED   38170390
  REMARK    GeneRIF: CRL2[APPBP2]-mediated TSPYL2 degradation counteracts human
            mesenchymal stem cell senescence.
REFERENCE   3  (bases 1 to 2815)
  AUTHORS   Zhang,X., Wu,X., Yao,W. and Wang,Y.H.
  TITLE     A tumor-suppressing role of TSPYL2 in thyroid cancer: Through
            interacting with SIRT1 and repressing SIRT1/AKT pathway
  JOURNAL   Exp Cell Res 432 (1), 113777 (2023)
   PUBMED   37696385
  REMARK    GeneRIF: A tumor-suppressing role of TSPYL2 in thyroid cancer:
            Through interacting with SIRT1 and repressing SIRT1/AKT pathway.
REFERENCE   4  (bases 1 to 2815)
  AUTHORS   Cardano,M., Magni,M., Alfieri,R., Chan,S.Y., Sabbioneda,S.,
            Buscemi,G. and Zannini,L.
  TITLE     Sex specific regulation of TSPY-Like 2 in the DNA damage response
            of cancer cells
  JOURNAL   Cell Death Dis 14 (3), 197 (2023)
   PUBMED   36918555
  REMARK    GeneRIF: Sex specific regulation of TSPY-Like 2 in the DNA damage
            response of cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2815)
  AUTHORS   Liu,Z., Li,C., Yu,C., Chen,Z., Zhao,C. and Ye,L.
  TITLE     TSPYL2 reduced gefitinib resistance and DNA damage repair via
            suppressing SIRT1-mediated FOXO3 deacetylation
  JOURNAL   Future Med Chem 14 (6), 407-419 (2022)
   PUBMED   35192400
  REMARK    GeneRIF: TSPYL2 reduced gefitinib resistance and DNA damage repair
            via suppressing SIRT1-mediated FOXO3 deacetylation.
REFERENCE   6  (bases 1 to 2815)
  AUTHORS   Ozbun,L.L., Martinez,A. and Jakowlew,S.B.
  TITLE     Differentially expressed nucleolar TGF-beta1 target (DENTT) shows
            tissue-specific nuclear and cytoplasmic localization and increases
            TGF-beta1-responsive transcription in primates
  JOURNAL   Biochim Biophys Acta 1728 (3), 163-180 (2005)
   PUBMED   15823505
  REMARK    GeneRIF: This paper characterizes monkey DENTT cDNA and makes a
            comparison with human and mouse DENTT
REFERENCE   7  (bases 1 to 2815)
  AUTHORS   Chai,Z., Sarcevic,B., Mawson,A. and Toh,B.H.
  TITLE     SET-related cell division autoantigen-1 (CDA1) arrests cell growth
  JOURNAL   J Biol Chem 276 (36), 33665-33674 (2001)
   PUBMED   11395479
REFERENCE   8  (bases 1 to 2815)
  AUTHORS   Ozbun,L.L., You,L., Kiang,S., Angdisen,J., Martinez,A. and
            Jakowlew,S.B.
  TITLE     Identification of differentially expressed nucleolar TGF-beta1
            target (DENTT) in human lung cancer cells that is a new member of
            the TSPY/SET/NAP-1 superfamily
  JOURNAL   Genomics 73 (2), 179-193 (2001)
   PUBMED   11318608
REFERENCE   9  (bases 1 to 2815)
  AUTHORS   Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
            Schadendorf,D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   10 (bases 1 to 2815)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA076199.1 and BC024270.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022117.3.
            
            Summary: This gene encodes a member of the testis-specific protein
            Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily.
            The encoded protein is localized to the nucleolus where it
            functions in chromatin remodeling and as an inhibitor of cell-cycle
            progression. This protein may play a role in the suppression of
            tumor growth. [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.79191.1,
                                           SRR3476690.914913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375442.8/ ENSP00000364591.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA076199.1         8-20
            14-2815             BC024270.1         1-2802
FEATURES             Location/Qualifiers
     source          1..2815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..2815
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /note="TSPY like 2"
                     /db_xref="GeneID:64061"
                     /db_xref="HGNC:HGNC:24358"
                     /db_xref="MIM:300564"
     exon            1..939
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2214
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /note="cell division autoantigen 1; cutaneous T-cell
                     lymphoma-associated tumor antigen se20-4; differentially
                     expressed nucleolar TGF-beta1 target; CTCL tumor antigen
                     se20-4; testis-specific protein Y encoded-like 2;
                     CASK-interacting nucleosome assembly protein; TSPY-like
                     protein 2; nuclear protein of 79 kDa; cutaneous T-cell
                     lymphoma-associated antigen se20-4;
                     differentially-expressed nucleolar TGF-beta1 target
                     protein; CTCL-associated antigen se20-4"
                     /codon_start=1
                     /product="testis-specific Y-encoded-like protein 2"
                     /protein_id="NP_071400.1"
                     /db_xref="CCDS:CCDS14350.1"
                     /db_xref="GeneID:64061"
                     /db_xref="HGNC:HGNC:24358"
                     /db_xref="MIM:300564"
                     /translation="MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQ
                     RPRLQEETEAAQVLADMRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIE
                     SGYGEAPPPTESLEALPTPEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLV
                     DPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQA
                     LEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRI
                     SILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGR
                     LVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPL
                     RYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDI
                     KISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNNESADDHETTDNN
                     ESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQDSSDSDNEAD
                     EASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKDQADYEDVI
                     EIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDVLQVPNG
                     WANPGKRGKTG"
     exon            940..1017
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1129
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1275
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1370
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..2050
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2815
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /note="hexamer: AATAAA"
     polyA_site      2815
                     /gene="TSPYL2"
                     /gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
                     SE204; TSPX"
                     /note="major polyA site"
ORIGIN      
        1 agagcgaggt ggtgaggaga gctggttgcg tgagtctcct cagctctgct taccggtgcg
       61 actagcggca gcgacgcggc taaaagcgaa ggggcgagtg cgagtcccct gagctgtacg
      121 aacgcggtcg ccatggaccg cccagatgag gggcctccgg ccaagacccg ccgcctgagc
      181 agctccgagt ctccacagcg cgacccgccc ccgccgccgc cgccgccgcc gctcctccga
      241 ctgccgctgc ctccacccca gcagcgcccg aggctccagg aggaaacgga ggcggcacag
      301 gtgctggccg atatgagggg ggtgggactg ggccccgcgc tgcccccgcc gcctccctat
      361 gtcattctcg aggagggggg gatccgcgca tacttcacgc tcggtgctga gtgtcccggc
      421 tgggattcta ccatcgagtc ggggtatggg gaggcgcccc cgcccacgga gagcctggaa
      481 gcactcccca ctcctgaggc ctcggggggg agcctggaaa tcgattttca ggttgtacag
      541 tcgagcagtt ttggtggaga gggggcccta gaaacctgta gcgcagtggg gtgggcgccc
      601 cagaggttag ttgacccgaa gagcaaggaa gaggcgatca tcatagtgga ggatgaggat
      661 gaggatgagc gggagagtat gaggagcagc aggaggcggc ggcggcggcg gaggaggaag
      721 cagaggaagg tgaagaggga aagcagagag agaaatgccg agaggatgga gagcatcctg
      781 caggcactgg aggatattca gctggatctg gaggcagtga acatcaaggc aggcaaagcc
      841 ttcctgcgtc tcaagcgcaa gttcatccag atgcgaagac ccttcctgga gcgcagagac
      901 ctcatcatcc agcatatccc aggcttctgg gtcaaagcat tcctcaacca ccccagaatt
      961 tcaattttga tcaaccgacg tgatgaagac attttccgct acttgaccaa tctgcaggta
     1021 caggatctca gacatatctc catgggctac aaaatgaagc tgtacttcca gactaacccc
     1081 tacttcacaa acatggtgat tgtcaaggag ttccagcgca accgctcagg ccggctggtg
     1141 tctcactcaa ccccaatccg ctggcaccgg ggccaggaac cccaggcccg tcgtcacggg
     1201 aaccaggatg cgagccacag ctttttcagc tggttctcaa accatagcct cccagaggct
     1261 gacaggattg ctgagattat caagaatgat ctgtgggtta accctctacg ctactacctg
     1321 agagaaaggg gctccaggat aaagagaaag aagcaagaaa tgaagaaacg taaaaccagg
     1381 ggcagatgtg aggtggtgat catggaagac gcccctgact attatgcagt ggaagacatt
     1441 ttcagcgaga tctcagacat tgatgagaca attcatgaca tcaagatctc tgacttcatg
     1501 gagaccaccg actacttcga gaccactgac aatgagataa ctgacatcaa tgagaacatc
     1561 tgcgacagcg agaatcctga ccacaatgag gtccccaaca acgagaccac tgataacaac
     1621 gagagtgctg atgaccacga aaccactgac aacaatgaga gtgcagatga caacaacgag
     1681 aatcctgaag acaataacaa gaacactgat gacaacgaag agaaccctaa caacaacgag
     1741 aacacttacg gcaacaactt cttcaaaggt ggcttctggg gcagccatgg caacaaccag
     1801 gacagcagcg acagtgacaa tgaagcagat gaggccagtg atgatgaaga taatgatggc
     1861 aacgaaggtg acaatgaggg cagtgatgat gatggcaatg aaggtgacaa tgaaggcagc
     1921 gatgatgacg acagagacat tgagtactat gagaaagtta ttgaagactt tgacaaggat
     1981 caggctgact acgaggacgt gatagagatc atctcagacg aatcagtgga agaagagggc
     2041 attgaggaag gcatccagca agatgaggac atctatgagg aaggaaacta tgaggaggaa
     2101 ggaagtgaag atgtctggga agaaggggaa gattcggacg actctgacct agaggatgtg
     2161 cttcaggtcc caaacggttg ggccaatccg gggaagaggg ggaaaaccgg ataagggttt
     2221 tccccttttg gggatcacct ctctgtatcc cccacccact atcccatttg ccctcctcct
     2281 cagctagggc cacgcggccc cacattgcac ttctgggggg tgaccgactt cgtacacggg
     2341 tttaaagttt atttttatgg tttagtcatt gcagagttct tattttgggg ggagggaaag
     2401 ggggctagtc cccttctttt ggccctccgc ccccgcaggc ttctgtgtgc tgctaactgt
     2461 atttattgtg atgccttggt cagggcccct ctacccactt ctcccagtca gttgtggccc
     2521 cagcccctct ccctgtgctg tgtggagtgg acaccctgac ccccgaagcg gggagggccg
     2581 ctgtggcctt cgtcacagcc gcgcagtgcc catggaggcg ctgctgccac cttcctctcc
     2641 caagttcttt ctccatccct ctcctcttcc cgccgcgccg ctagcccgcc tcggtgtcta
     2701 tgcaaggccg cttcgccatt gcggtattct ttgcggtatt cttgtccccg tcccccagaa
     2761 ggctcgcctc tccccgtgga ccctgttaat cccaataaaa ttctgagcaa gttca
//
