LOCUS       NM_001282469            1161 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens testis specific protein Y-linked 10 (TSPY10),
            transcript variant 1, mRNA.
ACCESSION   NM_001282469 XM_003403496
VERSION     NM_001282469.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1161)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1161)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC121114.1 and DB545400.1.
            
            On May 17, 2019 this sequence version replaced NM_001282469.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC121114.1, ERR279874.771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428845.6/ ENSP00000406407.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-945               BC121114.1         5-949
            946-1161            DB545400.1         280-495
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yp11.2"
     gene            1..1161
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /note="testis specific protein Y-linked 10"
                     /db_xref="GeneID:100289087"
                     /db_xref="HGNC:HGNC:37473"
     exon            1..532
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..973
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Testis-specific Y-encoded protein 3; Testis-specific
                     Y-encoded protein 1; Cancer/testis antigen 78"
                     /codon_start=1
                     /product="testis-specific Y-encoded protein 10 isoform 1"
                     /protein_id="NP_001269398.1"
                     /db_xref="CCDS:CCDS65365.1"
                     /db_xref="GeneID:100289087"
                     /db_xref="HGNC:HGNC:37473"
                     /translation="MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEA
                     VQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGP
                     MTPESALEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWA
                     NVIANHPQMSALITDEDEDMLSYMVSLEVEEEKHPVHLCKIMLFFRSNPYFQNKVITK
                     EYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEIL
                     CKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS"
     exon            533..610
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /inference="alignment:Splign:2.1.0"
     exon            611..722
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..868
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /inference="alignment:Splign:2.1.0"
     exon            869..950
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1161
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /note="hexamer: AATAAA"
     polyA_site      1161
                     /gene="TSPY10"
                     /gene_synonym="CT78; TSPY; TSPY1; TSPY3"
                     /note="major polyA site"
ORIGIN      
        1 ggcccttcgc gcgcagtccc ttagggggcg cctggaagcc cggcgcatgc gccctgaggg
       61 ctcgctgacc taccgggtgc cagagaggct gcggcagggt ttctgtggcg tgggtcgggc
      121 agcacaggcc ttggtgtgtg cgagtgccaa ggagggcacc gccttcagga tggaggctgt
      181 acaggagggg gcggccgggg tggagagtga gcaggcggct ttgggggagg aggcggtgct
      241 gctgttggat gacataatgg cggaggtgga ggtggtggcg gaggaggagg gcctcgtgga
      301 gcggcgggag gaggcccagc gggcacagca ggctgtgcct ggccctgggc ccatgacccc
      361 agagtctgca ctggaggagc tgctggccgt tcaggtggag ctggagccgg ttaatgccca
      421 agccaggaag gccttttctc ggcagcggga aaagatggag cggaggcgca agccccacct
      481 agaccgcaga ggcgccgtca tccagagcgt ccctggcttc tgggccaatg ttattgcaaa
      541 ccacccccag atgtcagccc tgatcactga cgaagatgaa gacatgctga gctacatggt
      601 cagcctggag gtggaagaag agaagcatcc tgttcatctc tgcaagatca tgttgttctt
      661 tcggagtaac ccctacttcc agaataaagt gattaccaag gaatatctgg tgaacatcac
      721 agaatacagg gcttctcatt ccactccaat tgagtggtat ccggattatg aagtggaggc
      781 ctatcgccgc agacaccaca acagcagcct taacttcttc aactggttct ctgaccacaa
      841 cttcgcagga tctaacaaga ttgctgagat cctatgtaag gacctgtggc gcaatcccct
      901 gcaatactac aagaggatga agccacctga agagggaaca gagacgtcag gggactccca
      961 gttgttgagt tgaatatgat ggagcatcag attttaccta atacagcaga actcctaaaa
     1021 agttacagcc atatgcagga cggcagtact cagcatggtc ttatgcacag gaactaaagg
     1081 aaaaacagat cgagtcacaa aaattcagga agagggggta aatgtggatt gtatggaatg
     1141 aaaaataaac attctcaagg a
//
