LOCUS       NM_004758               7698 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens TSPO associated protein 1 (TSPOAP1), transcript
            variant 1, mRNA.
ACCESSION   NM_004758
VERSION     NM_004758.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7698)
  AUTHORS   Wang,Q., Zhang,D., Feng,W., Guo,Y., Sun,X., Zhang,M., Guan,Z. and
            Duan,M.
  TITLE     Long noncoding RNA TSPOAP1 antisense RNA 1 negatively modulates
            type I IFN signaling to facilitate influenza A virus replication
  JOURNAL   J Med Virol 94 (2), 557-566 (2022)
   PUBMED   30968963
  REMARK    GeneRIF: Long noncoding RNA TSPOAP1 antisense RNA 1 negatively
            modulates type I IFN signaling to facilitate influenza A virus
            replication.
REFERENCE   2  (bases 1 to 7698)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 7698)
  AUTHORS   Ricigliano,V.A.G., Morena,E., Colombi,A., Tonietto,M., Hamzaoui,M.,
            Poirion,E., Bottlaender,M., Gervais,P., Louapre,C., Bodini,B. and
            Stankoff,B.
  TITLE     Choroid Plexus Enlargement in Inflammatory Multiple Sclerosis:
            3.0-T MRI and Translocator Protein PET Evaluation
  JOURNAL   Radiology 301 (1), 166-177 (2021)
   PUBMED   34254858
  REMARK    GeneRIF: Choroid Plexus Enlargement in Inflammatory Multiple
            Sclerosis: 3.0-T MRI and Translocator Protein PET Evaluation.
REFERENCE   4  (bases 1 to 7698)
  AUTHORS   Mencacci,N.E., Brockmann,M.M., Dai,J., Pajusalu,S., Atasu,B.,
            Campos,J., Pino,G., Gonzalez-Latapi,P., Patzke,C., Schwake,M.,
            Tucci,A., Pittman,A., Simon-Sanchez,J., Carvill,G.L., Balint,B.,
            Wiethoff,S., Warner,T.T., Papandreou,A., Soo,A., Rein,R.,
            Kadastik-Eerme,L., Puusepp,S., Reinson,K., Tomberg,T., Hanagasi,H.,
            Gasser,T., Bhatia,K.P., Kurian,M.A., Lohmann,E., Ounap,K.,
            Rosenmund,C., Sudhof,T.C., Wood,N.W., Krainc,D. and Acuna,C.
  TITLE     Biallelic variants in TSPOAP1, encoding the active-zone protein
            RIMBP1, cause autosomal recessive dystonia
  JOURNAL   J Clin Invest 131 (7) (2021)
   PUBMED   33539324
  REMARK    GeneRIF: Biallelic variants in TSPOAP1, encoding the active-zone
            protein RIMBP1, cause autosomal recessive dystonia.
REFERENCE   5  (bases 1 to 7698)
  AUTHORS   Tsai,C.C., Chen,T.Y., Tsai,K.J., Lin,M.W., Hsu,C.Y., Wu,D.C.,
            Tsai,E.M. and Hsieh,T.H.
  TITLE     NF-kappaB/miR-18a-3p and miR-4286/BZRAP1 axis may mediate
            carcinogenesis in Helicobacter pylori-Associated gastric cancer
  JOURNAL   Biomed Pharmacother 132, 110869 (2020)
   PUBMED   33113427
  REMARK    GeneRIF: NF-kappaB/miR-18a-3p and miR-4286/BZRAP1 axis may mediate
            carcinogenesis in Helicobacter pylori-Associated gastric cancer.
REFERENCE   6  (bases 1 to 7698)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7698)
  AUTHORS   Kahle,J.J., Gulbahce,N., Shaw,C.A., Lim,J., Hill,D.E.,
            Barabasi,A.L. and Zoghbi,H.Y.
  TITLE     Comparison of an expanded ataxia interactome with patient medical
            records reveals a relationship between macular degeneration and
            ataxia
  JOURNAL   Hum Mol Genet 20 (3), 510-527 (2011)
   PUBMED   21078624
REFERENCE   8  (bases 1 to 7698)
  AUTHORS   Bucan,M., Abrahams,B.S., Wang,K., Glessner,J.T., Herman,E.I.,
            Sonnenblick,L.I., Alvarez Retuerto,A.I., Imielinski,M., Hadley,D.,
            Bradfield,J.P., Kim,C., Gidaya,N.B., Lindquist,I., Hutman,T.,
            Sigman,M., Kustanovich,V., Lajonchere,C.M., Singleton,A., Kim,J.,
            Wassink,T.H., McMahon,W.M., Owley,T., Sweeney,J.A., Coon,H.,
            Nurnberger,J.I., Li,M., Cantor,R.M., Minshew,N.J., Sutcliffe,J.S.,
            Cook,E.H., Dawson,G., Buxbaum,J.D., Grant,S.F., Schellenberg,G.D.,
            Geschwind,D.H. and Hakonarson,H.
  TITLE     Genome-wide analyses of exonic copy number variants in a
            family-based study point to novel autism susceptibility genes
  JOURNAL   PLoS Genet 5 (6), e1000536 (2009)
   PUBMED   19557195
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 7698)
  AUTHORS   Mittelstaedt,T. and Schoch,S.
  TITLE     Structure and evolution of RIM-BP genes: identification of a novel
            family member
  JOURNAL   Gene 403 (1-2), 70-79 (2007)
   PUBMED   17855024
  REMARK    GeneRIF: RIMBP1 is identified in humans.
REFERENCE   10 (bases 1 to 7698)
  AUTHORS   Galiegue,S., Jbilo,O., Combes,T., Bribes,E., Carayon,P., Le Fur,G.
            and Casellas,P.
  TITLE     Cloning and characterization of PRAX-1. A new protein that
            specifically interacts with the peripheral benzodiazepine receptor
  JOURNAL   J Biol Chem 274 (5), 2938-2952 (1999)
   PUBMED   9915832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004687.2, BE246483.1, BC150279.1, BC146852.1, BC171787.1,
            AF039571.1, AB014512.2 and AI811889.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004758.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF039571.1, BC146852.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343736.9/ ENSP00000345824.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC004687.2         84786-84789
            5-35                BE246483.1         2-32
            36-711              BC150279.1         1-676
            712-5218            BC146852.1         1-4507
            5219-5974           BC171787.1         4508-5263
            5975-6602           AF039571.1         5297-5924
            6603-7694           AB014512.2         6388-7479
            7695-7698           AI811889.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..7698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..7698
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /note="TSPO associated protein 1"
                     /db_xref="GeneID:9256"
                     /db_xref="HGNC:HGNC:16831"
                     /db_xref="MIM:610764"
     exon            1..1208
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             876..6449
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /note="isoform a is encoded by transcript variant 1;
                     peripheral-type benzodiazepine receptor-associated protein
                     1; RIMS-binding protein 1; peripheral benzodiazepine
                     receptor-interacting protein; benzodiazepine receptor
                     (peripheral) associated protein 1; benzodiazapine receptor
                     peripheral-associated protein 1"
                     /codon_start=1
                     /product="peripheral-type benzodiazepine
                     receptor-associated protein 1 isoform a"
                     /protein_id="NP_004749.2"
                     /db_xref="CCDS:CCDS11605.1"
                     /db_xref="GeneID:9256"
                     /db_xref="HGNC:HGNC:16831"
                     /db_xref="MIM:610764"
                     /translation="MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIAD
                     TPPAALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPE
                     DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVR
                     RLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLS
                     ETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQ
                     RQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKE
                     QRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR
                     ATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQ
                     LEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQC
                     RSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPK
                     DLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPE
                     VDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEGPNENPEAELPLTA
                     GEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLTSLPPELADLSHSSGP
                     ELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSPSPEGLGEPPAVPYPRRLV
                     VLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAPPKAVLENLDLWAGPLH
                     ISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEITWVPGNSNLAHAIY
                     LNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWERLEQRAATLQFT
                     TLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYADGQKIME
                     VASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASLPARVS
                     CPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGSHED
                     PPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSS
                     TQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQE
                     EEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP
                     LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPG
                     QCPLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNG
                     PQASGRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKC
                     LEISIEYDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRL
                     PAWEKGEPERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAEL
                     VPARSPSETLAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDA
                     DGFYQGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYST
                     AHTTGPPPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNM
                     DVEAELPFRAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRT
                     PQAESQRTRRRRVQC"
     exon            1209..1316
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1445
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1625
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1817
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1895
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1979
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2069
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2192
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2297
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2348
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2369
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2574
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2747
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2863
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2973
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3804
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3956
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4334
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4574
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4766
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4767..5606
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5706
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5707..5858
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5859..6027
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6028..6099
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6100..6132
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6133..6236
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6237..6308
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6309..6419
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6420..6481
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6482..7698
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7677..7682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /note="hexamer: AATAAA"
     polyA_site      7698
                     /gene="TSPOAP1"
                     /gene_synonym="BZRAP1; DYT22; PBR-IP; PRAX-1; PRAX1;
                     RIM-BP1; RIMBP1"
                     /note="major polyA site"
ORIGIN      
        1 aattctgagg ctcagccctc ctcggagccc accatctcga ggctcctgga ctgtaaggga
       61 cccctgcagt ccccagagca gaggccagca ggggctgaga ctatgaggca agcagcccat
      121 cgacccaggc ctccttagga ccagcccagc cacccagcaa gcgaaagagc agcagcagag
      181 agcagagccg gagataaagg accacagcgg accactgggg atcaccccca gcagctcctg
      241 aagcctctgg ccgggctgag gggttgcgac agacggccag acccacagac actgacagac
      301 acacaacgac accgatgcac acagctgcac gacactgaca cactcagata caaccaggga
      361 cagcatcaca tactgccaca gccctgcaat acagacaccc acacacacac acacaaacaa
      421 ctggcaactc tgaaatgggc agacagtgac acacagcacc acccccctca acacacagaa
      481 gtgggggcac ccatcttccc aacacatgag acagcattga cctgcacgga cagacctgga
      541 gacacacaca cgcaccctca cccaggcgca gctgtcggtg gcctctgcac atcctcccta
      601 cccccacagg gacaccctcg ctcctccaca tactcgcgca cacacacagc taccagcaaa
      661 catagctcac atacccctgg ctccagctcc agcagccctg gcgccttctg cagcctcctt
      721 tgtgggtggg gaagagctca gccaaccttg gatggagcgt cggtgaagca agagctcaga
      781 ggggagaggg gctggcctgg catgaccctc gccagtcccc ccacctggct gggtgatgtc
      841 ccccggcccg ggttctgggg ccccttggca gtaccatgga gcaactgaca accctcccac
      901 ggcctgggga ccctggagcc atggagccat gggcactgcc cacctggcat agctggactc
      961 caggtcgagg gggtgaacct agcagtgcag ccccaagcat cgctgatact cctccggcag
     1021 ctctgcagct tcaagaactg aggtctgagg agagttccaa gcccaaagga gacgggagct
     1081 ccaggcccgt ggggggaact gaccctgaag gagcagaggc ttgtctgccc agcctgggcc
     1141 agcaagcatc cagctctgga cccgcctgcc agaggccaga ggatgaggaa gtggaggctt
     1201 tcctgaaggc caagctgaat atgagctttg gggacaggcc caatctggag ctgctgaggg
     1261 ccctggggga gctgcggcag cgctgtgcca tccttaagga ggaaaaccag atgctgagga
     1321 agagcagctt ccctgagaca gaagagaagg tgcggaggct gaagaggaag aacgccgagc
     1381 tggcggtcat tgccaagcgc ctggaggaga gggcccgaaa gctgcaggaa acgaacctga
     1441 gggtggtgag tgcccccttg ccccggccgg ggaccagctt ggagttgtgt cggaaggccc
     1501 tagcccgcca gcgagcccgg gacctcagtg agacagccag tgcactgctg gccaaggaca
     1561 agcagattgc tgccttgcag cgggagtgca gggagctgca ggccaggctc actctggtgg
     1621 gcaaggaggg tccccagtgg ctccacgtgc gggacttcga tcggctgctg cgcgagtccc
     1681 agcgggaggt gctgcggctg cagaggcaga tcgcgctgcg caaccagcgg gagacgctcc
     1741 cgctcccgcc gtcctggccc ccgggccctg ctctccaggc cagagcaggg gcgcctgctc
     1801 ccggggcccc gggagaggcc acgccccagg aggatgcgga caacctaccc gtgattctag
     1861 gggagccaga gaaagagcag agggtgcagc agctggaatc ggagctcagc aagaagcgga
     1921 agaaatgcga gagcctggag caggaagccc ggaaaaagca gaggcgatgt gaggagctgg
     1981 aactgcagct gagacaagcg cagaatgaga atgcccgcct ggtggaggag aactcccggc
     2041 tcagtgggag agccacagag aaggagcagg tggagtggga gaatgcggag ctgaggggcc
     2101 agctcctggg ggtgacacag gagagggact cagcccttcg caagagccag ggcctgcaga
     2161 gcaagctgga gagcctggag caagtgctga agcacatgcg ggaggtggcc cagcggcggc
     2221 agcagctgga ggtggagcat gaacaggctc ggctcagcct acgggagaag caggaggagg
     2281 tccggagact gcagcaggcc caggctgaag cccagaggga acatgaagga gccgtgcagc
     2341 tgctggagtc taccttggat tccatgcagg cccgggttcg agagctcgaa gaacagtgcc
     2401 gcagccaaac cgagcagttc agcctcctgg cacaggaact ccaggctttc cgcctgcacc
     2461 cgggcccctt ggatctgctc acatctgccc tggactgtgg gagccttgga gactgcccac
     2521 cacccccctg ctgctgctcc attccccagc cttgccgggg gtctggcccc aaagaccttg
     2581 acctcccgcc gggctcccct gggcgctgca ccccaaagtc ttccgagcct gcccctgcca
     2641 ctctcactgg ggtccctcga aggacagcca agaaggcaga gtctctctcc aactcctccc
     2701 actccgagtc catccacaac agccccaagt catgccctac acctgaggtg gacacagcca
     2761 gtgaggtaga ggagctggag gcagacagtg tctccctgct cccagctgcg ccagagggca
     2821 gccggggagg agccaggatc caggtcttcc tagcacgtta tagctacaac ccctttgagg
     2881 gtcccaatga gaatccagaa gcagagcttc cgctgacagc tggcgagtac atctacatct
     2941 atggcaacat ggatgaggat ggcttttttg aaggagagct catggatggc cgaaggggcc
     3001 tggtcccttc caattttgta gagcgtgtgt cggatgatga cctcctgacc tccctccctc
     3061 cagagctggc cgatttgtcc cacagctcag gccctgaact cagtttcctg agtgtaggtg
     3121 ggggtggcag cagtagcggg ggccaaagca gtgtgggaag gagccagccc agacctgagg
     3181 aggaggatgc aggggacgag ctcagtctga gcccatcacc ggagggcctg ggcgagcctc
     3241 ctgccgtgcc ttacccccgc cgtctggtgg tcctcaagca gctggcccac agcgtggtgc
     3301 tggcctggga gccgcctcct gagcaagtgg agctacacgg cttccatatc tgtgtgaatg
     3361 gggagctgcg acaggccctg gggcctgggg cgccacccaa ggccgtgctg gagaacctgg
     3421 acctgtgggc cgggcccctt cacatttctg tccaggccct gactagccgg ggcagctctg
     3481 acccactgcg ctgttgcttg gcggtgggtg cccgggccgg agtggtgccc agccagctgc
     3541 gggtccatcg gttgacagcc acatctgctg agatcacctg ggtgcccggc aatagcaact
     3601 tggcccatgc catctacctc aatggggaag agtgcccacc tgccagcccc agtacctact
     3661 gggccacctt ctgccactta cggcctggca caccctatca ggcccaagtg gaggctcagc
     3721 tcccacccca agggccctgg gaaccaggct gggagaggct ggagcagcgg gctgccaccc
     3781 tgcagttcac cacactccca gcaggcccac ctgatgcccc tctggatgtg cagatcgagc
     3841 ctgggccctc ccctgggatc ttgatcatca gttggctccc agtcaccatc gatgctgctg
     3901 gcacatccaa cggtgtccgg gtcacaggct atgccatcta cgctgatggg cagaagatca
     3961 tggaggtggc ctcacccacg gcaggcagtg tactggtgga gttgtcccag ctgcagctgc
     4021 tgcaggtgtg tcgtgaggtg gtcgtgcgca ccatgtcgcc ccacggggag tcggcggact
     4081 ccatcccggc tcctatcact cccgccctgg ctccggccag cctgccagcc cgagtctcct
     4141 gcccctcacc gcacccaagc ccagaggcca gagcgcccct tgcttcagcc tccccagggc
     4201 ctggagaccc cagctctcct ctccagcacc ctgctcccct tggaactcaa gagcctccag
     4261 gagcaccccc tgcaagccct tccagagaga tggcaaaagg gtcccacgag gaccctccag
     4321 caccttgctc ccaggaggag gctggggcag cagtgctggg cacctcagag gagaggacag
     4381 ccagcacatc taccctgggt gagaaggacc ctggccccgc agctccctca ctggccaagc
     4441 aggaggccga gtggactgca ggagaggcct gtccggcctc cagctccacc cagggagcac
     4501 gggcccagca ggcgccaaat accgagatgt gccaaggagg agacccaggg tctgggctga
     4561 ggcccagggc tgagaaggag gacacagcag agcttggggt tcatctggtg aactccctcg
     4621 tggaccacgg ccgcaactca gacctgtcag acatccagga ggaagaggaa gaggaggagg
     4681 aggaggagga agaggagctg ggttccagga cttgctcctt ccagaagcag gttgctggca
     4741 acagcatcag ggagaatggg gccaagtccc agcccgaccc cttttgtgag actgacagcg
     4801 atgaggagat cttggagcag atcctggagc tgcccctcca gcagttctgt agcaagaagc
     4861 tctttagcat cccggaggag gaggaagagg aagaggagga cgaggaggag gagaagtcag
     4921 gggcaggctg ttcttcccga gaccctggcc cgcctgaacc tgcattgctg gggctgggct
     4981 gtgacagtgg tcagccccga agacctggcc agtgtccctt gtctcctgag tcctccaggg
     5041 ctggagactg cctggaagac atgcctggat tagttggtgg aagcagccgg aggagaggag
     5101 ggggctcccc tgagaagccc ccaagccgca ggcggcctcc agatccccga gaacactgca
     5161 gccgacttct cagcaacaat gggccccagg cctctggacg actgggcccc acacgggaga
     5221 ggggtggcct ccccgtaatt gagggcccca ggactggact agaggctagc gggagaggcc
     5281 ggctgggccc ttcccggagg tgctcccgtg gccgggcgct ggagcctggc ctggccagct
     5341 gcctttcccc caagtgcttg gaaatcagca ttgaatatga ttcggaggat gagcaggagg
     5401 cgggcagcgg gggcatcagc atcaccagct cctgctaccc tggagatggg gaggcctggg
     5461 gcacagcaac tgtaggaagg cccagggggc ctccgaaggc caattcaggc cccaagccct
     5521 acccacgcct cccagcctgg gagaaagggg aaccagagcg gagaggccgc agtgcgacgg
     5581 gcagagccaa ggagccactc tcccgggcaa cagagaccgg agaggccaga gggcaggacg
     5641 gctctgggcg gaggggcccc cagaagagag gtgtccgagt cctcaggcca agcactgcag
     5701 agctagtccc tgcgaggagc ccctcagaaa cactggctta ccagcaccta cccgtcagga
     5761 tctttgtggc tctgtttgac tatgaccccg tgtcaatgtc gcccaatcct gatgctggag
     5821 aagaagagct tcccttccga gagggtcaga tcctgaaggt gtttggggac aaggatgccg
     5881 atggcttcta ccagggcgaa ggtgggggcc ggacaggcta cattccctgc aacatggtgg
     5941 ctgaggtggc tgtggacagc cctgctggga gacagcaact gctccagcgg ggttatttgt
     6001 ccccagatat tctccttgag ggctcaggga atggtccgtt tgtgtactcc acagcccaca
     6061 caactgggcc tcctcccaag ccccgccgct ccaagaaagc tgagtcggaa ggccctgccc
     6121 agccctgtcc aggcccccct aagctggtcc cctctgctga cctgaaagct ccccactcca
     6181 tggtggctgc atttgactac aacccccagg agagttcccc caatatggac gtggaggcag
     6241 agctgccctt ccgggcaggg gatgtcatta ctgtgtttgg gggcatggac gatgacggtt
     6301 tctactatgg ggaattaaat ggacaaaggg gcctggttcc atccaacttc ctggagggcc
     6361 ctgggcctga ggcaggcggc ctggacaggg aacccaggac accccaggct gagagtcaga
     6421 gaacgaggag gagaagagtc cagtgctaga tggagataga tatatgtaga gagagcaaca
     6481 tgactggggc tgcaccacac aagggtcccc agggccccca ggtgggcctt gtacccccag
     6541 ctctggcagc gcccccagga ttgaacgtgg ggagccccag ggcagaagcg agaaggtgtg
     6601 gggtttcttc tccaagggga agcagctcct caggaggctg ggctctggga agaaggagtg
     6661 aagctgtggc ccatcctgca ggcagaagag gccctgagag gcccccagat cactgtctct
     6721 gctgagcagg gaaggctcag actgggccca gagcccccgt tcttctgcgt taacactgtg
     6781 gcattcagag ggaatcaaag agccttggtg aaggtcagag ctaaatggct ccttaaggat
     6841 gaactctcta gagaagcacc ttcctcctac aggaggggaa actgagccca cagtgagtat
     6901 gtaacttgac caaggtcact gagccaggac tggacccagg accctcgcgt cctggtccac
     6961 ccacctcgtc tactagtgtc ccacagtgct gcgctagtcc cttctgccac ccttcccagt
     7021 cccaggacgg gccctggagg gagaaaggag cctgtgcccc ctgatggctc tggctgtcct
     7081 gatcctgtct tccctcccct gaaggaaagt ttgcactgga ttttattgga gccccatctc
     7141 cccagcgggc aggcgggcgg agcctgtata tatgtatata ctcagtgcct cagttcagct
     7201 tcctccacct cgcttccact gcacaggccc aggaaggaga aaggccaagc caaagtgggc
     7261 cccaccctgc ccccgtcgtg ctccatcctt ccctgccggg gcctgctggc ccctgtaagg
     7321 tcccgccccc aaagaccctg gggccagcgg ggccgaaagc ggagttgggt ttgccttatt
     7381 ttgctcattg gattcaagtt cttttgcata gttttcttct aacccctgtt ggagtccagg
     7441 ggctggagaa aaggacagat ttatgcagct attttcatac attccctgtt cagagtgggg
     7501 taggggttct ccgccgttac ccgatccact ccatccccca ccctctgagg ggtgagtgtg
     7561 tctttgcatg tttcctttgc tgtggtggga gatagtttga ctgaaccccc accttgacct
     7621 tggtctccag gggtgtggaa tggtggggga atttgtttaa aaagacattt tattataata
     7681 aagtctattt tcacaaaa
//
