LOCUS       NM_001159726             831 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens translocator protein 2 (TSPO2), transcript variant 2,
            mRNA.
ACCESSION   NM_001159726
VERSION     NM_001159726.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 831)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 831)
  AUTHORS   Manceau,H., Lefevre,S.D., Mirmiran,A., Hattab,C., Sugier,H.R.,
            Schmitt,C., Peoc'h,K., Puy,H., Ostuni,M.A., Gouya,L. and
            Lacapere,J.J.
  TITLE     TSPO2 translocates 5-aminolevulinic acid into human erythroleukemia
            cells
  JOURNAL   Biol Cell 112 (4), 113-126 (2020)
   PUBMED   31989647
REFERENCE   3  (bases 1 to 831)
  AUTHORS   Marginedas-Freixa,I., Hattab,C., Bouyer,G., Halle,F., Chene,A.,
            Lefevre,S.D., Cambot,M., Cueff,A., Schmitt,M., Gamain,B.,
            Lacapere,J.J., Egee,S., Bihel,F., Le Van Kim,C. and Ostuni,M.A.
  TITLE     TSPO ligands stimulate ZnPPIX transport and ROS accumulation
            leading to the inhibition of P. falciparum growth in human blood
  JOURNAL   Sci Rep 6, 33516 (2016)
   PUBMED   27641616
  REMARK    GeneRIF: TSPO ligands can induce Plasmodium falciparum death by
            increasing the uptake of porphyrins through a TSPO2-VDAC complex,
            which leads to an accumulation of reactive oxygen species.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 831)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., He,X., Chanock,S. and Lan,Q.
  TITLE     PTEN identified as important risk factor of chronic obstructive
            pulmonary disease
  JOURNAL   Respir Med 103 (12), 1866-1870 (2009)
   PUBMED   19625176
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 831)
  AUTHORS   Fan,J., Rone,M.B. and Papadopoulos,V.
  TITLE     Translocator protein 2 is involved in cholesterol redistribution
            during erythropoiesis
  JOURNAL   J Biol Chem 284 (44), 30484-30497 (2009)
   PUBMED   19729679
  REMARK    GeneRIF: identify the TSPO2 family of proteins as mediators of
            cholesterol redistribution-dependent erythroblast maturation during
            mammalian erythropoiesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC144710.1 and AI052224.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-699               BC144710.1         1-699
            700-831             AI052224.1         1-132               c
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..831
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /note="translocator protein 2"
                     /db_xref="GeneID:222642"
                     /db_xref="HGNC:HGNC:21256"
                     /db_xref="MIM:619409"
     exon            1..91
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            92..284
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..624
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /note="benzodiazapine receptor (peripheral)-like 1;
                     peripheral-type benzodiazepine receptor-like protein 1"
                     /codon_start=1
                     /product="translocator protein 2"
                     /protein_id="NP_001153198.1"
                     /db_xref="CCDS:CCDS34444.1"
                     /db_xref="GeneID:222642"
                     /db_xref="HGNC:HGNC:21256"
                     /db_xref="MIM:619409"
                     /translation="MRLQGAIFVLLPHLGPILVWLFTRDHMSGWCEGPRMLSWCPFYK
                     VLLLVQTAIYSVVGYASYLVWKDLGGGLGWPLALPLGLYAVQLTISWTVLVLFFTVHN
                     PGLALLHLLLLYGLVVSTALIWHPINKLAALLLLPYLAWLTVTSALTYHLWRDSLCPV
                     HQPQPTEKSD"
     exon            285..426
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..824
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      799..804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /note="hexamer: AATAAA"
     polyA_site      824
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /note="major polyA site"
ORIGIN      
        1 tccaagtgcc agaggagtgc tgtggagaaa agaagtccat ggaagccagg agatgggcaa
       61 ggtgtggcct ggggttggag agagctcaga gattttgcct cttcaaggtg aatgcggctt
      121 caaggggcta tctttgtgct cctgccccac ctggggccca tcctggtctg gctgttcact
      181 cgtgatcaca tgtctggttg gtgtgagggc ccgaggatgc tgtcctggtg cccattctac
      241 aaagtcttat tgcttgtaca gacagccatc tactctgtcg tgggctatgc ctcctacctg
      301 gtgtggaagg acctgggagg gggcttgggg tggcccctgg ccctgcctct tggcctctat
      361 gctgttcagc tcaccatcag ctggactgtc ctggttctct ttttcacagt ccacaaccct
      421 ggtctggccc tgctgcacct gctgctgctg tatgggctgg tggtgagcac agcactgatc
      481 tggcatccca tcaacaaact ggctgccctg ttactgctgc cctacctagc ctggctcacc
      541 gtgacttcag ccctcaccta ccacctgtgg agggacagcc tttgtccagt gcaccagcct
      601 cagcccacgg agaagagtga ctgaggccct agggcatggg agaggaggga cgcccagggt
      661 ggggaggaag agtctgcaag cagggctgtg gagttagggt tcaccccaat gggaccaccc
      721 tcctgggtcc cctggtgccg tttttcctta gaaatcagag aaatgggaaa gggggggaaa
      781 ctgattttac acttaaataa taaaatccta ttagtaactc tgaaaaaaaa a
//
