LOCUS       NM_001010873            1045 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens translocator protein 2 (TSPO2), transcript variant 1,
            mRNA.
ACCESSION   NM_001010873 XM_167072
VERSION     NM_001010873.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1045)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1045)
  AUTHORS   Manceau,H., Lefevre,S.D., Mirmiran,A., Hattab,C., Sugier,H.R.,
            Schmitt,C., Peoc'h,K., Puy,H., Ostuni,M.A., Gouya,L. and
            Lacapere,J.J.
  TITLE     TSPO2 translocates 5-aminolevulinic acid into human erythroleukemia
            cells
  JOURNAL   Biol Cell 112 (4), 113-126 (2020)
   PUBMED   31989647
REFERENCE   3  (bases 1 to 1045)
  AUTHORS   Marginedas-Freixa,I., Hattab,C., Bouyer,G., Halle,F., Chene,A.,
            Lefevre,S.D., Cambot,M., Cueff,A., Schmitt,M., Gamain,B.,
            Lacapere,J.J., Egee,S., Bihel,F., Le Van Kim,C. and Ostuni,M.A.
  TITLE     TSPO ligands stimulate ZnPPIX transport and ROS accumulation
            leading to the inhibition of P. falciparum growth in human blood
  JOURNAL   Sci Rep 6, 33516 (2016)
   PUBMED   27641616
  REMARK    GeneRIF: TSPO ligands can induce Plasmodium falciparum death by
            increasing the uptake of porphyrins through a TSPO2-VDAC complex,
            which leads to an accumulation of reactive oxygen species.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1045)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., He,X., Chanock,S. and Lan,Q.
  TITLE     PTEN identified as important risk factor of chronic obstructive
            pulmonary disease
  JOURNAL   Respir Med 103 (12), 1866-1870 (2009)
   PUBMED   19625176
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1045)
  AUTHORS   Fan,J., Rone,M.B. and Papadopoulos,V.
  TITLE     Translocator protein 2 is involved in cholesterol redistribution
            during erythropoiesis
  JOURNAL   J Biol Chem 284 (44), 30484-30497 (2009)
   PUBMED   19729679
  REMARK    GeneRIF: identify the TSPO2 family of proteins as mediators of
            cholesterol redistribution-dependent erythroblast maturation during
            mammalian erythropoiesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031778.1, BU655765.1, BU657409.1, BC137565.1 and AI052224.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001010873.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU655765.1, BC137560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373161.6/ ENSP00000362255.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL031778.1         88075-88105
            32-115              BU655765.1         11-94
            116-251             BU657409.1         70-205
            252-920             BC137565.1         1-669
            921-1045            AI052224.1         8-132               c
FEATURES             Location/Qualifiers
     source          1..1045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1045
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /note="translocator protein 2"
                     /db_xref="GeneID:222642"
                     /db_xref="HGNC:HGNC:21256"
                     /db_xref="MIM:619409"
     exon            1..312
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..505
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..845
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /note="benzodiazapine receptor (peripheral)-like 1;
                     peripheral-type benzodiazepine receptor-like protein 1"
                     /codon_start=1
                     /product="translocator protein 2"
                     /protein_id="NP_001010873.1"
                     /db_xref="CCDS:CCDS34444.1"
                     /db_xref="GeneID:222642"
                     /db_xref="HGNC:HGNC:21256"
                     /db_xref="MIM:619409"
                     /translation="MRLQGAIFVLLPHLGPILVWLFTRDHMSGWCEGPRMLSWCPFYK
                     VLLLVQTAIYSVVGYASYLVWKDLGGGLGWPLALPLGLYAVQLTISWTVLVLFFTVHN
                     PGLALLHLLLLYGLVVSTALIWHPINKLAALLLLPYLAWLTVTSALTYHLWRDSLCPV
                     HQPQPTEKSD"
     exon            506..647
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..1045
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1020..1025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /note="hexamer: AATAAA"
     polyA_site      1045
                     /gene="TSPO2"
                     /gene_synonym="BZRPL1"
                     /note="major polyA site"
ORIGIN      
        1 agatgtgctg ccgcattcgt gactagaaaa gagtccccag gaatttctgg ctcctgcctt
       61 cagattgtga actttccagg ttggtagatc agcttaggta gaacagttct cggtgagggc
      121 cagctacata cctggctaag cgctgcccac tgcagaaaag ctcatcaccc gggacctgat
      181 ctccaggact cagaagcact tggaggaagg cctattcact tagaagcagt taccagtgct
      241 gggcagtgtc ctccaagtgc cagaggagtg ctgtggagaa aagaagtcca tggaagccag
      301 gagatgggca agattttgcc tcttcaaggt gaatgcggct tcaaggggct atctttgtgc
      361 tcctgcccca cctggggccc atcctggtct ggctgttcac tcgtgatcac atgtctggtt
      421 ggtgtgaggg cccgaggatg ctgtcctggt gcccattcta caaagtctta ttgcttgtac
      481 agacagccat ctactctgtc gtgggctatg cctcctacct ggtgtggaag gacctgggag
      541 ggggcttggg gtggcccctg gccctgcctc ttggcctcta tgctgttcag ctcaccatca
      601 gctggactgt cctggttctc tttttcacag tccacaaccc tggtctggcc ctgctgcacc
      661 tgctgctgct gtatgggctg gtggtgagca cagcactgat ctggcatccc atcaacaaac
      721 tggctgccct gttactgctg ccctacctag cctggctcac cgtgacttca gccctcacct
      781 accacctgtg gagggacagc ctttgtccag tgcaccagcc tcagcccacg gagaagagtg
      841 actgaggccc tagggcatgg gagaggaggg acgcccaggg tggggaggaa gagtctgcaa
      901 gcagggctgt ggagttaggg ttcaccccaa tgggaccacc ctcctgggtc ccctggtgcc
      961 gtttttcctt agaaatcaga gaaatgggaa agggggggaa actgatttta cacttaaata
     1021 ataaaatcct attagtaact ctgaa
//
