LOCUS       NM_000714                836 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens translocator protein (TSPO), transcript variant PBR,
            mRNA.
ACCESSION   NM_000714
VERSION     NM_000714.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 836)
  AUTHORS   Zhang,M., Qian,X.H., Hu,J., Zhang,Y., Lin,X., Hai,W., Shi,K.,
            Jiang,X., Li,Y., Tang,H.D. and Li,B.
  TITLE     Integrating TSPO PET imaging and transcriptomics to unveil the role
            of neuroinflammation and amyloid-beta deposition in Alzheimer's
            disease
  JOURNAL   Eur J Nucl Med Mol Imaging 51 (2), 455-467 (2024)
   PUBMED   37801139
  REMARK    GeneRIF: Integrating TSPO PET imaging and transcriptomics to unveil
            the role of neuroinflammation and amyloid-beta deposition in
            Alzheimer's disease.
REFERENCE   2  (bases 1 to 836)
  AUTHORS   Blum,N., Mirian,C., Maier,A.D., Mathiesen,T.I., Vilhardt,F. and
            Haslund-Vinding,J.L.
  TITLE     Translocator protein (TSPO) expression in neoplastic cells and
            tumor-associated macrophages in meningiomas
  JOURNAL   J Neuropathol Exp Neurol 82 (12), 1020-1032 (2023)
   PUBMED   37952221
  REMARK    GeneRIF: Translocator protein (TSPO) expression in neoplastic cells
            and tumor-associated macrophages in meningiomas.
REFERENCE   3  (bases 1 to 836)
  AUTHORS   Peyronneau,M.A., Kuhnast,B., Nguyen,D.L., Jego,B., Sayet,G.,
            Caille,F., Lavisse,S., Gervais,P., Stankoff,B., Sarazin,M.,
            Remy,P., Bouilleret,V., Leroy,C. and Bottlaender,M.
  TITLE     [18F]DPA-714: Effect of co-medications, age, sex, BMI and TSPO
            polymorphism on the human plasma input function
  JOURNAL   Eur J Nucl Med Mol Imaging 50 (11), 3251-3264 (2023)
   PUBMED   37291448
  REMARK    GeneRIF: [[18]F]DPA-714: Effect of co-medications, age, sex, BMI
            and TSPO polymorphism on the human plasma input function.
REFERENCE   4  (bases 1 to 836)
  AUTHORS   Garland,E.F., Dennett,O., Lau,L.C., Chatelet,D.S., Bottlaender,M.,
            Nicoll,J.A.R. and Boche,D.
  TITLE     The mitochondrial protein TSPO in Alzheimer's disease: relation to
            the severity of AD pathology and the neuroinflammatory environment
  JOURNAL   J Neuroinflammation 20 (1), 186 (2023)
   PUBMED   37580767
  REMARK    GeneRIF: The mitochondrial protein TSPO in Alzheimer's disease:
            relation to the severity of AD pathology and the neuroinflammatory
            environment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 836)
  AUTHORS   Conti,E., Grana,D., Angiulli,F., Karantzoulis,A., Villa,C.,
            Combi,R., Appollonio,I., Ferrarese,C. and Tremolizzo,L.
  CONSRTM   ImmunAD-Brianza Network
  TITLE     TSPO Modulates Oligomeric Amyloid-beta-Induced Monocyte Chemotaxis:
            Relevance for Neuroinflammation in Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 95 (2), 549-559 (2023)
   PUBMED   37574731
  REMARK    GeneRIF: TSPO Modulates Oligomeric Amyloid-beta-Induced Monocyte
            Chemotaxis: Relevance for Neuroinflammation in Alzheimer's Disease.
REFERENCE   6  (bases 1 to 836)
  AUTHORS   Yakovlev,A.G., Ruffo,M., Jurka,J. and Krueger,K.E.
  TITLE     Comparison of repetitive elements in the third intron of human and
            rodent mitochondrial benzodiazepine receptor-encoding genes
  JOURNAL   Gene 155 (2), 201-205 (1995)
   PUBMED   7721091
REFERENCE   7  (bases 1 to 836)
  AUTHORS   Chang,Y.J., McCabe,R.T., Rennert,H., Budarf,M.L., Sayegh,R.,
            Emanuel,B.S., Skolnick,P. and Strauss,J.F. 3rd.
  TITLE     The human 'peripheral-type' benzodiazepine receptor: regional
            mapping of the gene and characterization of the receptor expressed
            from cDNA
  JOURNAL   DNA Cell Biol 11 (6), 471-480 (1992)
   PUBMED   1326278
REFERENCE   8  (bases 1 to 836)
  AUTHORS   Riond,J., Mattei,M.G., Kaghad,M., Dumont,X., Guillemot,J.C., Le
            Fur,G., Caput,D. and Ferrara,P.
  TITLE     Molecular cloning and chromosomal localization of a human
            peripheral-type benzodiazepine receptor
  JOURNAL   Eur J Biochem 195 (2), 305-311 (1991)
   PUBMED   1847678
REFERENCE   9  (bases 1 to 836)
  AUTHORS   Awad,M. and Gavish,M.
  TITLE     Peripheral-type benzodiazepine receptors in human cerebral cortex,
            kidney, and colon
  JOURNAL   Life Sci 49 (16), 1155-1161 (1991)
   PUBMED   1654492
REFERENCE   10 (bases 1 to 836)
  AUTHORS   Sieghart,W., Eichinger,A., Riederer,P. and Jellinger,K.
  TITLE     Comparison of benzodiazepine receptor binding in membranes from
            human or rat brain
  JOURNAL   Neuropharmacology 24 (8), 751-759 (1985)
   PUBMED   3018615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP420304.1, AF075589.1 and
            BC001110.2.
            
            On Nov 22, 2018 this sequence version replaced NM_000714.5.
            
            Summary: Present mainly in the mitochondrial compartment of
            peripheral tissues, the protein encoded by this gene interacts with
            some benzodiazepines and has different affinities than its
            endogenous counterpart. The protein is a key factor in the flow of
            cholesterol into mitochondria to permit the initiation of steroid
            hormone synthesis. Alternatively spliced transcript variants have
            been reported; one of the variants lacks an internal exon and is
            considered non-coding, and the other variants encode the same
            protein. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (PBR) consists of four exons and
            encodes the protein PBR.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.69304.1,
                                           SRR1163658.202768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337554.8/ ENSP00000338004.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               BP420304.1         26-510
            486-804             AF075589.1         334-652
            805-836             BC001110.2         800-831
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..836
                     /gene="TSPO"
                     /gene_synonym="BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS;
                     pk18; PKBS; PTBR; TSPO1"
                     /note="translocator protein"
                     /db_xref="GeneID:706"
                     /db_xref="HGNC:HGNC:1158"
                     /db_xref="MIM:109610"
     exon            1..46
                     /gene="TSPO"
                     /gene_synonym="BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS;
                     pk18; PKBS; PTBR; TSPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            47..257
                     /gene="TSPO"
                     /gene_synonym="BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS;
                     pk18; PKBS; PTBR; TSPO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..585
                     /gene="TSPO"
                     /gene_synonym="BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS;
                     pk18; PKBS; PTBR; TSPO1"
                     /note="mitochondrial benzodiazepine receptor;
                     peripheral-type benzodiazepine receptor; benzodiazepine
                     peripheral binding site"
                     /codon_start=1
                     /product="translocator protein"
                     /protein_id="NP_000705.2"
                     /db_xref="CCDS:CCDS33661.1"
                     /db_xref="GeneID:706"
                     /db_xref="HGNC:HGNC:1158"
                     /db_xref="MIM:109610"
                     /translation="MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHP
                     PHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGA
                     RQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHG
                     WRGGRRLPE"
     exon            258..396
                     /gene="TSPO"
                     /gene_synonym="BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS;
                     pk18; PKBS; PTBR; TSPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..836
                     /gene="TSPO"
                     /gene_synonym="BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS;
                     pk18; PKBS; PTBR; TSPO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      814..819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPO"
                     /gene_synonym="BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS;
                     pk18; PKBS; PTBR; TSPO1"
                     /note="hexamer: AATAAA"
     polyA_site      836
                     /gene="TSPO"
                     /gene_synonym="BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS;
                     pk18; PKBS; PTBR; TSPO1"
                     /note="major polyA site"
ORIGIN      
        1 aactcctgcc aggcagtgcc cttcccggag cgtgccctcg ccgctgagct cccctgaaca
       61 gcagctgcag cagccatggc cccgccctgg gtgcccgcca tgggcttcac gctggcgccc
      121 agcctggggt gcttcgtggg ctcccgcttt gtccacggcg agggtctccg ctggtacgcc
      181 ggcctgcaga agccctcgtg gcacccgccc cactgggtgc tgggccctgt ctggggcacg
      241 ctctactcag ccatggggta cggctcctac ctggtctgga aagagctggg aggcttcaca
      301 gagaaggctg tggttcccct gggcctctac actgggcagc tggccctgaa ctgggcatgg
      361 ccccccatct tctttggtgc ccgacaaatg ggctgggcct tggtggatct cctgctggtc
      421 agtggggcgg cggcagccac taccgtggcc tggtaccagg tgagcccgct ggccgcccgc
      481 ctgctctacc cctacctggc ctggctggcc ttcacgacca cactcaacta ctgcgtatgg
      541 cgggacaacc atggctggcg tgggggacgg cggctgccag agtgagtgcc cggcccacca
      601 gggactgcag ctgcaccagc aggtgccatc acgcttgtga tgtggtggcc gtcacgcttt
      661 catgaccact gggcctgcta gtctgtcagg gccttggccc aggggtcagc agagcttcag
      721 aggtggcccc acctgagccc ccacccggga gcagtgtcct gtgctttctg catgcttaga
      781 gcatgttctt ggaacatgga attttataag ctgaataaag tttttgactt ccttta
//
