LOCUS       NM_006675               4322 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tetraspanin 9 (TSPAN9), transcript variant 1, mRNA.
ACCESSION   NM_006675 NM_031285
VERSION     NM_006675.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4322)
  AUTHORS   Qi,Y., Lv,J., Liu,S., Sun,L., Wang,Y., Li,H., Qi,W. and Qiu,W.
  TITLE     TSPAN9 and EMILIN1 synergistically inhibit the migration and
            invasion of gastric cancer cells by increasing TSPAN9 expression
  JOURNAL   BMC Cancer 19 (1), 630 (2019)
   PUBMED   31242895
  REMARK    GeneRIF: expression of the membrane protein TSPAN9 regulates
            gastric cancer cell migration and invasion by inhibiting the
            FAK-RAS-ERK1/2 signaling pathway. The extracellular secretory
            protein EMILIN1 can increase this tumor suppressive effect by
            promoting the expression of TSPAN9.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4322)
  AUTHORS   Li,P.Y., Lv,J., Qi,W.W., Zhao,S.F., Sun,L.B., Liu,N., Sheng,J. and
            Qiu,W.S.
  TITLE     Tspan9 inhibits the proliferation, migration and invasion of human
            gastric cancer SGC7901 cells via the ERK1/2 pathway
  JOURNAL   Oncol Rep 36 (1), 448-454 (2016)
   PUBMED   27177197
  REMARK    GeneRIF: The proliferation, migration and invasion of human gastric
            cancer SGC7901 cells were significantly inhibited by overexpression
            of Tspan9.
REFERENCE   3  (bases 1 to 4322)
  AUTHORS   Stiles,K.M. and Kielian,M.
  TITLE     Role of TSPAN9 in Alphavirus Entry and Early Endosomes
  JOURNAL   J Virol 90 (9), 4289-4297 (2016)
   PUBMED   26865714
  REMARK    GeneRIF: TSPAN9 is an endosomal tetraspanin whose depletion has a
            pronounced effect on the entry of several viruses that fuse in the
            early endosome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4322)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   5  (bases 1 to 4322)
  AUTHORS   Yamaguchi,T., Nakaoka,H., Yamamoto,K., Fujikawa,T., Kim,Y.I.,
            Yano,K., Haga,S., Katayama,K., Shibusawa,T., Park,S.B., Maki,K.,
            Kimura,R. and Inoue,I.
  TITLE     Genome-wide association study of degenerative bony changes of the
            temporomandibular joint
  JOURNAL   Oral Dis 20 (4), 409-415 (2014)
   PUBMED   23746317
REFERENCE   6  (bases 1 to 4322)
  AUTHORS   Kotha,J., Zhang,C., Longhurst,C.M., Lu,Y., Jacobs,J., Cheng,Y. and
            Jennings,L.K.
  TITLE     Functional relevance of tetraspanin CD9 in vascular smooth muscle
            cell injury phenotypes: a novel target for the prevention of
            neointimal hyperplasia
  JOURNAL   Atherosclerosis 203 (2), 377-386 (2009)
   PUBMED   18799160
  REMARK    GeneRIF: tetraspanin CD9 has a role in determining vascular smooth
            muscle cell injury phenotypes
REFERENCE   7  (bases 1 to 4322)
  AUTHORS   Protty,M.B., Watkins,N.A., Colombo,D., Thomas,S.G., Heath,V.L.,
            Herbert,J.M., Bicknell,R., Senis,Y.A., Ashman,L.K.,
            Berditchevski,F., Ouwehand,W.H., Watson,S.P. and Tomlinson,M.G.
  TITLE     Identification of Tspan9 as a novel platelet tetraspanin and the
            collagen receptor GPVI as a component of tetraspanin microdomains
  JOURNAL   Biochem J 417 (1), 391-400 (2009)
   PUBMED   18795891
  REMARK    GeneRIF: Findings suggest a role for Tspan9 in regulating platelet
            function in concert with other platelet tetraspanins and their
            associated proteins.
REFERENCE   8  (bases 1 to 4322)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   9  (bases 1 to 4322)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   10 (bases 1 to 4322)
  AUTHORS   Serru,V., Dessen,P., Boucheix,C. and Rubinstein,E.
  TITLE     Sequence and expression of seven new tetraspans
  JOURNAL   Biochim Biophys Acta 1478 (1), 159-163 (2000)
   PUBMED   10719184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125807.9, BC071881.1,
            AC005912.1 and AC005865.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006675.4.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            Alternatively spliced transcripts encoding the same protein have
            been identified. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027366.1, SRR3476690.487745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000011898.10/ ENSP00000011898.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC125807.9         87379-87439
            62-1431             BC071881.1         1-1370
            1432-3464           AC005912.1         1-2033              c
            3465-4322           AC005865.1         45011-45868
FEATURES             Location/Qualifiers
     source          1..4322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33-p13.32"
     gene            1..4322
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /note="tetraspanin 9"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
     exon            1..75
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     exon            76..142
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     exon            143..222
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..879
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /note="transmembrane 4 superfamily member tetraspan NET-5;
                     new EST tetraspan 5; tspan-9"
                     /codon_start=1
                     /product="tetraspanin-9"
                     /protein_id="NP_006666.1"
                     /db_xref="CCDS:CCDS8520.1"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
                     /translation="MARGCLCCLKYMMFLFNLIFWLCGCGLLGVGIWLSVSQGNFATF
                     SPSFPSLSAANLVIAIGTIVMVTGFLGCLGAIKENKCLLLSFFIVLLVILLAELILLI
                     LFFVYMDKVNENAKKDLKEGLLLYHTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVL
                     GENTVPDRCCMENSQGCGRNATTPLWRTGCYEKVKMWFDDNKHVLGTVGMCILIMQIL
                     GMAFSMTLFQHIHRTGKKYDA"
     exon            223..414
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     exon            415..489
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     exon            490..591
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     exon            592..723
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     exon            724..807
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     exon            808..4322
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4295..4300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /note="hexamer: AATAAA"
     polyA_site      4322
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /note="major polyA site"
ORIGIN      
        1 gtttccgctg gcggcggcgg cggcggcggt gccggagcgc gagcagagcg gagaccccca
       61 ggtcctgcgg gcgcggaata tcctggaacc ttcttttgtt tgtcagcagc caaggtgttt
      121 ccaggaagtt cagagagaac agaatttaag aagtgcaaca tggccagggg ctgcctctgc
      181 tgcttgaagt acatgatgtt cctcttcaat ttgatattct ggctctgtgg ctgtgggctg
      241 ctgggagtgg gcatctggct ctccgtgtcc caaggcaact ttgccacctt ctcccccagc
      301 ttcccttcgt tgtctgcagc caacctggtc attgccatag gcaccattgt catggtgacg
      361 ggcttcctcg gctgcctggg ggccatcaag gaaaacaagt gcctcctcct cagctttttc
      421 atcgtcctgt tggtcatcct cctagcagag ctgatcttac tcatcctctt ctttgtctac
      481 atggacaagg tgaacgagaa cgccaagaag gacctgaagg aaggcctgct gctgtaccac
      541 accgagaaca acgtggggct gaagaacgcc tggaacatca tccaggctga gatgcgatgc
      601 tgtggtgtca ctgactacac agactggtac ccagtgctgg gggagaacac ggttcccgac
      661 cgctgctgca tggagaactc ccagggctgc gggcgcaacg ccaccacgcc tttgtggaga
      721 acgggctgct atgaaaaggt gaagatgtgg ttcgatgaca ataagcacgt gctgggcacg
      781 gtggggatgt gcatcctcat catgcagatc ctgggcatgg ccttctccat gaccctcttc
      841 cagcacatcc accggactgg taagaagtac gacgcatgag cgggctggcc gggagtgccc
      901 accccgccct gctgccctgt ggagggaaga ggattgagct ttgtgtcacc tgcctgcgct
      961 ctccagatat gacccctgca cccacccccc acagcctgcc ctaccccacc taccctgcct
     1021 cagcctcgga cttctcagtg ggtggagtgc cagggaggag gaggcacacg gagacctggg
     1081 gctcggggcc cctggattcc tgcatctgca tatgcgtatt tgccaaagac gacagggtgg
     1141 gctggggtgc gctccggagg aacccccggc actgatgggc ttctgcccct gcccttcctc
     1201 acactgacac tttgtcccca catggggtgg ggagcagagt gcccgccccg tggagatacc
     1261 gccccagcgg gggctgcgac atccatggcc accatggggc acctggcggg gcgggggtct
     1321 gccggcctct gggcaaggcc cctggagcat ctcgcccagg ctttttatac cttacaatgt
     1381 aactttttta ttttatttta ctctatgatt attcaggaat attatctctc agataagttt
     1441 agggttagat ttctgatttg taacttttta ctgtgttgat ttctttaatg gtttgacttt
     1501 ttttccctga gggtgaggga tgggtgggaa gagaggacat ctgtccagtc tcaatcagga
     1561 cagaccaccg tgcgacaccc aggaggctct cggatggggc gcgcctgcgc cctcagaacg
     1621 tgtgggaagg agggggcgtg gacaggacac gggaccttgc caggcctggt gtctgaggac
     1681 aggagcctgg gagaggcggg tggagcgtga agcaggctgg aggtgcccct gcacgggagg
     1741 tggcgtttgc taaccaatcg agctggaaat gccagggcag gggggcccca cggtgctgtg
     1801 gcagagctag aggggtcctt agacttttca ctgatgagca gttgttggtt ttttctttct
     1861 cccttcctcc cgctctctgc tggcacgcga ggcttcccct tccaccccat gtgggtattc
     1921 ccacaacagg ttctgcacac cccagttatt tcacagacat tcctgctaga aactgtcaga
     1981 caaatacctc tctagttcgg atgctgctca ctttccccct tgcttctgga aggggaagca
     2041 gtccttaggt tttgctgtgc tgggacagtg gcaggggacc cacaggggtg aggacccacg
     2101 gtcctccccg ccagccttgc tcagctgtgg gttgccctgc tgggaaggag ggaatcacgt
     2161 ccacctgggt cccaagatct tcgcctcctt ccctggggcc acggacatca gcagtgggtt
     2221 gggtggcgat tatatcatct gtgatcccaa ggagaagaaa tacagaaaac ccaagagagg
     2281 tcagactggc tcttgttacc ggagccacgg gaagaaagca gccggagtca cgcacgtgca
     2341 gagctgggca tgggagagaa acgggctggg gagtgaggcc aggagtggga ttcagctgca
     2401 gcagggcgcc ccctccaaac tgcagctggt ctggcttact gttttgccgt tcaaaaaggt
     2461 cgcgaatccg tgggactgag cacggggacc tcacccgcta gccagcgtct gctgcacttg
     2521 atcaggtggg gccttggtgg gcggctgcct ttcctataca gtttgtcttg tcaccctggt
     2581 ttcccactgg ggccaggtct cttctccagc ctccacctgc ctgtctgatc caagagctga
     2641 gacacggcca cccagcacca gtcactcctc tgttcacctt aagtaacaca caaatcggga
     2701 acaggaggac agaaccgttg gcattatcag gattcgtgtt ttgtgggggt gggagtggag
     2761 agtagggtgg tcttgtgagt tgtgcagggt gaagaccgct tccctgagac aggggcagtg
     2821 gtgctgatgg aatgtggggg aggcccacat ttgagcaaag ctgccctgcc cttgtcccct
     2881 ggcctggctt cctggtaagg agtttcagcc gcctccgcag gaacccccaa agtgcagatt
     2941 ccggagcaga cacatccggg cggagagact cagcagacaa gtgctgcagt tgcacggtgg
     3001 gacccggggc ctcgtgcgtt ttttgctgtg ggtggggtgg gtgggttggt ttatgcctat
     3061 caatgcaatt tttaattttt gttaatatca acagcaaaag cctagtgcat tgggagatgt
     3121 gcaacctccc tgaaaatctt ttctgtttct ggagtacttc aggggtggcc tctggcccca
     3181 gagcctttgc cacagtgctc ccaccagccc ccacctcatc cgtctgtttg cagagcctca
     3241 tctacaggtc cccacgctgc cttctttact cactctgcgc ttggccgttt tgttatttgg
     3301 cttagtctac attgggcgga agtctgtgtg cacagagtgg gtgttccttc gagccccttc
     3361 cactcagagg gccacaccca gcgatgccag tgaaggtggc acagcctctc ttcagtttct
     3421 cctgactgtg atctcactgg ggtagaattc ccctgagaga attccctcac tcacggctcc
     3481 ctttgccaga gtcagttcaa tcaggtctga tgtgagcaat ttacacactt gtctcagaaa
     3541 gtccctcagg gtttgtagag gactgcaggg gggcatccgc tgcagactca gcctttctct
     3601 gcagccatcc tgcagtgggg gtgagcgggc acaggctgag aactgctctt gggtggtgga
     3661 agcaggtgtc acggtgcaag tctccccctg cacccctccc ccagcttgag ccgtgtcacc
     3721 cccctctccc tccagcatgg gcctgtgtct caggctctct ggaaggtggc cctgccccgg
     3781 accctcttgc aggtgtcctg gtttgacttg gaactagatg gccatctttc caggctttgg
     3841 tggcccaaga gcagtctggg tggatggaag tggctgtccc ctcctctcca gcccctgccc
     3901 acccactggt ggaggtgcta actagcaggg acgtggcata ggatgggagc tgggcgtgag
     3961 gtgcttgggg tccattcttt gtccctcagc ttctcagagt ccggccagcc cttgtgttcc
     4021 cgtgccccac actttcctcc tccccactgc agtgagtcaa tagtccaggg tggggcctgg
     4081 cctccctgcc ctgattgggg actcaggagg tgaggcctgg ggggcttcct gccccctcct
     4141 tgcccacctg cctgcccccg ggcagcacgg gagggagagc agggtgagca cgcttgttgg
     4201 tttcagatgc actttctgct tgcattgccg tatctgtgcg ttccttcatc ctggtcctgg
     4261 ctttatggaa caccatgttt ttagcatgtt tttaaataaa aacggataaa gtgtcaaaag
     4321 ca
//
