LOCUS       NM_004615               1742 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens tetraspanin 7 (TSPAN7), mRNA.
ACCESSION   NM_004615
VERSION     NM_004615.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Lu,B., Liu,Y., Yao,Y., Zhu,D., Zhang,X., Dong,K., Xu,X., Lv,D.,
            Zhao,Z., Zhang,H., Yang,X., Fu,W., Huang,R., Cao,J., Chu,J., Pan,X.
            and Cui,X.
  TITLE     Unveiling the unique role of TSPAN7 across tumors: a pan-cancer
            study incorporating retrospective clinical research and
            bioinformatic analysis
  JOURNAL   Biol Direct 19 (1), 72 (2024)
   PUBMED   39175035
  REMARK    GeneRIF: Unveiling the unique role of TSPAN7 across tumors: a
            pan-cancer study incorporating retrospective clinical research and
            bioinformatic analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Mrozowska,M., Gornicki,T., Olbromski,M., Partynska,A.I.,
            Dziegiel,P. and Rusak,A.
  TITLE     New insights into the role of tetraspanin 6, 7, and 8 in physiology
            and pathology
  JOURNAL   Cancer Med 13 (14), e7390 (2024)
   PUBMED   39031113
  REMARK    GeneRIF: New insights into the role of tetraspanin 6, 7, and 8 in
            physiology and pathology.
            Review article
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   McLaughlin,K., Acreman,S., Nawaz,S., Cutteridge,J., Clark,A.,
            Knudsen,J.G., Denwood,G., Spigelman,A.F., Manning Fox,J.E.,
            Singh,S.P., MacDonald,P.E., Hastoy,B. and Zhang,Q.
  TITLE     Loss of tetraspanin-7 expression reduces pancreatic beta-cell
            exocytosis Ca2+ sensitivity but has limited effect on systemic
            metabolism
  JOURNAL   Diabet Med 39 (12), e14984 (2022)
   PUBMED   36264270
  REMARK    GeneRIF: Loss of tetraspanin-7 expression reduces pancreatic
            beta-cell exocytosis Ca[2+] sensitivity but has limited effect on
            systemic metabolism.
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Perot,B.P. and Menager,M.M.
  TITLE     Tetraspanin 7 and its closest paralog tetraspanin 6: membrane
            organizers with key functions in brain development, viral
            infection, innate immunity, diabetes and cancer
  JOURNAL   Med Microbiol Immunol 209 (4), 427-436 (2020)
   PUBMED   32468130
  REMARK    GeneRIF: Tetraspanin 7 and its closest paralog tetraspanin 6:
            membrane organizers with key functions in brain development, viral
            infection, innate immunity, diabetes and cancer.
            Review article
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   McLaughlin,K.A., Tombs,M.A. and Christie,M.R.
  TITLE     Autoimmunity to tetraspanin-7 in type 1 diabetes
  JOURNAL   Med Microbiol Immunol 209 (4), 437-445 (2020)
   PUBMED   32314012
  REMARK    GeneRIF: Autoimmunity to tetraspanin-7 in type 1 diabetes.
            Review article
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Serru,V., Le Naour,F., Billard,M., Azorsa,D.O., Lanza,F.,
            Boucheix,C. and Rubinstein,E.
  TITLE     Selective tetraspan-integrin complexes (CD81/alpha4beta1,
            CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting
            tetraspan interactions
  JOURNAL   Biochem J 340 (Pt 1) (Pt 1), 103-111 (1999)
   PUBMED   10229664
REFERENCE   7  (bases 1 to 1742)
  AUTHORS   Takagi,S., Fujikawa,K., Imai,T., Fukuhara,N., Fukudome,K.,
            Minegishi,M., Tsuchiya,S., Konno,T., Hinuma,Y. and Yoshie,O.
  TITLE     Identification of a highly specific surface marker of T-cell acute
            lymphoblastic leukemia and neuroblastoma as a new member of the
            transmembrane 4 superfamily
  JOURNAL   Int J Cancer 61 (5), 706-715 (1995)
   PUBMED   7768645
REFERENCE   8  (bases 1 to 1742)
  AUTHORS   Virtaneva,K.I., Emi,N., Marken,J.S., Aruffo,A., Jones,C.,
            Spurr,N.K. and Schroder,J.P.
  TITLE     Chromosomal localization of three human genes coding for A15, L6,
            and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of
            proteins
  JOURNAL   Immunogenetics 39 (5), 329-334 (1994)
   PUBMED   8168850
REFERENCE   9  (bases 1 to 1742)
  AUTHORS   Li,S.H., McInnis,M.G., Margolis,R.L., Antonarakis,S.E. and
            Ross,C.A.
  TITLE     Novel triplet repeat containing genes in human brain: cloning,
            expression, and length polymorphisms
  JOURNAL   Genomics 16 (3), 572-579 (1993)
   PUBMED   8325628
REFERENCE   10 (bases 1 to 1742)
  AUTHORS   Emi,N., Kitaori,K., Seto,M., Ueda,R., Saito,H. and Takahashi,T.
  TITLE     Isolation of a novel cDNA clone showing marked similarity to
            ME491/CD63 superfamily
  JOURNAL   Immunogenetics 37 (3), 193-198 (1993)
   PUBMED   8420826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB475293.1, D29808.1 and
            AA757687.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_004615.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface glycoprotein and may have a
            role in the control of neurite outgrowth. It is known to complex
            with integrins. This gene is associated with X-linked cognitive
            disability and neuropsychiatric diseases such as Huntington's
            chorea, fragile X syndrome and myotonic dystrophy. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018036.1, AB062057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378482.7/ ENSP00000367743.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB475293.1         174-183
            11-1741             D29808.1           1-1731
            1742-1742           AA757687.1         11-11               c
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..1742
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /note="tetraspanin 7"
                     /db_xref="GeneID:7102"
                     /db_xref="HGNC:HGNC:11854"
                     /db_xref="MIM:300096"
     exon            1..86
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..755
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /note="T-cell acute lymphoblastic leukemia associated
                     antigen 1; transmembrane 4 superfamily member 2;
                     transmembrane 4 superfamily 2b; tetraspanin protein;
                     transmembrane protein A15; cell surface glycoprotein A15;
                     CD231 antigen; membrane component, X chromosome, surface
                     marker 1; tspan-7; membrane component chromosome X surface
                     marker 1"
                     /codon_start=1
                     /product="tetraspanin-7"
                     /protein_id="NP_004606.2"
                     /db_xref="CCDS:CCDS14248.1"
                     /db_xref="GeneID:7102"
                     /db_xref="HGNC:HGNC:11854"
                     /db_xref="MIM:300096"
                     /translation="MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTL
                     GTYISLIAENSTNAPYVLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAE
                     LVAGISGFVFRHEIKDTFLRTYTDAMQTYNGNDERSRAVDHVQRSLSCCGVQNYTNWS
                     TSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKGCYDLVTSFMETNMGIIAG
                     VAFGIAFSQLIGMLLACCLSRFITANQYEMV"
     exon            87..275
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /inference="alignment:Splign:2.1.0"
     exon            276..350
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /inference="alignment:Splign:2.1.0"
     exon            351..446
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /inference="alignment:Splign:2.1.0"
     exon            447..602
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /inference="alignment:Splign:2.1.0"
     exon            603..686
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /inference="alignment:Splign:2.1.0"
     exon            687..762
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1742
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1720..1725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /note="hexamer: AATAAA"
     polyA_site      1742
                     /gene="TSPAN7"
                     /gene_synonym="A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1;
                     TALLA-1; TM4SF2; TM4SF2b; XLID58"
                     /note="major polyA site"
ORIGIN      
        1 gtagtatggc atcgaggaga atggagacca aacctgtgat aacctgtctc aaaaccctcc
       61 tcatcatcta ctccttcgtc ttctggatca ctggggtgat cctgctggct gttggagtct
      121 ggggcaaact tactctgggc acctatatct cccttattgc cgagaactcc acaaatgctc
      181 cctatgtgct catcggaact ggcaccacta ttgttgtctt tggcctgttt ggatgctttg
      241 ctacatgtcg tggtagccca tggatgctga aactgtatgc catgtttctg tccctggtgt
      301 tcctggctga gctcgtagct ggcatttcag ggtttgtgtt tcgtcatgag atcaaggaca
      361 ccttcctgag gacttacacg gacgctatgc agacttacaa tggcaatgat gagaggagcc
      421 gggcagtgga ccatgtgcag cgcagcctga gctgctgtgg tgtgcagaac tacaccaact
      481 ggagcaccag cccctacttc ctggagcatg gcatcccccc cagctgctgc atgaacgaaa
      541 ctgattgtaa tccccaggat ctacacaatc tgactgtggc cgccaccaaa gttaaccaga
      601 agggttgtta tgatctggta actagtttca tggagactaa catgggaatc atcgctggag
      661 tggcgtttgg aatcgcattc tcccagttaa ttggcatgct gctggcctgc tgtctgtccc
      721 ggttcatcac ggccaatcag tatgagatgg tgtaaggaga agtctttcaa gaatgacgga
      781 ataagagacc tgttttaaaa aggaactgca gcaatctttg aaagacttcc aaagaatgtt
      841 agagcacagt acataataca cttgccctgc tccctctccc ccttacccca caacgtgcaa
      901 ctgacactcc cacccagtct ctgctccacc tttcagccca cgtcacgtgt agtgtccatt
      961 ttgtgaagcc ctgttgtgcc acagagtgta gccaggtccc cctgcagcta gtcctagtga
     1021 acctcacccc gaggccctgc atgggccagc ccctccatct gtacttggtc caactgcaac
     1081 tcatcatcgg tgactggtta tcacaccatc gctggcccct ttgggccctg catgtagtgt
     1141 gggaggctcc tgttagctcc tcactgtggt aaatgccaca cacctttaag tagataagca
     1201 gacgatagtt atctgttctt ttgacttaat ctcatttggt ttgattttcc ctctactaag
     1261 gctttcctac cttcttcagg ctgcctaaga catgtaacga aacacttcaa taattgtcca
     1321 tgaggagaaa aaaagcatgt gtcatgcatg aaggaaactg aacttgaggt ggcctccttg
     1381 cttgttacat acctgggtat gtgtaggcag tttagtgcat ctttgcctct cggttgaaac
     1441 ctgtataacc ctgttacaaa gctgtgttgt tgcttcttgt gaaggccatg atattttgtt
     1501 tttccccaat taattgctat tgtgttattt tactacttct ctctgtattt tttcttgcat
     1561 tgacattata gacattgagg acctcatcca aacaatttaa aaatgagtgt gaagggggaa
     1621 caagtcaaaa tatttttaaa agatcttcaa aagtaatgcc tctgtctagc atgccaacaa
     1681 gaatgcattg atattgtgaa catttgtgat atatgtatta ataaatagag caattacaag
     1741 ca
//
